Universal Bacterium-Vectored COVID-19 Vaccine Expressing Early SARS-CoV-2 Conserved Proteins Cross-Protects Against Late Variants in Hamsters by Qingmei Jia, Helle Bielefeldt-Ohmann, Saša Masleša-Galić, Richard A. Bowen, Marcus A. Horwitz

“…In this study, we evaluate the efficacy of rLVS Δ<i>capB</i>/MN and an enhanced version, rLVS Δ<i>capB</i>::RdRp/MN, which additionally expresses the conserved RNA-dependent RNA polymerase (RdRp) protein from the same strain, in a hamster model. <b>Methods:</b> Both vaccine candidates were administered orally or intranasally to golden Syrian hamsters (equal numbers of males and females) and evaluated against intranasal challenge with SARS-CoV-2 Delta (B.1.617.2-AY.1) and Omicron (BA.5) variants. …”
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Invasive minimal Microvascular Resistance Is a New Index to Assess Microcirculatory Function Independent of Obstructive Coronary Artery Disease by Guus A. de Waard, Sukhjinder S. Nijjer, Martijn A. van Lavieren, Nina W. van der Hoeven, Ricardo Petraco, Tim P. van de Hoef, Mauro Echavarría‐Pinto, Sayan Sen, Peter M. van de Ven, Paul Knaapen, Javier Escaned, Jan J. Piek, Justin E. Davies, Niels van Royen

“…In this study we propose minimal microvascular resistance (mMR) as a new measure of microcirculatory dysfunction and aim to determine whether mMR is influenced by CAD. Methods and Results We obtained 482 simultaneous measurements of intracoronary Doppler flow velocity and pressure. …”
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6-Gingerol, an active compound of ginger, attenuates NASH-HCC progression by reprogramming tumor-associated macrophage via the NOX2/Src/MAPK signaling pathway by Qiurui Li, Meng Wang, Xuekuan Huang, Shang Wang, Chunli Li, Pan Li, Wei Xiang, Ling Yao, Chengdan Deng, Mingming Zhang, Jianwei Wang

“…The therapeutic effects and underlying mechanisms of NASH-HCC, however, remain poorly understood. Methods Network pharmacology, bioinformatics, single-cell RNA sequencing analysis, and molecular docking were used to identify the main active compounds, targets, and possible mechanisms of ginger in treating NASH-HCC. …”
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Q-Ball high-resolution fiber tractography: Optimizing corticospinal tract delineation near gliomas and its role in the prediction of postoperative motor deficits– A proof of concep... by Pavlina Lenga, Moritz Scherer, Robin Peretzke, Peter Neher, Jessica Jesser, Andreas W. Unterberg, Sandro Krieg, Daniela Becker

“…Research question: This study compares the results of conventional DTI-FT and q-ball (QBI)-high resolution FT with patient's postoperative morbidity, relating postoperative MD with the nearest distance from the lesion to the CST (nD-LCST). Materials and methods: In this ongoing prospective trial, we utilized probabilistic High-Resolution Fiber Tracking (HRFT) through q-ball imaging (QBI-FT) and conventional Diffusion Tensor Imaging Fiber Tracking (DTI-FT), based on equal and standard diffusion-weighted MRI. …”
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Features of Celiac Disease in children and adolescents with Down syndrome: a single-center experience of annual screening by Martina Lattuada, Paola Rebora, Paola Rebora, Chiara Fossati, Alessandra Lazzerotti, Lucia Paolini, Alessandro Cattoni, Alessandro Cattoni, Roberto Panceri, Maria Grazia Valsecchi, Maria Grazia Valsecchi, Andrea Biondi, Andrea Biondi, Giovanna Zuin

“…Among patients with CD and DS, 93% had histological damage equal to 3rd grade of Marsh-Oberhuber classification at diagnosis. …”
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Retrospective cohort of prenatal home ultrasound utilization and maternal-neonatal outcomes by Anat Pardo, Erkan Kalafat, Shira Hazon, Monica Pailis, Emilie Klochendler-Frishman, Or Lee Rak, Ofri Samueloff, Rachel Gomez-Tolub, Anat Shmueli, Noam Pardo, Tomer Sela, Leor Wolff, Asnat Walfisch, Arnon Wiznitzer, Eran Hadar

