Current Advances and Challenges in CAR-T Therapy for Hematological and Solid Tumors by Zhang G, Bai M, Du H, Yuan Y, Wang Y, Fan W, Zhu H, Wu D, He P, Xue B

“…This review aims to provide a comprehensive overview of the current landscape and future perspectives of CAR-T therapy in both hematological malignancies and solid tumors.Methods: A thorough literature search was conducted to identify relevant preclinical and clinical studies, as well as review articles, focusing on CAR-T therapy in various hematological malignancies and solid tumors. …”
Get full text

Coilin Affects the Prognosis of Hepatocellular Carcinoma Through Cell Cycle and Apoptosis by Lu L, Zhou X, Zheng J, Li D

“…We investigated the diagnostic and prognostic value of COIL expression in HCC.Patients and Methods: This study evaluated the expression and prognostic significance of COIL using data from the TCGA and local hospital samples, with 374 and 118 liver cancer patients in the TCGA database and local hospital, respectively. …”
Get full text

Effectiveness and Safety of Neoadjuvant Immunochemotherapy with and without Surgery in Patients with Resectable Esophageal Squamous Cell Carcinoma: A Retrospective Cohort Study by Liao X, Chen X, Hong W, Chen F, Li G, Li L

“…Xuqiang Liao,1,* Xianshan Chen,1,* Wenyuan Hong,1,2,* Fengxia Chen,1 Gao Li,1 Liang Li1 1Department of Thoracic Surgery, Hainan General Hospital, Hainan Affiliated Hospital of Hainan Medical University, Haikou, Hainan, People’s Republic of China; 2Hainan Medical University, Haikou, Hainan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Gao Li, Email drligaokeyan@163.com Liang Li, Email nigoli@126.comBackground: This study aimed to retrospectively compare the effectiveness and safety of neoadjuvant immunochemotherapy with and without surgery for locally advanced esophageal squamous cell carcinoma (ESCC).Methods: This study included patients with ESCC who received neoadjuvant immunochemotherapy from May 2021 to July 2023. …”
Get full text

Health-promoting behavior and its determinants towards non-communicable diseases among adult residents of the Gedeo zone, South Ethiopia: the application of the health belief model by Habtamu Endashaw Hareru, Tizalegn Tesfaye Mamo, Mesfin Abebe, Berhanu Gidisa Debela

“…Statistically significant factors were declared at p-value of less than or equal to 0.05.ResultsThe overall means score for health-promoting behavior was 73.88 ± 16.79. …”
Get full text

Enhanced hemodynamic stability and patient satisfaction with ciprofol-remifentanil versus propofol-remifentanil for sedation in shorter-duration fiberoptic bronchoscopy: a prospect... by Jia Nie, Yongguo Zhang, Yan Wang, Liang Fang, Huanhuan Ma, Yu Zhang, Hai-ying Wang

“…ObjectiveThis study aimed to compare the efficacy and safety of ciprofol-remifentanil versus propofol-remifentanil in patients undergoing fiberoptic bronchoscopy (FOB).MethodsIn this prospective, randomized, double-blind, non-inferiority trial, 209 patients undergoing FOB were enrolled and equally divided into two groups (n = 106 each). …”
Get full text

Cardiovascular risk factors in a treatment-naïve, human immunodeficiency virus-infected rural population in Dikgale, South Africa by Felistas Mashinya, Marianne Alberts, Robert Colebunders, Jean-Pierre van Geertruyden

“…Biochemical parameters were tested using standard biochemical methods. HIV testing and CD4 counts were performed using the Alere Determine™ HIV 1/2 Ag/Ab kit and The Alere Pima™ Analyser. …”
Get full text

Patient Interaction Phenotypes With an Automated SMS Text Message–Based Program and Use of Acute Health Care Resources After Hospital Discharge: Observational Study by Klea Profka, Agnes Wang, Emily Schriver, Ashley Batugo, Anna U Morgan, Danielle Mowery, Eric Bressman

“…ObjectiveOur primary aim was to identify and characterize distinct patient interaction phenotypes with a postdischarge automated SMS text messaging program. MethodsThis was a secondary analysis of data from a randomized controlled trial that tested a 30-day postdischarge automated SMS text messaging intervention. …”
Get full text

Impact of Subchorionic Hematoma on Pregnancy Outcomes in Obstetric Antiphospholipid Syndrome by Cang R, Ding X, Tian Z, Fu Z, He M, Liang Y

