Recombinant Hydrophobic Polypeptide MBAY Loaded Into SPION-Exosome Realizes Sustained-Release to Improve Type 2 Diabetes Mellitus by Zong X, Xiao S, Xia H, Guo D, Wu J, Zhuang M, Rao L

“…Therefore, in our study, the transmembrane hydrophobic structure of the exosome signature protein CD81 was fused with BAY 55-9837 to obtain MBAY with sustained-release capability.Methods: MBAY was fabricated via genetic engineering, and the dissociation constant (Kd) was determined to assess its affinity for vasoactive intestinal peptide receptor type 2 (VPACII). …”
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A Machine-Learning Model for the Prediction of Triple-Negative Breast Cancer Based on Multiparameter MRI by Cai Y, Li Y, Wang W, Zhou Y, Wang J, Zhang L, Lu H

“…Yuxin Cai,1,* Yanbo Li,1,* Wenqi Wang,1 Yaqiu Zhou,1 Jingbo Wang,1 Lina Zhang,1,2 Hong Lu1 1Department of Breast Imaging, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, People’s Republic of China; 2Second Department of Breast Cancer, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hong Lu, Department of Breast Imaging, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin’s Clinical Research Center for Cancer, Key Laboratory of Breast Cancer Prevention and Therapy, Tianjin Medical University, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, People’s Republic of China, Tel +86-18622221319, Email honglu@tmu.edu.cnObjective: To explore the difference between triple-negative breast cancer (TNBC) and non-triple-negative breast cancer (non-TNBC) based on multi-parametric MRI imaging features and construct a prediction model to identify TNBC.Methods: A retrospective study enrolled 1353 women with 1376 malignant lesions who had no additional therapy before surgery between January 2019 and December 2020 in a single center. …”
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Results of direct comparison of the clinical efficacy of ixekizumab and adalimumab: data from the SPIRIT H2H study by T. V. Korotaeva

“…This review presents the data obtained at 24-week follow-up.Of the 684 screened patients, 566 (82.7%) were included in the study; moreover, the distribution of the patients was equal between the ADA (n=283) and IXE (n=283) groups. …”
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A population-based study of neonatal air transport in the Arctic region of Norway from 1994 to 2023 by Lene Nymo Trulsen, Lene Nymo Trulsen, Lisa Gullhav Hansen, Lisa Gullhav Hansen, Nils Thomas Songstad, Astri Lang, Claus Klingenberg, Claus Klingenberg

“…Background and aimsRegionalized centralization of moderate and high-risk pregnancies is essential, but a well-organized postnatal transport service is equally important. This study evaluates the overall activity and clinical outcomes of the neonatal air transport team (NATT) at the University Hospital of North Norway (UNN) in Tromsø, covering a large catchment area in the Arctic region of Norway.MethodsMedical data from all neonatal air transports between the years 1994–2023 were recorded prospectively. …”
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Efficacy and Safety of Ultrasound-Guided Pulsed Radiofrequency Therapy of Stellate Ganglion on Refractory Painful Diabetic Peripheral Neuropathy by Wang J, Xu W, Wang Q, Yang P, Kan Y, Huang C, Lin F

“…Therefore, the study aimed to explore whether ultrasound-guided pulsed radiofrequency (PRF) therapy of the stellate ganglion (SG) in type 2 diabetes mellitus (T2DM) patients with painful DSPN could decrease pain severity and the need for analgesics.Methods: Fifty-six T2DM patients with refractory painful DSPN were enrolled in this study, who then received bilateral ultrasound-guided PRF therapy of SG. …”
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Exploring Pain Empathy Among Doctors, Nurses and Patients: A Scoping Review by Zhou WQ, Gao YT, Zhang CR, Xing Y, Zhou LS, Luan W

“…Wan-Qiong Zhou,1,* Yi-Tian Gao,2,* Cheng-Rui Zhang,3 Ying Xing,3 Lan-Shu Zhou,2 Wei Luan1 1Department of Nursing, Shuguang Hospital Affiliated With Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 2College of Nursing, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 3College of Nursing, Shanghai Jiao Tong University, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei Luan, Department of Nursing, Shuguang Hospital affiliated with Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Shanghai, People’s Republic of China, Tel +86 15921317982, Email luanwei_shuguang@126.com Lan-Shu Zhou, College of Nursing, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai, People’s Republic of China, Tel +86 13761801446, Email zhoulanshu@hotmail.comPurpose: This review aims to systematically assess the existing body of research on pain empathy among healthcare workers and patients, with the goal of enhancing both understanding and clinical application.Methods: Studies were retrieved from seven databases: PubMed, EBSCO, The Cochrane Library, Embase, CBM, CNKI, and Wanfang, with a search date limit from database inception to September 13, 2024. …”
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Personality's Time Perspective as a Resource for Overcoming the Identity Crisis at Different Stages of Life Realization by E.M. Meshcheryakova, A.V. Seryy, M.S. Yanitskiy

