Kuoxin Decoction Alleviated Left Ventricular Remodeling by Inhibiting Cardiomyocyte Apoptosis Through ASK1/JNK/Cx43 Signaling Pathway in cTnTR141W Transgenic Mice and in vitro by Ma M, Fan H, Dong Y, Feng T, Peng L, Zhou M, Liu F, Lee R, Wu R, Wu Q, Wang Y

“…Mengjiao Ma,1,* Hua Fan,1,* Yidan Dong,1,2 Tianyi Feng,1 Longping Peng,1 Maolin Zhou,1 Feifei Liu,1 RueyJyh Lee,1 Rongxue Wu,3 Qiong Wu,1,3 Youhua Wang1 1Department of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 2Department of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 3Department of Medicine/Cardiology, Biological Sciences Division, University of Chicago, Chicago, IL, USA*These authors contributed equally to this workCorrespondence: Youhua Wang, Department of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China, Email doctorwyh@163.com Qiong Wu, Department of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China, Email wuqiong1203@126.comPurpose: Combined with RNA sequencing and experimental verification methods to investigate KXD’s potential role and underlying mechanisms in cTnTR141W transgenic mice and H9c2 cells.Methods: UPLC-Q-TOF-MS analysis was employed to identify the absorbed constituents from KXD in mice blood. cTnTR141W transgenic mice were given with KXD via gavage for 4 weeks. …”
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Long-Term Physiological Adaptations Induced by Short-Interval High-Intensity Exercises: An RCT Comparing Active and Passive Recovery by Mario Mauro, Bernardino Javier Sánchez-Alcaraz Martínez, Pasqualino Maietta Latessa, Sofia Marini, Stefania Toselli

“…<b>Background:</b> High-intensity interval training (HIIT) is one of the most debated methods involving several parameters that could be modulated, but the long-term adaptations it induces are still unclear. …”
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Structure of intra- and intergroup relationships among key parameters of physical development, physical fitness, and biological age in students aged 17–20 by Oleksandr Pryimakov, Marek Sawczuk, Georgiy Korobeynikov, Stanislav Prysiazhniuk, Anatoly Skrypko, Nataliya Mazurok

“…Indicators from three sets related to students’ physical condition (PC) were recorded: physical development (PD), physical fitness (PF), and both chronological and biological age (BA). Methods of correlation, variance, regression, and canonical analysis were applied to process the experimental data. …”
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Disulfidptosis-Related Genes as Novel Biomarkers and Therapeutic Targets in Dilated Cardiomyopathy by Fan J, Xu S, Zeng Y, Xu A, Wang X, Wang H, Kang P, Fu Y, Fan H, Zhou Y

“…A predictive model was constructed using four machine learning methods, and its performance was validated with independent datasets. …”
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HUMANE: Harmonious Understanding of Machine Learning Analytics Network—global consensus for research on artificial intelligence in medicine by Neha Deo, Faisal A. Nawaz, Clea du Toit, Tran Tran, Chaitanya Mamillapalli, Piyush Mathur, Sandeep Reddy, Shyam Visweswaran, Thanga Prabhu, Khalid Moidu, Sandosh Padmanabhan, Rahul Kashyap

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A Predictive Model Using Six Genes DNA Methylation Markers to Identify Individuals With High Risks of High-Grade Squamous Intraepithelial Lesions and Cervical Cancer by Ding H, Ke Z, Xiao X, Xin B, Xiong H, Lu W

“…Therefore, new detection methods that can improve the accuracy of cervical cancer screening are needed.Methods: In the present study, cervical exfoliated cell samples were collected from 228 Chinese individuals, including 114 healthy control individuals, 46 patients with LSIL, 21 patients with HSIL and 47 patients with cervical cancer. …”
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Lower Free Triiodothyronine is a Risk Factor of Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus by Chen Y, Sun L, Chen M, Zhang H, Song B, Wang H, Jiang A, Zhang L, Li S, Wang J, Wang W, Zhang H

