Deep learning-assisted analysis of biomarker changes after increase of dosing from aflibercept 2 mg to 8 mg in therapy-resistant neovascular age-related macular degeneration by Siegfried Priglinger, Jakob Siedlecki, Benedikt Schworm, Franziska Eckardt, Michael Hafner, Ben Asani, Caspar Liesenhoff, Alexander Kufner, Johannes Benedikt Schiefelbein

“…Unfortunately, not all patients respond equally well to the drugs, and some show recurrences during treatment. …”
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Association Between Systemic Immune-Inflammatory Indices and Severity of Coronary Artery Lesions in Patients With Coronary Artery Disease in Different Glucose Metabolic States by Jin X, Liu Y, Jia W, Xu R, Guan X, Cui M, Zhang H, Wu H, Wei L, Qi X

“…However, the relationship between SII and the severity of coronary artery lesions in participants with coronary artery disease (CAD) in different glucose metabolic states has not been fully elucidated.Methods: A total of 2727 patients with CAD were enrolled between January 2018 and April 2022. …”
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Predictive Value of Albumin to Fibrinogen Ratio and CALLY Index for Diagnosis of Ulcerative Colitis and Mucosal Healing After Vedolizumab Treatment by Su K, Xiao S, Wang M, Wang K, Fan Q, Sha S, Cheng Y, Liu X, Shi H

“…The aim of this study was to evaluate the clinical significance of AFR and CALLY index in UC.Methods: The study included 109 UC patients and 126 healthy controls. …”
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Associations Between Psychological Stress and the Risk of First Onset of Major Depression Disorder: Results from a Longitudinal Study in 6,985 Chinese First-Year Students by Wang F, Rong L, Luo L, Mu F, Qian L, Qian Y, Zhang X, Lang Y, Wang W, Liu Y, Zhang Y, Wang J

“…This study aimed to estimate the effect of psychological stress on the risk of first onset MDD in a sample of Chinese freshmen.Methods: Using a longitudinal design, 8079 Chinese first-year students were recruited at baseline, and 6985 were followed up one year later. …”
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Functional Liver Imaging Score to Predict Clinically Significant PHLF for Hepatocellular Carcinoma After Resection by Zheng X, Zhang Y, Huang H, Luo N

“…Xihua Zheng,* Yumin Zhang,* Huiying Huang, Ningbin Luo Departments of Radiology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ningbin Luo, Departments of Radiology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China, Fax +860734-5312000, Email luoningbin2012@hotmail.comPurpose: To develop a model based on Functional Liver Imaging Score (FLIS) to estimate the risk of clinically significant post-hepatectomy liver failure (PHLF) for hepatocellular carcinoma (HCC) after resection.Patients and Methods: This retrospective study analyzed 885 patients with HCC who undergoing liver resection at our medical center between January 2017 and December 2021. …”
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Association of Metabolic Score for Visceral Fat (METS-VF) with Gout Risk in Patients with Hypertension and Hyperuricemia: A Multicenter Study Based on the Chinese Population by Ji L, Jiang W, Huang J, Xu Y, Zhou L, Zhao Z, Jiang C

“…Visceral adipose tissue (VAT) plays a crucial role in cardiometabolic diseases, and the metabolic score for visceral fat (METS-VF) is a non-invasive tool for estimating VAT and predicting cardiometabolic risk.Methods: We conducted a multicenter cross-sectional study involving 8877 patients with hypertension and hyperuricemia from three Chinese medical centers between March 2021 and September 2024. …”
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Associations Between Postoperative Symptom Clusters and Functional Status in Lung Cancer Patients: A Cross-Sectional Study by Liu Y, Lin S, Bai M, Yi H

