Lower Free Triiodothyronine is a Risk Factor of Diabetic Peripheral Neuropathy in Patients with Type 2 Diabetes Mellitus by Chen Y, Sun L, Chen M, Zhang H, Song B, Wang H, Jiang A, Zhang L, Li S, Wang J, Wang W, Zhang H

“…Yang Chen,1,* Lijie Sun,1,* Minghui Chen,1,* Hui Zhang,2 Bing Song,3 Hongxiao Wang,3 Aijun Jiang,1,4 Li Zhang,5 Sumei Li,1 Jumei Wang,1 Wei Wang,1 Haoqiang Zhang1 1Department of Endocrinology, Centre for Leading Medicine and Advanced Technologies of IHM, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, People’s Republic of China; 2Henan Key Laboratory of Rare Diseases, Endocrinology and Metabolism Center, The First Affiliated Hospital, and College of Clinical Medicine of Henan University of Science and Technology, Luoyang, People’s Republic of China; 3Department of Endocrinology, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People’s Republic of China; 4University of Science and Technology of China, Hefei, People’s Republic of China; 5ShuCheng People’s Hospital, Luan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei Wang; Haoqiang Zhang, Email hfww2001@ustc.edu.cn; drhqzhang@ustc.edu.cnPurpose: Our objective is to investigate the potential involvement of free triiodothyronine (FT3), a key bioactive compound found in thyroid hormones (THs) in the pathogenesis of diabetic peripheral neuropathy (DPN) in patients diagnosed with type 2 diabetes mellitus (T2DM).Patients and Methods: A total of 121 T2DM patients were recruited. …”
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Combined Analysis of Transcriptome and Mendelian Randomization Reveals AKT1 and PPARG as Biomarkers Related to Glucose Metabolism in Sepsis by Ma J, Li W, Ma Q, Ding L, Wang Z, Wang R, Huang Y, Ma G, Gao J

“…Jie Ma,1,2,* Wendi Li,3 Qianqian Ma,1 Liying Ding,4 Zhaoyun Wang,1 Rong Wang,1 Yanan Huang,1 Gang Ma,2,* Jun Gao1,* 1Department of Anesthesia and Perioperative Medicine, First People’s Hospital of Yinchuan, The Second Clinical Medical College of Ningxia Medical University, Yinchuan, Ningxia, 750001, People’s Republic of China; 2Department of Anesthesia and Perioperative Medicine, General Hospital of Ningxia Medical University, The First Clinical Medical College of Ningxia Medical University, Yinchuan, Ningxia, 750004, People’s Republic of China; 3Department of Child Rehabilitation Education, Ningxia Rehabilitation Center for the Disabled, Yinchuan, Ningxia, 750002, People’s Republic of China; 4Department of Gynecology, Gynecology Clinic of Li Ying, Wuzhong, Ningxia, 751100, People’s Republic of China*These authors contributed equally to this workCorrespondence: Gang Ma, Department of Anesthesia and Perioperative Medicine, General Hospital of Ningxia Medical University, The First Clinical Medical College of Ningxia Medical University, Yinchuan, Ningxia, 750004, People’s Republic of China, Email magang2671@163.com Jun Gao, Department of Anesthesia and Perioperative Medicine, First People’s Hospital of Yinchuan, The Second Clinical Medical College of Ningxia Medical University, Yinchuan, Ningxia, 750001, People’s Republic of China, Email gaojun1605@sina.comIntroduction: This study aimed to identify diagnostic and therapeutic biomarkers related to glucose metabolism in sepsis, as hyperglycemia and blood glucose fluctuations influence sepsis progression.Methods: Datasets from public databases were analyzed using various methods, including differential expression analysis, PPI network screening, machine learning algorithms and Mendelian randomization. …”
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Prognostic Analysis of Elderly Patients with Hepatocellular Carcinoma: an Exploration and Machine Learning Model Prediction Based on Age Stratification and Surgical Approach by Cai C, Zhu H, Li B, Tang C, Ren Y, Guo Y, Li J, Wang L, Li D, Li D

“…This study established a machine learning-driven predictive model to identify key prognostic determinants and evaluate age/surgical approach impacts, overcoming limitations of traditional statistical methods.Methods: This retrospective study included 252 postoperative HCC patients aged ≥ 65 years (mean age 69.0± 4.3; 68.25% male). …”
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Long-Term Efficacy of Chlorine-Based Disinfectants Vs Multi-Enzymatic Detergent with Hypochlorous Acid for Waterline Disinfection in Inactive Dental Chair Units by Zheng YY, Wang YY, Guo Q, Shen CY, Huang R, Wang L, Sun H

