Identifying cross-tissue molecular targets of lung function by multi-omics integration analysis from DNA methylation and gene expression of diverse human tissues by Shisheng Peng, Jinlong Fang, Weiliang Mo, Guodong Hu, Senquan Wu

“…In this research, we used a cross-tissue multi-omics post-GWAS analysis to explain the associations between DNA methylation, gene expression, and lung function. Methods We conducted integration analyses of lung function traits using genome-wide association study (GWAS) summary data alongside expression quantitative trait loci (eQTLs) and DNA methylation quantitative trait loci (mQTLs) derived from whole blood, utilizing multi-omics SMR and Bayesian colocalization analysis. …”
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Ciprofol Ameliorates Myocardial Ischemia/Reperfusion Injury by Inhibiting Ferroptosis Through Upregulating HIF-1α by Ding J, Wang BY, Yang YF, Kuai LY, Wan JJ, Zhang M, Xia HY, Wang Y, Zheng Z, Meng XW, Peng K, Ji FH

“…Herein, we assessed the effects of ciprofol on ferroptosis during myocardial I/R injury.Methods: Experimental models of myocardial I/R injury in mice (ischemia for 30 min and reperfusion for 24 h) and hypoxia/reoxygenation (H/R) injury in H9c2 cardiomyocytes (hypoxia for 6 h followed by 6 h of reoxygenation) were established. …”
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Serum Lipid Biomarkers for the Diagnosis and Monitoring of Neuromyelitis Optica Spectrum Disorder: Towards Improved Clinical Management by Li R, Wang J, Wang J, Xie W, Song P, Zhang J, Xu Y, Tian D, Wu L, Wang C

“…This study aimed to identify serum lipid biomarkers for the diagnosis and monitoring of NMOSD and to assess their potential to improve clinical decision-making.Methods: We conducted a comprehensive serum proteomic analysis in a discovery cohort of NMOSD patients and controls to identify lipid-related proteins associated with NMOSD. …”
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Identification of Anoikis-Related Genes in Chronic Kidney Disease Based on Bioinformatics Analysis Combined with Experimental Validation by Liu H, Mei M, Zhong H, Lin S, Luo J, Huang S, Zhou J

“…We aimed to establish the Anoikis-related gene signature in CKD by bioinformatics analysis.Methods: We retrieved 3 datasets from the Gene Expression Omnibus (GEO) database to obtain differentially expressed genes (DEGs), followed by Gene Ontology (GO), Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, Gene Set Enrichment Analysis (GSEA) and Gene Set Variation Analysis (GSVA) of them, which were intersected with Anoikis-related genes (ARGs) to derive Anoikis-related differentially expressed genes (ARDEGs). …”
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Irisin Mitigates Doxorubicin-Induced Cardiotoxicity by Reducing Oxidative Stress and Inflammation via Modulation of the PERK-eIF2α-ATF4 Pathway by Zhang Z, Yu X, Li J, Shen X, Fu W, Liu Y, Dong X, Wang Z

“…This study investigates the potential cardioprotective function of irisin in reducing the cardiac injury induced by DOX.Methods: In vitro, H9c2 cells were pretreated with irisin (20 nM) for 24 hours before exposure to DOX (1 μM). …”
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University Students’ Knowledge, Attitudes, and Practices Regarding Cervical Spine Health by Liu Y, Wang H, Liu H, Li L

“…This study investigated their knowledge, attitudes, and practices (KAP) concerning cervical spine health.Methods: From May 25 to June 16, 2023, a cross-sectional survey was conducted among students at various Chinese universities. …”
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Retrospective Analysis of Gut Microbiota and Metabolomic Profiles in Pregnant Women: Association with Cesarean Section Risk by Yuan J, Wang Y, Liu L

“…This study aimed to investigate gestation-specific alterations in gut microbiota and serum metabolomes and evaluate their association with CS risk.Methods: We conducted a retrospective analysis of 80 healthy pregnant women with singleton pregnancies who delivered at our hospital between January 2022 and December 2023. …”
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Comparison of the effect of Tabata training on soft and hard surfaces on left ventricular structure and function and some physical fitness factors in elite beach soccer players by Hamed Mohamadi Bazneshin, Arsalan Damirchi, Hamid Arazi

