Comparison of cefixime and amoxicillin plus metronidazole in the treatment of chronic periodontitis by Dukić Smiljka, Matijević Stevo, Daković Dragana, Čutović Tatjana

“…The aim of this study was to examine patients with chronic periodontitis in order to evaluate the efficacy of non-surgical therapy and combination of amoxicillin and metronidazole compared with cefixime, which has not been so far used for the treatment of this disease. Methods. Adult patients with chronic periodontitis (n = 90) underwent non-surgical periodontal treatment (zero-day) and then randomly divided into three groups. …”
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Effect of Biodegradable and Polypropylene Film Packaging on the Safety Profile of Jelly Marmalade by Pesterev Mikhail A., Rudenko Oxana S., Kondrat’ev Nikolay B., Bazhenova Alla E., Usachev Ivan S.

“…However, the barrier properties of biodegradable films still remain understudied. Study objects and methods. The research featured the safety profile of gelatinous confectionery products during storage in biodegradable and polypropylene films. …”
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Effects of Multiple Intravenous Doses of Perioperative Vitamin C on Pain Management Following Total Hip Arthroplasty by Han G, Ye Y, Kang P

“…Guangtao Han,1,* Yuna Ye,2,* Pengde Kang1 1West China hospital of Sichuan University, Chengdu, Sichuan, People’s Republic of China; 2Department of Stomatology, Baiyin People’s Hospital, Baiyin, Gansu Province, People’s Republic of China*These authors contributed equally to this workCorrespondence: Pengde Kang, West China hospital of Sichuan University, Chengdu, Sichuan, People’s Republic of China, Email kangpengde69@126.comPurpose: Although the benefits of numerous intravenous vitamin C doses during the perioperative phase on postoperative pain following total hip arthroplasty for whether patients could have pain relief for a longer period of time have not yet been tested, a single dose of vitamin C can assist control pain after the procedure on the first post-operative day.Methods: One hundred patients undergoing total hip arthroplasty (THA) at our institution were enrolled in this prospective, double-blind, placebo-controlled, randomized experiment. …”
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Efficacy and Safety of HER2-Targeted Agents for Breast Cancer with HER2-Overexpression: A Network Meta-Analysis. by Qiuyan Yu, Zhenli Zhu, Yan Liu, Jun Zhang, Ke Li

“…<h4>Impact</h4>This study suggests that both T-DM1 and PEHC therapy are potentially and equally useful treatments for HER2+ breast cancer.…”
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Late results of surgical treatment of critical ischemia of the lower extremities after one-staged direct revascularization by M. M. Lopit, V. І. Rusyn, P. A. Boldizhar, F. V. Gorlenko, O. M. Kochmar

“…Occlusion of anterior tibial artery was revealed most frequently – in 72% of the patients, than in fibular - in 42% of patients (p=0.00), and equally frequently with occlusion of posterior tibial artery – in 68% (p=0.61). …”
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Possible relationship between pre-pregnancy maternal body mass index and offspring hippocampus: An experimental study in albino Wistar rat by Zahraa A. Greash, Layla Omran Elmajdoub, Eman Fayad, Ali H. Abu Almaaty

“…On postnatal day1, pups were randomly adjusted to 8/dam with equal gender ratio. On 15 day postpartum, all pups were sacrificed. …”
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One-Year Risk Prediction of Elevated Serum Uric Acid Levels in Older Adults: A Longitudinal Cohort Study by Zhang D, Xu X, Ye Z, Zhang Z, Xiao J

“…Dexian Zhang,1,2,&ast; Xinxin Xu,2,3,&ast; Zhibin Ye,1,2 Zhenxing Zhang,1,2 Jing Xiao1,2 1Department of Nephrology, Huadong Hospital, Fudan University, Shanghai, People’s Republic of China; 2Shanghai Key Laboratory of Clinical Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai, People’s Republic of China; 3Clinical Research Center for Geriatric Medicine, Huadong Hospital, Fudan University, Shanghai, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Zhenxing Zhang; Jing Xiao, Department of Nephrology, Huadong Hospital, Fudan University, Shanghai, People’s Republic of China, Email contraindication@163.com; jingxiao13@fudan.edu.cnObjective: To develop and externally validate a nomogram to predict elevated serum uric acid (SUA) levels in older adults.Study Design: This is a longitudinal Chinese cohort study.Methods: A cohort of 2788 older adults was established at Huadong Hospital, followed-up for at least one year, and screened for risk factors for elevated SUA levels. …”
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The Miasma Mentality: Investigating the Association Between Beliefs in Noxious Fumes and Obstructive Pulmonary Disease (COPD), Symptoms, and Quality of Life by Zhao Y, Ma Y, Geng L, Nie J, Yu X, Kang Z, Liu Y, Su Y

