Epigenetic Regulation of Sorbitol Dehydrogenase in Diabetic Retinopathy Patients: DNA Methylation, Histone Acetylation and microRNA-320 by Amin R, Permana H, Kartasasmita AS, Hilmanto D, Hidayat R

“…Ramzi Amin,1,* Hikmat Permana,2,* Arief Sjamsulaksan Kartasasmita,3,* Dany Hilmanto,4,* Rachmat Hidayat5,* 1Department of Ophthalmology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia; 2Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; 3Department of Ophthalmology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; 4Department of Pediatrics, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; 5Department of Medical Biology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia*These authors contributed equally to this workCorrespondence: Ramzi Amin, Department of Ophthalmology, Faculty of Medicine, Universitas Sriwijaya, Jl Dr Moh Ali KM 3.5, Palembang, South Sumatera, 30126, Indonesia, Tel +62 882 2505 3819, Email ramziamin20@gmail.comPurpose: This study aimed to investigate the correlation between epigenetic markers and sorbitol dehydrogenase (SDH) levels in patients with type 2 diabetes and diabetic retinopathy (DR).Patients and Methods: We conducted a case control study on 40 patients with type 2 diabetes and DR and 40 patients with type 2 diabetes without DR. …”
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Comparison of microscopic vs. endoscopic technique in revision stapes surgery: a systematic literature review by Federico Maria Gioacchini, Massimo Ralli, Massimo Re, Giannicola Iannella, Alfonso Scarpa, Valerio Di Pasquale Fiasca, Giovanni Motta, Arianna Di Stadio

“…IntroductionIn this study, we aimed to evaluate the differences in hearing outcomes and surgical complications after revision stapes procedure using endoscopic and microscopic techniques.MethodsSystematic literature review was performed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) checklist. …”
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B Cell Activation, Differentiation, and Their Potential Molecular Mechanisms in Osteoarthritic Synovial Tissue by Lu P, Li Y, Yang S, Yao H, Tu B, Ning R

“…Peizhi Lu,1,2,* Ya Li,1,2,* Shuo Yang,2 Haoyu Yao,2 Bizhi Tu,2 Rende Ning1,2 1Graduate School, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China; 2Department of Orthopedics, the Third Affiliated Hospital of Anhui Medical University, the First People’s Hospital of Hefei, Hefei, Anhui, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bizhi Tu, Department of Orthopedics, the Third Affiliated Hospital of Anhui Medical University, the First People’s Hospital of Hefei, Hefei, Anhui, People’s Republic of China, Tel +86 15357483840, Email 1301535636@qq.com Rende Ning, Graduate School, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China, Tel +86 13956966305, Email nrd1972@outlook.comObjective: The objective of this study was to characterize the activation and differentiation of B cells in the synovium of osteoarthritis (OA) and to explore the underlying molecular mechanisms.Methods: Peripheral blood and synovial samples from OA patients at different stages were collected, and flow cytometry was employed to analyze the activation and differentiation of B cells. …”
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Long term survival analysis of cementless Spotorno femoral stem in young patients by Murat Mert, Cenk Ermutlu, Emrah Kovalak, Ethem Ünkar, Sibel Çağlar Okur

“…Spotorno stems perform equally well in all etiologies with no difference in terms of survivorship. …”
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Novel Proteomic Insights into Hip Fractures in the Elderly: Unraveling Immunologic Biomarkers, Temporal Expression Patterns, and Clinical Correlations by Lu Y, Liu J, Chen W, Hu P, Pei Y, Gao Y, Lu H, Wang L, Zhang Y

“…Yining Lu,1,2,* Jiaoran Liu,3,* Wei Chen,1 Pan Hu,4 Yan Pei,2 Yiming Gao,2 Hairong Lu,5 Ling Wang,1,2 Yingze Zhang1 1Department of Orthopedic Research Center, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Orthopedic Oncology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 3Department of Ultrasound Diagnosis, Bethune International Peace Hospital, Shijiazhuang, Hebei, People’s Republic of China; 4Trauma Medicine Center, Peking University People’s hospital, Beijing, China; National Center for Trauma Medicine, Beijing, People’s Republic of China; 5Department of Geriatric orthopedics, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yingze Zhang, Department of Orthopedic Research Center, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China, Email yzzhang@hebmu.edu.cn Ling Wang, Department of Orthopedic Oncology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China, Email wangling2016uw@126.com; wangling2021@hebmu.edu.cnBackground: Hip fractures in the elderly triggers a severe inflammatory immune response.Methods: Peripheral blood samples from 16 elderly hip fracture patients and 16 healthy controls were analysed for 92 inflammatory biomarkers using proximity extension assay (PEA) at different stages after trauma.Results: Dynamic trends in inflammatory proteins after surgery were assessed. …”
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Resilience and Affiliate Stigma Among Parents of Children with Autism Spectrum Disorder: The Mediating Role of Life Satisfaction and the Moderating Role of Ostracism by Chen H, Ding Y, Xu D, Xiong Z

