Effects of Different Blood Flow Restriction Training Modes on Body Composition and Maximal Strength of Untrained Individuals by Hualong Chang, Xudong Yang, Biao Chen, Jianli Zhang

“…Background: The objective of this study was to examine the impacts of absolute cuff pressure blood flow restriction (A-BFR) training and incremental cuff pressure blood flow restriction (I-BFR) training, under equal cuff pressures, on body composition and maximal strength among untrained adults. …”
Get full text

Effects of Aerobic Versus Resisted Intradialytic Exercises on Quality of Life, Pain, and Physiological Outcomes in Chronic Kidney Disease by Rania Nagy Karkousha, Amira Hussin Draz, Nesreen Gharib ElNahas, Efrem Kentiba, Mohamed Magdy ElMeligie

“…Patients were randomly assigned equally to either the resistance exercise group or the aerobic exercise group and underwent respective exercise interventions for 8 weeks. …”
Get full text

Succinate Facilitates CD4+ T Cell Infiltration and CCL1 Production to Promote Myofibroblast Activation and Renal Fibrosis in UUO Mice by Tao Y, Zhang W, Liu D, Cao H, Yi X, Deng X, Li P, Shen X, Zhou H

“…However, the precise pathogenic mechanisms of succinate in obstructive nephropathy remain to be elucidated.Methods: Succinate was supplemented in the drinking water to study its impact on the pathogenesis of obstructive nephropathy induced by unilateral ureteral obstruction (UUO) in mice. …”
Get full text

Predictors of Cervical Cancer Screening Uptake among Healthcare Providers in Siaya County, Kenya by Zilper Imbuye, Damaris Ochanda, John Arudo

“…Methods: The study was conducted in Siaya County hospitals and adopted analytical cross-sectional study design. …”
Get full text

General practitioners’ familiarity, attitudes and practices with regard to Attention Deficit Hyperactivity Disorder (ADHD) in children and adults by Charmaine Louw, Marietjie M. Oswald, Mariechen D. Perold

“…The study also briefly explored the training models of GPs in South Africa. Methods: The research questions were addressed by means of a survey approach, using quantitative measures. …”
Get full text

Combining Dual Biologics Therapy for Severe Asthma: A Series of Ten Cases by Chen Y, Wang L, Xie J

“…Dual biologic therapy has emerged as a promising strategy, but its efficacy and safety are not yet fully understood.Objective: To describe the characteristics, endotyping features, decision-making process and therapeutic response of patients with severe asthma on dual biologic therapy in a real-world setting.Methods: We present ten patients on dual biologics for severe asthma. …”
Get full text

Causal Pathways Between Breast Cancer and Cardiovascular Disease Through Mediator Factors: A Two-Step Mendelian Randomization Analysis by Lu W, Li K, Wu H, Li J, Ding Y, Li X, Liu Z, Xu H, Zhu Y

“…Our study endeavors to investigate the causal association between BC and CVD, with a focus on identifying potential metabolic mediators and elucidating their mediation effects in this causality.Methods: In this study, we conducted two-sample Mendelian randomization (MR) to estimate the causal effect of BC (overall BC, ER+ BC, ER- BC) from the Breast Cancer Association Consortium (BCAC) on CVD including coronary heart disease (CHD), hypertensive heart disease (HHD), ischaemic heart disease (IHD), and heart failure (HF) from the FinnGen consortium. …”
Get full text

Clinical Characteristics and Prognostic Factors of Severe COVID-19 by Yang Y, Huang Z, Pei Y, Huang Y, Chen C, Zhou T

“…We aimed to identify the severe cases in early stages to improve the prognosis and mortality.Patients and Methods: We collected the clinical data of 98 patients with severe COVID-19, who were admitted to the Second Affiliated Hospital of Soochow University (Jiangsu, China) from December 2022 to November 2023. …”
Get full text

Aloe Vera Gel and Rind-Derived Nanoparticles Mitigate Skin Photoaging via Activation of Nrf2/ARE Pathway by Sun Z, Zheng Y, Wang T, Zhang J, Li J, Wu Z, Zhang F, Gao T, Yu L, Xu X, Qian H, Tan Y

“…Aloe vera, known for its natural active ingredients that benefit the skin, aloe-derived exosome-like nanoparticles (ADNPs) have not yet been studied for their potential in delaying skin aging.Methods: In this study, nanoparticles were isolated from two different sites, aloe vera gel and aloe vera rind (gADNPs and rADNPs), and characterized by TEM, SEM, AFM, NTA and BCA. …”
Get full text

