A Five-Gene Signature for the Prediction of Event-Free Survival of Both Pediatric and Adult Acute Myeloid Leukemia by Dechang Chen, Alvin J. Liu, Li Sheng, Zhenqiu Liu, Irina Elcheva

“…EFS represents the time patients survive without disease recurrence, progression, or further treatment, a crucial metric for evaluating drug efficacy and assessing the clinical benefits of treatment. <b>Methods:</b> We performed an integrated analysis of adult TCGA and pediatric TARGET expression datasets to pinpoint genes and pathways associated with EFS in both adult and pediatric AML. …”
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Influence of platelet-rich plasma on RANKL and IL-1 immunohistochemical expression in periodontitis-related bone cell proliferation and differentiation by Hana H. Mustafa, Snur M.A. Hassan, Sozan Ali Mohammed, Mardin O. Mohammed, Hadia Karim Zorab, Hardi Fattah Marif

“…A rat model of experimentally generated periodontitis was used to assess the impact of PRP preparation on the expression of the osteoclastogenic and pro-inflammatory markers respectively; RANKL and IL-1β. Material and Methods: To induce periodontitis by silk ligature, thirty-six adult male Sprague Dawleys rats were used and they were allocated into three equal groups (n = 12): group I consisted of intact periodontal tissue, group II; rat-induced periodontitis without treatment by PRP, and group III of periodontitis + 10 µL PRP injection. …”
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Inhibitory Effects of Paclitaxel-Loaded Iron Oxide Nanoparticles on Non-Small Cell Lung Cancer by Enhancing Autophagy-Dependent Ferroptosis and Apoptosis Pathways by Deng R, Liang G, Chen W, Nie Q, Wen J

“…However, inhibitory effect and possible mechanism of IONP@ PTX on non-small-cell lung cancer (NSCLC) remain unclear.Objective: This work aimed to assess inhibitory effects and potential mechanisms of IONP@PTX on lung cancer A549 cells and further explore the nanomedicine delivery systems for applications in cancer therapies.Methods: Morphology features and qualities of IONP@PTX were directly assessed. …”
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Effectiveness and safety of direct oral anticoagulants versus vitamin K antagonists in atrial fibrillation patients with liver disease: a systematic review and meta-analysis by Qiang Zhou, Xiang Liu, Shuyu Liu, Zhichun Gu, Yanzi Wu, Yuansu Yang, Yingying Tao, Meng Wei

“…IntroductionPatients with atrial fibrillation (AF) and liver disease, particularly cirrhosis, are frequently excluded from anticoagulation trials, leaving the optimal therapeutic strategy uncertain.MethodsThis study aimed to compare the effectiveness and safety of direct oral anticoagulants (DOACs) and vitamin K antagonists (VKAs) in patients with AF and liver disease. …”
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Association of SCN1A Gene Polymorphisms with Sodium Valproate Resistance in Pediatric Epilepsy: A Retrospective Case-Control Study by Wang H, Geng T, Deng N

“…Elucidating the genetic mechanisms underlying sodium valproate resistance could revolutionize personalized treatment strategies, particularly in pediatric epilepsy.Objective: To explore the relationship between polymorphisms in the sodium channel α 1 subunit gene (SCN1A) and resistance to sodium valproate therapy in pediatric epilepsy patients.Methods: A retrospective analysis included 89 pediatric patients with sodium valproate-resistant epilepsy (resistant group) and 89 patients responsive to sodium valproate (responder group), and 89 healthy controls. …”
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Bibliometric and Visualized Analysis of Artemisinin and Its Derivatives in Cancer by Feng J, He Y, Bai T, You Q, Zhu H, Jia C, Liu B, Li S

“…Until now, there have been no systematic scientometrics studies to analyze the research trend of artemisinin and its derivatives in cancer.Aim of the Study: We conducted this bibliometric study with the aim of providing researchers in the field with an all-around summary of artemisinin and its derivatives in cancer, visualizing current research advances, identifying hotspots, and ultimately outlining cutting-edge trends for future development.Methods: A total of 927 relevant publications from 1990 to 2023 were accessed from the WOSCC database and analyzed bibliometrically utilizing software including CiteSpace VOSviewer and Microsoft Excel.Results: Global publications in artemisinin and tumor therapy have steadily increased. …”
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Association Between Four Non-Insulin-Based Insulin Resistance Indices and the Risk of Post-Stroke Depression by Wang P, Wang M, Xie Z, Zhi Z, Wang Y, Liu F, Liu Y, Zhao L