“…Rong Cang,1,* Xuelei Ding,1,* Zan Tian,2 Zijie Fu,3 Meijuan He,1 Ying Liang4 1Department of Gynecological Endocrinology, The Fourth Hospital of Shijiazhuang (Obstetrics and Gynecology Hospital Affiliated to Hebei Medical University), Shijiazhuang, Hebei, People’s Republic of China; 2Department of Dermatology, Hebei Provincial Hospital of Traditional Chinese Medicine, Shijiazhuang, Hebei, People’s Republic of China; 3Department of Gynecology, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 4Department of Reproductive Medicine, The Fourth Hospital of Shijiazhuang (Obstetrics and Gynecology Hospital Affiliated to Hebei Medical University), Shijiazhuang, Hebei, 050011, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ying Liang, Email liangyly@126.comObjective: This study aimed to investigate the effects of subchorionic hematoma (SCH) in patients with obstetric antiphospholipid syndrome (OAPS) on pregnancy outcomes, as well as the clinical value of anticoagulant therapy.Methods: This retrospective study included 109 OAPS patients treated at the Fourth Hospital of Shijiazhuang from December 2019 to December 2021. …”
Get full text

The effect of tactile versus auditory stimulation on reducing pain associated with invasive procedures among preterm neonates at NICUs by Entsar Shehata Mohammed, Seham Mohammed Elmwafie, Fatma Sayed Abdelaziz Mohamed, Safaa Salah Ismail

“…The study hypothesized that preterm neonates who receive tactile stimulation will exhibit lower pain scores than those who receive auditory stimulation. Methods A comparative (three-group) quasi-experimental design included 90 preterm neonates divided equally into three groups (tactile stimulation group = 30, auditory stimulation group = 30, and control group = 30) at NICU affiliated with Beni-Suef University Hospital. …”
Get full text

Focal Staphylococcus Aureus Septic Arthritis Elicits Age and TLR2-Dependent Periarticular Bone Loss by Schultz M, Hu Z, Deshmukh M, Henning P, Lerner UH, Mohammad M, Jin T

“…While intra-articular injections of S. aureus LPPs induces local bone resorption in mice, the influence of aging and TLR2 expression on bone mineral density (BMD) after S. aureus bacteremia remains unclear.Methods: We analyzed distal femoral BMD in young and old TLR2 knock-out and wild-type mice following intravenous S. aureus infection. …”
Get full text

Interleukin-6 as a Pan-Cancer Prognostic Inflammatory Biomarker: A Population-Based Study and Comprehensive Bioinformatics Analysis by Xie H, Wei L, Ruan G, Zhang H, Shi H

“…This study aimed to provide a comprehensive assessment of the prognostic value of IL-6 and its immunotherapeutic features using a population-based pan-cancer analysis and comprehensive bioinformatic analysis.Patients and Methods: In the cohort study, 540 patients were included to explore the prognostic value of serum IL-6 levels in cancer. …”
Get full text

TyG-WC Index as a Superior Predictor of Hyperuricemia Risk in the Hypertensive Population: A Prospective Cohort Study by Zhang Q, Liu J, Zhang R, Wang C, Song Y, Wang X, Zeng F

“…Qin Zhang,1,* Jian Liu,2,* Ruize Zhang,3 Changfen Wang,4 Yanyan Song,5 Xi Wang,2 Fanling Zeng6 1Department of Cardiology, Xi Chang People’s Hospital, Xi Chang, Sichuan Province, 615000, People’s Republic of China; 2Department of Cardiology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China; 3Dougherty Valley High School, San Ramon, CA, 94582, USA; 4Department of Cardiology, People’s Hospital of Qianxinan Prefecture, Guizhou Province, People’s Republic of China; 5Department of Endocrinology, Chongqing Jianshe Hospital, Chongqing, People’s Republic of China; 6Health Management Ctr, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xi Wang; Fanling Zeng, The First Affiliated Hospital of Chongqing Medical University, No. 1 Youyi Road, Yuzhong District, Chongqing, 400016, People’s Republic of China, Email 201884@cqmu.edu.cn; zengfanling@hospital.cqmu.edu.cnObjective: To evaluate the predictive value of the triglyceride-glucose waist circumference index (TyG-WC) for hyperuricemia (HUA) risk in the hypertensive population.Methods: This prospective cohort study involved 831 hypertensive patients with normal uric acid levels, who underwent continuous health examinations for five years. …”
Get full text

Surgical outcomes of women undergoing radical resection of deep endometriosis of the sacral plexus: A prospective cohort study by Gernot Hudelist, Ezgi Darici Kurt, Gábor Szabó, Dominika Miklos, Theresa Hudelist, Attila Bokor