“…Yang Chen,1,&ast; Lijie Sun,1,&ast; Minghui Chen,1,&ast; Hui Zhang,2 Bing Song,3 Hongxiao Wang,3 Aijun Jiang,1,4 Li Zhang,5 Sumei Li,1 Jumei Wang,1 Wei Wang,1 Haoqiang Zhang1 1Department of Endocrinology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, People’s Republic of China; 2Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, People’s Republic of China; 3Department of Endocrinology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People’s Republic of China; 4University of Science and Technology of China, Hefei, People’s Republic of China; 5ShuCheng People’s Hospital, Luan, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Wei Wang; Haoqiang Zhang, Email hfww2001@ustc.edu.cn; drhqzhang@ustc.edu.cnPurpose: Our objective is to investigate the potential involvement of free triiodothyronine (FT3), a key bioactive compound found in thyroid hormones (THs) in the pathogenesis of diabetic peripheral neuropathy (DPN) in patients diagnosed with type 2 diabetes mellitus (T2DM).Patients and Methods: A total of 121 T2DM patients were recruited. …”
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Combined Analysis of Transcriptome and Mendelian Randomization Reveals AKT1 and PPARG as Biomarkers Related to Glucose Metabolism in Sepsis by Ma J, Li W, Ma Q, Ding L, Wang Z, Wang R, Huang Y, Ma G, Gao J

“…Jie Ma,1,2,&amp;ast; Wendi Li,3 Qianqian Ma,1 Liying Ding,4 Zhaoyun Wang,1 Rong Wang,1 Yanan Huang,1 Gang Ma,2,&amp;ast; Jun Gao1,&amp;ast; 1Department of Anesthesia and Perioperative Medicine, First People’s Hospital of Yinchuan, The Second Clinical Medical College of Ningxia Medical University, Yinchuan, Ningxia, 750001, People’s Republic of China; 2Department of Anesthesia and Perioperative Medicine, General Hospital of Ningxia Medical University, The First Clinical Medical College of Ningxia Medical University, Yinchuan, Ningxia, 750004, People’s Republic of China; 3Department of Child Rehabilitation Education, Ningxia Rehabilitation Center for the Disabled, Yinchuan, Ningxia, 750002, People’s Republic of China; 4Department of Gynecology, Gynecology Clinic of Li Ying, Wuzhong, Ningxia, 751100, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Gang Ma, Department of Anesthesia and Perioperative Medicine, General Hospital of Ningxia Medical University, The First Clinical Medical College of Ningxia Medical University, Yinchuan, Ningxia, 750004, People’s Republic of China, Email magang2671@163.com Jun Gao, Department of Anesthesia and Perioperative Medicine, First People’s Hospital of Yinchuan, The Second Clinical Medical College of Ningxia Medical University, Yinchuan, Ningxia, 750001, People’s Republic of China, Email gaojun1605@sina.comIntroduction: This study aimed to identify diagnostic and therapeutic biomarkers related to glucose metabolism in sepsis, as hyperglycemia and blood glucose fluctuations influence sepsis progression.Methods: Datasets from public databases were analyzed using various methods, including differential expression analysis, PPI network screening, machine learning algorithms and Mendelian randomization. …”
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Prognostic Analysis of Elderly Patients with Hepatocellular Carcinoma: an Exploration and Machine Learning Model Prediction Based on Age Stratification and Surgical Approach by Cai C, Zhu H, Li B, Tang C, Ren Y, Guo Y, Li J, Wang L, Li D, Li D

“…This study established a machine learning-driven predictive model to identify key prognostic determinants and evaluate age/surgical approach impacts, overcoming limitations of traditional statistical methods.Methods: This retrospective study included 252 postoperative HCC patients aged ≥ 65 years (mean age 69.0± 4.3; 68.25% male). …”
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Long-Term Efficacy of Chlorine-Based Disinfectants Vs Multi-Enzymatic Detergent with Hypochlorous Acid for Waterline Disinfection in Inactive Dental Chair Units by Zheng YY, Wang YY, Guo Q, Shen CY, Huang R, Wang L, Sun H

