Bergenin Alleviates Myocardial Ischemia/Reperfusion Injury via Regulating SIRT1 Through Ferroptosis by Jia L, Yang S, Yin J, Feng O, Wang Z, Jia M

“…Lingmei Jia,1,* Siqi Yang,1,* Jun Yin,2 Ouhua Feng,2 Zhigang Wang,1 Min Jia,1 1Cardiovascular Medicine Department, The Second Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China; 2Cardiovascular Medicine Department, Jingxing County Hospital, Shijiazhuang, People’s Republic of China*These authors contributed equally to this workCorrespondence: Min Jia; Zhigang Wang, Cardiovascular Medicine Department, The Second Hospital of Hebei Medical University, Shijiazhuang, People’s Republic of China, Tel +86-13732219367 ; +86-15131127511, Email jiamin10086@163.com; 15131127511@163.comObjective: This study aimed to investigate the protective effect of bergenin on myocardial ischemia/reperfusion (I/R) injury and to elucidate its underlying mechanism.Methods: The in vivo model of myocardial I/R injury was established by transient ligation of the left anterior descending coronary artery in Sprague-Dawley rats, which were divided into sham, I/R, I/R+bergenin, and I/R+bergenin+erastin (an agonist of ferroptosis) groups.After the model was established, the rats underwent echocardiography to assess the cardiac function. …”
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Clinical Characteristics Analysis of 30 Cases of Interferon-γ Autoantibody-Positive Patients with Concurrent Mycobacterial Infection: A 6-Year Retrospective Study by Zhao CY, Song C, He HW, Huang XZ, Meng XY, Huang AC, Xu CY, Luo LL, Xi SY, Lan YQ, Li WW, Lin YR, Zhu QD

“…Chun-Yan Zhao,1,2,* Chang Song,1,2,* Hua-Wei He,1,* Xian-Zhen Huang,1 Xia-Yan Meng,1 Ai-Chun Huang,1 Chao-Yan Xu,1 Li-Li Luo,1 Shao-Yong Xi,3 Yan-Qun Lan,1 Wei-Wen Li,1 Yan-Rong Lin,1 Qing-Dong Zhu1 1Department of Tuberculosis, The Fourth People’s Hospital of Nanning, Nanning, People’s Republic of China; 2Clinical Medical School, Guangxi Medical University, Nanning, People’s Republic of China; 3Department of Clinical Laboratory, The Fourth People’s Hospital of Nanning, Nanning, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qing-Dong Zhu; Yan-Rong Lin, Department of Tuberculosis, The Fourth People’s Hospital of Nanning, No. 1 Changgang Two-Li, Xingning District, Nanning, 530023, People’s Republic of China, Tel +8615207717261 ; +860771-5636973, Email zhuqingdong2003@163.com; linyanrong2009@126.comPurpose: This study aimed to investigate and elucidate the clinical characteristics, immune status, infection types and patterns, treatment responses, and disease progression in patients with positive anti-interferon-gamma (IFN-γ) autoantibodies in combination with Mycobacterium infections.Patients and Methods: We conducted a retrospective analysis of clinical data from patients with positive anti-IFN-γ autoantibodies and concurrent Mycobacterial infections, including Mycobacterial infections (MTB) and non-tuberculous mycobacteria (NTM). …”
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Immune pre-stimulation by injected yeast beta-glucan as a strategy to prevent calf diarrhea and bovine respiratory disease during the first 74 days of age by Fang Yan, Zhihong Zhang, Xiaorong Zhan, Wenqian Yang, Junhu Yao, Xiurong Xu

“…The CON group received an equal volume of sterile saline at the same time. …”
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Impact of Probiotics Supplementation on Enteral Feed Tolerance in Very Low Birth Weight Neonates: An Open Label Randomised Controlled Trial by Narain Das Vaswani, Hunny Verma, Jagjit Singh Dalal, Seema Lekhwani, Kirty Verma, Neeraj Kumar, Mohan Lal Kundu, Dinkar Yadav

“…A total of 100 participants were recruited and divided equally into two groups (n=50 each): the probiotic group and the control group. …”
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Role of Antimicrobial Stewardship in Modulating Antibiotic Use and Mitigating Bacterial Resistance in a Tertiary Care Setting During COVID-19 by Zhang X, Zhou L, Peng P, Zhang W, Liang C