“…This service provides a handheld, app-connected ultrasound device for remote basic fetal monitoring, with its use determined at the discretion of the patient as a supplement - rather than a replacement - to standard prenatal care. Methods Retrospective analysis comparing maternal and neonatal outcomes among users versus non-users of the home ultrasound service, between January 2020 and December 2022. …”
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Investigating the prevalence of three medically important pathogens in Ixodes pacificus from southern Oregon by Andrew T. Partin, Emilio E. DeBess, Phillip Q. Spinks, Michael J. Yabsley, Michael J. Yabsley, Michael J. Yabsley, Kayla B. Garrett, Kayla B. Garrett, Kayla B. Garrett, James R. Clover, Geoffrey R. Taylor

“…Ixodes pacificus is common in southern Oregon yet there are few published studies on the distribution of tick-borne pathogens in this region. MethodsUsing real-time quantitative PCR, we assessed the prevalence of B. burgdorferi s.l., B. miyamotoi, and A. phagocytophilum among 2,463 unfed I. pacificus adults and nymphs combined into 260 pools (131 nymph, 129 adult) with nearly equal numbers of each life stage from 12 locations in Jackson County, Oregon. …”
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Adverse Drug Reactions to SGLT2i Reported by Type 2 Diabetes New Users: An Active Surveillance Study by Camelia Bucșa, Ioana Frenț, Ramona Stefan, Adriana Fodor, Georgeta Inceu, Andreea Farcaș, Adriana Rusu, Monica Negovan, Cristina Mogoșan

“…<b>Results</b>: In total, 64 patients, with genders being equally represented and with a median age of 59 years (Q1, Q3: 51, 64) were followed-up with. …”
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Acupuncture improves the symptoms, serum ghrelin, and autonomic nervous system of patients with postprandial distress syndrome: a randomized controlled trial by Zi-tong Fu, Cun-zhi Liu, Mi-Rim Kim, Yi-duo Liu, Yu Wang, Yi-Ming Fu, Jing-Wen Yang, Na-Na Yang

“…Sixty-two PDS patients were randomly assigned equally to acupuncture or sham acupuncture arm (3 sessions per week for 4-week). …”
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Exploring Mortality and Prognostic Factors of Heart Failure with In-Hospital and Emergency Patients by Electronic Medical Records: A Machine Learning Approach by Yu CS, Wu JL, Shih CM, Chiu KL, Chen YD, Chang TH

“…To improve the explainability of the AI models, Shapley Additive Explanations methods were also conducted.Conclusion: Exploring HF mortality and its patterns related to clinical risk factors by machine learning models can help physicians make appropriate decisions when monitoring HF patients’ health quality in the hospital.Keywords: mortality, risk factor, cardiovascular disease, multivariate statistical analysis, machine learning, artificial intelligence…”
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SKIN AVILABLE MASTOID AREA ON THE STAGE OF ITS STRAIN by D.S. Avetikov, D.V. Steblovskii, I.I. Starchenko

“…Objective: To investigate the morphological features skin-fat grafts mastoid areas at different stages of deformation. Materials and methods. The experiment used 25 skin-fat grafts, 5 of which stretched for 5, 10, 15, 20, 25 mm respectively. …”
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Comparative diagnostic accuracy of pre-test clinical probability scores for the risk stratification of patients with suspected pulmonary embolism: a systematic review and Bayesian... by Ali Etemadi, Mohammadmobin Hosseini, Hamed Rafiee, Amir Mahboubi, Tara Mahmoodi, Toshiki Kuno, Yaser Jenab, Claire E. Raphael, Wilbert S. Aronow, Kaveh Hosseini, Jay Giri

“…Diagnostic test accuracy indices were synthesized using beta-binomial Bayesian methods. Results Forty studies (37,027 patients) were included in the meta-analysis. …”
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Evaluation of the efficiency and safety of combined therapy with a symptomatic sustained-release drug and hyaluronic acid versus monotherapy with hyaluronic acid in patients with... by K. A. Berdyugin, I. V. Kadyntsev, O. V. Berdyugina, E. A. Taskina, N. G. Kashevarova

“…Searching for new treatment methods and regimens for OA is relevant.Objective: to evaluate the efficiency and safety of therapy with a symptomatic sustained-release drug (Alflutop) in combination with intra-articular hyaluronic acid (HA) injection versus monotherapy with HA in patients with knee OA in routine clinical practice.Patients and methods. …”
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Potential Causal Relationship Between Chronic Obstructive Pulmonary Disease and Diabetes: A Bidirectional Two-Sample Mendelian Randomization Study by Wang X, Chen X, Feng R, Jiang H, Liu W