“…Yali Liu,1,* Siya Lin,2,* Meirong Bai,1 Huochun Yi3 1Department of Thoracic Surgery, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, 361004, People’s Republic of China; 2School of Nursing, Fujian Medical University, Fuzhou, Fujian, 350122, People’s Republic of China; 3Center of Clinical Laboratory, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian, 361004, People’s Republic of China*These authors contributed equally to this workCorrespondence: Meirong Bai, Department of Thoracic Surgery, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, 201 hubin South Road, Siming District, Xiamen, Fujian, 361004, People’s Republic of China, Email 157576198@qq.com Huochun Yi, Center of Clinical Laboratory, Zhongshan Hospital Xiamen University, School of Medicine, Xiamen University, 201 hubin South Road, Siming District, Xiamen, Fujian, 361004, People’s Republic of China, Email yhc1818@163.comBackground: Symptom clusters in cancer symptom management research, providing a scientific basis for developing effective strategies for symptom assessment and intervention aimed at improving patient quality of life and survival.Objective: To analyze symptom clusters in postoperative lung cancer patients, examine its influenced factor, and explore the relationship between postoperative symptom clusters and functional status in lung cancer patients.Methods: Between August 2023 and February 2024, 441 lung cancer patients who underwent surgical treatment in the Department of Thoracic Surgery at a tertiary hospital in Xiamen were selected. …”
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Construire des ressources relationnelles pour franchir des frontières multiples : Trajectoires de jeunes Tunisiens by Hasnia-Sonia Missaoui

“…This information was then analysed using methods relating to the analysis of social relations, in particular the so-called “name generator” protocol. …”
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Bioinformatics and Network Pharmacology Identify the Therapeutic Role of Guominkang in Allergic Asthma by Inhibiting PI3K/Akt Signaling by Zhang H, Zhang H, Wang L, Zhang Y, Hu L, Liu J, Zhou Y, Wang J

“…The aim of this study was to explored the mechanism of action through which GMK combats AA.Methods: Potential target genes for the compounds were identified from the database and subjected to functional enrichment analysis. …”
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Treatment of Psoriasis with II-17 Inhibitors: Comparison of Long-Term Effectiveness and Drug Survival of Secukinumab vs Ixekizumab in Real-World Practice by Lam J, Cazzaniga S, Seyed Jafari SM, Maul JT, Feldmeyer L, Bossart S, Yawalkar N, Heidemeyer K

“…The study aimed to compare the characteristics of patients treated with secukinumab or ixekizumab and in addition to analyze associated factors and independent predictors of drug survival in a real-world setting.Methods: This study was designed as a single-center retrospective study. …”
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A Nomogram Based on Tumor Response to Induction Chemotherapy and Plasma Epstein–Barr Virus DNA Level after Induction Chemotherapy to Explore Individualized Treatment of... by Liu F, Ma C, Chen M, Chen K, Zhu L, Li L, Zhu X, Qu S, Yan C

“…A nomogram was subsequently constructed to explore the individualized optimal cumulative cisplatin dose (CCD) in concurrent chemoradiotherapy (CCRT).Methods: A total of 581 LA-NPC patients were included, randomly divided into training and validation cohorts in a 7:3 ratio. …”
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Effect of Vitamin D Level on Female Vaginitis in Xi’an, China by Guan J, Dong Y, Zhang W, Gui Q, Luo D, Wen H, Dang X, Liang D, Hu S, Zhang Y, Liao G, Zhang L, Lu Z

“…Therefore, this study focused on the therapeutic effects of vitamin D on vaginitis.Methods: The study provided a statistical description of 5978 vaginitis patients who visited Shaanxi Provincial People’s Hospital, presenting data in absolute numbers (%) and mean ± standard deviation (median quartiles were used for non-normally distributed variables). …”
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Artificial Intelligence Enabled Fully Automated CMR Function Quantification for Optimized Risk Stratification in Patients Undergoing Transcatheter Aortic Valve Replacement by Ruben Evertz, Torben Lange, Sören J. Backhaus, Alexander Schulz, Bo Eric Beuthner, Rodi Topci, Karl Toischer, Miriam Puls, Johannes T. Kowallick, Gerd Hasenfuß, Andreas Schuster

“…Fully automated biventricular volumetric assessments enable efficient and equal risk prediction compared to conventional manual approaches. …”
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Exploring the Validity of an Instrument That Measures Final Year Medical Students’ Career Choice Preferences by Guru A, Henning MA, Webster CS, Kool B, Wilkinson TJ, Bagg W