“…This study aimed to assess the impact of AMS at a Chinese tertiary care hospital on inpatient antimicrobial use and bacterial resistance during the COVID-19 outbreak.Methods: An interrupted time-series regression analysis was conducted to compare inpatient antimicrobial use between pre- and post-intervention periods. …”
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Distribution of Pathogenic Bacteria and Drug Resistance in ICU of a Newly Built Hospital by Zeng H, Liu R, Cheng C, Yang N, Luo L, Long S, Zhou R, Yan K, Huang H

“…Hui Zeng,1,* Rong Liu,1,2,* Chuanli Cheng,2,* Nana Yang,2 Luwen Luo,1,2 Shengshuang Long,3 Renjia Zhou,4 Kai Yan,1 Huantao Huang1 1Nursing Department of the Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 2School of Nursing of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 3Infection Department of the Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 4ICU of the Second Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hui Zeng, Email zenghui.1221@163.comObjective: This study investigated the distribution and resistance patterns of pathogens in the intensive care unit of a newly established hospital in Guizhou Province to promote the rational use of antibiotics to reduce multidrug resistance.Methods: A retrospective analysis was conducted on the distribution of pathogens and changes in drug resistance in the ICU of a newly built hospital in Guizhou Province from March 2019 to December 2023. …”
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Differential Diagnosis Value of Neutrophil Gelatinase Associated Lipocalin as a Noninvasive Biomarker in Perianal Fistulizing Crohn’s Disease by Ma K, Li Y, Wu J, Fu Y, Yin L, Xu S, Weng F, Yao Y, Wang C

“…This study aimed to evaluate NGAL’s potential as a noninvasive diagnostic biomarker between pfCD and cryptoglandular (CG) perianal fistula, and its correlation with disease severity in pfCD.Methods: Serum, fecal, and fistula tissue samples were collected from 96 patients with pfCD and 97 patients with CG perianal fistula as controls. …”
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Identification of Cuproptosis-Related Genes and Their Potential Role in COPD Pathogenesis: A Bioinformatics Analysis by Shen Q, Huang JB, Zhu M, Ji DJ, Huang SJ, Li J

“…Imbalance in copper (Cu2+) metabolism is related to a series of diseases, but its role in COPD has not been specified.Methods: A dataset relevant to COPD was downloaded from Gene Expression Omnibus database, among which a total of 18 cuproptosis-related genes (CRGs) were screened. …”
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MUC1 and glycan probing of CA19-9 captured biomarkers from cyst fluids and serum provides enhanced recognition of ovarian cancer by Shamima Afrin Ruma, Rufus Vinod, Shruti Jain, Kaisa Huhtinen, Johanna Hynninen, Janne Leivo, Kim Pettersson, Karin Sundfeldt, Kamlesh Gidwani

“…Abstract Glycosylation changes of circulating proteins carrying the CA19-9 antigen may offer new targets for detection methods to be explored for the diagnosis of epithelial ovarian cancer (EOC). …”
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Global, regional, and national burden of cutaneous malignant melanoma from 1990 to 2021 and prediction to 2045 by Chengling Liu, Xingchen Liu, Li Hu, Xin Li, Haiming Xin, Sailin Zhu

“…To address this, we analyzed epidemiological patterns and investigated risk factors for CMM-related mortality.MethodsThis study analyzed CMM using data from the 2021 Global Burden of Diseases survey, covering 204 countries and territories. …”
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Protective effect of erythropoietin preconditioning on kidney ischemia-reperfusion injury by ZHANG Jiong, WANG Jia, WANG Fang, LI Gui-sen

“…Objective To explore the protective effect of erythropoietin(EPO)on renal ischemia-reperfusion injury(IRI)in rats.Methods Thirty male SD rats were randomly divided into sham operation group(Sham),renal IRI group(IRI)and EPO pretreatment group(EPO),10 rats in each group.The renal IRI model was constructed by clamping the left renal pedicle for 1h,removing the right kidney,and reperfusion for 24 h.In EPO group,EPO(1 000U/kg)was intraperitoneally injected at 1hbefore operation,while Sham group and IRI group were intraperitoneally injected with equal volume of normal saline.The left renal pedicle was clamped for 45 min in EPO and IRI groups,but not in Sham group.Renal perfusion was restored for 24 h,and then kidneys and serum were obtained.Enzyme linked immunosorbent assay(ELISA)was used to detect serum creatinine(SCr),blood urea nitrogen(BUN),pro-inflammatory cytokines [interleukin-6(IL-6);interferon gamma(IFN-γ)and tumor necrosis factor alpha(TNF-α)]and anti-inflammatory cytokine(IL-10 and TGF-β).The reverse transcriptase polymerase chain reaction(RT-PCR)was used to detect renal pro-inflammatory cytokines(IL-6,IFN-γand TNF-α)and anti-inflammatory cytokines[IL-10 and transforming growth factor beta(TGF-β)]mRNA expression levels.Western blotting was used to detect EPO receptor(EPOR),phosphorylated EPOR(p-EPOR),tyrosine kinase-2(JAK2),signal transducer and activator of transcription 3(STAT3),phosphorylated JAK2(p-JAK2),phosphorylated STAT3(pSTAT3)protein expression levels.Periodic acid Schiff staining(PAS)was used to examine the pathological changes of renal tissues.Results As compared with Sham group,the expression levels of pEPOR,p-JAK2,p-STAT3,SCr,BUN,IL-6,TNF-αand IFN-γwere significantly increased,pathological changes of renal tissues obviously alleviated,and expression levels of IL-10 and TGF-βwere markedly reduced in IRI group.There was no significant difference in EPOR,JAK2 and STAT3levels between Sham group and IRI group.As compared with IRI group,the expression levels of p-EPOR,p-JAK2,p-STAT3,IL-10 and TGF-βwere significantly increased,the levels of SCr,BUN,IL-6,TNF-αand IFN-γwere significantly reduced,and the pathological changes of renal tissues were significantly alleviated in EPO group,but there was no significant difference in EPOR,JAK2 and STAT3expression between IRI group and EPO group.Conclusions EPO preconditioning can alleviate inflammation by inhibiting renal IRI,which may be related with the activation of EPOR/JAK2/STAT3 signaling pathway.…”
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Global Burden of Alzheimer’s Disease Attributable to High Fasting Plasma Glucose: Epidemiological Trends and Machine Learning Insights by Ma Y, Huang S, Dong Y, Jin Q

“…This study aims to analyze global trends in AD death rates and disability-adjusted life years (DALYs) rates attributable to HFPG from 1990 to 2021 and assess the potential of glucose-related biomarkers in predicting cognitive impairment.Methods: Data from the Global Burden of Disease 2021 database were used to analyze AD death rates and DALY rates due to HFPG across 204 countries. …”
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Comparison of Percutaneous Transforaminal Endoscopic Surgery (PTES) With MIS-TLIF for Treating Lumbar Degenerative Disease in Obese Patients by Fan W, Chen Y, Zhou T, Xu Y, Gu Y

“…Wenshuai Fan,1,2,* Yuheng Chen,1,* Tianyao Zhou,1 Yun Xu,3,4 Yutong Gu1,4 1Department of Orthopaedic Surgery, Zhongshan Hospital Fudan University, Shanghai, People’s Republic of China; 2Department of Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 3Centre for Rehabilitation Medicine, Department of Pain Management, Zhejiang Provincial People’s Hospital, Zhejiang, People’s Republic of China; 4Shanghai Southwest Spine Surgery Center, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yutong Gu, Zhongshan Hospital Fudan University, 180 Fenglin Road, Shanghai, 200032, People’s Republic of China, Email 447574313@qq.com Yun Xu, Zhejiang Provincial People’s Hospital, Hangzhou Medical College, Hangzhou, 310014, People’s Republic of China, Email xuyun65204@163.comPurpose: The purpose of this study is to compare clinical outcomes of obese patients with lumbar degenerative disease (LDD) receiving either percutaneous transforaminal endoscopic surgery (PTES) or minimally invasive surgery-transforaminal lumbar interbody fusion (MIS-TLIF).Methods: There were 26 patients underwent PTES, and 29 patients were treated with MIS-TLIF between June 2014 and June 2019. …”
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Evaluation of the tubular penetration of two different types of nanoparticle root canal sealers over apically separated files: a scanning electron microscopic study (in vitro study... by Alaa H. Nagdi, Nayera A. Mokhless, Mahmoud R. Aboelseoud

“…Aim of the study This study aimed to evaluate tubular penetration of two nanoparticles modified root canal sealers compared to conventional sealers using ultrasonic activation over an apically separated file analyzed by scanning electron microscopy (SEM). Materials and methods Forty extracted single canaled mandibular premolar teeth were decoronated and prepared using M-Pro (IMD, Shanghai, China) nickel titanium rotary files which were intentionally separated at apical third. …”
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Distribution of Angle Alpha in a Large Population in Eastern China: An Analysis of the 30705 Eyes Using the Ray Tracing Aberrometer by Hua Z, Zeng Q, Zhang L, Shen J, Yang J

“…Zhixiang Hua,1– 5,* Qiulin Zeng,6,* Limei Zhang,7 Jiying Shen,7,* Jin Yang1– 5,* 1Department of Ophthalmology and the Eye Institute, Eye and Ear, Nose, and Throat Hospital, Fudan University, Shanghai, People’s Republic of China; 2The Key Laboratory of Myopia, Ministry of Health, Shanghai, People’s Republic of China; 3Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, People’s Republic of China; 4Key National Health Committee of the Key Laboratory of Myopia, Fudan University, Shanghai, People’s Republic of China; 5The Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, People’s Republic of China; 6Department of Ophthalmology, Shanghai Xinshijie Dongqu Eye Hospital, Shanghai, People’s Republic of China; 7Department of Ophthalmology, Shanghai Heping Eye Hospital, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jin Yang, Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, People’s Republic of China, Tel +008613671632525, Email jin_er76@hotmail.com Jiying Shen, Department of Ophthalmology, Shanghai Heping Eye Hospital, Shanghai, People’s Republic of China, Tel +008613817505149, Email susu22yoyo@163.comPurpose: To describe the distribution of angle alpha orientation and magnitude in a large population and to analyze the impact of eye laterality, gender, and age on angle alpha.Setting: EENT Hospital of Fudan University and Shanghai Heping Eye Hospital, 2017– 2023.Design: A retrospective analysis utilizing the iTrace system to examine preoperative angle alpha in patients undergoing cataract surgery.Methods: Angle alpha orientation and magnitude were collected from 30,705 individuals. …”
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Exploring Melasma Patients’ Needs Through Social Media: A Qualitative Study by Liu X, Liu X, Han Y, Cheng Y, Luo H, Liu Y, Li D, Guo W, Jiang H, Guo L, Jiang X

“…Xinjin Liu,1,2,* Xu Liu,1,2,* Yanbing Han,1,2 Yifei Cheng,1,2 Hongjie Luo,1,2 Yichen Liu,1,2 Dingling Li,1,2 Weihong Guo,1,2 Haoyu Jiang,1,2 Linghong Guo,1,2 Xian Jiang1,2 1Department of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 2Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xian Jiang, Department of Dermatology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, People’s Republic of China, Tel +86 189 8060 1693, Email jiangxian@scu.edu.cn Linghong Guo, Department of Dermatology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, People’s Republic of China, +86 18380131660, Email Linhom.guo@foxmail.comPurpose: To identify the primary concerns and unmet needs of patients with melasma on social media using qualitative analysis and AI-based keyword extraction.Patients and Methods: We conducted a qualitative study of melasma patient discussions using publicly available posts on Facebook and Baidu. …”
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Parents’ perspective on children’s access to healthcare services and associated factors: a cross-sectional study by Nona Salimi, Javad Javan-Noughabi, Vahid Ghavami, Reza Matinfar, Fatemeh Kokabisaghi

“…This research aimed to explore parents’ perspective on children’s access to healthcare services and its associated factors. Methods In this cross-sectional study, 317 parents of children aged ≤ 18, chosen by two-stage cluster sampling participated. …”
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NOSOLOGICAL DIAGNOSIS OF JUVENILE ARTHRITIS AT DIFFERENT FOLLOW-UP STAGES by Svetlana Olegovna Salugina

“…Objective: to define the nosological category of juvenile arthritis (JA) in patients of different ages with different disease stages and follow-up periods. Subjects and methods. Group 1 included 135 children, mainly girls (60.7%), aged 1 to 16 years (range 7.9±5.0 years) with early-onset JA, the duration of which was 2 weeks to 6 months (range 2.9±1.6 months) who were further followed up for 2 years. …”
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MHR Was Associated with Hyperuricemia Risk in Patients with Type 2 Diabetes Mellitus: The Mediating Effect of Body Mass Index by Huang B, Li X, Zhang XX, Li SW, Wang M, Chen Q, Cao YD, Cui JQ

“…Therefore, our study specifically investigates the relationship between MHR and HUA in a T2DM population.Methods: This cross-sectional study enrolled 1,261 T2DM patients. …”
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Varicella-zoster virus vasculopathy: a rare complication of Ramsay Hunt Syndrome: a literature review by Di Wu, Mian Song

“…The aim of this review was to analyze clinical and neuroimaging findings, laboratory findings, treatment and outcome of these patients.MethodsWe report a literature review that includes all case reports identified via PubMed on RHSII complicated by VZV Vasculopathy. …”
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