“…The present study aims to investigate the association between parental resilience and affiliate stigma, examine the mediating role of life satisfaction in this relationship, and assess the moderating effect of ostracism on these pathways.Methods: This study employed a cross-sectional design to examine the relationship between resilience and affiliate stigma among parents of children with ASD, as well as the underlying mechanism. …”
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How does head position affect laryngeal vision with a video laryngeal mask airway? by Caridad G. Castillo-Monzón, Hugo Antonio Marroquín-Valz, Tomasz Gaszynski, Manuel Cayuela, Javier Orozco, Pawel Ratajczyk

“…The objective of this study is to evaluate and compare the optimal position for placement of a video laryngeal mask airway.MethodsThis prospective, observational, transversal, and analytical study was performed in 72 consecutive patients. …”
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THE FORMATION OF FUTURE PSYCHOLOGISTS’ PROFESSIONAL ASPIRATIONS IN THE PROCESS OF STUDYING THE DISCIPLINE «PEDAGOGY AND PSYCHOLOGY OF HIGHER SCHOOL» by Nataliia P. Volkova, Olena O. Lavrentieva

“…Among them are the motivational component (the complex of motives, needs, guidelines in professional activities), the cognitive one (knowledge of the content and structure of professional aspirations, their impact on professional readiness and success of the specialist, as well as the methods and technologies of their formation), the activity one (the degree of formation of the organizational, psychology and diagnostic, prognostic, reflexive, and communicative skills) and the reflexive one (the structure of reflexive, critical and creative thinking of future psychologists). …”
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Effects of Food on the Pharmacokinetics and Safety of HA121-28 Tablet, a Novel Multi-Targeting Tyrosine Kinase Inhibitor, in Healthy Chinese Subjects: A Phase I Clinical Trial by Liu Y, Li X, Zhang M, Men Y, Wang Y, Zhu X, Zheng L

“…The objectives of this study were to assess the effect of high-fat and high-calorie food on the pharmacokinetic (PK) profile and safety of HA121-28 tablet in healthy subjects.Patients and Methods: A single-dose, randomized, open-label, two-period, crossover-designed phase I clinical trial was conducted. …”
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Comparison of Modified Mallampati Classification and Acromio-Axillo-Suprasternal Notch Index in Predicting Difficult Laryngoscopy: A Prospective cohort study. by Mohamed Noufal P.K, Padma Amar Vishal, Gopala Krishna Kommula

“…AASNI showed higher sensitivity (83.3%) and NPV (93.9%) compared to MMP (41.67% and 83.7%, respectively), while MMP had greater specificity (87.8%). Both tools shared equal PPV (50%) and diagnostic accuracy (77.36%). …”
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Application of Intravenous Chloroprocaine in Gastrointestinal Endoscopy: A Randomized Controlled Trial by Zhang P, Zhang J, Zhao Y, Chen J, Wang S

“…This trial was conducted to test the hypothesis that chloroprocaine can reduce the requirement for propofol and alleviate injection pain during gastrointestinal endoscopy.Methods: Sixty patients undergoing gastrointestinal endoscopy were enrolled and randomly divided into study group (Group CP) and control group (Group C). …”
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The effect of probiotic, prebiotic, and synbiotic supplements on anthropometric measures and respiratory infections in malnourished children: a systematic review and meta-analysis... by Masoumeh Paiandeh, Mahsa Maghalian, Sakineh Mohammad-Alizadeh-Charandabi, Mojgan Mirghafourvand

“…Results Twelve studies with a total of 3,086 children (aged up to 6 years, equally distributed between boys and girls) were included. …”
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ROS-Responsive Biomimetic Nanocomplexes of Liposomes and Macrophage-Derived Exosomes for Combination Breast Cancer Therapy by Xu M, Bai L, Sun M, Yan X, Xiong Y, Wang Y, Guo Y, Liu X, Yu L, Zhong X, Ran M, Wang B, Tang Y, Lee RJ, Xie J

