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6021
The Dose-Dependent Effects of Fluorocitrate on the Metabolism and Activity of Astrocytes and Neurons
Published 2025-01-01“…Whether FC at such concentrations may affect neuronal metabolism and function <i>in vivo</i> remains unclear. Methods: We examined the effects of FC on the ATP levels and Ca<sup>2+</sup> activity of the astrocytes and neurons in the motor cortices of living mice using two-photon microscopy. …”
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6022
Acupuncture Ameliorates Alzheimer’s-Like Cognitive Impairment and Pathological Changes via Regulating the Intestinal Fungal Community in APP/PS1 Mice
Published 2025-04-01“…However, the potential regulatory effects of acupuncture on the fungal microbiota have been largely overlooked.Methods: APP/PS1 mice were used as AD animal model and randomly divided into the AD model (AD) group, the acupuncture (Ac) group, and the probiotics (Pr) group. …”
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6023
Screening results correlating to personality disorder traits in a new employee population of People&#39;s Republic of China
Published 2016-10-01“…To understand the current mental status and further improve the mental health level of the new employee population of People&rsquo;s Republic of China, we conducted a cross-sectional study to screen the prevalence and correlates of personality disorder (PD) traits in this population.Methods: This study included all male participants who were new employees (those who had started working in approximately the last three months) from 12 machinery factories in People&rsquo;s Republic of China. …”
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6024
Identifying Key Prognostic Indicators for Relapse and Chronic Epilepsy in Autoimmune Encephalitis: Insights from a Multicenter Retrospective Study
Published 2024-12-01“…Qingwei Lai,1,* Yue Chen,1,* Wei Wang,2,* Zhangxu Lian,3,* Tengfei Liu,4 Chunmei Wen5 1Department of Neurology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People’s Republic of China; 2Department of Neurology, Yancheng First People’s Hospital, Yancheng, People’s Republic of China; 3Department of Neurology, Xuzhou Central Hospital, Xuzhou, People’s Republic of China; 4Department of Neurology, Xuzhou Mining Group General Hospital, Xuzhou, People’s Republic of China; 5Department of Neurology, Yancheng Third People’s Hospital, Yancheng, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qingwei Lai, Department of Neurology, Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou, Jiangsu, 221002, People’s Republic of China, Tel +8651685802193, Email lqw8696@163.comObjective: The aims of this study were to investigate clinical factors associated with encephalitis relapse and chronic epilepsy development, and to evaluate the effectiveness of immunotherapy on encephalitis relapse.Methods: Patients with autoimmune encephalitis diagnosed as positive for neuronal surface antibodies in five general hospitals were included. …”
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6025
Strategic Optimization of Nanoparticle Characteristics to Enhance Tumor Targeting and Doxorubicin Delivery
Published 2025-05-01“…To improve its specificity and therapeutic efficacy, multivalent targeting strategies are being developed.Methods: A chimeric polypeptide consisting of an elastin-like polypeptides (ELP) copolymer with a repeating IL-4 receptor-specific targeting peptide, AP-1, and a (GGCGSCGSC)2 sequence encoding 6 cysteine residues (C6) at the carboxyl-terminus for Dox conjugation was designed. …”
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6026
Comparison Between Norepinephrine Alone Versus Norepinephrine/Vasopressin Combination for Resuscitation in Septic Shock
Published 2021-05-01“…They were randomly divided into two equal groups; NE group (received NE infusion) and VP/NE group (received NE and VP infusion). …”
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6027
Association of serum lactate dehydrogenase levels with non-alcoholic fatty liver disease and advanced hepatic fibrosis in the United States: a cross-sectional study using NHANES da...
