Comprehensive Analysis of Multi-Omics Data on RNA Polymerase as an Adverse Factor in Head and Neck Squamous Cell Carcinoma by Gu YJ, Zhang J, Liu YJ, Zhang Q, Geng QF

“…While RNA polymerases (POLRs) have been implicated in various transcriptional mechanisms, their impact on the tumor microenvironment (TME) remains poorly understood.Methods: We analyzed publicly available pan-cancer cohorts to evaluate the expression and genomic alterations of POLRs. …”
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A Population Pharmacokinetics Study of Venetoclax Concomitant with Voriconazole in Patients with Hematologic Malignancies by Yang J, Wang H, Liu D, Cao W, Xing H, Wang P

“…This study aimed to develop a population pharmacokinetics (PopPK) model to characterize the PK properties of venetoclax when co-administered with voriconazole.Methods: Patients (≥ 18 years of age) treated with venetoclax for hematologic malignancies and concomitant with voriconazole were enrolled. …”
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Pressure makes diamonds? The impact of closed incision negative pressure wound therapy on complications following abdominoplasty in patients with massive weight loss—results from a... by Torsten Schulz, Toralf Kirsten, Katharina Theresa Vogel, Stefan Langer, Rima Nuwayhid

“…The objective of this research was to assess the influence of ciNPWT on post-operative wound complications in this demanding patient collective. Methods: We conducted a retrospective case-control study. …”
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Mechanical behavior of hybrid glenoid components compared to all‐PE components: a finite element analysis by Nicolas Bonnevialle, Julien Berhouet, Paul Pôtel, Jacobus Hendrik Müller, Shoulder Friends Institute, Arnaud Godenèche

“…Finally, risk of fatigue failure of the cement mantle is equal for hybrid and all‐PE components, as no difference in %CCV was observed. …”
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Exploring Potential Causal Links: How Parkinson’s Disease Brain Damage Impacts Liver Health–A Mendelian Randomization and Transcriptomic Study by Liu T, Chen Q, Wu H, Li J, Xian M, Lu K, Zhu C, Wei J

“…Tingting Liu,1,2,* Qi Chen,3,* Haojie Wu,1 Jingwen Li,1 Meiyan Xian,1 Keke Lu,1,2 Chaoyang Zhu,1,2 Jianshe Wei1,2 1School of Life Sciences, Henan University, Kaifeng, People’s Republic of China; 2Translational Neuromedicine and Neurourology Center, Huaihe Hospital of Henan University, Kaifeng, People’s Republic of China; 3School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianshe Wei, Email jswei@henu.edu.cnBackground: Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by slow movements, muscle rigidity, tremors, and changes in gait and posture. …”
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Application and Analysis of Random Forest and Support Vector Classification in Risk Prediction of Childhood Obesity and Hyperuricemia by Wang Y, Shi S, Wei X, Wu Y, Shi Y, Cai J

“…Machine learning (ML) offers an effective framework for constructing efficient risk prediction models in pediatric populations.Objective: This study aimed to develop and evaluate two ML models—Random Forest (RF) and Support Vector Classification (SVC)—to predict the risk of childhood obesity and hyperuricemia by integrating clinical and biochemical variables.Methods: A total of 101 children were enrolled, including 60 with obesity and 41 with obesity plus hyperuricemia. …”
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Effects of Xuefu Zhuyu Decoction on Inflammatory Factors and the NF-kappaB Signaling Pathway in Rats Model of Radicular Pain by Liu X, Jiang T, Lu B

“…The rats in the treatment groups received different doses of XFZYD via oral administration, while the control and model groups received an equal volume of normal saline once daily for 7 days. …”
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An online intervention relationship enhancement couple therapy program versus systematic desensitization on sexual performance anxiety in women undergoing infertility treatment wit... by Maryam Afzal Dehkordi, Tahmineh Farajkhoda, Mahdi Khanabadi, Farimah Shamsi

“…Objective: This study aimed to compare the effectiveness of relationship enhancement couple therapy program (RECT) vs. systematic desensitization (SD) on sexual anxiety. Materials and Methods: A parallel randomized clinical trial was conducted on 68 women with infertility in Shahrekord, Iran, in January 2022. …”
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Age and Sex Differences in Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis by Veronika A. Myasoedova, Alessio L. Ravani, Beatrice Frigerio, Donato Moschetta, Vincenza Valerio, Ilaria Massaiu, Mauro Amato, Damiano Baldassarre, Paolo Poggio

“…A virtual analysis revealed that age-related cIMT is equal between sexes but postponed by 10 years in women. …”
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Optimization of the operating mode of a squirrel-cage induction motor by D. A. Vasiliev, L. A. Panteleeva, E. I. Gracheva

“…For the investigated engine AIR100S4, the critical value is sξ=0.0613 at a network frequency of 50 Hz. The method proposed in the work allows to reduce the loss of active power by 3-5% in the motor windings.…”
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Male sexuality and the risk of developing benign prostatic hyperplasia and prostate cancer: is there a connection? by M. I. Kogan, M. E. Efremov, V. L. Medvedev, A. D. Anosov, T. P. Agapova, T. G. Sinyavskaya