Identification and Experimental Verification of Potential Immune Cell-Associated Gene Biomarkers in Human Intervertebral Disc Degeneration by Shi WH, Zou HS, Wang XY, Lu J, Yu HQ, Zhang PP, Huang LL, Chu PC, Liang DC, Zhang YN, Li B

“…This study aimed to conduct a bioinformatic analysis to identify biomarkers associated with IDD immune cells.Methods: We obtained the gene expression profiles of IDD by downloading the Gene Expression Omnibus Series (GSE)150408 and GSE124272 from the Gene Expression Omnibus (GEO) database. …”
Get full text

Sex differences in cardiorespiratory control under hypoxia: the roles of oxygen desaturation and hypoxic exposure time by André Luiz Musmanno Branco Oliveira, Gabriel Dias Rodrigues, Gabriel Dias Rodrigues, Bruno Moreira Silva, Philippe de Azeredo Rohan, Pedro Paulo da Silva Soares

“…Accordingly, we hypothesized that sex differences in cardiovascular and ventilatory responses would be more pronounced with equal hypoxia duration (iso-time) but less pronounced at similar oxygen desaturation levels (iso-saturation).MethodsTwenty-two (12 females) healthy individuals were exposed to normoxia (10 min at FiO2 = 0.21) and hypoxia (10 min at FiO2 = 0.115), respectively. …”
Get full text

Sleep-Aiding Effect of Casein-Derived Peptide TPTLN and Its Underlying Mechanism by DENG Shijie, LIU Ling, HUANG Ju, FENG Fengqin, ZHAO Minjie, DU Juan

“…Objective: To investigate the sleep-aiding effect of casein-derived peptide TPTLN and explore its possible mechanism of action. Methods: Thirty mice were divided equally into three groups, an experimental, a positive control and a blank control group, which were gavaged with TPTLN at a dose of 5 mg/kg mb, intraperitoneally injected with diazepam at a dose of 1 mg/kg mb, and gavaged with sterilized water at a dose of 5 mg/kg mb, respectively. …”
Get full text

Causal Relationships Between Blood Lipid Levels and Chronic Obstructive Pulmonary Disease: A Mendelian Randomization Analysis by Huang P, Zhao Y, Wei H, Wu W, Guo Z, Ma S, Xu M, Wang Q, Jia C, Xiang T, Li H

“…Therefore, this study employed Mendelian randomization (MR) analysis to investigate the potential causal connection between blood lipids and COPD.Materials and Methods: A genome-wide association study (GWAS) on COPD was conducted, encompassing a total of 112,583 European participants from the MRC-IEU. …”
Get full text

Impact of Circadian Rhythm and Sleep Architecture Changes on Prognosis in Patients with Acute Hemorrhagic Stroke by Yuan X, Fu Y, Ou Y, Xue J, Yang N, Liu H, Wang T, Wang J, Yan C, Zhang P

“…This study aims to characterize these changes and explore their association with clinical prognosis, offering new insights for diagnosis and treatment.Methods: We enrolled 100 acute hemorrhagic stroke patients who underwent continuous, contactless sleep monitoring via a smart mattress for 3– 5 consecutive days. …”
Get full text

Investigating the Analgesic Mechanisms of Acupuncture for Cancer Pain: Insights From Multimodal Bioelectrical Signal Analysis by Huang J, Zhao L, Xie Y, Wang C, Yang X, Huang H, Zhang D

“…This study investigates the neurophysiological mechanisms underlying acupuncture’s analgesic effects using multimodal bioelectrical signal analysis.Patients and Methods: Fifteen cancer pain patients underwent acupuncture while wearing portable, multi-sensor devices to capture bioelectrical signals. …”
Get full text

Multicenter Surveillance of Pseudomonas aeruginosa Isolates From Blood: Clinical Distribution Characteristics and Antibiotic Resistance Trends in Hebei Province, China (2016–... by Qiang C, Liu X, Qin P, Wen H, Li Z, Yang J, Niu Y, Wang W, Ouyang Z, Zhao M, Li J, Zhang Y, Zhao J