“…This study aimed to explore the validity of an instrument that measures the factors that influence Aotearoa New Zealand (NZ) medical students’ career choices.Methods: The Medical Schools Outcomes Database (MSOD) questionnaire containing 24 question items entitled “Factors Influencing Career Choice” (FICC) section was psychometrically analyzed. …”
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Functional Connectivity Alterations Associated with COVID-19-Related Sleep Problems: A Longitudinal Resting-State fMRI Study by Chen HB, Li L, Sun YK, Liu Y, Chen W, Liu P, Liao YH, Xie A

“…Purpose: This study investigated SP-related brain functional connectivity (FC) alterations.Patients and methods: Fifty-five COVID-19 survivors with SP (COVID_SP) and 33 without SP (COVID_NSP), matched for demographics, completed PSQI and underwent rs-fMRI at baseline and 2-month follow-up. …”
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Clinical Features, Outcomes, and Antifungal Susceptibility Profiles of Invasive Candida Infections in a Tertiary Care Hospital in China by Yao D, Chen J, Zhang G

“…Dongting Yao,1,2,* Jia Chen,3,* Guanyi Zhang3 1Department of Laboratory Medicine, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, People’s Republic of China; 2Shanghai Key Laboratory of Embryo Original Diseases, Shanghai, 200030, People’s Republic of China; 3Department of Laboratory Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guanyi Zhang, Department of Laboratory Medicine, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, 200030, People’s Republic of China, Tel/Fax +86-021-64385700, Email zhangguanyi1233@163.com Dongting Yao, Department of Laboratory Medicine, The International Peace Maternity and Child Health Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200030, People’s Republic of China, Tel/Fax +86-021-64070434, Email yaodongting@126.comPurpose: Given the increasing incidence of invasive Candida infection worldwide, particularly among immunocompromised and critically ill patients, we aimed to assess the distribution of Candida species as well as their clinical features and responses to common antifungal agents through a retrospective analysis of patient data in a Chinese traditional medicine hospital.Patients and Methods: In this retrospective single-center study, we analyzed data from 301 patients with invasive Candida infection at our hospital between 2020 and 2022, We report the clinical characteristics, species distribution, and in-vitro susceptibility profiles of Candida isolates to eight antifungal agents. …”
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Procyanidin Improves Erectile Function in Rats by Inhibiting PDE5A Activity by Su Y, Shui J, Qi D, Bai J, Xu X, Huang Y, Li R, Wu Q, Wang H, Cao C, Su Z, Zhang S

“…This study aims to validate the efficacy of procyanidin as a treatment for ED.Methods: The binding affinity of procyanidin for PDE5A was assessed by molecular docking, molecular dynamics (MD) simulations, and microscale thermophoresis (MST) assay. …”
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Identification and Validation of circDOCK1/miR-138-5p/GRB7 Axis for Promoting Breast Cancer Progression by Zhang Y, Yang M, Wang Y, Zhao J, Lee PY, Ma Y, Qu S

“…This study aims to explore novel circular RNAs and their mechanisms of biological function in breast cancer.Methods: Six HER2-positive breast cancer tissues and paired normal tissues were obtained for the whole transcriptome RNA sequencing. …”
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Etiological Factors and Development of a Predictive Model for Urinary Tract Infections in Cervical Cancer Patients Undergoing Intensity-Modulated Radiotherapy by Yao Y, Tao L, Ma L, Fan Y, Zheng D, Wang J, Chen W

“…Furthermore, to explore the risk factors and predictive factors associated with urinary tract infections, and to establish a personalized risk prediction model.Methods: A retrospective study analyzed 160 cervical cancer patients undergoing intensity-modulated radiotherapy at the People’s Hospital of Ningxia Hui Autonomous Region from 2020 to 2023. …”
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Association Between Serum Uric Acid to High-Density Lipoprotein Cholesterol Ratio and Pneumonia After Endovascular Treatment of Vertebrobasilar Artery Occlusion by Lan W, Yuan K, Xiao L, Qiu F, Sun W, Xu L, Cao H, Zhu W, Du M, Liu X

“…We aimed to explore the association of UHR with pneumonia after endovascular thrombectomy (EVT) in patients with vertebrobasilar artery occlusion (VBAO).Methods: We retrospectively enrolled participants diagnosed with acute VBAO treated with EVT within 24 hours of estimated occlusion time from the multicenter PERSIST study. …”
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