“…Therefore, we explored the relationship between four non-insulin-based IR indices and post-stroke depression (PSD).Patients and Methods: A total of 638 consecutive AIS patients were enrolled in this prospective cohort study. …”
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How does integrated knowledge translation work? A realist review by Anita Kothari, Shannon L. Sibbald, Chris McCutcheon, Whitney Berta, Robin Urquhart, Tanya Horsley, Leigha Comer, Ian D. Graham

“…Abstract Background Integrated knowledge translation (IKT), or research co-production, is a research approach where researchers and knowledge users carry out a study as equal partners. A growing evidence base demonstrates that IKT produces research findings that are useful, usable and used. …”
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Impact of late effects after treatment for bladder cancer with radical cystectomy on Quality of life: a case-control study by Rikke V. Milling, Ninna K. Nielsen, Charlotte Graugaard-Jensen, Peter Christensen, Helle Pappot, Jørgen B. Jensen

“…In spite of this, MIBC patients overall QoL was equal to that of the controls. …”
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Prevalence of periodontitis based on retrospective radiographic evaluation at dental hospital in Eastern Province of Saudi Arabia: A retrospective study by Afsheen Tabassum, Marwa Madi, Ahmed Alabdulaziz, Yousif Al Nasrallah, Mohammed Alabdulaziz, Intisar Ahmad Siddique, Farhat Kazmi

“…Logistic regression analysis was used to evaluate the predictors of periodontitis. A P-value equal to or under 0.05 reflected statistical significance. …”
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Progesterone peak influences embryonic developmental morphokinetics on trigger day? A retrospective study by D. Baldini, V. M. Bartoli, A. Mastrorocco, D. Ferri, M. Dellino, A. S. Laganà, S. Hatirnaz, G. M. Baldini, A. Malvasi, A. Vimercati, G. Trojano

“…Aim of the study is to evaluate the impact of PPR exceeding 1.5 ng/ml at the time of hCG-trigger on embryo morphokinetic parameters and to identify predictive biomarkers of in IntraCytoplasmic Sperm Injection (ICSI) cycles outcomes. Methods It is a retrospective study including patients underwent ICSI cycles in the period 2020–2023. 58 patients were recruited in the study group showing P levels in the trigger day greater than or equal to 1.5 ng/ml. …”
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Mid-Term Impact of Conduction System Pacing on Overall Cardiac Performance: A Non-Randomized, Prospective, Single-Center Echocardiographic Study by Catalin Pestrea, Ecaterina Cicala, Roxana Enache, Marcela Rusu, Radu Gavrilescu, Adrian Vaduva, Madalina Ivascu, Florin Ortan, Dana Pop

“…</b> HBP and LBBAP are equally protective for harmful changes in both atria and ventricles. …”
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Seroprevalence of Leptospirosis among High-Risk Individuals in Morocco by Mohamed El Azhari, Mathieu Picardeau, Imad Cherkaoui, Mohamed Anouar Sadat, Houda Moumni, Kamal Marhoum El Filali, Hassan Ghazal, Abderrahmane Maaroufi, Salsabil Hamdi, Naima El Mdaghri, Pascal Bourhy

“…In the remaining 8 MAT-positive sera, MAT showed equal titers against more than one serogroup. Conclusion. …”
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Effectiveness of Self-Help Plus in its digital version in reducing anxiety and post-traumatic symptomatology among nursing home workers during the COVID-19 pandemic: secondary anal... by Marianna Purgato, Federico Tedeschi, Corrado Barbui, José Luis Ayuso-Mateos, Roberto Mediavilla, Marianna Riello, Debora Zaccoletti, David MacTaggart, Elena Rusconi

