An integrative review on the risk factors, prevention, and control strategies for carbapenem-resistant Acinetobacter baumannii colonization in critically ill patients by Shihan Zhang, Shihan Zhang, Jie Xiao, Jie Xiao, Yanan Li, Yanan Li, Wei Li, Yihui Li, Yihui Li, Mingmin Pang, Mingmin Pang, Meichen Yan, Meichen Yan, Hui Han, Hui Han, Yi Cui, Yi Cui, Xuehai Zhang, Xuehai Zhang, Hao Wang, Hao Wang

“…Recent studies indicate that colonization typically precedes infection, suggesting the effectiveness and necessity of preventing CRAb colonization as a primary method to lower infection risks. As CRAb infections tend to draw more attention due to their severe symptoms and poor outcomes, understanding the link between colonization and infection is equally vital. …”
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Anti-Breast Cancer Properties and In Vivo Safety Profile of a Bis-Carbazole Derivative by Jessica Ceramella, Camillo Rosano, Domenico Iacopetta, Iméne Ben Toumia, Leila Chekir-Ghedira, Mouna Maatouk, Annaluisa Mariconda, Pasquale Longo, Patrick Dallemagne, Christophe Rochais, Maria Stefania Sinicropi

“…Pursuing the aim of obtaining carbazoles with less negative features, a lot of chemically modified compounds have been produced and evaluated. <b>Objectives/Methods</b>: In this paper, we describe the in vitro and in vivo evaluation of a bis-carbazole derivative with strong anticancer properties against two breast cancer cell lines. …”
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Potentialities and critical issues of liquid biopsy in clinical practice: An umbrella review by Nicola Veronese, Claudio Luchini, Stefano Ciriminna, Katia Spinelli, Santo Fruscione, Paola Mattiolo, Miriam Belluzzo, Veronica Messina, Lee Smith, Mario Barbagallo, Walter Mazzucco

“…We found that 75/211 had an excellent accuracy (AUC >0.90), with one comparison with an AUC equal to 1, i.e., Cell-Free Human Papillomavirus DNA (cfHPV-DNA) for HPV-positive oropharyngeal squamous cell carcinoma. …”
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A Randomized, Prospective and Crossover Study, Comparing the Eradication Rate After 10 Days of Concomitant Therapy to Bismuth Quadruple Therapy Among a Sample of the Lebanese Popul... by Jad Chidiac, MD, Reine-Marie Kahwaji, MD, Souheil Hallit, PharmD, MSc, MPH, PhD, Yara Yazbeck, MD, Bassem Akiki, MD, Charbel Yazbeck, MD

“…Conclusions: Bismuth quadruple therapy and concomitant therapy are both equally effective first-line treatment regimens for the eradication of H pylori. …”
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A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children by Anna Nikula, Stefan Lundeberg, Malin Ryd Rinder, Mitja Lääperi, Katri Sandholm, Maaret Castrén, Lisa Kurland

“…The objective of this study was to evaluate whether intranasal dexmedetomidine could provide more effective analgesia and sedation during a procedure than intranasal esketamine. Methods This was a double-blind equally randomized (1:1) superiority trial of 30 children aged 1–3 years presenting to the Emergency Department with a laceration or a burn and requiring procedural sedation and analgesia. …”
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Parameters of radical resection in laparoscopic and open colon and rectal cancer surgery by Krdžić Igor, Kenić Marko, Šćepanović Milena, Soldatović Ivan, Ilić-Živojinović Jelena, Radovanović Dragan

“…The aim of this study was to determine whether laparoscopic approach provides all parameters of oncological radicality as open surgery of colorectal cancer. Methods. The study included 122 patients with carcinoma of colon and rectum, divided into two equal groups: patients operated on by laparoscopic and those operated on by open approach. …”
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Folate-Modified Smart Responsive Nanosystems for Enhancing Anti-Tumor Therapy Through Calcium Overload and Chemotherapy by Tang Y, Huang J, Cui C, Yang F, Li K, Gao B, Fu S, Yang X

