IL-6 and CD4+/CD8+ are Important Indicators for Predicting Prognosis in Elderly AECOPD Patients: A Retrospective Study by Liu Q, Wang Y, Cao X, Zhang S, Xie J

“…Qingqing Liu,1,2,* Yanhui Wang,1,2,* Xueshuai Cao,1,2 Shan Zhang,1,2 Juan Xie1,2 1Department of General Medicine, Shanghai Fifth People’s Hospital, Fudan University, Shanghai, People’s Republic of China; 2Center of Community-Based Health Research, Fudan University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Juan Xie, Email abclux@126.comPurpose: Evaluating the role of IL-6 and CD4+/CD8+ in predicting the prognosis of elderly patients with acute exacerbations of chronic obstructive pulmonary disease (AECOPD).Patients and Methods: This study retrospectively enrolled 413 elderly patients who were hospitalized for AECOPD between January 2019 and December 2021. …”
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A Nomogram for Predicting Survival in Patients with SARS-CoV-2 Omicron Variant Pneumonia Based on Admission Data by Yang Y, Li D, Nie J, Wang J, Huang H, Hang X

“…This study aimed to develop a nomogram for predicting survival using chest computed tomography (CT) imaging features and laboratory test results based on admission data.Patients and Methods: A total of 436 patients with SARS-CoV-2 pneumonia (323 and 113 in the training and validation groups, respectively) were enrolled. …”
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Effects of Curcumin on Iron Overload in Rats by Gülüzar Özbolat, Arash Alizadeh Yegani

“…This study investigated the effects of curcumin on iron overload in rats. Methods: Forty male Wistar rats weighing 139.78 ± 11.95 gm (Mean ± SD) were divided into three equal groups: (i) controls; (ii) iron overload group that received six doses of iron dextran 1000 mg/kg–1 by intraperitoneal injections (i.p.); and (iii) iron overload curcumin group that received six doses of curcumin (1000 mg/kg BW by i.p.).  …”
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Availability of basic first aid training for cardiac arrest for people with disabilities by A. A. Birkun, Ye. A. Kosova, K. I. Redkokosh, A. S. Gapon

“…The aim was to study the digital accessibility (web accessibility) of massive open online courses in cardiopulmonary resuscitation (CPR) for PWD.Material and methods. A search was carried out for free English-language online courses teaching the principles and rules of providing first aid in cardiac arrest. …”
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Association of depression with sleep quality might be greater than that of pain intensity among outpatients with chronic low back pain by Wang H, Fu T, Hsu S, Hung C

“…This study aimed to investigate this issue.Patients and methods: A total of 225 outpatients with CLBP were enrolled from a general orthopedics clinic. …”
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Long-term results of elbow synovectomy and debridement in rheumatoid arthritis by Anastasia Aleksandrovna Roskidailo, S A Makarov, V N Amirdzhanova

“…Objective: to evaluate the efficiency of surgical treatment and the quality of life (QL) in patients with rheumatoid arthritis (RA) and elbow damage. Subjects and methods. Fifty-three patients who had undergone elbow synovectomy and debridement were examined 11±5.2 years postoper atively. …”
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Value of Shear Wave Elastography in the Evaluation of Chronic Kidney Disease by Lakshmana SK, Koteshwar P, Kamath T

“…We obtained a YM measurement cut-off value of 4.43 kPa, a value less than or equal to this suggested a no diseased kidney. This yielded sensitivity and specificity of 92.6% and 80.6%, respectively, with an AUROC of 0.92.Conclusion: Our results demonstrated that shear wave elastography may provide a low-cost, non-invasive method for the morphological assessment and progression of the disease status in chronic kidney disease patients with CKD.Keywords: chronic kidney disease, shear wave elastography, renal parenchymal stiffness…”
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Blood Eosinophil Count in Asthma Is Associated With Increased Abdominal Aortic Diameter and Increased Vascular Stiffness by Biener L, Budimovska A, Skowasch D, Pizarro C, Frisch BC, Nickenig G, Stumpf MJ, Schaefer CA, Schahab N

“…Blood eosinophil count (BEC) is implicated in both eosinophilic asthma and arterial wall inflammation.Objective: To explore the possible association of BEC in asthma and abdominal aortic artery changes.Methods: 112 outpatients were prospectively enrolled in this exploratory study. …”
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Effects of mini-dose esketamine–dexmedetomidine combination supplemented intravenous analgesia on postoperative sleep quality in elderly patients after total knee arthroplasty: a p... by Xiaoyan Wang, Xiaoli Ji, Jinfeng Liu, Caicai Liu, Yanhua Luo

“…However, the effectiveness of mini-dose esketamine–dexmedetomidine supplemented intravenous analgesia on postoperative sleep quality remains to be elucidated.Methods and analysis 110 elderly patients undergoing total knee arthroplasty will be randomly assigned to different regimens of patient-controlled intravenous analgesia with a total volume of 100 mL in either the experimental group (sufentanil 1.5 µg/kg+esketamine 25 mg+dexmedetomidine 100 µg) or the control group (sufentanil 1.5 µg/kg+equal vol of placebo, ie, saline). …”
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Effective Dosage of Ciprofol for the Induction of General Anesthesia Across Diverse Age Groups in Adults: A Single-Center, Prospective, Non-Randomized Sequential Trial by Deng L, Zhang C, Tan M, Zeng W, Luo G, Li P

