Proteomic Analysis of Retinas in a Rat Model of High-Fat Diet-Induced Type 2 Diabetes: Implications of Interventional Targets for Nonproliferative Diabetic Retinopathy by Pang X, Bai S, Feng Z, Zhang Y, Hu B, Zhang Y

“…Xueyi Pang,* Siqiong Bai,* Zhinan Feng, Yumin Zhang, Bojie Hu, Yan Zhang Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, 300384, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bojie Hu; Yan Zhang, Tianjin Key Laboratory of Retinal Functions and Diseases, Tianjin Branch of National Clinical Research Center for Ocular Disease, Eye Institute and School of Optometry, Tianjin Medical University Eye Hospital, Tianjin, 300384, People’s Republic of China, Tel +86 22 86428700 ; +86 22 86428863, Fax +86 22 86428777, Email bhu07@tmu.edu.cn; yanzhang04@tmu.edu.cnPurpose: This study aimed to establish a high-fat diet (HFD)-induced rat model of type 2 diabetes mellitus (T2DM) and employed tandem mass tag (TMT) proteomics to search for novel interventional targets for nonproliferative diabetic retinopathy (NPDR).Patients and Methods: Six-week-old male Sprague–Dawley rats were randomly divided into a T2DM group fed a HFD and a normal group (NOR group) fed normal chow. …”
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Assessing the influence of Katana™ Cleaner on the clinical performance of bulk-fill restorations in endodontically treated teeth: study protocol for a randomized clinical study by Jacqueline Vitória do Nascimento Azevedo, Ceci Nunes Carvalho, Hadda Lyzandra Austriaco Leite, Suellen Nogueira Linares Lima, Wallace Vieira Mendes, Sebastião Marinho Pinheiro Neto, Andrés Felipe Millian Cardenas, Fabiana Suellen Figueredo Siqueira, Rossana Aboud Matos de Almeida, Etevaldo Matos Maia Filho

“…Methods The study will be a blinded randomized clinical trial conducted according to the Consolidated Standards of Reporting Trials (CONSORT) statement. …”
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Evaluating the efficacy of rumination-focused cognitive-behavioral therapy in alleviating depression, negative affect, and rumination among patients with recurrent major depressive... by Mohsen Hasani, Saeedeh Zenoozian, Reza Ahmadi, Sahel Khakpoor, Soleiman Saberi, Reza Pirzeh, Omid Saed

“…Participants were randomly assigned in equal proportions to either the group-based Rumination-Focused Cognitive-Behavioral Therapy (g-RFCBT) condition or a waitlist (WL) control group. …”
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Dual-Mode Treatment of Hepatocellular Carcinoma Using RGD Cyclopeptide-Modified Liposomes Loaded with Ce6/DOX by Xu W, Zheng J, Zhang J, Shi H, Peng W, Liu Y, Feng G, Wang Y, Liang YJ, Chen J

“…Therefore, an effective drug delivery system must enhance drug accumulation at the target site, enable selective drug release there, and facilitate escape from lysosomes.Methods: cRGD-Lipo@Ce6/DOX was prepared by modifying c(RGDyK) onto the surface of drug-loaded liposomes containing Chlorin e6 (Ce6) and doxorubicin (DOX) through an amide reaction. …”
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Expression and Clinical Significance of Irisin in Serum and Placenta Tissues of Pregnant Women with Severe Preeclampsia by Ren Y, Bi H, Zhang J, Yin Q, Zhang X, Gong X, Li Y, Shi J

“…Irisin levels in the serum and placental tissues of healthy pregnant women and those with early- and late-onset SPE were measured and compared.Methods: A total of 70 pregnant women treated at our hospital from January to November 2023 were selected for this study. …”
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Digital Mental Health Interventions for Young People Aged 16-25 Years: Scoping Review by Courtney Potts, Carmen Kealy, Jamie M McNulty, Alba Madrid-Cagigal, Thomas Wilson, Maurice D Mulvenna, Siobhan O'Neill, Gary Donohoe, Margaret M Barry

“…The findings reveal a diverse landscape of studies, equally focusing on the prevention and promotion of mental health and the treatment of mental ill health, most commonly using cognitive behavioral therapy (63/145, 43.4%). …”
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Cordycepin Ameliorates Renal Interstitial Fibrosis by Inhibiting Drp1-Mediated Mitochondrial Fission by Sun Y, Jin S, Chen J, Zhang J, Lu Y, Gu Q, Yan Z, Chen W, Chen A, Fang Y, Geng W, Xu X, Song N