“…Yu-Ying Zheng,1,2,* Yuan-Yuan Wang,1,3,* Qian Guo,1,4 Chan-Yuan Shen,1,5 Rong Huang,1,2 Li Wang,1,6 Huan Sun1,2 1State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan, 430079, People’s Republic of China; 2Department of Comprehensive Emergency, School & Hospital of Stomatology, Wuhan University, Wuhan, Hubei Province, 430079, People’s Republic of China; 3Center for Oral and Maxillofacial Surgery, School & hospital of stomatology (Optics Valley Branch), Wuhan University, Wuhan, Hubei Province, 430075, People’s Republic of China; 4Center for Orthodontics and Pediatric Dentistry, School & hospital of stomatology (Optics Valley Branch), Wuhan University, Wuhan, Hubei Province, 430075, People’s Republic of China; 5Department of Center for Emergency and General Dentistry, School & hospital of stomatology (Optics Valley Branch), Wuhan University, Wuhan, Hubei Province, 430075, People’s Republic of China; 6Department of Nursing, School & Hospital of Stomatology, Wuhan University, Wuhan, Hubei Province, 430079, People’s Republic of China*These authors contributed equally to this workCorrespondence: Huan Sun, Department of Comprehensive Emergency, School & Hospital of Stomatology, Wuhan University, No. 237 of Luoyu Road, Hongshan District, Wuhan, 430079, Hubei Province, People’s Republic of China, Tel +86 13986003844, Email sunhuansh01@163.com Li Wang, Department of Nursing Department, School & Hospital of Stomatology, Wuhan University, No. 237 of Luoyu Road, Hongshan District, Wuhan, 430079, Hubei Province, People’s Republic of China, Tel +86 027-87686387, Email liwangwlwl@126.comObjective: This study aimed to evaluate the long-term efficacy of two disinfection methods for waterline systems in inactive dental chair units (DCUs).Methods: On-site sampling and quantitative bacterial analysis were conducted to compare the effectiveness of chlorine-based disinfectants and a combination of multi-enzymatic detergent with hypochlorous acid in controlling microbial contamination in waterline systems of inactive DCUs.Results: No statistically significant differences in disinfection efficacy were observed between the treatment and control groups immediately after disinfection or on the third day post-disinfection (p > 0.05). …”
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α-Methyl-Tryptophan Inhibits SLC6A14 Expression and Exhibits Immunomodulatory Effects in Crohn’s Disease by Su Y, Li J, Chen Y, Bao J, Lei Z, Ma M, Zhang W, Liu Q, Xu B, Hu T, Hu Y

“…Traditional diagnostic and therapeutic methods have limitations, necessitating the exploration of more effective strategies.Methods: In this study, we employed the Gene Expression Omnibus database to identify genes that are differentially expressed in CD. …”
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Clinical Characteristics, Risk Factors, and Predictors of Nonobese Fatty Liver Disease: A Cross-Sectional Study by Zhang X, Wang S, Xu S, Min R, Ling Y, Sun S, Gong R

“…Xiaomei Zhang,1,2,* Shi Wang,3,* Sanping Xu,1 Rui Min,2 Yan Ling,1 Shiran Sun,4,* Rui Gong1,* 1Health Management Center, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 3Department of Breast and Thyroid Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 4Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China*These authors contributed equally to this workCorrespondence: Rui Gong; Shiran Sun, Email gongrui@hust.edu.cn; sunshiranwh@163.comPurpose: This study aimed to investigate the risk factors and predictors of non-obese fatty liver disease in the Chinese population.Patients and Methods: A total of 6,014 adults who underwent physical examinations at Union Hospital of Huazhong University of Science and Technology from March 2019 to March 2023 were included in this study. …”
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TRPC5 Promotes Intermittent Hypoxia-Induced Cardiomyocyte Injury Through Oxidative Stress by Qiu X, Yao Y, Chen Y, Li Y, Sun X, Zhu X