“…To mitigate chemotherapy drug toxicity and enhance drug delivery efficiency, we combined ROS-responsive cationic liposomes (cLip) with macrophage-derived exosomes to create biomimetic nanocomplex (E-cLip-DTX/si) for co-delivery docetaxel (DTX) and Bcl-2 siRNA.Methods: We encapsulated docetaxel (DTX) and Bcl-2 siRNA as model drugs into biomimetic nanocomplexes and validated their antitumor efficacy in vitro and in vivo.Results: In vitro and vivo tests show that E-cLip-DTX/si can react to ROS, promote apoptosis of tumor cells effectively, and prolong circulation time. …”
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Glycine influence on cerebral blood flow parameters in practically healthy individuals evaluated with transcranial Doppler sonography by E. V. Mashkovtseva, N. A. Rudnikova, V. S. Kopylova, Y. R. Nartsissov

“…The amino acid glycine has been widely used in neurological practice for over 30 years, which helps improve hemodynamic characteristics and metabolic processes in the brain tissue.The aim of the work was to analyze the effect of a sublingual administration of glycine on the cerebral blood flow velocity in practically healthy subjects using transcranial Doppler (TCD) sonography.Material and methods. The pilot randomized controlled study included 20 healthy subjects aged 25 to 65 years, equally divided into 2 groups, one of which took glycine sublingually at a dose of 300 mg/day for 30 days, and the second group was a control group and did not receive the drug. …”
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Local power flow control by L. M. Chetochnikova, N. I. Smolentsev, N. V. Tomskich, D. A. Gimgina, D. A. Lavrentieva

“…Solving  the  problem  of  high-quality  and  uninterrupted  power  supply  to  consumers requires  a  new  approach  associated  with  the  use  of  modern  Smart  Grid  technologies,  equally related to energy and information technology. …”
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Elevated serum asprosin and ANGPTL8 gene expression as novel biomarkers for the diagnosis and prognosis of acute coronary syndrome by Zainulabdin Abdulnabi Abdulah Albreej, Gholamreza Dehghan, Alireza Nourazarian, Naser Aslanabadi, Jamshid Assadi

“…Asprosin and angiopoietin-like protein 8 (ANGPTL8) have recently emerged as potential biomarkers for ACS diagnosis.MethodsThis comparative study included 100 participants, equally divided into ACS patients and healthy controls with matched demographics. …”
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Central Serous Chorioretinopathy from the Point of View of OCT-Angiography. Part 1. Chorioretinal Blood Flow Changes by A. G. Shchuko, S. I. Zhukova, T. N. Iureva, A. N. Zlobina

“…At the same time, the reports appeared in recent years indicate that an equally important link in pathogenesis is the disturbances of the choroidal blood flow. …”
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Lipopolysaccharide in Bile Promotes the Neutrophil Extracellular Traps-Induced Gallstone Formation by Activating the Gallbladder Immune Barrier by Yu J, Meng Z, Liu X, Zheng Y, Xue D, Hao C, Wang L

“…However, the specific immune mechanisms underlying the cholesterol gallstone formation have not been fully elucidated.Methods: In this study, gallbladderand bile samples from 8 asymptomatic patients with cholelithiasis undergoing cholecystectomy and 11 healthy liver transplant donors were collected for tissue transcriptome sequencing and differential analysis. …”
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Application of Multi-Inflammatory Index to Predict Atrial Fibrillation Risk in Patients with Coronary Heart Disease: A Retrospective Machine Learning Study by Hou L, Su K, Zhao J, He T, Li Y

“…This study aims to investigate the value of the multi-inflammatory index (MII) in predicting the occurrence of atrial fibrillation in patients with coronary heart disease.Methods: A retrospective analysis was conducted on patients who visited our hospital from January 1, 2020, to December 31, 2023, including a total of 1392 patients. …”
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Rhinocerebral Mucormycosis in Patients with Diabetes Mellitus After a New Coronavirus Infection (COVID-19): СT and MRI Patterns Data by I. S. Gabdulganieva, N. R. Munirova, A. R. Zaripova, V. I. Anisimov

“…Lesions of the nasal cavity and paranasal sinuses in RCM were found in 100% of our observations, with approximately equal single and bilateral lesions of 54% and 46%, respectively. …”
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