“…However, their causal relationship still needs to be confirmed.Methods: We conducted a comprehensive bidirectional two-sample Mendelian randomization (MR) analysis to evaluate the causal links between COPD and both type 1 diabetes (T1D) and T2D by using genome-wide association study (GWAS) summary statistics in European and Asian populations. …”
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Olive Oil Solution of Volatile Oil from Citri Reticulatae Pericarpium Viride Alleviates Slow-Transit Constipation via Regulating SCF/c-Kit Signaling Pathway and Intestinal Flora by Zou S, Xie B, An Z, Li F, Cui L, Zhang Z, Bu W, He D

“…This study aimed to explore the mechanisms by which volatile oil from Citri Reticulatae Pericarpium Viride (VOCRPV) alleviates slow-transit constipation (STC).Methods: The main active ingredients in VOCRPV were determined by High-Performance Liquid Chromatography (HPLC). …”
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lectrical cardiometry compared to transesophageal doppler for hemodynamics monitoring and fluid management in pediatrics undergoing Kasai operation. A randomized controlled trial. by M. Lotfy, K. Yassen, O. El Sharkawy, R. Elshoney, A. Moustafa

“…FTc negatively correlated with SVV and CVP . Conclusions Both methods were able to monitor the trend changes of CO and equally guide fluid management, with a good degree of reliability, but their limits of agreement werenoted to be wide. …”
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Kuoxin Decoction Alleviated Left Ventricular Remodeling by Inhibiting Cardiomyocyte Apoptosis Through ASK1/JNK/Cx43 Signaling Pathway in cTnTR141W Transgenic Mice and in vitro by Ma M, Fan H, Dong Y, Feng T, Peng L, Zhou M, Liu F, Lee R, Wu R, Wu Q, Wang Y

“…Mengjiao Ma,1,&amp;ast; Hua Fan,1,&amp;ast; Yidan Dong,1,2 Tianyi Feng,1 Longping Peng,1 Maolin Zhou,1 Feifei Liu,1 RueyJyh Lee,1 Rongxue Wu,3 Qiong Wu,1,3 Youhua Wang1 1Department of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 2Department of Cardiology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 3Department of Medicine/Cardiology, Biological Sciences Division, University of Chicago, Chicago, IL, USA&amp;ast;These authors contributed equally to this workCorrespondence: Youhua Wang, Department of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China, Email doctorwyh@163.com Qiong Wu, Department of Cardiology, Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China, Email wuqiong1203@126.comPurpose: Combined with RNA sequencing and experimental verification methods to investigate KXD’s potential role and underlying mechanisms in cTnTR141W transgenic mice and H9c2 cells.Methods: UPLC-Q-TOF-MS analysis was employed to identify the absorbed constituents from KXD in mice blood. cTnTR141W transgenic mice were given with KXD via gavage for 4 weeks. …”
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Long-Term Physiological Adaptations Induced by Short-Interval High-Intensity Exercises: An RCT Comparing Active and Passive Recovery by Mario Mauro, Bernardino Javier Sánchez-Alcaraz Martínez, Pasqualino Maietta Latessa, Sofia Marini, Stefania Toselli

“…<b>Background:</b> High-intensity interval training (HIIT) is one of the most debated methods involving several parameters that could be modulated, but the long-term adaptations it induces are still unclear. …”
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Structure of intra- and intergroup relationships among key parameters of physical development, physical fitness, and biological age in students aged 17–20 by Oleksandr Pryimakov, Marek Sawczuk, Georgiy Korobeynikov, Stanislav Prysiazhniuk, Anatoly Skrypko, Nataliya Mazurok

“…Indicators from three sets related to students’ physical condition (PC) were recorded: physical development (PD), physical fitness (PF), and both chronological and biological age (BA). Methods of correlation, variance, regression, and canonical analysis were applied to process the experimental data. …”
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Disulfidptosis-Related Genes as Novel Biomarkers and Therapeutic Targets in Dilated Cardiomyopathy by Fan J, Xu S, Zeng Y, Xu A, Wang X, Wang H, Kang P, Fu Y, Fan H, Zhou Y

“…A predictive model was constructed using four machine learning methods, and its performance was validated with independent datasets. …”
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