Ameliorative effect of Naja haje venom against arthritic influence of Freund's complete adjuvant FCA in paw and ankle of male rats by Nabil A. Soliman, Amr A. Shalaby, Mayada R. Farag, Shimaa Kamal, Sara M. Abdelkarem Alashqar, Mohamed Ahmed Ammar, Suzan Attia Mawed

“…Aim: While there are a number of therapeutic options for arthritis, their side effects restrict their use and encourage the search for alternative, natural remedies. Methods: In male rats, we examined the anti-inflammatory and anti-arthritic properties of Naja haje venom (NHV). …”
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Efficacy of Topical Azithromycin versus Systemic Doxycycline in Treatment of Meibomian Gland Dysfunction by Marwa Aly Zaky, Adel Galal Zaky, Moataz Fayez Elsawy, Kareem Fatehy Shehata, Mohamed Samy Abd Elaziz

“…Randomly, patients were classified into two equal groups: Group 1 was treated twice daily for 4 weeks with topical azithromycin 1% eye drops, while group 2 received oral doxycycline 100 mg capsules twice daily for 4 weeks. …”
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Comparing recommended doses of angiotensin receptor blockers and ACE inhibitors (CORD Study) by J. Spinar, J. Vftovec, M. Soucek, L. Dusek, T. Pavlik

“…Losartan and ramipril demonstrated equal antihypertensive effectiveness and a tendency to improve metabolic parameters. …”
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Deep Learning and Radiomics in Triple-Negative Breast Cancer: Predicting Long-Term Prognosis and Clinical Outcomes by Cheng C, Wang Y, Zhao J, Wu D, Li H, Zhao H

“…They are extensions of conventional imaging diagnostic methods and have demonstrated tremendous potential in image segmentation, reconstruction, recognition, and classification. …”
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SPP1 as a Prognostic and Immunotherapeutic Biomarker in Gliomas and Other Cancer Types: A Pan-Cancer Study by Wang K, Wan J, Zheng R, Xiao Y, Lv F, Ge H, Yang G, Cheng Y

“…This study investigates the role of Secreted Phosphoprotein 1 (SPP1) as a prognostic and immunotherapeutic biomarker in gliomas and other cancers through pan-cancer analysis.Methods: A comprehensive pan-cancer analysis was conducted using datasets from UCSC TCGA Pan-Cancer, TCGA-GBM, UALCAN, and single-cell sequencing data from GEO and TISCH. …”
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Different patterns of pre-excitation in a large Italian cohort of asymptomatic non-competitive athletes evaluated by telecardiology screening: Prevalence and ECG features by Martina Molinari, Sergio Setti, Natale Daniele Brunetti, Nicola Di Nunno, Maria Alberta Cattabiani, Giuseppe Molinari

“…The highest incidence (29 WPW patterns) was observed in the 10–15 year group with an equal sex ratio (M/F:16/13).Intermittent pre-excitation was found in 8 NCAs. …”
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Disruption of Gut Microbiota and Associated Fecal Metabolites in Collagen-Induced Arthritis Mice During the Early Stage by Wu D, Yin M, Cao D, Zhang X, Zhu Y, Wei Y, Li Y, Wen C, Zhou J

“…Further revealing the microbiota and related metabolic disorders in the preclinical stage of RA (pre-RA) is of great significance for exploration of disease mechanisms.Methods: DBA/1 mice were injected with type II collagen on days 0 and 21 to establish collagen-induced arthritis (CIA) mouse model. …”
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Causal Relationship Between Depression, Sleep Disorders, and Constipation: A Mendelian Randomization and Mediation Analysis by Wang JX, Wei KY, Lin W, Liu YJ

“…The inverse-variance weighted (IVW) method was applied as the primary analytical approach. …”
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L-shaped correlation between serum alpha-1-acid glycoprotein concentration and urinary albumin creatinine ratio in females: a cross-sectional survey by Junjie Wang, Junjie Wang, Li Xiao, Yuxuan Zhang, Zhou Li

“…We divided all participants equally into three groups based on their serum AGP concentration. …”
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A Precipitation Forecast Score Based on Potential Impact by Liujie PAN, Hongfang ZHANG, Chunjuan QI, Shan LU, Lili DU

“…In traditional contingency tables， the hit and false alarm events are given equal weights when calculating the precipitation TS score.The weight of missed precipitation events with different amounts that satisfy the threshold conditions is also the same.At the same time， the frequency calculation method for hit events of different precipitation amounts within the threshold range is also the same.However， these methods lack precision in the verification of high-resolution grid precipitation forecasts.In fact， the impact of differences in observed precipitation values， even when predictions hit the threshold， may be completely different.Additionally， the impact of differences in the forecasting and observation of precipitation values in missed precipitation events may also vary greatly.The article proposes a precipitation impact forecast score based on the comprehensive consideration of precipitation hit rate， missed alarm ratio， and precipitation amount."…”
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Serial Blood Pressures Versus a Single Repeat Blood Pressure in a Family Medicine Clinic by Ann Philbrick, Caroline Carlin, Christopher Fallert

“… Purpose. The best method to measure blood pressure (BP) in a clinic setting is debatable. …”
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Gender disparities in literacy: an analysis of regional and age-group variations in Somalia by Mukhtaar Axmed Cumar, Abdisalan Hassan Muse, Befekadu Zeleke Kidane, Jibril Abdikadir Ali

“…Further studies employing qualitative methods and longitudinal designs are recommended to deepen understanding of the dynamics underlying these disparities.…”
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Identification and Quantification of the Component Composition of the Active Substance Gentamicin Sulfate by ¹Н and ¹³С NMR Spectroscopy by S. V. Moiseev, N. E. Kuz’mina, E. Yu. Severinova, E. P. Simonova, V. V. Kosenko