“…Yingxue Sun,1,* Shi Jin,1,* Jun Chen,2,* Jian Zhang,1 Yufei Lu,1 Qiuyu Gu,1 Zhixin Yan,1 Weize Chen,1 Annan Chen,1 Yi Fang,1 Wenye Geng,3 Xialian Xu,1 Nana Song1 1Department of Nephrology, Zhongshan Hospital, Fudan University; Shanghai Medical Center of Kidney; Shanghai Institute of Kidney and Dialysis; Shanghai Key Laboratory of Kidney and Blood Purification; Hemodialysis Quality Control Center of Shanghai, Shanghai, 200032, People’s Republic of China; 2Department of Pathology, Changzheng Hospital, Naval Military Medical University, Shanghai, 200003, People’s Republic of China; 3Scientific Research Department of Shanghai Medical College, Fudan Zhangjiang Institute, Fudan University, Shanghai, 201203, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xialian Xu; Nana Song, Division of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China, Tel +86-021-64041990-2138, Fax +86-021-64038038, Email xu.xialian@zs-hospital.sh.cn; song.nana@zs-hospital.sh.cnObjective: This study aimed to investigate the mechanisms and specific targets of cordycepin in the treatment of renal fibrosis using a unilateral ischemia-reperfusion (UIR) model.Methods: A UIR mouse model was established, followed by intraperitoneal injections of cordycepin and Mdivi-1. …”
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Development of a Nomogram for Prognostic Prediction of Large Hepatocellular Carcinoma With HBV After TACE Combined Conversion Therapy by Xu W, Ding X, Xu Y, Zhang Y, Xu H, Guo L, Li L

“…Wei Xu,1,* Xia Ding,2,* Yan Xu,3 Yongchuang Zhang,1 Huaxiao Xu,1 Lin Guo,1 Lei Li1 1Department of Interventional Radiology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital), Qingdao, Shandong, 266042, People’s Republic of China; 2Department of Oncology, Qingdao Hospital, University of Health and Rehabilitation Sciences (Qingdao Municipal Hospital), Qingdao, Shandong, 266071, People’s Republic of China; 3Department of Oncology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences (Qingdao Central Hospital), Qingdao, Shandong, 266042, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lei Li, Department of Interventional Radiology, Qingdao Central Hospital, University of Health and Rehabilitation Sciences(Qingdao Central Hospital), Qingdao, Shandong, 266042, People’s Republic of China, Email 369542019@qq.comBackground: Surgical resection (SR) following transarterial chemoembolization (TACE) is a promising option for large hepatocellular carcinoma (LHCC) with HBV, and identification of these patients at high-risk of prognosis may help individualized treatment.Purpose: To develop and validate pre- and postoperative prognostic nomograms integrating clinico-therapeutic-pathological features for predicting overall survival (OS) after TACE combined therapy.Materials and Methods: Between May 2010 and October 2021, 255 consecutive patients with LHCC receiving conversion therapy of TACE combined with Lenvatinib plus PD-1 inhibitors were included from three tertiary-care hospitals. …”
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A Comprehensive Study of Part-Solid Lung Adenocarcinoma with Lymph Node Metastasis: Clinical, Pathological, and Radiological Perspectives by Zhao Z, Gan H, Fu BJ, Li W, Lv F, Chu Z

“…This study aims to comprehensively investigate the clinical, pathological, and CT characteristics of part-solid LUADs with LNM.Patients and Methods: This study collected 70 pathologically confirmed part-solid LUADs at two centers, including 35 cases with LNM and 35 matched cases without LNM based on size, CT pattern, and pathological subtype. …”
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A Tentative Clinical Study: Colistin Combined with Ceftazidime/Avibactam in the Treatment of Carbapenem-Resistant Gram-Negative Bacilli Infection by Zhang R, Zheng Z, Lu Y, Shi K, Lin Z, Tang S, Shao Z, Yang X, Liu J

“…This study aimed to assess the efficacy of colistin (COL) combined with ceftazidime/avibactam (CAZ/AVI) in the treatment of CR-GNB infections.Patients and Methods: A retrospective, single-center observational study was conducted on patients diagnosed with CR-GNB infections who were treated with COL combined with CAZ/AVI (C/C), COL combined with Tigecycline (C/T), and COL combined with meropenem (C/M). …”
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Effect of Telemonitoring on Moderate and Severe Exacerbations in Patients with COPD: Pooled Analysis of Two Randomized Controlled Trials in Denmark by Hyldgaard C, Ringbæk T, Andersen FD, Hansen EF, Jensen MS, Fenger-Grøn M, Trolle C, Ulrik CS

“…Patients were equally randomized to telemonitoring (N=251) in addition to usual care for six months or usual care alone (N=252). …”
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Medical Hemorrhoid Gel Ameliorates Croton Oil-Induced Hemorrhoids by Suppressing the NLRP3 Inflammasome Activation via NF-κB Signaling Pathway by Ai Z, Yuan D, Li Y, Cai J, Zhou D, Liu W

“…This study aims to systematically evaluate the safety, efficacy, and mechanism of action of MHG in treating HD.Methods: The phytochemical composition of MHG was characterized using UPLC-QTOF-MS/MS and GC-MS/MS analyses. …”
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Single-Cell Sequencing Combined with Transcriptome Sequencing to Explore the Molecular Mechanisms Related to Skin Photoaging by Hu X, Du S, Chen M, Yang H, He J, Zhang L, Tan B, Wu T, Duan X