“…Yu-Ying Zheng,1,2,&amp;ast; Yuan-Yuan Wang,1,3,&amp;ast; Qian Guo,1,4 Chan-Yuan Shen,1,5 Rong Huang,1,2 Li Wang,1,6 Huan Sun1,2 1State Key Laboratory of Oral &amp; Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School &amp; Hospital of Stomatology, Wuhan University, Wuhan, 430079, People’s Republic of China; 2Department of Comprehensive Emergency, School &amp; Hospital of Stomatology, Wuhan University, Wuhan, Hubei Province, 430079, People’s Republic of China; 3Center for Oral and Maxillofacial Surgery, School &amp; hospital of stomatology (Optics Valley Branch), Wuhan University, Wuhan, Hubei Province, 430075, People’s Republic of China; 4Center for Orthodontics and Pediatric Dentistry, School &amp; hospital of stomatology (Optics Valley Branch), Wuhan University, Wuhan, Hubei Province, 430075, People’s Republic of China; 5Department of Center for Emergency and General Dentistry, School &amp; hospital of stomatology (Optics Valley Branch), Wuhan University, Wuhan, Hubei Province, 430075, People’s Republic of China; 6Department of Nursing, School &amp; Hospital of Stomatology, Wuhan University, Wuhan, Hubei Province, 430079, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Huan Sun, Department of Comprehensive Emergency, School &amp; Hospital of Stomatology, Wuhan University, No. 237 of Luoyu Road, Hongshan District, Wuhan, 430079, Hubei Province, People’s Republic of China, Tel +86 13986003844, Email sunhuansh01@163.com Li Wang, Department of Nursing Department, School &amp; Hospital of Stomatology, Wuhan University, No. 237 of Luoyu Road, Hongshan District, Wuhan, 430079, Hubei Province, People’s Republic of China, Tel +86 027-87686387, Email liwangwlwl@126.comObjective: This study aimed to evaluate the long-term efficacy of two disinfection methods for waterline systems in inactive dental chair units (DCUs).Methods: On-site sampling and quantitative bacterial analysis were conducted to compare the effectiveness of chlorine-based disinfectants and a combination of multi-enzymatic detergent with hypochlorous acid in controlling microbial contamination in waterline systems of inactive DCUs.Results: No statistically significant differences in disinfection efficacy were observed between the treatment and control groups immediately after disinfection or on the third day post-disinfection (p &gt; 0.05). …”
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&alpha;-Methyl-Tryptophan Inhibits SLC6A14 Expression and Exhibits Immunomodulatory Effects in Crohn&rsquo;s Disease by Su Y, Li J, Chen Y, Bao J, Lei Z, Ma M, Zhang W, Liu Q, Xu B, Hu T, Hu Y

“…Traditional diagnostic and therapeutic methods have limitations, necessitating the exploration of more effective strategies.Methods: In this study, we employed the Gene Expression Omnibus database to identify genes that are differentially expressed in CD. …”
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Clinical Characteristics, Risk Factors, and Predictors of Nonobese Fatty Liver Disease: A Cross-Sectional Study by Zhang X, Wang S, Xu S, Min R, Ling Y, Sun S, Gong R

“…Xiaomei Zhang,1,2,&ast; Shi Wang,3,&ast; Sanping Xu,1 Rui Min,2 Yan Ling,1 Shiran Sun,4,&ast; Rui Gong1,&ast; 1Health Management Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 3Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 4Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Rui Gong; Shiran Sun, Email gongrui@hust.edu.cn; sunshiranwh@163.comPurpose: This study aimed to investigate the risk factors and predictors of non-obese fatty liver disease in the Chinese population.Patients and Methods: A total of 6,014 adults who underwent physical examinations at Union Hospital of Huazhong University of Science and Technology from March 2019 to March 2023 were included in this study. …”
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TRPC5 Promotes Intermittent Hypoxia-Induced Cardiomyocyte Injury Through Oxidative Stress by Qiu X, Yao Y, Chen Y, Li Y, Sun X, Zhu X