“…TRPC5 levels in H9c2 cells were determined via RT-qPCR and Western blotting (WB) methods. H9c2 cells overexpressing TRPC5 were subjected to either normoxic or intermittent hypoxia conditions. …”
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Development and Validation of Machine Learning Models for Outcome Prediction in Patients with Poor-Grade Aneurysmal Subarachnoid Hemorrhage Following Endovascular Treatment by Du S, Wu Y, Tao J, Shu L, Yan T, Xiao B, Lv S, Ye M, Gong Y, Zhu X, Hu P, Wu M

“…Therefore, it is urgently needed to investigate the risk factors and develop a critical decision model in the subtype of such patients.Methods: We extracted the target variables from an ongoing registry cohort study, PROSAH-MPC, which was conducted in multiple centers in China. …”
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Identifying Patients’ Preference During Their Hospital Experience. A Sentiment and Topic Analysis of Patient-Experience Comments via Natural Language Techniques by Yuan J, Chen X, Yang C, Chen J, Han P, Zhang Y, Zhang Y

“…We adopted a mixed-methods approach involving a literature review, human annotation, and natural language processing technique to analyze free-text comments. …”
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Lipidomic profile of seminal plasma in non-obstructive azoospermia with sperm maturation arrest by S. I. Gamidov, T. V. Shatylko, A. Kh. Tambiev, A. O. Tokareva, V. V. Chagovets, T. B. Bitsoev, N. L. Starodubtseva, A. Yu. Popova, V. E. Frankevich

“…The study aimed to assess the semen lipid profile in patients with sperm maturation arrest. Materials and methods. Samples of seminal plasma for lipid composition of 24 men with normozoospermia and 64 men with azoospermia were studied. …”
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Si-ITGA6-Loaded Liposomes Inhibit Capsule Fibrosis via the FAK/PI3K/Akt Signaling Pathway in Adhesive Capsulitis of Shoulder by Qi B, Wang Q, Shi S, Wang Q, Jiang W, Wang C, Li D, Sun Y, Yi C

“…The liposome-based siRNA delivery system was utilized for in vivo experiments due to its non-immunogenicity, stability, and low off-target effects compared to other siRNA delivery methods. We aimed to provide a potential approach for targeted therapy of ACS.Methods: Capsules from rotator cuff tear (RCT) patients with or without ACS were collected. …”
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Zinc Doped Synthetic Polymer Composites for Bone Regeneration: A Promising Strategy to Repair Bone Defects by Chen L, Zhou C, Xie Q, Xia L, Liu L, Bao W, Lin H, Xiong X, Zhang H, Zheng Z, Zhao J, Liang W

“…The use of advanced fabrication methods will help overcome pelletization issues to improve the therapeutic application of Zn-doped polymer composites in bone tissue regeneration. …”
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Efficacy and safety of 650 nm invasive laser acupuncture on non-specific chronic low back pain: a randomized clinical trial by Yejin Hong, Dongwoo Nam, Dongwoo Nam, Changsop Yang, Byoung-Kab Kang, Ae-Ran Kim, Kyung Min Shin, Jihye Kim, Saerom Jeon, Gwang-Cheon Park, Jae-Hong Kim, Jae-Hong Kim

“…BackgroundThe study aims to determine whether 650 nm invasive laser acupuncture (ILA) is safe and effective for pain relief in patients with non-specific chronic low back pain (NSCLBP).MethodsThis randomized clinical trial was conducted in two hospitals in Korea. …”
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Markers of Epstein–Barr virus in clinical assessment of Russian patients with nasopharyngeal cancer by K. V. Smirnova, N. B. Senuta, I. V. Botezatu, A. V. Ignatova, T. E. Dushenkina, A. A. Zolotarev, A. V. Lichtenstein, V. E. Gurtsevich

“…Epstein–Barr virus (EBV) is equally widespread in the endemic and non-endemic world regions for nasopharyngeal cancer (NPC). …”
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Detection of EGFR Mutations (Ex19Del, T790M, S768I, C797S, Ex20ins, G719X, L858R, L861Q) in Non-small Cell Lung Carcinoma and its Association with Various Clinicopathological Param... by Aditya A Mundra, Abha Mathur, Ram Mohan Jaiswal, Maneesh Vijayvargiya, Neha Sethi, Manoj Sharma, Shweta Bansal, Shikha Goyal