“…However, the specific mechanism of skin photoaging is not yet completely elucidated.Methods: Gene expression profiles for photoaging patients were obtained from the Gene Expression Omnibus (GEO) collection. …”
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Multi-Omics Analysis Identifies Immune Regulatory Networks in Sepsis-Associated Liver Injury: Experimental Validation and Clinical Relevance by Hong Y, Chen Q, Xie H, Ma M, Gan S, Zhang Y, Xu Z

“…This study aimed to identify key immune-related genes (IRGs) driving T cell-mediated responses in SILI and evaluate their diagnostic potential.Methods: Cecal ligation and puncture (CLP) was performed to establish a murine sepsis model (n=7/group), with sham-operated controls. …”
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Uric Acid Metabolism and Its Relationship with Glucose and Lipid Metabolism in Overweight and Obese Children and Adolescents: A Cross-Sectional Study in South China by Tang B, Li Y, Lin J, Zhu Y, Chen D, Mou Y, Zhu S

“…This study aims to analyze the characteristics of serum uric acid (SUA) metabolism in overweight and obese children and adolescents in South China, exploring its associations with metabolic parameters.Methods: A single-center retrospective study was conducted, involving children and adolescents aged 3 to 18 years diagnosed with overweight and obesity. …”
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A Novel Inflammation-Marker-Based Prognostic Model for Advanced Pulmonary Lymphoepithelioma-Like Carcinoma by Chen X, Liu T, Mo S, Yang Y, Chen X, Hong S, Zhou T, Chen G, Zhang Y, Ma Y, Ma Y, Zhang L, Zhao Y

“…Xueyuan Chen,1,* Tingting Liu,1,* Silang Mo,1,* Yuwen Yang,1 Xiang Chen,1 Shaodong Hong,1 Ting Zhou,1 Gang Chen,1 Yaxiong Zhang,1 Yuxiang Ma,2 Yuanzheng Ma,1 Li Zhang,1 Yuanyuan Zhao1 1Medical Oncology Department, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, Guangzhou, 510060, People’s Republic of China; 2Department of Clinical Research, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center, Guangzhou, 510060, People’s Republic of China*These authors contributed equally to this workCorrespondence: Li Zhang; Yuanyuan Zhao, Sun Yat-sen University Cancer Center, 651 Dong Feng Road East, Guangzhou, 510060, People’s Republic of China, Email zhangli@sysucc.org.cn; zhaoyy@sysucc.org.cnPurpose: This study aimed to investigate the prognostic value of inflammation markers for advanced pulmonary lymphoepithelioma-like carcinoma (PLELC) and develop an effective prognostic model based on inflammation markers to predict the overall survival (OS) of this population.Methods: Cox regression analysis was performed on 18 clinical and inflammation features, and a nomogram was created to predict overall survival (OS). …”
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Left atrial strain in assessing heart failure with preserved ejection fraction in hypertensive patients by E. S. Mazur, V. V. Mazur, N. D. Bazhenov, O. V. Nilova, T. O. Nikolaeva

“…Further, 172 patients with confirmed or excluded HFpEF were randomly divided into two equal cohorts. In the training cohort, HFpEF was diagnosed in 44 (51,2%) patients, in the validation cohort — in 50 (58,1%). …”
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Longitudinal Changes in Peripheral and Alveolar Monocyte and Inflammatory Biomarkers are Distinct in Hypercapnia Patients Following Pulmonary Sepsis-Induced ARDS by Zhao J, Ji Y, Li B, Yang K, Sun Q, Ma T, Xie K

“…Our study was designed to compare initial values and longitudinal changes in cellular composition and inflammatory biomarkers between pneumonia sepsis-induced ARDS patients without hypercapnia and hypercapnia patients.Methods: Between Dec 2022-Apr 2023, we prospectively studied 61 severe pneumonia patients. …”
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Exploring the Mechanisms of Lijin Fang on Treg/Th17 Cell Imbalance in COPD Based on Network Pharmacology by Li ZH, Chen SN, Pan L, Liu R, Liang W, Luo MQ, Liao HF, Feng J, Wang HZ, Huang YG, Zheng JH

“…This study explores the therapeutic potential of the traditional Chinese medicine(TCM) formula, Lijin Fang (LJF), focusing on its ability to restore Treg/Th17 balance.Methods: We employed bioinformatics and in vitro cell experiments to analyze the active components and targets of LJF. …”
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Development and validation of the health belief model scale for early childhood caries prevention behaviors of parents by Ketian Wang, Gillian Hiu Man Lee, Pei Liu, Hey Ching Wong, Xiaoli Gao, Samuel Yeung Shan Wong, May Chun Mei Wong

“…Specifically, the scale targeted parents with young children. Methods The initial item pool was set up by adapting existing HBM scales to assess parents’ health beliefs regarding their children’s ECC under six HBM domains and then underwent face and content validation. …”
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