“…TRPC5 levels in H9c2 cells were determined via RT-qPCR and Western blotting (WB) methods. H9c2 cells overexpressing TRPC5 were subjected to either normoxic or intermittent hypoxia conditions. …”
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Comparing Effectiveness of Active and Passive Client Follow-Up Approaches in Sustaining the Continued Use of Long Acting Reversible Contraceptives (LARC) in Rural Punjab: A Multice... by Waqas Hameed, Syed Khurram Azmat, Moazzam Ali, Muhammad Ishaque, Ghazunfer Abbas, Erik Munroe, Rebecca Harrison, Wajahat Hussain Shamsi, Ghulam Mustafa, Omar Farooq Khan, Safdar Ali, Aftab Ahmed

“…Participants in the first two study groups received counselling on scheduled follow-up from the field workers at 1, 3, 6, 9, and 12 month post-insertion whereas participants in the third group were asked to contact the health facility if in need of medical assistance relating to LARC method use. Study participants were recruited with equal allocation to each study group, but participants were not randomized. …”
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Development and Validation of Machine Learning Models for Outcome Prediction in Patients with Poor-Grade Aneurysmal Subarachnoid Hemorrhage Following Endovascular Treatment by Du S, Wu Y, Tao J, Shu L, Yan T, Xiao B, Lv S, Ye M, Gong Y, Zhu X, Hu P, Wu M

“…Therefore, it is urgently needed to investigate the risk factors and develop a critical decision model in the subtype of such patients.Methods: We extracted the target variables from an ongoing registry cohort study, PROSAH-MPC, which was conducted in multiple centers in China. …”
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Identifying Patients&amp;rsquo; Preference During Their Hospital Experience. A Sentiment and Topic Analysis of Patient-Experience Comments via Natural Language Techniques by Yuan J, Chen X, Yang C, Chen J, Han P, Zhang Y, Zhang Y

“…We adopted a mixed-methods approach involving a literature review, human annotation, and natural language processing technique to analyze free-text comments. …”
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S. Spitz nevus – Clinical, Dermatoscopic and Histological Features Correlation – Cases Report by T. Shulaia, N. Kiladze, A. Miriamidze

“…Spitz nevi in three clinical cases. Materials and methods. The content analysis, bibliosemantic method of studying the actual scientific researches concerning non-invasive methods of S. …”
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Lipidomic profile of seminal plasma in non-obstructive azoospermia with sperm maturation arrest by S. I. Gamidov, T. V. Shatylko, A. Kh. Tambiev, A. O. Tokareva, V. V. Chagovets, T. B. Bitsoev, N. L. Starodubtseva, A. Yu. Popova, V. E. Frankevich

“…The study aimed to assess the semen lipid profile in patients with sperm maturation arrest. Materials and methods. Samples of seminal plasma for lipid composition of 24 men with normozoospermia and 64 men with azoospermia were studied. …”
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Si-ITGA6-Loaded Liposomes Inhibit Capsule Fibrosis via the FAK/PI3K/Akt Signaling Pathway in Adhesive Capsulitis of Shoulder by Qi B, Wang Q, Shi S, Wang Q, Jiang W, Wang C, Li D, Sun Y, Yi C

“…The liposome-based siRNA delivery system was utilized for in vivo experiments due to its non-immunogenicity, stability, and low off-target effects compared to other siRNA delivery methods. We aimed to provide a potential approach for targeted therapy of ACS.Methods: Capsules from rotator cuff tear (RCT) patients with or without ACS were collected. …”
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Zinc Doped Synthetic Polymer Composites for Bone Regeneration: A Promising Strategy to Repair Bone Defects by Chen L, Zhou C, Xie Q, Xia L, Liu L, Bao W, Lin H, Xiong X, Zhang H, Zheng Z, Zhao J, Liang W

“…The use of advanced fabrication methods will help overcome pelletization issues to improve the therapeutic application of Zn-doped polymer composites in bone tissue regeneration. …”
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