“…Manukyan; methodology for the study of professional identity and personal identity by L.B. Schneider. The methods of statistical analysis (correlation analysis, Mann-Whitney U Test, Kruskal–Wallis test, regression analysis) were used in the processing of the obtained data. …”
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Coverage of continuum of Maternal, Newborn and Child Health (MNCH) care in a nationally representative sample of 40,687 mother–child dyads of India: a report from NFHS-5 by Jyoti Ghosal, Anita Nanda, Pallavi Behera, Meena Som, Madhusmita Bal, Manoranjan Ranjit, Srikanta Kanungo, Shridhar Murlidharrao Kadam, Sanghamitra Pati, Ambarish Dutta

“…Nineteen CoC interventions (Y/N) were added (equally-weighted) to construct a composite CoC score. …”
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Increased Incidence of Chronic Obstructive Pulmonary Disease in Women Due to Long-Term Passive Smoking by Liu Z, Jiao M, Lv J, Han Q

“…Zhenkun Liu,* Mingzhi Jiao,* Jiling Lv, Qizheng Han Department of Respiratory Medicine, Shandong Second Provincial General Hospital, Jinan, Shandong, 250000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jiling Lv, Department of Respiratory Medicine, Shandong Second Provincial General Hospital, No. 4 Duanxing West Road, Jinan, Shandong, 250000, People’s Republic of China, Tel +8615508603200, Email lvjiling1980@163.com Qizheng Han, Department of Respiratory Medicine, Shandong Second Provincial General Hospital, No. 4 Duanxing West Road, Jinan, Shandong, 250000, People’s Republic of China, Tel +8615168863190, Email hanqizheng@163.comObjective: To investigate the impact of long-term passive smoking on the pathogenesis of chronic obstructive pulmonary disease (COPD) in women.Methods: We conducted a community-based cross-sectional study involving 2,360 women aged ≥ 40 years in Jinan, China (October 1, 2022-April 30, 2023). …”
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Outcomes of Total Ankle Replacement are Worse in Patients with Ipsilateral Hindfoot Fusion by Emily Teehan MS, Allison L. Boden MD, Jensen Henry MD, Constantine Demetracopoulos MD

“…We hypothesized that TAR patients with ipsilateral hindfoot fusion would have higher rates of revision and worse PROs compared to controls. Methods: A retrospective review of prospectively collected data within an institutional registry was performed. …”
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A New Composite Integrative and Conjugative Element Mediates Multiple Drug Resistance from Streptococcus anginosus to Streptococcus agalactiae by Wang Y, Liu T, Yi S, Zhu Y

“…Yingting Wang,1,* Taoran Liu,1,* Sida Yi,2 Yuanting Zhu3,4 1Department of Critical Care Medicine, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, 510080, People’s Republic of China; 2Institute of Antibiotics, Huashan Hospital, Fudan University, Shanghai, People’s Republic of China; 3NHC Key Laboratory of Assisted Circulation, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510080, People’s Republic of China; 4Department of Cardiology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuanting Zhu, Department of Cardiology, The Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, People’s Republic of China, Tel +86-18501230142, Email zhuyuanting@sysush.comIntroduction: Integrative and conjugative elements (ICEs) are a category of horizontal mobile genetic elements (MGEs) that play important roles in mediating the spread of antimicrobial resistance in Streptococci.Methods: In this study, a novel ICE, namely ICESan 26_rplL, was identified from commensal Streptococcus anginosus through routine silico analyses. …”
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Novel Nanozyme-Based Multicomponent in situ Hydrogels with Antibacterial, Hypoxia-Relieving and Proliferative Properties for Promoting Gastrostomy Tube Tract Maturation by Xiao F, Yan B, Yuan T, He Y, Zhang X, He X, Peng W, Xu Y, Cao J

“…However, there is currently no relevant research to promote gastrostomy wound treatment and tract maturation.Methods: Herein, a nanozyme loaded bioactive hydrogels (MO-HPA) was developed to accelerate tract maturation and inhibit bacteria. …”
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Decoding ARF4 and EIF5B-Based Prognostic Signatures and Immune Landscape Following Insufficient Radiofrequency Ablation in Hepatocellular Carcinoma: Through Multi-Omics and Experim... by Zhang Y, Lu Y, Zheng S, Luo W, Tan M, Luo B

“…Hence, this study seeks to pinpoint immune biomarkers to improve treatment precision and prognostic accuracy for RFA patients.Methods: The study utilized data from The Cancer Genome Atlas (TCGA), Gene Expression Omnibus (GEO), and The International Cancer Genome Consortium (ICGC) database to investigate novel immune biomarkers influencing the prognosis of patients undergoing insufficient radiofrequency ablation (IRFA). …”
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Baolier Capsule’s Secret Weapon: Piperine Boosts Cholesterol Excretion to Combat Atherosclerosis by Wei M, LYu P, Li P, Hu J, Wu R, Ouyang Q, Guo K

