Prevalence, characteristics and management of migraine patients with triptan failure in primary care: the EMR France-Mig study by M. Lanteri-Minet, C. Casarotto, O. Bretin, C. Collin, M. Gugenheim, V. Raclot, A. Cases, P. A. Squara, W. Aissani, A. Saighi, H. Lefebvre

“…The aim of the France-Mig study was to quantify the population with triptan failure due to ineligibility or resistance, in the primary care setting, and describe their therapeutic management. Methods The France-Mig study was a retrospective analysis of a cohort of patients suffering from migraine in 2022 identified using data from the IQVIA electronic medical records (EMR). …”
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Tanshinone I Ameliorates Psoriasis-Like Dermatitis by Suppressing Inflammation and Regulating Keratinocyte Differentiation by Wang Q, Luo X, Su Y, Jin Y, Kuang Q, Li S, Shen W, Zhu Y

“…Tanshinone I (Tan-I) has recently been discovered to have immunomodulatory properties, but its role and mechanisms in treating psoriasis remain unclear.Objective: To evaluate the efficacy of Tan-I in the treatment of psoriasis and to determine the mechanisms involved.Methods: An imiquimod (IMQ)-induced psoriasis-like mouse model was treated topically with Tan-I (7.5 mg/kg/d) or a vehicle. …”
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Genetic Variants in the Adhesive G Protein-Coupled Receptor ADGRG6 are Associated with Increased Susceptibility to COPD in the Elderly Han Chinese Population of Southern China by Chen F, Zhao J, Mo R, Ding X, Zhang Y, Huang L, Xie T, Ding Y

“…However, the impact of genetic variations in ADGRG6 on chronic obstructive pulmonary disease (COPD) susceptibility has not yet been evaluated.Methods: Considering the high prevalence of COPD among the elderly population in China, this study specifically targets the elderly Han population in Southern China as the study subject. …”
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Untrained perceptual loss for image denoising of line-like structures in MR images. by Elisabeth Pfaehler, Daniel Pflugfelder, Hanno Scharr

“…Therefore, automatic image denoising using deep learning methods is of high interest. In this work, we concentrate on image denoising of MR images containing line-like structures such as roots or vessels. …”
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Identifying Therapeutic Targets and Potential Drugs for Diabetic Retinopathy: Focus on Oxidative Stress and Immune Infiltration by Peng H, Hu Q, Zhang X, Huang J, Luo S, Zhang Y, Jiang B, Sun D

“…This study investigated biomarkers connected to DR and oxidative stress and their connection with immune cell infiltration using bioinformatics analysis and found possible therapeutic medications.Methods: The Gene Expression Omnibus (GEO) database was used to obtain the gene expression data for DR. …”
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Investigating Drug-Induced Thyroid Dysfunction Adverse Events Associated With Non-Selective RET Multi-Kinase Inhibitors: A Pharmacovigilance Analysis Utilizing FDA Adverse Event Re... by Meng Z, Song L, Wang S, Duan G

“…Zhuda Meng,1,* Liying Song,2,* Shuang Wang,3,* Guosheng Duan4 1Department of Thyroid Surgery, Changzhi People’s Hospital, Changzhi, People’s Republic of China; 2Department of Thyroid Surgery, First Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 3Department of Gastroenterology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, 030032, People’s Republic of China; 4Radiotherapy Department, Shanxi Provincial Peoples Hospital: Fifth Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhuda Meng, Department of Thyroid Surgery, Changzhi People’s Hospital, Changzhi, 046000, People’s Republic of China, Email jzx23456m@163.comPurpose: This study aims to investigate the potential association between non-selective RET kinase inhibitors and thyroid dysfunction (TD) by conducting a pharmacovigilance analysis using data from the US FDA Adverse Event Reporting System (FAERS).Methods: Data for non-selective RET MKIs were obtained from the FAERS database, spanning the first quarter of 2015 to the fourth quarter of 2023. …”
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Retrograde Approach for Percutaneous Ventricular Septal Defect Closure: Is It Really Better Than Antegrade? by Nataliia S. Yashchuk, Igor O. Ditkivskyy, Alisa P. Soi, Bogdan V. Cherpak, Olha S. Borodinova, Yuliia V. Yermolovych