“…While established risk factors like smoking and occupational exposures are well-documented, patients’ beliefs—especially those from the miasma theory attributing disease to “bad air” in cultures like China—may also significantly influence health outcomes.Methods: This case-control study was conducted at Hospital of Hebei University of Traditional Chinese, involving 500 individuals diagnosed with COPD and 500 matched control participants. …”
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Сost-effectiveness of the second wave of protease inhibitors in the treatment of chronic hepatitis C (genotype 1) in patients not previously treated with antiviral drugs, and for r... by A. V. Rudakova, D. A. Gusev, A. N. Uskov, L. N. Konovalova, Yu. V. Lobzin

“…The protease inhibitors (PI) actively using for the treatment of chronic hepatitis C (CHC).The aim of this analysis was to evaluate the cost-effectiveness of narlaprevir and simeprevir in the CHC (genotype 1) therapy in treatment-naïve patients and relapses.Material and methods. Analysis of the cost-effectiveness of simeprevir and narlaprevir was conducted from the perspective of the health care system and base on QUEST-1, QUEST-2, ASPIRE and PIONEER clinical trials. …”
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Prevalence of Hyperuricemia and Rheumatoid Factor Positivity Among Patients Aged 35 and Above in Huye District, Southern Province of Rwanda by Umukundwa R, Akimana E, Nsanzimana V, Mapira HT, Musarurwa C

“…This study aimed to determine the prevalence of hyperuricemia and RF positivity in patients aged 35 and above in Huye district of Rwanda.Patients and Methods: We conducted a cross-sectional study from October 2023 to January 2024, enrolling 367 patients from Huye and Matyazo Health Centers. …”
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Evaluation of Very-High-Frequency Ultrasound Imaging Characteristics of Dermatofibroma by Dong B, Xia H, Liu Y, Tao H, Xia Y, Zhu F

“…Herein, we analyze the sonographic features and application value of VHF ultrasound in the diagnosis of DF.Methods: Clinical data from 153 patients with pathologically confirmed DF from January 2019 to December 2023 were retrospectively analyzed using high-resolution VHF ultrasound, including size, location, shape, edge, boundary, interior echo, blood supply and so on.Results: The VHF sonographic features of DF showed that the maximum diameter of the lesions was about 7.29 ± 2.85 mm (mean ± standard deviation). …”
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Magnitude and determinants of intimate partner violence against women in Somalia: evidence from the SDHS survey 2020 dataset by Abdirizak Hassan Abokor, Omer Adam Farih, Mustafe Abdillahi Ali, Christophe Chesneau, Abdisalam Hassan Muse

“…Purpose This study aims to identify the prevalence and key determinants of IPV in Somalia, including age groups, administrative regions, place of residence, educational level, household size, husband/partner’s education and work, respondent’s work, and total children ever born. Methods Data from the Somali Demographic and Health Survey (SDHS) 2020 were analyzed. …”
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Molecular Mechanisms in Idiopathic Mitral Valve Chordae Tendineae Rupture: Insights from Transcriptome Analysis and Inflammation Evaluation by Wang Q, Zhong L, Hua L, Pang S, Li Y, Zhang Z, Zhao J, Huang H

“…Qiuji Wang,1– 3,&ast; Lishan Zhong,1,2,&ast; Linbin Hua,1– 3 Shanwen Pang,1– 3 Yuxin Li,1,2 Zhaolong Zhang,1,2 Junfei Zhao,1,2 Huanlei Huang1– 3 1Department of Cardiac Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, People’s Republic of China; 2Guangdong Cardiovascular Institute, Guangzhou, 510030, People’s Republic of China; 3Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangzhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Huanlei Huang, Department of Cardiac Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Second Road, Yuexiu District, Guangzhou, Guangdong, People’s Republic of China, Email hhuanlei@hotmail.com Junfei Zhao, Department of Cardiac Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Second Road, Yuexiu District, Guangzhou, Guangdong, People’s Republic of China, Email zhaojunfei@gdph.org.cnObjective: This study investigates the molecular mechanisms and hub genes in idiopathic rupture of mitral valve chordae tendineae (iRCT).Methods: Histological changes were assessed via pathological staining, and transcriptome sequencing was performed on samples from 8 iRCT patients and 6 controls. …”
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Cubosomes as Delivery System to Repositioning Nitrofurantoin in Breast Cancer Management by Louis D, Rizkalla CMZ, Rashad A