“…This study aimed to investigate the pharmacological effects, principal active ingredients, and mechanisms of BLEC against hypercholesterolemia and AS.Methods: Adeno-associated virus tail vein injection was utilized to construct liver-specific LXRα knockout ApoE−/− mice. …”
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The Opioid-Sparing Effects of Intraoperative Esketamine Combined with Dexmedetomidine During Laparoscopic Major Abdominal Surgery: A Randomized Controlled Double-Blind Trial by Wang W, Chen Y, Li G, Chen Y, Wu J, Shi Y, Zhong M

“…However, the advantages of OS anesthesia strategy in laparoscopic abdominal major surgery are still unknown.Methods: 157 patients undergoing laparoscopic major abdominal surgery were randomly assigned to two groups: Remi (77, remifentanil) and OS (80, esketamine combined with dexmedetomidine), the drugs were administered at 0.2-0.5 mg/kg/h (remifentanil or esketamine) and 0.2-0.7μg/kg/h (remifentanil or dexmedetomidine) in two syringes, respectively The primary outcome was the numeric rating scale (NRS) pain score on postoperative day (POD)1. …”
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Dynamic Neutrophil-to-Lymphocyte Ratio at 3-4 weeks of Intensity-Modulated Radiotherapy Combined with Normal Liver Volume Predicts Radiation-Induced Hepatic Toxicity in Hepatocellu... by Chen L, Li J, Wang X, Chen S, Wu Y, Li J, Liang S

“…Lijun Chen,* Jizhou Li,* Xiaoting Wang, Shenshen Chen, Yi Wu, Jianxu Li, Shixiong Liang Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shixiong Liang, Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, 530021, People’s Republic of China, Email liangshixionglsx@163.com Jianxu Li, Department of Radiation Oncology, Guangxi Medical University Cancer Hospital, Nanning, 530021, People’s Republic of China, Email lijianxu1236@sr.gxmu.edu.cnPurpose: This study aimed to investigate whether early dynamic variation in circulating neutrophil-to-lymphocyte ratio(NLR) during intensity-modulated radiotherapy (IMRT) can predict radiation-induced hepatic toxicity (RIHT) in patients with hepatocellular carcinoma(HCC).Patients and methods: Neutrophil and lymphocyte counts of 103 HCC patients were measured every 2 weeks before, during and after completion of IMRT.Generalized estimating equations analyses was used to analyze the dynamic changes of neutrophil and lymphocyte counts. …”
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Like mother like daughter, the role of low human capital in intergenerational cycles of disadvantage: the Pune Maternal Nutrition Study by Akanksha A. Marphatia, Akanksha A. Marphatia, Jonathan C. K. Wells, Alice M. Reid, Aboli Bhalerao, Chittaranjan S. Yajnik

“…Increasing education and delaying girls' marriage may lead to sustained intergenerational improvements across Sustainable Development Goals 1 to 5, relating to poverty, hunger, health, education and gender equality.…”
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Corneal Alterations in Patients with Osteogenesis Imperfecta: An in vivo Corneal Confocal Microscopy Study by Mangiantini P, Mallone F, D’Andrea M, Albanesi L, Lucchino L, Celli L, Celli M, Lambiase A, Moramarco A

“…This study aimed to comprehensively evaluate corneal changes in a large sample of OI patients compared to controls using in vivo confocal microscopy (IVCM).Patients and Methods: Nineteen OI patients (mean age: 34.0 ± 16.00 years; 9 females, 10 males) and 20 healthy controls (mean age: 35.5 ± 12.00; 12 females, 8 males) were included, matched for age and gender. …”
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Supporting Muslim undergraduate medical students through medical school: lessons from a novel, student-led case-based learning intervention by Zain Mohammed, Zain Mohammed, Hafsah Ba, Linta Nasim, Emily Roisin Reid

“…The facilitators reflected that the students-as-experts aspect of the intervention equalized the usual faculty-student power dynamics. …”
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Efficacy and Survival Analysis of Radiotherapy for Internal Mammary Lymph Nodes After Modified Radical Mastectomy for T1-3N3M0 the Lateral Quadrant Breast Cancer by Han X, Jiang D, Zhu C, Li D, Yin H

“…Xiumei Han,1,* Die Jiang,1,* Chaomang Zhu,2,* Duojie Li,1 Hongmei Yin1 1Department of Radiotherapy, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, 233000, People’s Republic of China; 2Anhui Provincial Key Laboratory of Tumor Evolution and Intelligent Diagnosis and Treatment, Bengbu Medical University, Bengbu, Anhui, 233000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongmei Yin, Department of Radiotherapy, The First Affiliated Hospital of Bengbu Medical University, Bengbu, Anhui, 233000, People’s Republic of China, Tel/Fax +86 182 2655 8221, Email yhm062573@163.comPurpose: This study aimed to investigate the efficacy and survival analysis of internal mammary lymph nodes (IMLNI) radiotherapy after modified radical mastectomy for T1-3N3M0 The lateral quadrant breast cancer.Materials and Methods: A total of 124 patients who underwent adjuvant radiotherapy after modified radical mastectomy for breast cancer in the First Affiliated Hospital of Bengbu Medical University were included. …”
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