“…Among men with BPH, individuals with hypo-, normo-, and hypersexuality are found with approximately equal frequency, while PCa patients are hyposexual in 90.8% of cases, with only 9.2% being normosexual. …”
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Network Pharmacology Combined With Metabolomics Reveals the Mechanism of Yangxuerongjin Pill Against Type 2 Diabetic Peripheral Neuropathy in Rats by Jin R, Pei H, Yue F, Zhang X, Zhang Z, Xu Y, Li J

“…Pharmaceutical Factory, Beijing, 100079, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yi Xu; Jinsheng Li, Beijing Tongrentang Technology Development Co., Ltd. …”
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Cardioprotective effects of CoQ10 in pediatric patients with lysosomal storage disorders by Yasmine Abuzaid, Ghada Abdul Moemn Suliman, Osama Abd Rab El Rasool Toulba, Ahmed Abd El Basset Abo Elezz, Alshimaa Badraldeen, Heba Dawoud

“…The aim of this study: was to study the possible effects of Coenzyme Q10 as a cardioprotective and an antioxidant drug in patients with LSDs. Methods This study was a prospective case-control study conducted on 30 patients with LSDs and an equal number of healthy subjects of matched age and sex served as a control group at the unit of Medical Genetics and inborn errors of metabolism at the Pediatric Department of Tanta University Hospital. …”
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Phantom-based training of ultrasound-guided breast biopsy in medical education: a randomized controlled trial comparing handheld and high-end ultrasound by Barbara Greiner, Michael Akers, Florian Zeman, Andrea Goetz, Moritz Brandenstein, Christian Stroszczynski, Ernst Michael Jung, Simone Hammer

“…Operability and the individually perceived workload were rated equal. Conclusions Percutaneous biopsy performed by novices using HUDs is feasible, performance times, success rates, operability and the individually perceived workload were on par with HEUS-guidance. …”
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Impact of climate change on the potential global prevalence of Macrophomina phaseolina (Tassi) Goid. under several climatological scenarios by Peter F. Farag, Dalal Hussien M. Alkhalifah, Shimaa K. Ali, Aya I. Tagyan, Wael N. Hozzein

“…The area under curve (AUC) and true skill statistics (TSS) were assigned to evaluate the resulted models with values equal to 0.902 ± 0.009 and 0.8, respectively. These values indicated a satisfactory significant correlation between the models and the ecology of the fungus. …”
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Adherence to ADA Clinical Guidelines in Type 2 Diabetes Management in Public Health Clinics in Palestine by Abukhalil AD, Muhanna SA, Madi MN, Al-Shami N, Naseef HA, Rabba AK

“…Adherence to established guidelines is essential for effective management of this metabolic disease.Objective: This study aimed to evaluate the current practices of physicians in Palestine regarding their adherence to ADA guidelines for type 2 diabetes management.Methods: A retrospective, cross-sectional, multicenter study was conducted by reviewing patients’ medical records. …”
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Development of a Nomogram Integrating Modified Inflammation-Based Indexes for Predicting Overall Survival in Pancreatic Cancer: A Retrospective Study by Qin D, Huang K, Yao Z, Xi P, Jiang L, Wei R, Li S

“…Adjusting inflammation indices for liver function may enhance their clinical utility for predicting overall survival (OS) in PCA patients.Methods: Resected PCA cases were selected using specific criteria. …”
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Detecting early kidney injury due to host–virus interaction response in treatment-naive CHB—a pilot study by Puneet Gandhi, Kavita Peter, Subodh Varshney, Subodh Varshney, Mahendra Kumar Atlani, Mahendra Kumar Atlani, Kewal Krishan Maudar, Kewal Krishan Maudar

“…We aimed to evaluate and validate a set of protein biomarkers singularly and in combination for the early detection of subclinical kidney injury in patients with CHB naive to antiretroviral therapy.MethodsThis work is part of a prospective cross-sectional study for which 69 HBsAg-positive, treatment-naive patients with CHB with an equal number of age-matched healthy volunteers were considered. …”
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Digital Patient–Reported Cancer Symptom Management: Comparison of Black and White Participants by Mary Gullatte, Bridget Nicholson, Elizabeth Sloss, Natalya Alekhina, Ann Marie Moraitis, Eli Iacob, Gary Donaldson, Kathi Mooney

“…The intervention produced a significant improvement in symptom burden (p < 0.001), with a mean improvement of 0.14 symptom burden points per week with equal benefit between Blacks and Whites (p = 0.27). …”
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An Investigation into the Current Landscape, Challenges, and Training Imperatives of Clinical Research Among Anesthesiologists in China by Du Y, Chen R, Wu L, Chen Q, Yu T, Li H, Wang G

“…Yingjie Du,1,&ast; Ruirong Chen,1,&ast; Lili Wu,1 Quan Chen,2 Tiankuo Yu,1 He Li,1 Guyan Wang1 1Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of China; 2Department of Anesthesiology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Guyan Wang, Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of China, Email guyanwang2006@163.comObjective: This study aimed to investigate the status of anesthesiologists in clinical research in China, identify challenges, and propose strategies to improve research quality and anesthesiology services.Materials and Methods: A cross-sectional online survey was conducted among registered clinical anesthesiologists in China from April to May 2023. …”
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