“…This activation mechanism has led to its exploration for repositioning applications in controlling and treating breast cancer, which express a Nitro reductase gene.Methods: NITRO Cubosomes were developed using hot homogenization according to 23-full factorial design. …”
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Effect of transdermal immunomodulation on liver regeneration by E. G. Kuznetsova, O. M. Kuryleva, L. A. Salomatina, L. A. Kirsanova, Z. Z. Gonikova, A. O. Nikolskaya, N. P. Shmerko, V. I Sevastianov

“…Assessment of the mitotic index (MI) of hepatocytes 48 hours after EHR revealed a significant increase in MI in both groups in comparison with the baseline (before liver resection) equal to 0.14 ± 0.07‰. The MI in group 1 and group 2 animals was 12.70 ± 4.9‰ and 17.43 ± 4.90‰, respectively (p ≤ 0.05).Conclusion. …”
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Immune Dysregulation and Cellular Composition in Lichen Sclerosus Revealed by Integrative Epigenetic Analysis with Cell Type Deconvolution by Wang J, Fan H, Bao Z, Li G, Wang L, Zhang D

“…Its etiology is unknown, possibly involving immune dysregulation and inflammation.Methods: Study used DNA methylation (DNAme) and single-cell RNA sequencing (scRNA-seq) to compare LS with normal skin. …”
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Research on the Developmental Trajectory of Movement-Evoked Pain and Its Potential Predictors in Patients After Knee Arthroplasty by Ai S, Zhao S, Yan L, Hu H, Niu P, Zhu Y, Zheng M

“…Shanshan Ai,1,&ast; Sumin Zhao,1,&ast; Lihui Yan,1 Hangying Hu,1 Pengli Niu,2 Yueli Zhu,1,&ast; Meifang Zheng1,&ast; 1Department of Nursing, Integrated Traditional Chinese and Western Medicine of Linping District Hospital, Hangzhou, Zhejiang, People’s Republic of China; 2Department of Nursing, The First Hospital of Dalian Medical University, Dalian, Liaoning, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Yueli Zhu, Department of Nursing, Integrated Traditional Chinese and Western Medicine of Linping District Hospital, No. 15, Baojian Road, Linping District, Hangzhou, Zhejiang, 311100, People’s Republic of China, Tel +86 189 0681 1351, Email 2582840555@qq.comPurpose: This study aimed to investigate the developmental trajectory of movement-evoked pain after knee arthroplasty and analyze the predictors of different developmental trajectory categories.Patients and Methods: In this study, a total of 178 patients undergoing knee arthroplasty were recruited from the Department of Joint Surgery at a tertiary care hospital in China. …”
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Controlled Nitric Oxide-Releasing Nanovehicles for Enhanced Infected Wound Healing: A Study on PDA@BNN6 Encapsulated in GelMA Hydrogel by Yang J, Jia D, Qiao J, Peng X, Zhou C, Yang Y

“…This dual action promotes the healing of full-thickness skin wounds that are infected.Methods: Gel/PDA@BNN6 was developed, and both in vitro and in vivo experiments were carried out to evaluate its structure, physicochemical properties, antibacterial effects, effectiveness in promoting infected wound healing, and biocompatibility.Results: Gel/PDA@BNN6 was successfully synthesized, exhibiting a porous three-dimensional lattice structure and excellent mechanical properties. …”
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Extraperitoneal Open Radical Cystectomy: A New Standard in Frail Patients with Muscle-Invasive Bladder Cancer? by Daniel Porav-Hodade, Silvestru-Alexandru Big, Vlad-Ilie Barbos, Bogdan Gherle, Ernő Jerzicska, Victor Ona, Bogdan-Ovidiu Feciche

“…The purpose of this study was to evaluate the feasibility and the safety of extraperitoneal open RC in our experience; <b>Methods</b>: We retrospectively collected the data of 75 frail patients who underwent an extraperitoneal open RC, performed by a single experienced surgeon. …”
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Association Between Systemic Immune-Inflammation Index and Stress Urinary Incontinence in Adult Women: A Population-Based Study by Jiang M, Yao X, Jiang H

“…This study aims to explore the association between SII and SUI in women.Methods: Adult participants from the 2007– 2018 NHANES were included. …”
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