“…Thus, the aim of the present study was to compare the effect of six weeks of Tabata training on indoor hardcourt vs. sand on some physical fitness factors and the structure and function of the left ventricle in elite beach soccer players.Materials and Methods: Sixteen players from one of the Iran Premier Beach Soccer League teams were randomly divided into two equal groups including the sand group and the indoor group. …”
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Ultrasmall Antioxidant Copper Nanozyme to Enhance Stem Cell Microenvironment for Promoting Diabetic Wound Healing by Hou B, Li C, Yang F, Deng W, Hu C, Liu C, Chen Y, Xiao X, Huang X, Deng J, Xie S

“…Strategies to overcome these challenges are essential to enhance the therapeutic potential of stem cell therapy.Methods: Cu5.4O ultrasmall nanoparticles (Cu5.4O-USNPs), known for their excellent reactive oxygen species (ROS) scavenging properties, were utilized to protect adipose-derived stem cells (ADSCs) from oxidative stress injury. …”
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Parametric Population Pharmacokinetics Model Repository of Rifampicin: Model-Informed Individualized Therapy by Ju G, Liu X, Gu M, Chen L, Wang X, Li C, Yang N, Zhang G, Zhang C, Zhu X, He Q, Ouyang D

“…This study aims to construct a comprehensive rifampicin popPK model repository to support model-informed individualized therapy.Methods: A systematic review was conducted using PubMed, Web of Science, and Embase databases up to September 2023 to retrieve popPK model articles on rifampicin. …”
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Beam hardening of K-edge contrast agents: a phantom study comparing clinical energy-integrating detector and photon-counting detector CT systems by Amir Pourmorteza, Arnaud Richard Choux, Thomas Wesley Holmes, U. Joseph Schoepf, Marly van Assen, Carlo De Cecco, Tilman Emrich, Akos Varga-Szemes

“…Photon-counting detectors (PCD) are more susceptible to BH due to equal weighting of photons regardless of their energies. …”
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Real-World Effectiveness of Nirmatrelvir/Ritonavir in Hospitalized Older Adults with Severe Omicron COVID-19: A Retrospective Cohort Study from China by Chen Y, Liu L, Liu Y, Huang F, Guo L, Wan W, Jiang H

“…We aimed to estimate the effectiveness in older patients aged 80 and above with severe COVID-19.Methods: A retrospective study analyzed 263 COVID-19 patients aged 80 and above, admitted to the Department of Geriatrics at Jinling Hospital, affiliated with Nanjing University, between December 15, 2022, and January 15, 2023. …”
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Safety and Tolerability of Contezolid Versus Linezolid for Short-Term Treatment of Rifampicin-Resistant Pulmonary Tuberculosis: A Randomized Controlled Study by Wang J, Xue Y, Nie W, Ma L, Chu N, Du Y

“…Safer alternatives to linezolid are needed to address the safety concerns.Patients and Methods: A total of 27 patients with RR-TB (including MDR-TB) were randomly assigned to receive either contezolid (n=14) or linezolid (n=13) in combination with standardized background anti-TB regimens, that is, linezolid-bedaquiline (pyrazinamide)-levofloxacin (moxifloxacin)-cycloserine-clofazimine or contezolid-bedaquiline (pyrazinamide)-levofloxacin (moxifloxacin)-cycloserine-clofazimine. …”
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Fluctuations of Anterior Chamber Depth and Astigmatism in Pseudophakic Eyes by Tutchenko L, Patel S, Skovron M, Voytsekhivskyy OV, Gilevska F

“…Larysa Tutchenko,1,* Sudi Patel,2,* Mykhailo Skovron,1,* Oleksiy V Voytsekhivskyy,1,* Fanka Gilevska3,* 1Department of Corneal Pathology, Ophthalmic Oncology and Oculoplasty, Kyiv Clinical Ophthalmology Hospital Eye Microsurgery Center, Kyiv, 03680, Ukraine; 2Department of Cataract and Refractive Surgery, University Eye Clinic Svjetlost, Zagreb, 10000, Croatia; 3Department of Refractive Surgery, Eye Clinic Sistina Oftalmologija, Skopje, 1000 Republic of North Macedonia*These authors contributed equally to this workCorrespondence: Sudi Patel, Department of Cataract and Refractive Surgery, University Eye Clinic Svjetlost, Heinzelova 39, Zagreb, 10000, Croatia, Email drsudipatel1@gmail.comPurpose: To explore the significance of changes in anterior chamber depth (ΔACD) and astigmatism between 4 and 8 weeks following uneventful phacoemulsification.Patients and Methods: Anterior chamber depth (ACD, mm), autorefractometry and subjective refraction were monitored in pseudophakic eyes implanted with non-toric IOLs (group 1, SA60AT, n=36; group 2, SN60WF, n=34; group 3, ICBOO, n=16) and phakic control group (n=30, group 4a, for ACD and autorefractometry) over four weeks. …”
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Women’s Autonomy Decision Making Power on Postpartum Modern Contraceptive Use and Associated Factors in North West Ethiopia by Samrawit Yonas Tadesse, Amanu Aragaw Emiru, Tadese Ejigu Tafere, Melash Belachew Asresie