“…Precise drug delivery via folate-modified nanomaterials is an important measure to improve efficacy and reduce toxicity.Methods: CaCO3 nanoparticles served as the carrier for loading DOX and 5-Fu, followed by encapsulation with folic acid-modified polydopamine (PDA) to form a smart dual drug-carrying nanosystem called FA-DCFP. …”
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Real-World Analysis of the Efficacy and Adverse Events of T-DM1 in Chinese Patients With HER2-Positive Breast Cancer by Gu H, Zhu T, Ding J, Yang Z, Qi S, Guo G

“…Huayan Gu,1,&ast; Teng Zhu,2,&ast; JiaLing Ding,1 Zhi Yang,1 Shuangyi Qi,1 Guilong Guo1 1Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China; 2Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Guilong Guo, Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang Street, Wenzhou City, Zhejiang Province, People’s Republic of China, Email guoguilong@sina.comPurpose: This study efforts to explore the association of adverse events (AEs) with efficacy in HER2-positive breast cancer patients treated with TDM1.Methods and Materials: This retrospective study included women diagnosed with HER2+ BC treated with TDM1 from January 2012 to December 2023. …”
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Predictors of treatment delay among drug resistant tuberculosis patients in Uganda by Nabukenya Diana Kasozi, Lwanga Charles, Asiimwe JohnBosco, Luzze Henry

“…Abstract Background Drug resistant tuberculosis (DR-TB) continues to be a significant global public health concern despite the availability of effective TB medicines. Equally, delayed DR-TB treatment initiation is associated with increased morbidity, amplified resistance, transmission risk and poor treatment outcomes. …”
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CEREBROPROTECTIVE ACTIVITY OF NEW DERIVATIVES OF PIRIMIDINE4 1H ONE PIR9 AND PIR10 IN IRREVERSIBLE OCCLUSION OF THE COMMON CAROTID ARTERY by A. V. Voronkov, N. B. Shabanova, I. P. Kodonidi, I. S. Shatalov

“…The aim of this work is to study the cerebroprotective activity of the new derivatives of Pirimidine-4-(1H)-OHA PIR-9 and PIR-10 in irreversible occlusion of the common carotid artery. Materials and methods. The study was carried out on 120 male rats of the Wistar line, weighing 200-220 g, divided into 6 equal groups. …”
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Nerve Block Extends Nerve Function Recovery in Patients with Diabetic Foot Ulcers by Wei Q, Rong H, Zhang G, Xie Y, Dai W

“…The aim of this study is to investigate the minimum stimulation thresholds of the femoral and sciatic nerves, as well as the duration of nerve block, in patients diagnosed with diabetic foot.Methods: From July 2020 to March 2022, a prospective study was conducted involving patients aged 50– 80 scheduled for distal lower limb surgery. …”
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Clinical and Antibiotic Resistance Features for Extended-Spectrum Betalactamase-Producing Escherichia coli and Klebsiella pneumoniae Bloodstream Infections and Predictors of Poor P... by Yan W, Liang J, Liu M, Hu X, Zhang H, Guo J, Li L

“…Weijun Yan,&amp;ast; Jiahui Liang,&amp;ast; Minxue Liu, Xuehua Hu, Huan Zhang, Jing Guo, Linlin Li Department of Clinical Laboratory, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region, Nanning, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Linlin Li, Email lilinlin0810@126.comBackground: Neonatal bloodstream infections (BSIs) caused by extended-spectrum β-lactamase Enterobacterales (ESBL-E) are associated with high rates of morbidity and mortality. …”
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Usability Evaluation of Foods with Function Claims Labelling as Health Information in Japan: A User-Testing Study by Yamamoto M, Yamamoto K, Takano-Ohmuro H, Yamamoto R, Saruwatari J

“…It is important to explore ways to evaluate and improve labelling usability from the consumers’ perspective to ensure safe usage.Patients and Methods: We conducted user testing from the consumers’ perspective on labels of five different FFCs, utilizing semi-structured interviews with 50 participants of diverse ages and sexes. …”
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Dysbiosis and Metabolic Dysregulation of Salivary Microbiota in Schizophrenia by Wang J, Lu L, Ren L, Zhu R, Jiang Y, Qiao Y, Li Y

