Coagulation Parameters in Elderly Patients with Severe Pneumonia: Correlation with Disease Severity and Prognosis by Zhang Q, Liu Y, Tong C, Zhang L, Li R, Guo W, Li J

“…Qiuyue Zhang,1,* Yingchao Liu,1,* Chuntang Tong,2 Lina Zhang,3 Rongchen Li,1 Wenbin Guo,4 Jianliang Li5 1Department of Clinical Laboratory, The Second People’s Hospital of Liaocheng, Linqing, Shandong, 252600, People’s Republic of China; 2Department of Respiratory Medicine, The Second People’s Hospital of Liaocheng, Linqing, Shandong, 252600, People’s Republic of China; 3Department of Scientific Research Management Division, The Second People’s Hospital of Liaocheng, Linqing, Shandong, 252600, People’s Republic of China; 4Department of Intensive Care Unit, The Second People’s Hospital of Liaocheng, Linqing, Shandong, 252600, People’s Republic of China; 5Department of Thoracic Surgery, The Second People’s Hospital of Liaocheng, Linqing, Shandong, 252600, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianliang Li, Department of Thoracic Surgery The Second People’s Hospital of Liaocheng, 306 health Street, Linqing, Shandong, 252600, People’s Republic of China, Tel +86 15020622456, Email lijianliangl724@163.comObjective: This study aimed to investigate the levels of coagulation parameters in elderly patients with severe pneumonia and analyse their correlation with disease severity and prognosis.Methods: A retrospective study was conducted on 207 elderly patients (aged ≥ 60 years) with severe pneumonia admitted to our hospital between January 2022 and December 2023. …”
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Inhibitory effect of rutin on the growth and metastasis of osteosarcoma in vitro and in vivo by LI Xiang, WEI Ming, WU Wenxi, LUO Xiaoqin, YAO Biao, WU Siyu

“…Objective·To investigate the effects of rutin on proliferation, apoptosis, migration and invasion of osteosarcoma cells and its possible molecular mechanisms.Methods·Human osteosarcoma MG63 and U2OS cells were treated with rutin at concentrations of 10, 20 and 40 μmol/L, respectively. …”
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Doxycycline: An Antibiotic Attenuates Oxidant Stress, Perturbation of Lipid Metabolites, and Antioxidants against Vanadium Toxicity in Rat Hepatocytes by Ezeddin Salem Gassar, Negia Abdullah Emtawel Mohamed, Fatema Abdullah Emtawel, Rehab M. Elfakhri, Syed Saleem Haider

“…Aim The present study was designed to evaluate the protective effects of doxycycline against vanadium-induced hepatoxicity. Methods Sixty two male Sprague-Dawley rats (250–300 g) were equally divided into the following four groups: control group (received 0.2 mL of physiological saline), doxycycline control group (received 4 mg/kg body weight on day 1 and 2 mg/kg body weight daily thereafter), vanadium group (received elemental vanadium 1.5 mg/kg-body weight in distilled water), and concomitantly treated group (doxycycline + vanadium) received (doxycycline 4 mg/kg body weight on day 1 and 2 mg/kg body weight thereafter + vanadium 1.5 mg/kg body weight), all given orally for 10 consecutive days. …”
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The Value of Systemic Inflammatory Index and Nutritional Marker in Predicting Acute Calculus Cholecystitis and Its Severity by He B, He Q, Lai Z, Niu Z, Zhang J, Wang Y

“…Bing He,1,* Qiguang He,2,* Zhiyong Lai,3 Zhiqiang Niu,3 Jijun Zhang,3 Yingkai Wang3 1Department of First Clinical Medical College, Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China; 2Department of First Clinical Medical College, China Medical University, Shenyang, Liaoning, People’s Republic of China; 3Department of Biliopancreatic Surgery, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jijun Zhang; Yingkai Wang, Department of Biliopancreatic Surgery, The First Hospital of Shanxi Medical University, Taiyuan, Shanxi, People’s Republic of China, Email 1207978528@qq.com; 1120873027@qq.comBackground: The study aimed to evaluate the accuracy with which various nutritional and inflammatory indicators, including Neutrophil-to-Lymphocyte Ratio (NLR), Platelet-to-Lymphocyte Ratio (PLR), Systemic Immune-Inflammation Index (SII), Monocyte-to-Lymphocyte Ratio (MLR), Systemic Inflammatory Response Index (SIRI), and Prognostic Nutritional Index (PNI), can predict the severity of acute calculus cholecystitis.Methods: 109 cases of chronic calculus cholecystitis (CCC) and 130 cases of acute calculus cholecystitis (ACC), including 62 cases of acute simple cholecystitis (ASC), 35 cases of acute purulent cholecystitis (APC), and 33 cases of acute gangrenous cholecystitis (AGC), were encompassed in the retrospective cohort study. …”
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Changes in Knowledge and Compliance with Pitch Count Recommendations Among Youth Baseball Coaches: A Cross-Sectional Comparison at Two Time Points by Makita M, Onishi M, Kouno C, Kawabe R, Doi N, Tahu Y, Aoyama T, Nagai-Tanima M

“…Although it is important for coaches to have prior knowledge of injuries in order to prevent the incidence of Little League Elbow, few studies have assessed the actual experience of coaches.Methods: Of the 242 coaches belonging to the Kyoto Boys’ Baseball Association who participated, 172 with valid responses were analyzed. …”
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Bioinformatics-Based Exploration of the Ability of Ginkgetin to Alleviate the Senescence of Cardiomyocytes After Myocardial Infarction and Its Cardioprotective Effects by Li H, Wei D, Cao H, Han Y, Li L, Liu Y, Qi J, Wu X, Zhang Z

“…The aim of this study was to determine the protective effects and mechanisms of ginkgetin on postinfarction cardiomyocytes through bioinformatics and experimental validation.Methods: Bioinformatics analysis was performed to predict the underlying biological mechanisms of ginkgetin in the treatment of MI. …”
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Upregulation of NGF/TrkA-Related Proteins in Dorsal Root Ganglion of Paclitaxel-Induced Peripheral Neuropathy Animal Model by Kim Y, Je MA, Jeong M, Kwon H, Jang A, Kim J, Choi GE

“…The aim of this study was to understand the neurochemical changes induced by NGF/TrkA signaling in PTX-induced neuropathic pain.Methods: The PTX-induced CIPN mouse model was evaluated using nerve conduction velocity (NCV) and behavioral tests. …”
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Association Between Social Capital and Anxiety Among Older Adults in China: A Cross-Sectional Study by Meng L, Li P, Ye L, He Y, Zhong J

“…This study investigated whether there is an interactive effect of social capital and demographic factors on anxiety among Chinese older adults.Methods: A sample of 5115 Chinese older adults (≥ 60 years old) was extracted from cross-sectional survey data in the 2018 Chinese Longitudinal Health and Longevity Study (CLHLS). …”
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Resting-State Functional MRI Reveals Altered Seed-Based Connectivity in Diabetic Osteoporosis Patients by Li J, Liu M, Qin J, An Y, Zheng X, Mohamad NS, Ramli I

“…This study aims to further explore the abnormal functional connectivity between different brain regions based on the team’s previous research.Methods: Resting-state functional magnetic resonance imaging (rs-fMRI) data were obtained from 14 participants diagnosed with type 2 diabetes mellitus (T2DM) and osteoporosis. …”
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Improving nerve and muscle function: an exploration of targeted nerve function replacement following differential delay periods in a rat model by Chunxiao Tang, Yuanheng Li, Xinxian Fan, Jiamei Guo, Yifeng Lin, Yifan Gao, Lin Yang

“…This study evaluates TNFR efficacy in restoring denervated muscle function across different postoperative intervals in a rat model. Methods Thirty Sprague–Dawley rats (220–250 g) were divided into five equal groups (n = 6 per group): control (no transection), denervated (transection without repair), immediate TNFR after median nerve transection, 2-week delayed TNFR, and 4-week delayed TNFR. …”
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Características físicas de goiabas (Psidium guajava L.) submetidas a tratamento hidrotérmico Physical characteristics of guava (Psidium guajava L.) submitted to hot water treatment... by Stella M. J. Vieira, Sandra M. Couto, Paulo C. Corrêa, Ana E. O. dos Santos, Paulo R. Cecom, Danilo J. P. da Silva

“…The indiscriminate use of chemical products for eradication of plagues and diseases in the cultivation and also in the post harvest period is being substituted successfully by methods that do not cause harm to human beings or to the environment, reasons for which physical treatments (application of heat, cold or ionized radiation) are being intensively investigated. …”
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Sexual violence across gender identities and sexual orientations: a stratified, population-based, cross-sectional study among young people aged 16–29 years in Sweden by Matilda Löfström-Bredell, Eva Åkerman, Renita Sörensdotter, Sara Ström, Henrik Källberg, Marie Klingberg-Allvin