“…Background Healthcare workers (HCWs) face substantial daily work-related pressures, leading to frequent reports of depression, anxiety and post-traumatic stress disorder (PTSD) symptoms.Objective To compare the effects of Self-Help Plus in its digital version Doing What Matters in Times of Stress (DWM) to an equally structured activity in reducing anxiety and/or PTSD symptoms among HCWs.Methods We compared the proportion of participants with moderate-to-severe anxiety (General Anxiety Disorder Scale; GAD-7 ≥10) and/or PTSD symptoms (Impact of Event Scale-Revised (IES-R)) ≥26) between DWM and the alternative activity. …”
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Intersectionality and mental health in university students: a jeopardy index approach by Juliana Dias de Lima, Jessica Plácido, Beatriz Andrade, Letícia Dalcero Abend, Aline Josiane Waclawovsky, Daniel Alves Pires, Danilo Rodrigues Pereira da Silva, Fabianna Resende de Jesus-Moraleida, Helena Ferreira Moura, Nicole Leite Galvão Coelho, Renato Sobral Monteiro-Junior, Thiago Sousa Matias, Felipe Barreto Schuch, Andrea Camaz Deslandes

“…ABSTRACT OBJECTIVE: To explore the associations between current mental health symptoms and social disparities in university students. METHODS: We recruited participants from nine public universities in Brazil, from August to November 2022, using online advertisements and in-person lectures. …”
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Rationale and design of a large trial of perioperative ketamine for prevention of chronic post-surgical pain by Philip J. Peyton, Sabine Braat, Anurika De Silva, David Story, Lisbeth Evered, Paul S. Myles, Matthew Chan, Stephan Schug, Malcolm Hogg, Alex Holmes, Sofia Sidiropoulos, Kate Leslie

“…Eligible participants are randomised equally to perioperative intravenous ketamine or placebo for up to 72 h. …”
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Association Between Lipoprotein(a) and Risk Factors of Atherosclerosis in Russian Population (Data of Observational ESSE-RF study) by S. A. Shalnova, M. V. Ezhov, V. A. Metelskaya, S. E. Evstifeeva, V. I. Tarasov, G. A. Muromtseva, Yu. A. Balanova, A. E. Imaeva, A. V. Kapustina, A. A. Shabunova, O. A. Belova, I. A. Trubacheva, A. Y. Efanov, Z. T. Astakhova, N. V. Kulakova, S. A. Boytsov, O. M. Drapkina

“…To investigate the distribution of Lp(a) in the population of the regions participating in the Study “Epidemiology of Cardiovascular Diseases in the Regions of the Russian Federation” (ESSE-RF) and to evaluate its associations with cardiovascular risk factors.Material and methods. Representative samples of the male and female population of 7 regions of the Russian Federation, aged from 25 to 64 years, enrolled in the multi-center cross-sectional epidemiological study were analyzed. …”
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Multidose Dalbavancin Population Pharmacokinetic Analysis for Prolonged Target Attainment in Patients Requiring Long-Term Treatment by Giammarco Baiardi, Michela Cameran Caviglia, Silvia Boni, Antonello Di Paolo, Valeria Marini, Giuliana Cangemi, Alessia Cafaro, Emanuele Pontali, Francesca Mattioli

“…<b>Methods:</b> Pharmacokinetic analysis was based on a nonlinear mixed effects modelling approach performed in NONMEM v7.5/Pirana, while R was used for data management and graphical summaries. …”
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The effect of oral probiotics on CD4 count in patients with HIV infection undergoing treatment with ART who have had an immunological failure by Masoud Mortezazadeh, Saeed Kalantari, Nooshin Abolghasemi, Mitra Ranjbar, Saeedeh Ebrahimi, Abbas Mofidi, Babak Pezeshkpour, Ensieh Sadat Mansouri, Seyed Zia Tabatabaei, Mehdi Kashani

“…Probiotics play an important role in stimulating natural killer T cells, strengthening the functional gut barrier, and reducing systemic inflammation. Methods This study was a randomized double‐blind clinical trial involving 30 patients treated with antiretroviral therapy who had experienced immunological failure despite HIV viral suppression. …”
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HOMESIDE: home-based family caregiver-delivered music and reading interventions for people living with dementia: protocol of a randomised controlled trial by Sabine Braat, Felicity Anne Baker, Imogen Clark, Young-Eun Claire Lee, Thomas Wosch, Helen Odell-Miller, Nicola Lautenschlager, Jodie Bloska, Anna Bukowska, Ming H Hsu, Tone Kvamme, Agnieszka Smrokowska-Reichmann, Karette A Stensaeth

“…Dyads will be randomised equally to standard care (SC), a home-based music programme plus SC, or a home-based reading programme plus SC for 12 weeks. …”
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