“…This study aims to report on the surgical outcomes in terms of pain and neurological symptom reduction in women undergoing surgical resection of SPE. Material and Methods Thirty premenopausal patients with histologically confirmed SPE who underwent surgical resection of the disease between 2018 and 2024 were included in this multicenter prospective analysis. …”
Get full text

The impact of retail-sector delivery of artemether-lumefantrine on malaria treatment of children under five in Kenya: a cluster randomized controlled trial. by Beth P Kangwana, Sarah V Kedenge, Abdisalan M Noor, Victor A Alegana, Andrew J Nyandigisi, Jayesh Pandit, Greg W Fegan, James E Todd, Simon Brooker, Robert W Snow, Catherine A Goodman

“…This study in western Kenya aimed to evaluate the impact of providing subsidized artemether-lumefantrine (AL) through retail providers on the coverage of prompt, effective antimalarial treatment for febrile children aged 3-59 months.<h4>Methods and findings</h4>We used a cluster-randomized, controlled design with nine control and nine intervention sublocations, equally distributed across three districts in western Kenya. …”
Get full text

Enhanced Antitumor Immunity Through T Cell Activation with Optimized Tandem Double-OX40L mRNAs by Deng Z, Tian Y, Wang J, Xu Y, Liu Z, Xiao Z, Wang Z, Hu M, Liu R, Yang P

“…This study investigates the use of mRNA-based cancer agents as promising tools to combat and reverse refractory TIME conditions.Methods: We optimized and engineered an mRNA cancer agent encoding double tandemly repeated sequences of the T cell costimulator Oxford 40 ligand (diOX40L). …”
Get full text

Shen-Qi-Jie-Yu-Fang exerts effects on a rat model of postpartum depression by regulating inflammatory cytokines and CD4+CD25+ regulatory T cells by Li J, Zhao R, Li X, Sun W, Qu M, Tang Q, Yang X, Zhang S

“…Aim: To further investigate the effect of SJF on the immune system, including the inflammatory response system and CD4+CD25+ regulatory T (Treg) cells. Materials and methods: Sprague Dawley rats were used to create an animal model of PPD by inducing hormone-simulated pregnancy followed by hormone withdrawal. …”
Get full text

Type II diabetes mellitus risk assessment using FINDRISC questionnaire in systemic lupus erythematosus patients by L. V. Kondratieva, T. V. Popkova

“…Abdominal obesity and intake of antihypertensive drugs were more often documented in SLE patients, while all other risk factors were equally represented in SLE and control groups. On average 3 [2; 5] risk factors were found in each SLE patient. …”
Get full text

Bibliometric Analysis of Exosome Research in Spinal Cord Injury (2000&amp;ndash;May 2024). Trends, Collaborations, and Emerging Insights by Wang Z, Bi H, Li D, Zhang W, Wang C, Yang J, Shen X, Yan R, He F, Duan H

“…The present study was conducted to provide a systematic bibliometric analysis of research trends related to SCI and exosomes.Patients and Methods: Publications on exosomes in SCI were identified from the Web of Science Core Collection using specific search criteria. …”
Get full text

Outcomes after Cortical Bone Trajectory Screw versus Traditional Pedicle Screw in Single-Level Lumbar Spine Surgery: A Systematic Review and Meta-Analysis of Randomized Controlled... by Muhammad Talal Ibrahim, Cole Veliky, Elizabeth Yu

“…The systematic review aims to compare randomized controlled trials comparing CBTS with PS in single-level lumbar spine fusion surgery. Methods: A systematic search was conducted on PubMed (MEDLINE), Scopus, Embase, Web of Science, and Cochrane. …”
Get full text

CECT-Based Radiomic Nomogram of Different Machine Learning Models for Differentiating Malignant and Benign Solid-Containing Renal Masses by Qian L, Fu B, He H, Liu S, Lu R

“…Lu Qian,1,&ast; BinHai Fu,2,&ast; Hong He,2 Shan Liu,1 RenCai Lu2 1Department of Pathology, the First People’s Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, 650032, People’s Republic of China; 2Department of Nuclear Medicine, The First People’s Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, 650032, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: RenCai Lu, Department of Nuclear Medicine, The First People’s Hospital of Yunnan Province, the Affiliated Hospital of Kunming University of Science and Technology, No. 157 Jinbi Road, Kunming, Yunnan, 650032, People’s Republic of China, Tel +86 087163614503, Email lrc_09@126.comObjective: This study aimed to explore the value of a radiomic nomogram based on contrast-enhanced computed tomography (CECT) for differentiating benign and malignant solid-containing renal masses.Materials and Methods: A total of 122 patients with pathologically confirmed benign (n=47) or malignant (n=75) solid-containing renal masses were enrolled in this study. …”
Get full text