“…However, fewer studies have directly investigated the potential links between oral microbiota and SZ.Purpose: This study aimed to explore the relationship between salivary microbiota dysbiosis and SZ, examining microbial and metabolic alterations that may contribute to SZ pathophysiology.Methods: Salivary samples from 30 hospitalized patients diagnosed with SZ and 10 healthy controls were collected. …”
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Patients’ perception of quality of care in health facilities empanelled under Sehat-Card-Plus programme, in Khyber-Pakhtunkhwa, Pakistan by Kiran Sohail Azeemi, Shifa Salman Habib, Waqas Hameed, Junaid Ur Rehman Siddiqui, Ali Hussaini, Asma Altaf Hussain Merchant, Adil Haider, Sameen Siddiqi

“… Objective:This study aims to assess perceived quality of care among users of hospitals empanelled under SCP Programme, KP. Methods: The assumed satisfaction level was 80% among SCP users, and 10%-point lower satisfaction among SCP nonusers. …”
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Analysis of Pharmacokinetic Parameters of Acetylsalicylic Acid for Prediction of Potential Nephrotoxic Effects by L. M. Krasnykh, O. A. Goroshko, G. F. Vasilenko, G. I. Gorodetskaya, V. V. Smirnov, T. A. Rodina

“…The study of the pharmacokinetics of acetylsalicylic acid products will contribute to timely detection and correction of side effects caused by this medicinal product.The aim of the study was to evaluate potential nephrotoxic effects following a single oral administration of 75 mg of acetylsalicylic acid, based on the analysis of the pharmacokinetic parameters.Materials and methods: the study involved 24 healthy volunteers who received 75 mg of acetylsalicylic acid (tablets) once orally. …”
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Multidomain Cognitive Tele-Neurorehabilitation Training in Long-Term Post-Stroke Patients: An RCT Study by Marianna Contrada, Gennarina Arabia, Martina Vatrano, Caterina Pucci, Isabel Mantia, Federica Scarfone, Giusi Torchia, Maria Quintieri, Antonio Cerasa, Loris Pignolo

“…A randomized controlled trial (RCT) study was conducted to compare the effectiveness of a TNR multidomain cognitive approach to conventional face-to-face cognitive treatment. Methods: A total of 30 patients with stroke were equally enrolled and randomly assigned to the experimental and control groups. …”
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Prototyping neural networks to evaluate the risk of adverse cardiovascular outcomes in the population by L. A. Bogdanov, E. A. Komossky, V. V. Voronkova, D. E. Tolstosheev, G. V. Martsenyuk, A. S. Agienko, E. V. Indukaeva, A. G. Kutikhin, D. P. Tsygankova

“…To develop a neural network basis for the design of artificial intelligence software to predict adverse cardiovascular outcomes in the population.Materials and Methods. Neural networks were designed using the database of 1,525 participants of PURE (Prospective Urban Rural Epidemiology Study), an international, multi-center, prospective study investigating disease risk factors in the urban and rural areas. …”
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Adverse birth outcome and associated factors among mothers with antepartum hemorrhage in public hospitals Tigray, northern Ethiopia, 2020 by Tomas Amare Abraha, Gebremedhin Kinfe Gebremariam, Berhane Teklay Asfaha, Tensay Kahsay Weldegebreal, Desta Hailu Aregawi

“…Rural residence [AOR = 2.16, 95%CI (1.069, 4.38)], three and below antenatal care follow-up visits [AOR = 6.6, 95%CI (3.345,13.10)], bad obstetric history [AOR = 2.8, 95%CI (1.044,7.691)], and having less than or equal 11 g/dl hemoglobin level at admission were [AOR = 3.7,95%Cl (1.93,6.914)] found as predictors of adverse birth outcome in this study. …”
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The main trends of dynamics of incomes of Russians in times of economic crisis by O. L. Petryakova

“…High prosperity, material security still (as well as the 90th years, as well as at the beginning of this century) are on an equal basis with a family and children the leading value of Russians. …”
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