“…These characteristic signals provided spectral markers indicative of the gentamicins of interest in the sample, with normalised integrated intensities equal to the mole fractions of the analytes. The authors compared NMR and HPLC measurements of the active substance composition.Conclusions. …”
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Challenges in Thirst Management for Intubated Patients in the ICU: A Qualitative Study of Healthcare Provider and Patient Perspectives by Yuan Y, He LF, Luo Q, Zhang X, Chen F, Hu RJ

“…You Yuan,1,* Li-Feng He,1,* Qian Luo,1 Xia Zhang,1 Fang Chen,1 Ru-Jun Hu1– 3 1Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 2Department of Nursing, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 3School of Nursing, Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ru-Jun Hu, Department of Nursing, Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Huichuan District, Zunyi, Guizhou Province, 563000, People’s Republic of China, Tel +86 15085060545, Email hurujunok@163.comObjective: This study aims to examine the challenges associated with thirst management among patients undergoing tracheal intubation in intensive care units (ICUs), and to inform the development of more effective clinical strategies.Methods: A qualitative research design was employed using semi-structured interviews with 32 participants, including healthcare professionals and patients who had experienced tracheal intubation and associated thirst in the ICU. …”
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A Ferritin-Based Eg95 Nanoparticle Vaccine Adjuvanted with pCpG Eliciting Robust Immune Responses Against Cystic Echinococcosis in Mice Model by Gao X, Zhu X, Liu X, Zhou C, Shang Y, Wu T, Jia H, Zhang Z, Li Y, Xin T

“…The commercial Quil-A-adjuvanted Eg95 vaccine was empirically effective for CE control; however, it is expensive and has side effects and insufficient immunity.Purpose: This study aimed to employ a novel adjuvant consisting of a delivery system and an immune potentiator and assess its adjuvanticity to Eg95 antigen, thereby developing a safe and cost-effective novel vaccine against the disease.Methods: A ferritin-based Eg95 nanoparticle antigen was prepared and then mixed with a plasmid containing the TLR9 agonist CpG to formulate a novel nanovaccine. …”
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CURRENT APPROACH TO DEVELOPMENT OF BIOSIMILAR PRODUCTS CONTAINING MONOCLONAL ANTIBODIES AS AN ACTIVE SUBSTANCE – NON-CLINICAL AND CLINICAL STUDIES OF THE FIRST RUSSIAN RITUXIMAB BI... by S. M. Alekseev, K. D. Kaplanov, R. A. Ivanov, E. V. Chernyaeva

“…Within the whole study period  the frequency of AEs, including severe AEs (grade 3-4), associated with the use of monotherapy, were equal in both arms without any significant differences. …”
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Comparison of Outcomes of Classical Lichtenstein and Modified Lichtenstein in Patients with Indirect Inguinal Hernia by Ghulam Fatima Komal Memon, Shahid Hussain Mirani, Sadia Saher Memon, Dharmoon Arija, Halar Habibullah, Meena Sadaf

“…Patients aged 18–70 years (American Society of Anesthesiologists class I–III) undergoing surgery for indirect inguinal hernia were included and equally divided into classical and modified Lichtenstein repair groups. …”
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Tofacitinib in early active axial spondyloarthritis: protocol of a randomized double-blind, placebo-controlled, multicenter phase IV study, FASTLANE by Valeria Rios Rodriguez, Lidia Sánchez-Riera, Hildrun Haibel, Caroline Höppner, Murat Torgutalp, Fabian Proft, Judith Rademacher, Elke Binder, Annette Diehl, Ivana Vranic, Yuxi Zhao, Rajiv Mundayat, Arne Yndestad, Denis Poddubnyy

“…Recently, the Assessment in SpondyloArthritis International Society (ASAS) defined early axSpA as a diagnosis of axSpA with a duration of axial symptoms equal to or less than 2 years. Tofacitinib is a Janus kinase (JAK) inhibitor for the treatment of ankylosing spondylitis. …”
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Evaluation of Clinical Symptoms of Unilateral S1 Nerve Injury Caused by Disc Herniation the via High Resolution MRI and DTI by Zhang C, Hao W, Guo X, Zhang Y, Fu H, Zhang J

“…ChaoYang Zhang,1,* Wei Hao,1,* Xiaobo Guo,2 Yuna Zhang,1 Hao Fu,1 Jiashan Zhang1 1Department of Radiology, Jincheng General Hospital, Jincheng, Shanxi, People’s Republic of China; 2Department of Orthopaedics, Jincheng General Hospital, Jincheng, Shanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: ChaoYang Zhang, Email Zhangchaoyang8717@163.comBackground: The status of the herniated disc or nucleus pulposus and the extent of injury and clinical symptoms of the compressed S1 nerve fiber bundle were evaluated by high-resolution Magnetic resonance imaging (MRI) and Diffusion tensor imaging (DTI) techniques.Methods: Forty-two clinically proven patients with unilateral S1 nerve root compression were selected as the case group (n=42), and 20 healthy volunteers were selected as the control group (n=20). …”
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Autologous bone marrow-derived progenitor cell transplantation for myocardial regeneration after acute infarction by Obradović Slobodan, Rusović Sinisa, Balint Bela, Ristić-Anđelkov Anđelka, Romanović Radoslav, Baskot Branislav, Vojvodić Danilo, Gligić Branko

“…This pilot trial reports investigation of safety and feasibility of autologous bone marrow-derived progenitor cell therapy for faster regeneration of the myocardium after infarction. Methods and results. Four male patients (age range 47-68 years) with the first extensive anterior, ST elevation, acute myocardial infarction (AMI), were treated by primary angioplasty. …”
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