“…A P-value less than or equal to 0.05 at 95% confidence interval was set to test statistical significance. …”
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Tubeimoside I Inhibits the Proliferation of Liver Cancer Through Inactivating NF-κB Pathway by Regulating TNFAIP3 Expression by Zhang Y, Zhou M, Zhu L, Chen L, Zhang H, Huang Z, Zhou H

“…Specifically, we sought to elucidate the underlying mechanisms through which TBMS1 exerts its anticancer effects.Methods: The effects of TBMS1 on the viability, proliferation, and apoptosis of two liver cancer cell lines, MHCC97-H and SNU-449, were comprehensively assessed using Cell Counting Kit-8 (CCK-8), colony formation, 5-ethynyl-2′-deoxyuridine (EDU) assay, and flow cytometry assays. …”
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Associations Between the Polymorphisms in the Coding Sequence of SLCO1B1 and Blood Lipid Levels Before and After Treatment by Atorvastatin in the Chinese Han Adults with Dyslipidem... by Chen C, Tian Y, Jia F, Feng M, Zhang G, Li Q, Zhang Y, Sun N, Hu S, Ji Z

“…This study endeavors to evaluate the relationship between polymorphisms in the coding sequence (CDS) of SLCO1B1 gene and blood lipid levels before and after atorvastatin treatment among the Chinese Han adults with dyslipidemia.Patients and Methods: A total of 165 Chinese Han adults undergoing atorvastatin therapy were enrolled in this study and followed up quarterly. …”
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Preoperative Prediction of a Rare and Highly Aggressive Subtype of Hepatocellular Carcinoma Based on Multimodal Imaging and Clinical Indicators by Chen K, Zhu Y, Liu H, Deng M, Kong W, Wang W

“…Keke Chen,1,* Yuli Zhu,1,* Han Liu,2,* Minying Deng,3 Wentao Kong,4 Wenping Wang1 1Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, 200032, People’s Republic of China; 2Department of Ultrasound, Huashan Hospital, Fudan University, Shanghai, 200040, People’s Republic of China; 3Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai, 200032, People’s Republic of China; 4Department of Ultrasound, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wentao Kong, Email breezewen@163.com Wenping Wang, Email puguang61@126.comPurpose: To develop and validate a reliable preoperative non-invasive diagnostic model for dual-phenotype hepatocellular carcinoma (DPHCC) by integrating multimodal imaging and clinical indicators, thereby facilitating clinical decision-making.Patients and Methods: 222 pathologically confirmed patients (61 with DPHCC, 161 with non-DPHCC) were retrospectively enrolled in this study and randomly assigned to training and validation cohorts in an 8:2 ratio. …”
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S-values for bone marrow dosimetry in preclinical radiopharmaceutical studies with rodents by Mohammed Obaid, Arman Rahmim, William P. Segars, Julia Brosch-Lenz, Carlos Uribe

“…Two phantoms of different resolutions and equal mass were created. 3D dose distributions were simulated and the corresponding organ to organ S-values were calculated. …”
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Evaluating the Knowledge of Computed Tomography and Magnetic Resonance Imaging Parameters Between Undergraduate Students and Radiographers in Jeddah, Saudi Arabia: A Cross-Sectiona... by Aljuaid LA, Alblowi MA, Almary SY, Alshamrani KM, Subahi AM

“…Previous studies have showed a significant knowledge gap regarding CT and MRI parameters; thus, this study aimed to evaluate the effectiveness of university curricula and clinical practice in hospitals among undergraduate students and technologists in Jeddah.Methods: Quantitative data were collected through a validated structured cross-sectional survey administered to a cluster sample of undergraduate students and radiographers in Jeddah. …”
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