Preoperative chronic opiate use associated with a worse joint-specific function and quality of life before and after total hip and knee arthroplasty by Eliott S. Martinson, Nick D. Clement, Deborah J. MacDonald, Chloe E. H. Scott, Colin R. Howie

“…However, patients were equally satisfied with outcomes. Cite this article: Bone Jt Open 2025;6(4):405–412.…”
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Novel Obstetric Air Cushion for the Prevention of Hypotension During Spinal Anesthesia for Cesarean Section: A Randomized Controlled Clinical Trial by Dong Y, Cao WW, Weng H, Liu R, Huang DD

“…We assessed the effect of a novel obstetric air cushion pretreatment on the incidence of hypotension after spinal anesthesia.Patients and Methods: Eighty parturients were randomly assigned to the air cushion or blank control group (Group A or B, respectively). …”
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Prognostic Value of the Triglyceride-Glucose Index Combined with Non-HDL-C/HDL-C Ratio for Predicting Coronary Microvascular Dysfunction in ACS Patients Post-PCI by Hang S, Tang N, Li K, Zhang Q, Hao J, Zhang Y, Qi C

“…This study aimed to evaluate the combined predictive value of the triglyceride-glucose index (TyG) and non-HDL-C/HDL-C ratio (NHHR) for CMD in ACS patients post-PCI.Methods: A retrospective analysis of 542 ACS patients undergoing PCI (2021– 2023) was conducted. …”
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Impact of root canal shaping using TruNatomy on postoperative pain and operative torque generation: a randomized clinical trial by Tarek Ali Al-Mosalmy, Heba Maged El-Far, Madiha Mahmoud Gomaa, Dina Ahmed Morsy

“…Aim To compare the effect of canal shaping using TruNatomy (TN) rotary system to RaCe (RC) rotary system on post-operative pain in necrotic maxillary bi-rooted premolars, while simultaneously inspecting the real-time dynamic forces produced during instrumentation. Methods In this parallel group superiority trial, following power calculation, 40 patients diagnosed with pulp necrosis in asymptomatic bi-rooted maxillary premolars were recruited and randomly allocated into two equal groups (n = 20) according to the instrumentation system used. …”
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PANoptosis-Relevant Subgroups Predicts Prognosis and Characterizes the Tumour Microenvironment in Ovarian Cancer by Chen Y, Deng Z, Chen J, Lin J, Zou J, Li S, Sun Y

“…However, its prognostic relevance in OC remains unclear.Methods: Utilizing data from The Cancer Genome Atlas (TCGA), we analyzed transcriptomic and clinical signatures of OC patients. …”
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Health Literacy, Label Comprehension, and Consumer Perceptions of Quasi-Drug Information Among Korean Adults: A Cross-Sectional Study by Ko Y, Kim HJ, Lee SM

“…This study aimed to evaluate HL and its impact on comprehending quasi-drug labels, assess consumer perceptions of key label elements and their perceived importance, and provide actionable recommendations for improving label design and health communication.Methods: An online cross-sectional survey of 500 Korean adults (aged 20– 69) was conducted in September 2023 using proportionate stratified sampling based on the 2020 Korean Census. …”
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Model-Informed Precision Dosing of Remimazolam in General Anesthesia Patients by Chen Y, Zhang ZJ, Zhang XF, Peng Y, Jiao Z, Wu JX

“…Yueting Chen,1,* Zuo-Jing Zhang,2,* Xiao-Feng Zhang,2 Yuan Peng,2 Zheng Jiao,1,* Jing-Xiang Wu2,* 1Department of Pharmacy, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Zheng Jiao, Department of Pharmacy, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, People’s Republic of China, Email jiaozhen@online.sh.cn Jing-Xiang Wu, Department of Anesthesiology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Xuhui District, Shanghai, 200030, People’s Republic of China, Tel +86 021-22200000-3302, Fax +86 021-32260806, Email wjx1132@163.comPurpose: This study aimed to characterize the pharmacokinetics/pharmacodynamics (PK/PD) of remimazolam in patients under general anesthesia using a population analysis and to develop a web-based dashboard tool that directly displays the optimal dosing regimen for general anesthesia.Patients and Methods: A total of 20 patients received remimazolam for general anesthesia, during which intensive arterial blood samples and bispectral index (BIS) values were collected. …”
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A randomised trial to compare the safety, tolerability and efficacy of three drug combinations for intermittent preventive treatment in children. by Kalifa Bojang, Francis Akor, Ousman Bittaye, David Conway, Christian Bottomley, Paul Milligan, Brian Greenwood