“…To the best of our knowledge, there is currently no published literature comparing the immediate and longterm outcomes of these two techniques for transcatheter VSD closure. Materials and methods. From August 2012 to January 2025, 254 patients underwent percutaneous ventricular septal defect closure using various devices. …”
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IMPACT OF VITAMIN D DEFICIENCY OR INSUFFICIENCY ON THE SEVERITY OF COVID-19 IN HOSPITALIZED PATIENTS by Olga A. Golubovska, Kyrylo O. Chalyy, Oleksandra V. Bezrodna, Anastasiia A. Holubovska

“…The MR among patients aged 65 years and older with normal vitamin D levels was 30.0% (95% CI 4.8-65.0), but in patients with vitamin D deficiency/insufficiency it was approximately 1.5 times higher and equal to 44.7% (95% CI 29.0-61.1). Conclusions. …”
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Specnuezhenide Alleviates Senile Osteoporosis by Activating TGR5/FXR Signaling in Bone Marrow Mesenchymal Stem Cells and RANKL-Induced Osteoclasts by Deng X, Lin B, Xiao W, Wang F, Xu P, Wang N

“…In this study, the effects of SPN on d-galactose (d-gal)-induced mice, bone marrow mesenchymal stem cells (BMSCs), and nuclear factor-κB ligand-induced osteoclasts were examined.Methods: Micro-computed tomography was used to observe the bone microstructure. …”
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Jiawei Erzhiwan Ameliorates Androgenetic Alopecia by Regulating the SIRT1/JNK/p38 MAPK Pathway by Huang Z, Li Y, Xie Y, Fu H, Weng Z, Yuan J, Wu L, Lin W, Cao Y, Ding B

“…However, the underlying mechanisms is still unknown.Patients and Methods: In this study, the phytochemical ingredients in WJWE were characterized via UPLC‒MS/MS analysis. …”
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Using Network Pharmacology and in vivo Experiments to Uncover the Mechanisms of Radix Paeoniae Rubra and Radix Angelicae Sinensis Granules in Treating Diabetes Mellitus-Induced Ere... by Wang J, Guo Y, Huang J, Yan J, Ma J

“…This study investigates the mechanisms and targets of Radix Paeoniae Rubra and Radix Angelicae Sinensis Granules (RAG) in treating DMED using network pharmacology and animal models.Methods: We identified RAG’s active ingredients and potential targets from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform. …”
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Rbms3 Upregulation in Mesenchymal Stem Cells Impairs Fracture Healing in Type 2 Diabetes Mellitus by Liu C, Yu Y, Tian L, Liu Y, Zhang D, Yu A

“…Although some research has been conducted to address this, the specific mechanisms remain poorly understood and warrant further exploration.Methods: We downloaded transcriptomic and single-cell RNA sequencing (scRNA-seq) data, performed multiple analyses (differential expression, ssGSEA, co-expression, GO, KEGG, GSEA, and cell clustering identification), and utilized tools (GeneMINIA and Metascape) to investigate alterations in MSCs under diabetic condition. …”
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Impact of implant abutment materials on force damping response and marginal fit of implant supported restoration by Amr Mohammed Hussein Elmesery, Amany Mohammed Korsel, Waleed Elshahawy

“…The study offers novel insights into stress distribution and marginal gaps, aiming to optimize implant-supported restoration outcomes. Methods Forty implant abutments were divided into four equal groups: Shofu HC, Tessera, BioHPP, and Titanium. …”
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The association between the vitamin B1 intake and risk of non-melanoma skin cancer in U.S. adults: a cross-sectional study by Shiyi Huang, Lungang Shi, Yang Ma, Yuebin Zhu, Yingshi Liang, Haofeng Huang

“…Therefore, this study aims to explore the potential association between vitamin B1 consumption and the risk of developing NMSC.MethodsThe authors conducted a cross-sectional study utilizing data from six cycles of the National Health and Nutrition Examination Survey (NHANES) database spanning 2005 to 2016. …”
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Research on Equivalent Circuit Model of Flat Linear Induction Electromagnetic Pump Considering End Effect by BAI Yifan1, YAN Xin2, BI Keming2, YANG Chunwei1, DING Ming1