“…This study also aims to examine the categories of perpetrators of sexual violence reported by young people. Methods A population-based, cross-sectional survey using stratified random sampling (response rate = 23.7%) yielded a sample of 9,430 respondents. …”
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Vancomycin-Loaded Isogenous Membrane Vesicles for Macrophage Activation and Intracellular Methicillin-Resistant Staphylococcus aureus Elimination by Dou J, Shang W, Peng H, Yang Y, Chen J, Rao Y, Tan L, Hu Z, Wang Y, Huang X, Yang Y, Wu J, Hu Q, Xiao C, Rao X

“…Conventional antibiotics exhibit limited efficacy against intracellular MRSA due to poor cellular penetration.Methods: Vancomycin (VAN) was encapsulated into membrane vesicles (ΔagrAMVs) derived from the attenuated S. aureus strain RN4220ΔagrA, generating VAN-loaded nanoparticles (ΔagrAMV-VAN). …”
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Development of an eHealth Intervention Including Self-Management for Reducing Sedentary Time in the Transition to Retirement: Participatory Design Study by Lisa Hultman, Caroline Eklund, Petra von Heideken Wågert, Anne Söderlund, Maria Lindén, Magnus L Elfström

“…Further, the aim was to develop a digital prototype of such an eHealth intervention. MethodsThe study used the participatory design approach to include end users, researchers, and a web designer as equal partners. …”
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Risk Factors for Development and Mortality of Carbapenem-Resistant Pseudomonas aeruginosa Bloodstream Infection in a Chinese Teaching Hospital: A Seven-Year Retrospective... by Dong L, Huang Y, Zhang S, Xu B, Li B, Cao Y

“…The aim of this study was to investigate the risk factors for the development and mortality of patients with carbapenem-resistant P. aeruginosa bloodstream infection (CRPA BSI).Methods: A total of 112 patients with CRPA BSI and 112 patients with carbapenem-sensitive P. aeruginosa (CSPA) BSI were included from a Chinese teaching hospital from January 2017 to December 2023 in this retrospective cohort study. …”
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Combining Hepatic Arterial Interventional Therapies with Lenvatinib and Programmed Cell Death-1 Inhibitors for Hepatocellular Carcinoma with Portal Vein Tumor Thrombosis: A Single-... by Shen X, Shao T, Yu J, Zhang Z

“…This study aimed to investigate the efficacy and safety of hepatic arterial interventional therapies (HAIT) combined with lenvatinib and programmed cell death-1 (PD-1) inhibitors for HCC patients with PVTT.Methods: In this retrospective study, HCC patients with PVTT treated with HAIT combined with lenvatinib and PD-1 inhibitors (H-L-P group) or lenvatinib plus PD-1 inhibitors (L-P group) between June 2020 and December 2023 were analyzed. …”
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Lipid-lowering therapy in outpatients of different ages with coronary artery disease by S. K. Zyryanov, S. B. Fitilev, A. V. Vozzhaev, I. I. Shkrebniova, N. N. Landyshev, Ya. G. Voronko, A. M. Lutsenko

“…LLT prescription rates were equally high in all ages — 92,9%, 85,9%, and 81,6% in groups 1, 2, and 3 respectively (p>0,05). …”
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Proposal of a Risk Stratification Model for Recurrence After Excisional Treatment of High-Grade Cervical Intraepithelial Neoplasia (HG-CIN) by Francesco Cantatore, Nadia Agrillo, Alessandro Camussi, Lucrezia Colella, Massimo Origoni

“…This approach assumes that all patients have an equal risk of disease recurrence, regardless of individual characteristics. …”
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Correction of long-standing flexion contracture of digits with surgical release and distraction histogenesis by Anupama Singh, Ankur Bhatnagar

“…Average days of distraction were almost equal in both Z plasty and SSG cover patients. In 50% of patients with Z plasty distraction time was <15 days. …”
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Elementary school compliance with a state recess minimum requirement by racial and geographic factors: a cross-sectional study by Erin K. Howie, Samantha M. Harden, Daheia J. Barr-Anderson, Christopher R. Long

“…The purpose of this study was to determine the current implementation of one state system as a case study to investigate minimum recess requirement and to compare the implementation between school geographic and racial factors. Methods A cross-sectional, observational study of the implementation of one state’s minimum daily recess requirement of 40-minutes recess was conducted during the 2023–2024 academic year. …”
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