“…Thus, we have investigated whether SP plus AQ, SP plus piperaquine (PQ) and dihydroartemisinin (DHA) plus PQ might be equally safe and effective when used for IPT in children in an area of seasonal transmission.…”
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Physical development and sociocultural context influences on children’s physical activity by Alessandro Hervaldo Nicolai Ré, Maria Teresa Cattuzzo, David Stodden, Guilherme dos Santos, Albert Lucas Olinto Tertuliano, Carlos Bandeira de Mello Monteiro, Diogo Henrique Constantino Coledam, Anthony David Okely

“…Health policies should encourage equal gender participation in culturally significant sports or activities of a particular region/country, specifically within the family context.…”
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Determination of administered activities for the treatment of Graves' disease with iodine-131: Proposition of a simplified dosimetric procedure by Idrissa Adamou Soli, Djibrillou Moussa Issoufou, Skander Rahabi, Ada Ali, Eric Adehossi, Salah Eddine Bouyoucef

“…Empirical determination of activity in the treatment of GD gives higher activities (1.5 times) to patients than dosimetric methods based on the determination of extrapolated effective half-life.…”
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Increased Stress Hyperglycemia Ratio Predicts Poor Clinical Outcome in Critically Ill COPD Patients: A Retrospective Study by Qiao M, Yang H, Qin M, Li Y, Wang H

“…The present study aimed to investigate the relationship between SHR and adverse clinical outcomes in critically ill COPD patients.Methods: A total of 1,580 patients diagnosed with COPD were included in this retrospective cohort study. …”
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Awareness, Beliefs, and Psychological Impact of Patients with Alopecia Areata in Saudi Arabia: A Multi-Center Study by Almulhim NA, Alojail HY, Aljughayman MA, Almarri FH, Alsultan NH, Albash LA, Almukhaimar SK, Alkhamis AA, Albaqshi MA, Alkhawajah AA

“…This study aims to assess the awareness, beliefs, and psychological impact of patients with Alopecia Areata.Patients and Methods: This cross-sectional study was conducted in Eastern and Central provinces of Saudi Arabia and utilized online questionnaires to evaluate knowledge, beliefs, and psychological effects of patients with Alopecia Areata. …”
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OBJECTIVE ACCOMMODATION RESPONSE VALUE (COMPLETENESS OF CYCLOPLEGIA) AFTER DIAGNOSTIC INSTILLATIONS OF DIVERSE MEDICATIONS by N. A. Tarasova, E. P. Tarutta, G. A. Markosian, M. V. Maksimova

“…Purpose: to compare the extent of cycloplegia by residual accommodation response after instillations of various medications. Materials and methods. 54 patients, aged 8 to 23, with varied degrees of myopia were instilled twice, with an interval of 10 minutes, with one of the following medications: Cyclopentolate 1 %, Tropicamide 1 %, Midrimax, and Phenylephrine 2.5 %. …”
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The Temporal Changes in Ankle Joint Pathology, Pain and Secondary Osteoporosis in Collagen-Induced Arthritis Rats by Liu Q, Nan N, Li W, Dong M, Pu W, Liu Y, Zhao J, Hao H

“…Pain is the most important symptom of RA, and some patients with well-controlled inflammation may still experience pain.Purpose: To explore the relationship and dynamic changes between synovial inflammation and pain and bone destruction in collagen-induced arthritis (CIA) model rats, and to choose a better time window for drug treatment.Methods: The CIA model rats were constructed for 1, 2, 3, and 4-week groups. …”
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Comparative long-term efficacy of short-term spinal cord stimulation versus bipolar pulsed radiofrequency for refractory postherpetic neuralgia: a 24 month prospective study by Yun Li, Junnan Wang, Yang Chen, Feng Qiu, Tao Sun, Xuli Zhao

“…This study compares the long-term efficacy and safety of short-term spinal cord stimulation (stSCS) versus bipolar pulsed radiofrequency (bPRF) in managing refractory PHN. Methods In this prospective, controlled observational study, 140 PHN patients (aged ≥ 18 years; PHN duration ≥ 3 months) with inadequate pain relief from standard therapies were enrolled and randomized equally into two groups (n = 70 each). …”
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Mendelian Randomization Analysis Supports a Causal Relationship Between Circulating Inflammatory Proteins and Basal Cell Carcinoma by Fu ZD, Wang Y, Yan HL, Wu JH

“…Zhi-da Fu,1,2,* Yao Wang,3,* Hong-li Yan,2 Jian-hua Wu1 1Department of Dermatology, Changhai Hospital, Naval Medical University, Shanghai, People’s Republic of China; 2Center for Reproductive Medicine, Changhai Hospital, Naval Medical University, Shanghai, People’s Republic of China; 3Shanghai International Travel Healthcare Center, Shanghai Customs District, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jian-hua Wu, Department of Dermatology, Changhai Hospital, Naval Medical University, Shanghai, People’s Republic of China, Email wujh_chyy@163.com Hong-li Yan, Center for Reproductive Medicine, Changhai Hospital, