Pragmatic, multicentre, factorial, randomised controlled trial of sepsis electronic prompting for timely intervention and care (SEPTIC trial): a protocol by Daniel Brodie, Manish Sharma, Matthew J Cummings, Hassan Mohamed, William N Southern, Edward J Schenck, Benjamin L Ranard, David Y Zhang, Jeremy R Beitler, Min Qian, Jo R Applebaum, Jason S Adelman, Shing M Lee, Richard Trepp, Hanson Hsu, Jean Scofi, Sarah C Rossetti, Natalie H Yip, Baruch S Fertel

“…Despite widespread use, it is unknown whether these sepsis screening and alert tools improve the delivery of high-quality sepsis care.Methods and analysis The Sepsis Electronic Prompting for Timely Intervention and Care (SEPTIC) master protocol will study two distinct populations in separate trials: emergency department (ED) patients (SEPTIC-ED) and inpatients (SEPTIC-IP). …”
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Exploring the Impact of the Multimodal CAPABLE eHealth Intervention on Health-Related Quality of Life in Patients With Melanoma Undergoing Immune-Checkpoint Inhibition: Prospective... by Itske Fraterman, Lucia Sacchi, Henk Mallo, Valentina Tibollo, Savannah Lucia Catherina Glaser, Stephanie Medlock, Ronald Cornet, Matteo Gabetta, Vitali Hisko, Vadzim Khadakou, Ella Barkan, Laura Del Campo, David Glasspool, Alexandra Kogan, Giordano Lanzola, Roy Leizer, Manuel Ottaviano, Mor Peleg, Konrad Śniatała, Aneta Lisowska, Szymon Wilk, Enea Parimbelli, Silvana Quaglini, Mimma Rizzo, Laura Deborah Locati, Annelies Boekhout, Lonneke V van de Poll-Franse, Sofie Wilgenhof

“…Baseline HRQoL was on average 10 points higher in the intervention group compared with controls, although equally matched on baseline and clinical characteristics. …”
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Bridging the Gap: A Qualitative Study Exploring the Impact of the Involvement of Researchers With Lived Experience on a Multisite Randomised Control Trial in the National Probation... by Elizabeth Simes, Stephen Butler, Elizabeth Allison, Barbara Barrett, Anthony Bateman, Angus Cameron, Mike Crawford, Alison Frater, Zoe Hoare, Mary McMurran, Paul Moran, Stephen Pilling, James Wason, Jessica Yakeley, Peter Fonagy

“…This qualitative study aimed to explore the value of involving researchers with lived experience of the criminal justice system as data collectors in the Mentalization for Offending Adult Males (MOAM), a multisite RCT conducted in the National Probation Service in England and Wales. Methods Semi‐structured interviews were conducted with 30 trial participants and 17 key stakeholders, either in person or via telephone. …”
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Imaging and Clinical Outcomes Six Months After Middle Meningeal Artery Embolization with Squid for Chronic Subdural Hematoma: A Prospective Study by Ángela H. Schmolling, Carlos Pérez-García, Isabel Bérmudez, Alfonso López-Frías, Eduardo Fandiño, Carmen Trejo, Santiago Rosati, Daniel Padrón, Lara Guardado, José Carlos Méndez, Juan Arrazola, Manuel Moreu

“…This study assesses MMA embolization with Squid, both as a standalone procedure and as an adjunct to surgery. <b>Methods:</b> Our prospective registry included 101 patients with 134 CSDH cases treated at two tertiary care centers from December 2020 to January 2024. …”
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Spectrum of gynecologic malignancies in Northeastern Nigeria by Dauda A. Katagum, Uchenna S. Ezenkwa, Sunday E. Achanya, Aliyu I. Lawan, Dauda E. Suleiman, Mairo U. Kadaura, Abba Kabir, Adamu I. Adamu, Abubakar Kolomi Modu, Hadiza Usman, Sophia H. L. George, Matthew Schlumbrecht, Bala M. Audu

“…Here, four-year multi-institutional data on gynecologic cancers in northeastern Nigeria were examined to determine their distribution by age and subtype.Patient and MethodsThis is a cross-sectional descriptive study using available data on histologically diagnosed gynecologic cancers archived in the pathology departments and/or cancer registries of six tertiary hospitals in northeastern Nigeria over four years. …”
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Efficiency of cell-based assays in detecting AChR antibodies in myasthenia gravis sera with low antibody concentrations as determined by radioimmunoprecipitation assay by John S. Tzartos, Aigli G. Vakrakou, Katerina Karagiorgou, Vasiliki Zouvelou, Elisabeth Chroni, Valentina Damato, Francesca Beretta, Stavroula Salakou, Eirini Sfyroera, Dimitra Veltsista, Konstantinos Voumvourakis, Sotirios Giannopoulos, Georgios Tsivgoulis, Socrates Tzartos, Socrates Tzartos, Socrates Tzartos

“…ObjectivesWe investigated whether the acetylcholine receptor (AChR) cluster cell-based assay (CBA) is effective in detecting AChR antibodies in sera from myasthenia gravis (MG) patients with low antibody concentrations, as determined by radioimmunoprecipitation assay (RIPA).MethodsIn this retrospective diagnostic cohort study, 193 RIPA-positive sera from MG patients were analyzed. …”
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Outcomes in Catheter Ablation of Sustained Ventricular Tachycardia in Myocarditis Compared with Ischemic Heart Disease by Sheng Su, Le Li, Xi Peng, Likun Zhou, Zhuxin Zhang, Yulong Xiong, Zhenhao Zhang, Mengtong Xu, Yan Yao

“…For myocarditis patients with VT, CA might be equally effective.…”
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Gender-based differences in career paths, parenthood and perspectives on professional barriers among Asian ophthalmologists by Claire L Peterson, Brian S.Y. Yeo, Shelley Yin-Hsi Chang, Rachel S Chong, Marcus Ang, Anna CS Tan, Tina Wong, Andrew S.H. Tsai

“…Background: Gender equality in Asia remains under-researched, especially within medical fields. …”
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A harmonized dataset relating alternative farmer management practices to crop yield, soil organic carbon stock, nitrous oxide emissions, and nitrate leaching generated using IPCC m... by Roberta Calone, Angela Fiore, Guido Pellis, Maria Luz Cayuela, Gabriele Mongiano, Alessandra Lagomarsino, Simone Bregaglio

“…Current methodologies from the Intergovernmental Panel on Climate Change (IPCC) forassessing the impacts of alternative farming practices on GHG emissions rely on global or country-specific coefficients. However, these methods often do not explicitly account for the combined effects of management practices on carbon and nitrogen cycles or productivity, as this is not required for national GHG inventories. …”
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Efficacy of Rikkunshito on Chemotherapy-Induced Nausea and Vomiting in Patients With Uterine Corpus or Cervical Cancer Treated With Cisplatin-Based Regimen-Placebo-controlled, Doub... by Yosuke Konno MD, Shunsuke Ohnishi MD, Shinichiro Minobe PhD, Eiji Nomura PhD, Takayuki Nagasawa PhD, Etsuko Fujimoto MD, Tatsuru Ohara PhD, Shin Nishio MD, Hisamori Kato PhD, Yoshihito Yokoyama PhD, Etsuko Miyagi PhD, Hideki Tokunaga PhD, Koji Nishino MD, Akira Kikuchi PhD, Yoshio Yoshida PhD, Takashi Iwata PhD, Daito Noguchi MD, Wataru Kudaka PhD, Shunsuke Oyamada PhD, Keisuke Ariyoshi PhD, Kota Kihara PhD, Hidemichi Watari MD

“…Patients were randomized with a 1:1 equal allocation ratio to the rikkunshito group or placebo groups and given oral administration on days 1 to 5 with standard antiemetics (granisetron, aprepitant, and dexamethasone). …”
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Study protocol of a randomised controlled trial of prostate radiotherapy in high-risk and node-positive disease comparing moderate and extreme hypofractionation (PRIME TRIAL) by Vedang Murthy, Indranil Mallick, Abhilash Gavarraju, Shwetabh Sinha, Rahul Krishnatry, Tejshri Telkhade, Arunsingh Moses, Sadhna Kannan, Gagan Prakash, Mahendra Pal, Santosh Menon, Palak Popat, Venkatesh Rangarajan, Archi Agarwal, Sheetal Kulkarni, Ganesh Bakshi

“…We hypothesise that a five-fraction schedule of extreme hypofractionation will be non-inferior to a moderately hypofractionated regimen over 5 weeks in efficacy and will have acceptable toxicity and quality of life while reducing the cost implications during treatment.Methods and analysis This is an ongoing, non-inferiority, multicentre, randomised trial (NCT03561961) of two schedules for National Cancer Control Network high-risk and/or node-positive non-metastatic carcinoma of the prostate. …”
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Monitoring of liver and kidney profiles in anesthesiologists working in a regional reference teaching hospital in Northern Italy: analysis of health surveillance data using a linea... by Alborz Rahmani, Guglielmo Dini, Alfredo Montecucco, Luca Priano, Marco Leonetti, Alessia Manca, Bruno Kusznir Vitturi, Paolo Durando

“…Results One hundred seventy subjects were included in the analysis, equally divided between exposed and unexposed. At the first and last periodic examination, liver and kidney markers were not statistically different in the 2 cohorts. …”
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An Integrated Nomogram Combining Deep Learning and Radiomics for Predicting Malignancy of Pulmonary Nodules Using CT‐Derived Nodules and Adipose Tissue: A Multicenter Study by Shidi Miao, Qifan Xuan, Hanbing Xie, Yuyang Jiang, Mengzhuo Sun, Wenjuan Huang, Jing Li, Hongzhuo Qi, Ao Li, Qiujun Wang, Zengyao Liu, Ruitao Wang

“…DCA showed that the DLRCN was clinically useful. Under equal specificity, the sensitivity of DLRCN increased by 8.6% compared to radiologist assessments. …”
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Food intake and influencing factors among primary and secondary school students in rural areas covered by the nutrition improvement program by Wenshuo YOU, Peipei XU, Wei CAO, Mulei CHEN, Qian GAN, Hongliang WANG, Ruihe LUO, Titi YANG, Hui PAN, Jianfen ZHANG, Xiaoning WANG, Qian ZHANG, Juan XU

“…ObjectiveTo analyze the food intake of primary and middle school students in areas implementing the Rural Compulsory Education Student Nutrition Improvement Program in 2021 and its influencing factors. MethodsFollowing the principle of random sampling, in 2021, in 727 national pilot counties in 31 provinces (autonomous regions, municipalities) and the Xinjiang Production & Construction Corps, approximately 10% of primary and middle schools were selected in urban and rural areas, respectively. …”
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The Combination of Curcumae Radix and Syzygium Aromaticum Extracts Mitigates Benign Prostatic Hyperplasia through Anti-Proliferative and Anti-Inflammatory Effects by Geum Hwa Lee, Yu Seob Shin, Ji Hyun Kim, Da hee Shim, Hwa Young Lee, Luo Zhao, Mohammad Mamun Ur Rashid, Hwang Eui Cho, Jong Jin Lee, Min Kyoung Kim, Do Sung Kim, Hyun Jun Park, Han Jung Chae

“…The study aimed to investigate the anti-proliferative mechanism of Curcumae Radix (CR) and Syzygium aromaticum (SA) extracts using RWPE-1 cells and testosterone propionate (TP)-induced BPH rats. Materials and Methods: In vitro experiments were performed to assess the synergistic anti-proliferative effects of an equal mixture of CR and SA extracts on TP-treated RWPE-1 cells. …”

The Prognostic Value of Platelet Kinetics Assessment in Pediatric Chronic Idiopathic Thrombocytopenic Purpura by Nebojsa Igrutinovic, Jelena Pantovic, Bojana Markovic, Marija Medovic, Milica Cekerevac, Vladimir Markovic, Strahinja Odalovic, Sanja Knezevic, Ana Vujic, Isidora Mihajlovic, Nevena Stojadinovic, Dragan Knezevic, Nina Urakovic, Ivana Andrejevic, Gordana J. Ristic, Vladimir Slavkovic, Kristina Andric, Rasa Medovic

“…The aim of this study was to examine the importance of APK as a prognostic instrument in the selection of therapy in children with chITP. <b>Methods:</b> Retrospective, observational research, which included chITP children who were treated and subjected to APK in Serbia for 25 years (total number was 152). …”
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Direct high-precision radon quantification for interpreting high-frequency greenhouse gas measurements by D. Kikaj, E. Chung, A. D. Griffiths, S. D. Chambers, G. Forster, G. Forster, A. Wenger, P. Pickers, P. Pickers, C. Rennick, S. O'Doherty, J. Pitt, K. Stanley, D. Young, L. S. Fleming, L. S. Fleming, K. Adcock, E. Safi, T. Arnold, T. Arnold

“…Here we describe standardized approaches regarding (1) instrument maintenance, (2) quality control of the raw data stream, (3) determination and removal of the instrumental background, (4) calibration methods, and (5) response time correction (by deconvolution). …”
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Mortality risk associated with clinical signs of possible serious bacterial infection (PSBI) in young infants in Africa and Asia: protocol for a secondary pooled analysis by Adejumoke Idowu Ayede, Samir K Saha, Saifuddin Ahmed, Mohammad Shahidul Islam, Gary L Darmstadt, Fabian Esamai, Antoinette Tshefu Kitoto, Ebunoluwa A Adejuyigbe, Yasir Bin Nisar, Shamim Ahmad Qazi, Vaishnavi Bhamidi, Khusbu Adhikari, Ivana Marić, Robinson D Wammanda

“…Introduction The WHO’s Integrated Management of Childhood Illness (IMCI) in young infants &lt;2 months of age includes the identification and management of signs of possible serious bacterial infection (PSBI). However, equal importance is given to all the PSBI signs, which signal the need for referral and hospital management, except for fast breathing in infants aged 7–59 days, for which outpatient treatment by clinical staff working at a health facility is recommended. …”
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The effectiveness and risks of Treating people with Idiopathic Pulmonary fibrosis with the Addition of Lansoprazole (TIPAL): study protocol for a randomised placebo-controlled mult... by Toby M Maher, A John Simpson, Anthony Cahn, David Thickett, Luke Vale, Allan B Clark, Nazia Chaudhuri, Ian Forrest, Lisa G Spencer, Christopher Ward, Stephen Jones, Ganesh Raghu, Andrew M Wilson, Helen Parfrey, Megan Jones, Matthew Hammond, Jaclyn Ann Smith, Shajahan Wahed

“…Patients are randomised equally to receive two capsules of lansoprazole or two placebo capsules, two times per day for 12 months. …”
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A Phase 1/1B Trial of Pembrolizumab and Trametinib in Advanced NSCLC Enriched for KRAS Mutations by Jonathan W. Riess, MD, MS, Matthew S. Lara, BS, Guillaume Luxardi, PhD, Miguel Lopez de Rodas, MD, Michiko Shimoda, PhD, Karen Kelly, MD, Primo N. Lara, MD, Laurel Beckett, PhD, Arta Monjazeb, MD, PhD, Kurt A. Schalper, MD, PhD, Emanual Maverakis, MD, David R. Gandara, MD

“…Five patients (33%) experienced at least one grade greater than or equal to 3 treatment-related adverse event including one dose-limiting toxicity (grade 3 esophagitis). …”
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