Published 2025-07-01“…LDH levels were measured using an enzymatic rate method. A fatty liver index (FLI) greater than or equal to 60 and an NAFLD fibrosis score (NFS) higher than 0.676 were found to be indicative of hepatic steatosis and advanced hepatic fibrosis. …”
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6028
Malassezia Globosa Aggravates Atopic Dermatitis by Influencing the Th1/Th2 Related Cytokines in Mouse Models
Published 2025-04-01“…Zhuoxuan Wu,1– 3,* Huiyuan Yu,1– 3,* Zunyi Chen,1– 3 Wei Liu,1– 3 Ping Xia1– 3 1Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2Department of Dermatology, Wuhan No.1 hospital, Wuhan, 430022, People’s Republic of China; 3Hubei Province and Key Laboratory of Skin Infection and Immunity, Wuhan, 430022, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ping Xia, Department of Dermatology, Wuhan No.1 hospital, Wuhan, 430022, People’s Republic of China, Tel +86 13886130960, Email alicexiaping@gmail.comPurpose: To establish atopic dermatitis (AD) mouse models infected with Malassezia globosa and study its effects and potential mechanisms.Methods: Twenty - four male BALB/c mice were randomly allocated into four groups: control, AD, M (normal mice treated with olive oil fungus suspension), and AD + M (AD mice treated with the same suspension). …”
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6029
The efficacy of training on the four quadrant brain processes on cognitive functions of students with mathematical disorders
Published 2023-11-01“…Both boys and girls are equally affected by mathematical disorders, and they usually start displaying problematic behaviors as soon as they begin math classes in school. …”
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6030
Exploring Potential Gender-Based Disparities in Referral for Transplant, Activation on the Waitlist and Kidney Transplantation in a Canadian Cohort
Published 2024-07-01“…Conclusion: Gender-based barriers to any of (or in this case each of) referral, activation, or transplantation result in inequities in access; identification of disparities at these critical decision points is an important first step toward ensuring equal access for all.…”
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6031
Image Classification Model Based on Contrastive Learning With Dynamic Adaptive Loss
Published 2025-01-01“…These experimental results fully demonstrate the effectiveness and feasibility of the proposed method.…”
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6032
GluN2B mRNA expression and molecular sequence in the brain of pigeons (Columba livia)
Published 2025-04-01“…Objectives: The current study sought to ascertain the mRNA expression and establish the complementary DNA (cDNA) sequences of pigeon brain's glutamate receptor 2B of N-methyl-D-aspartate (GluN2B) type. Material and Methods: Adult pigeons (Columba livia; n = 8, sharing an equal number of males and females) were used. …”
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6033
Association Between 10 Autoimmune Diseases and Risk of Pulmonary Tuberculosis: A Mendelian Randomization Study
Published 2025-06-01“…We performed a Mendelian randomization (MR) study to determine the causal genetic connections between liability to autoimmune diseases (AIDs) and PTB.Methods: After rigorous assessment, potential candidate SNPs for 10 AIDs and PTB were extracted from GWAS datasets. …”
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6034
Effects of Na/Ca/Fe intermetallic interactions on nitrogen transformations in high-alkali coal pyrolysis
Published 2025-03-01“…Na, Ca, Fe mono-metal and poly-metals were added to deashed coal by equal volume impregnation and sequential impregnation methods, and nitrogen transformation was studied in fixed-bed pyrolysis of high-alkali coal. …”
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6035
Dihydrosanguinarine enhances tryptophan metabolism and intestinal immune function via AhR pathway activation in broilers
Published 2025-07-01“…Subsequently, equal concentrations of sanguinarine and its metabolites were separately added to the diets. …”
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6036
Prevalence of Onchocerciasis and Associated Factors among Adults Aged ≥ 15 Years in Semen Bench District, Bench Maji Zone, Southwest Ethiopia: Community Based Cross-Sectional Study...
Published 2019-01-01“…Methods. Community based cross-sectional study was conducted on 553 study participants selected by multistage sampling in April 2018. …”
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6037
Final-Year Dental Students’ Perceived Confidence: Competencies in General Dentistry
Published 2025-06-01“…Both in-house training and outplacement equally improve the levels of competency development. …”
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6038
Time to Occurrence of Incontinence-Associated Dermatitis: An Experimental Animal Study
Published 2025-04-01“…Junfang Duan,1,* Yan Zhang,2,* Dajiang Yuan,3 Xiaoru Wang,1 Jian Peng,4 Junli Wang,1 Xiaojuan Liang,1 Chenli Xu1 1Department of Critical Care Medicine, The Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 2General Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 3Shanxi Cardiovascular Hospital, Taiyuan, 030024, People’s Republic of China; 4Anhui Institute of Pediatric Research, Anhui Provincial Children’s Hospital, Anhui, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chenli Xu, Department of Critical Care Medicine, Second Hospital of Shanxi Medical University, No. 382 of Wuyi Road, Xinghualing District, Taiyuan, 030001, People’s Republic of China, Tel +8619834513692, Email xuchenli0531@163.comObjective: To establish an animal model of Incontinence-Associated Dermatitis (IAD) and investigate inflammatory factor changes to determine the time frame for IAD onset.Methods: Twenty-eight male SPF mice were randomly assigned to four groups. …”
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6039
The Effect of Drug&ndash;Drug Interactions on the Pharmacokinetics of Isavuconazole: A Comprehensive Review
Published 2025-06-01“…Additionally, we aimed to evaluate whether the duration of combination therapy modulates the magnitude of DDIs and provide references for clinical medication.Methods: The literature concerning the interactions of isavuconazole was systematically retrieved from three retrieval platforms, PUBMED, EMBASE, and the Cochrane Library, using the search terms: “isavuconazole” or “isavuconazonium” or “Cresemba” and “interact&ast;”, or “cotreatment”, or “coadministration”, or “combination”, or “concomitant”. …”
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6040
A Qualitative Model of the Firm’s Sustainability Reporting(SR) Requirements in the Iranian Capital Market, Inspired by the Global Reporting Initiative (GRI) and the Sustainability...
Published 2025-04-01“…Finally, after the distribution of 200 instruments, the sample size equals 180 research experts, sampling methods (judgmental) and snowball sampling. …”
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