“…Results: A total of 37 cases were included in the study of which 21 were males and 16 were females. There was near equal distribution when a comparison of smoking status was done. …”
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Pyrethroid-resistant malaria vector Anopheles gambiae restored susceptibility after pre-exposure to piperonyl-butoxide: results from country-wide insecticide resistance monitoring... by Bilali Kabula, Yeromin P. Mlacha, Naomi Serbantez, Samwel L. Nhiga, Sigsbert Mkude, Samson Kiware, James S. Michael, Victor Mero, Sarah-Blythe Ballard, Adeline Chan, Said Abbasi, Charles D. Mwalimu, Nicodem J. Govella

“…Monitoring of insecticide resistance is, therefore, critical for the selection and assessment of the programmatic impact of insecticide-based interventions. Methods The study was conducted country-wide across 22 sentinel districts of Tanzania between May and July 2023 using standard World Health Organization susceptibility test with 1×, 5×, and 10× of deltamethrin, permethrin, and alpha-cypermethrin and discriminating concentrations of 0.25% pirimiphos-methyl. …”
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Socio-economic inequalities in minimum dietary diversity among Ethiopian children aged 6–23 months: a decomposition analysis by Nigusu Worku, Amare Mesfin Workie, Lamrot Yohannes, Mihret Getnet, Mihret Getnet, Wubshet Debebe Negash, Wubshet Debebe Negash, Adina Yeshambel Belay, Lakew Asmare, Hiwot Tadesse Alemu, Demiss Mulatu Geberu, Melak Jejaw, Kaleb Assegid Demissie, Misganaw Guadie Tiruneh, Asebe Hagos

“…Therefore, this study aimed to assess the socio-economic inequalities in minimum dietary diversity (MDD) practices among Ethiopian children aged 6–23 months and the potential contributing factors.MethodsThe study utilized the recent datasets of the Ethiopia Mini Demographic and Health Survey (EMDHS) of 2019. …”
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Effectiveness of ICS/LABA and LAMA/LABA in COPD due to biomass by Alejandra Ramírez-Venegas, Francisco Montiel-Lopez, Robinson E. Robles-Hernández, Bartolome R. Celli, Raúl H. Sansores, Maricruz Cassou-Martínez, José L. Pérez Lara-Albisua, Claudia González-González, María E. Mayar-Maya, Aloisa P. Hernández-Morales, Rafael J. Hernández-Zenteno, Ramcés Falfán-Valencia, Ireri Thirión-Romero, Oliver Pérez-Bautista, Rogelio Pérez-Padilla

“…Conclusions Among patients with COPD-B and COPD-C with a history of exacerbation, FF/VI was equally effective as UMEC/VI in preventing exacerbations and improving dyspnoea and HRQL.…”
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Effect of staining and whitening systems on color stability of computer aided design/computer aided manufacturing lithium disilicate glass ceramic by Nadia S. Al-Angari, Shahad Quwayhis, Nouf Almayouf, Shahad Meaigel, Abdulelah Aldahash, Sarah S. Al-Angari

“…Purpose: To investigate the effect of coffee stain and whitening systems on the color stability of CAD/CAM glazed lithium disilicate glass-ceramics (LDGCs). Methods:  68 glazed LDGC discs (12 × 10 × 2 mm) were fabricated using blocks of CAD/CAM systems (IPS e.max CAD ceramic). …”
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A comparative analysis of clinical outcomes in hematological patients afflicted with bacteremia attributable to carbapenem-resistant Klebsiella pneumoniae versus Escherichia coli by Jiali Wang, Jiali Wang, Jia Liu, Qingsong Lin, Qingsong Lin, Fengkui Zhang, Fengkui Zhang, Yizhou Zheng, Yizhou Zheng, Zhijian Xiao, Zhijian Xiao, Jianxiang Wang, Jianxiang Wang, Aiming Pang, Aiming Pang, Yi He, Yi He, Erlie Jiang, Erlie Jiang, Sizhou Feng, Sizhou Feng, Mingzhe Han, Mingzhe Han, Weihua Zhai, Weihua Zhai

“…Nevertheless, there is a paucity of studies that have undertaken a comparative analysis of clinical outcomes in patients afflicted with CRKP and EC.MethodsThis study was conducted with the aim of identifying the microbiological and clinical characteristics of hematological patients suffering from bacteremia caused by CRKP and CREC.ResultsThe cohort included 90 patients with equal proportions of CRKP BSI and CREC BSI from 2017 to 2022. …”
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