“…This study aims to determine the optimal dosage of ciprofol for inducing general anesthesia in adult patients of different ages and its correlation with Narcotrend index (NTI).Patients and Methods: 105 patients were stratified into three age groups: 18– 40 (Group A), 41– 65 (Group B), and 66– 85 (Group C) years. …”
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Nanotherapeutics for Macrophage Network Modulation in Tumor Microenvironments: Targets and Tools by Li R, Huang J, Wei Y, Wang Y, Lu C, Liu J, Ma X

“…In conclusion, nanotherapeutics targeting macrophages remains immense potential for the development of macrophage-mediated tumor treatment methods and will further enhance our understanding, diagnosis, and treatment of various malignants.Keywords: engineered macrophages, nanomedicine, cancer therapy, anti-tumor immunity…”
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The Application and Efficacy of Medication Safety Officer-Based Multidisciplinary Management in Reducing Adverse Drug Reaction and Improving Intravenous Management by Zhang X, Yan M, Qu X, Li Y, Liu L, Liu C

“…This study evaluates the effectiveness of medication safety officer (MSO)-based multidisciplinary management on managing IV fluids in children’s outpatient and emergency departments, aiming to reduce adverse drug reaction (ADR) and standardize IV infusion management.Methods: Implementing MSO-based multidisciplinary management integrates multidisciplinary supervision, information system optimization, and fostering medication safety culture. …”
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Using a Systems Thinking Approach to Increase Coastal Community Resilience against Environmental Shocks: A Case Study of Valiathura Coastal Area, India by Baker Matovu, Meltem Alkoyak-Yildiz, Isaac Lukambagire, Linda A. Etta, Yasin Bbira, Expedito Nuwategeka

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Hippocampal Anti-inflammatory Effect of Electroacupuncture at Baihui and Shenting on Cognitive Dysfunction Induced by Systemic Inflammation by CHEN Xiaomei, PANG Lina, WANG Zhifu

“…ObjectiveTo investigate the hippocampal anti-inflammatory mechanism of electroacupuncture at Baihui and Shenting on cognitive dysfunction induced by Lipopolysaccharide (LPS) intraperitoneal injection.MethodsA total of 45 clean grade adult C57BL/6 male mice (bodyweight 18-22 g) were randomly divided into control group, endotoxic brain injury group (model group) and endotoxic brain injury + electroacupuncture group (EA group). …”
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The sero-prevalence of brucellosis in cattle and their herders in Bahr el Ghazal region, South Sudan. by Nuol Aywel Madut, Adrian Muwonge, George William Nasinyama, John Bwalya Muma, Jacques Godfroid, Ambrose Samuel Jubara, James Muleme, Clovice Kankya

“…The bovine sero-prevalence was approximately equally distributed among the male 30.4% (26.9-34.2) and the females 32.5% (26.8-38.7). …”
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Comparison of Learning Curves and Clinical Outcomes in Unilateral Biportal Endoscopic Spinal Surgery Versus Percutaneous Transforaminal Endoscopic Surgery: A Cumulative Sum Analysi... by Yuan S, Chen R, Mei Y, Fan N, Wang T, Wang A, Du P, Xi Y, Zang L

“…This study aimed to evaluate the learning curves for unilateral biportal endoscopic spinal surgery (UBESS) and percutaneous transforaminal endoscopic surgery (PTES) by performing cumulative sum (CUSUM) analysis and to assess their efficacies in managing degenerative spinal diseases.Patients and Methods: This retrospective cohort study included 100 consecutive patients who underwent PTES and 100 consecutive patients who received UBESS. …”
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Effect of oral health education model on tooth brushing behavior and oral hygiene among children with intellectual disabilities by Muhammad Fiqih Sabilillah, Hari Kusnanto, Lisdrianto Hanindriyo, Sri Kuswandari

“…A total of 52 children were recruited, divided equally into two groups: 26 in the intervention group and 26 in the control group, taken from September 02 to October 11, 2024. …”
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A safety review and meta-analyses of bevacizumab and ranibizumab: off-label versus goldstandard. by Christine Schmucker, Christoph Ehlken, Hansjuergen T Agostini, Gerd Antes, Gerta Ruecker, Monika Lelgemann, Yoon K Loke

“…<h4>Background</h4>We set out a systemic review to evaluate whether off-label bevacizumab is as safe as licensed ranibizumab, and whether bevacizumab can be justifiably offered to patients as a treatment for age-related macular degeneration with robust evidence of no differential risk.<h4>Methods and findings</h4>Medline, Embase and the Cochrane Library were searched with no limitations of language and year of publication. …”
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Comparative study between the roles of intrauterine misoprostol versus the sublingual route for prevention of postpartum blood loss in elective cesarean sections: a randomized cont... by Adel Atef, Hadeer Salah Eldin Abdelrahman Mohamed Shehata, Yasmin Ahmed Bassiouny, Hesham Gaber Al-Inany

“…Objectives To assess the value of adding intrauterine misoprostol together with intravenous oxytocin injection compared with sublingual misoprostol together with intravenous oxytocin injection during elective cesarean section to reduce blood loss intraoperatively and prevent postpartum hemorrhage. Methods A total of 192 pregnant women were counseled and recruited from the labor and delivery unit at Kasr Al Aini Hospital, Cairo University, and equally randomized into two groups. …”
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Real-world results of the Zeiss selective laser trabeculoplasty in adult South African primary open-angle glaucoma patients by Brian Church, Pierre Wassermann

“…At 6 months, 69.3% of patients maintained IOP lower than or equal to pre-procedure IOP on fewer medications compared to baseline. …”
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