“…Cuixin Qiang,1,* Xiaoxuan Liu,1,* Pu Qin,1 Hainan Wen,2 Zhirong Li,1 Jing Yang,1 Yanan Niu,1 Weigang Wang,1 Zirou Ouyang,1 Min Zhao,1 Jiayiren Li,1 Yulian Zhang,1 Jianhong Zhao1 1The Second Hospital of Hebei Medical University, Hebei Provincial Center for Clinical Laboratories, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Laboratory Medicine, Affiliated Hospital of Chengde Medical University, Chengde, Hebei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianhong Zhao, The Second Hospital of Hebei Medical University, Hebei Provincial Center for Clinical Laboratories, Shijiazhuang, Hebei, People’s Republic of China, Tel +86 0311 66002711, Email zhaojh_2002@hebmu.edu.cnPurpose: To analyze the clinical distribution and antimicrobial resistance of Pseudomonas aeruginosa (P. aeruginosa) isolated from blood specimens in 75 hospitals in Hebei Province from 2016 to 2021 to aid in the rational selection of antimicrobial drugs.Patients and Methods: WHONET 5.6 and SPSS 24.0 were used to retrospectively analyze clinical distribution characteristics and variations in drug-resistance.Results: Between 2016 and 2021, 2208 P. aeruginosa strains were detected in blood specimens from Hebei Province. …”
Get full text

Correlation Between Lipid Accumulation Product and Metabolic Dysfunction-Associated Steatotic Liver Disease in Chinese Adults with Type 2 Diabetes Mellitus by Liu W, Xu L, Yu Y, Qiao L, Zhang L, Chu X, Jing H, Cao L

“…Wei Liu,1,* Lingling Xu,1,* Yuan Yu,2 Liang Qiao,1 Lijuan Zhang,1 Xiaoqiu Chu,1 Haibo Jing,3 Lin Cao1 1Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210028, People’s Republic of China; 2Department of Gastroenterology, Jiangning Hospital of Traditional Chinese Medicine, Nanjing, Jiangsu, 211100, People’s Republic of China; 3Department of General Surgery, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, 210028, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lin Cao, Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, NO. 100 Shizi Street, Hongshan Road, Nanjing, Jiangsu, 210028, People’s Republic of China, Tel/Fax +86-25-85608733, Email guodongcl@163.com Xiaoqiu Chu, Department of Endocrinology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, NO. 100 Shizi Street, Hongshan Road, Nanjing, Jiangsu, 210028, People’s Republic of China, Tel/Fax +86-25-85608735, Email chumickey@126.comObjective: To evaluate the value and feasibility of the lipid accumulation product (LAP) in the prediction of metabolic dysfunction-associated steatotic liver disease (MASLD) in Chinese adults with type 2 diabetes mellitus (T2DM).Methods: In this cross-sectional study, we assessed the value of LAP and other novel indices in the prediction of MASLD in Chinese adults with T2DM in a total of 642 patients. …”
Get full text

Correlation Between Thyroid Hormone and Controlled Attenuation Parameters: A Cross-Sectional Population-Based Study by Li S, Wu X, Yu J, Jiang J, Qi R, Chen B, Li Z

“…Sumei Li,1,* Xingye Wu,2,* Jingming Yu,2 Jiaqin Jiang,2 Ruibing Qi,2 Bing Chen,3 Zhengming Li2 1Department of Endocrinology and Metabolism, Guangxi Hospital Division of The First Affiliated Hospital, Sun Yat-sen University, Nanning, 530022, People’s Republic of China; 2Department of Endocrinology and Metabolism, Guangxi Academy of Medical Sciences and the People’s Hospital of Guangxi Zhuang Autonomous Region, Nanning, 530021, People’s Republic of China; 3Department of Endocrinology, Wuming Hospital of Guangxi Medical University, Nanning, 530199, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zhengming Li, Email zmli@gxams.org.cnObjective: The aim of the present study was to investigate how thyroid hormone levels are related to controlled attenuation parameters (CAP), which may provide insights for understanding the role of these factors in hepatic steatosis.Methods: A total of 3461 participants who underwent CAP diagnosis between 2018 and 2023 were included. …”
Get full text

Adaptation of global primary production model to the Greenland Sea conditions: parameterization and monitoring for 1998-2022 by Aleksandra Cherkasheva, Rustam Manurov, Piotr Kowalczuk, Alexandra N. Loginova, Monika Zabłocka, Astrid Bracher, Astrid Bracher

“…Field data showed good agreement between primary production measured with 14C and O2 evolution methods. From all the model setups, those including local chlorophyll a profile and local absorption spectrum best reproduced in situ data. …”
Get full text

Proteomic Profiling and Clinical Insights: The Role of MMP9 in Differentiating Psoriasis Vulgaris from Generalized Pustular Psoriasis by Gong T, Chen J, Xiao Z, Luo R, Tong Z, Ke H, Liu Z, Xiao C, Xiang N, Ji C

“…The IL-36 pathway has been identified as a key element in GPP pathogenesis.Objective: To explore protein expression between PV and GPP, providing insights into potential mechanisms.Methods: We performed proteomic analysis of tissue specimens from patients with PV and GPP to identify differentially expressed proteins. …”
Get full text