“…The developed analytical calculation methods and equivalent circuit model were tested against experimental data from FLIP found in a publicly available paper, indicating that the equivalent circuit model accurately predicts the FLIP’s performance parameters, with mean relative errors for head and efficiency around 5.38% and 7.91%, respectively. …”

Prevalence, Diagnosis, and Treatment of Generalized Anxiety Disorder in Working Individuals: A Cross-Sectional Study Using Health Claims and Survey Data in Japan by Matsuyama S, Otsubo T, Nomoto K, Misago R, Higa S

“…This study was, therefore, conducted targeting individuals with probable GAD, to estimate the prevalence of probable GAD as the primary outcome, and to assess medical consultation behavior, diagnosis, treatment, quality of life (QOL), severity of depression symptoms, and work productivity as secondary outcomes.Patients and Methods: This was conducted as a cross-sectional study focusing on individuals with probable GAD, using a database comprising medical claims data from May 2022 to November 2022, and linked survey data collected in November 2022, provided by DeSC Healthcare, Inc. …”
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When Technology Meets Anxiety:The Moderating Role of AI Usage in the Relationship Between Social Anxiety, Learning Adaptability, and Behavioral Problems Among Chinese Primary Schoo... by Ma G, Tian S, Song Y, Chen Y, Shi H, Li J

“…GuangYuan Ma,1,* ShiQin Tian,1,* Yang Song,1 Yi Chen,1 Hui Shi,1 JingChi Li2 1School of Humanities and Management Science, Southwest Medical University, Luzhou, 646000, People’s Republic of China; 2Department of Orthopedics, the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yang Song; Yi Chen, Email fookyuen666@163.com; chenyiswmu@163.comObjective: This study aims to examine the relationships between social anxiety, learning adaptability, AI technology usage, and behavioral problems among primary school students, with a focus on the mediating role of learning adaptability and the moderating role of AI usage.Methods: A cross-sectional survey was conducted among 1240 primary school students aged 8– 15 in Luzhou, Sichuan Province. …”
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Association of GWAS-Reported Variant of Matrix Metalloproteinase 12 Gene with Susceptibility to Ischemic Stroke in Southern Chinese Population by Chen L, Liao K, Zhang Y, Zheng S, He J, Tang H, Wu H, Zhong W, Li S, Li Y

“…This study aims to assess the genetic predisposition of the MMP12 rs660599 G > A variant with regard to IS risk and short-term outcomes in individuals from Southern China.Methods: The Multiplex SNaPshot assay was used to genotype rs660599 in 1035 IS patients and 1061 age-matched healthy controls. …”
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The Impact of Triglyceride-Glucose Index Trajectories on Incidence and Recurrent Cardiovascular Events: Evidence from a Retrospective Cohort Study by Xu Y, Wu G, Jiang L, Yang X, Wen C, Yang Y, Hu H

“…., Nanchang, People’s Republic of China; 5Department of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China; 6Department of Health Management Center, The Second Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hui Hu, Department of Health Management Center, The Second Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China, Email huhuiefy@163.comPatients and Methods: The study retrospectively collected 8086 clinical data from 2019 to 2021. …”
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Association of Diaphragmatic Mobility and Thickening Fraction with Postoperative Pulmonary Complications in Patients Undergoing Thoracic Surgery and Their Application in Prediction by Aisiaiti A, Ajiaikebaier A, Maimaitiming A, Geng Q, He B, Sun J, Zhang B

“…Abudushalamu Aisiaiti,* Aiwuzaili Ajiaikebaier,* Aini Maimaitiming, Qiang Geng, Bichen He, Jinhui Sun, Bing Zhang Center for Anesthesia and Perioperative Medicine, Xinjiang Medical University Affiliated Tumor Hospital, Urumqi, 830011, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bing Zhang, Center for Anesthesia and Perioperative Medicine, Xinjiang Medical University Affiliated Tumor Hospital, No. 789, Suzhou East Road, Urumqi, 830011, People’s Republic of China, Tel +86-9917819021, Email zb1325769256@163.comPurpose: To investigate the association of diaphragmatic mobility and thickening fraction with postoperative pulmonary complications (PPCs) in patients undergoing thoracic surgery and evaluate their values in predicting PPCs.Patients and Methods: One hundred and nine consecutive patients undergoing thoracic surgery were prospectively enrolled. …”
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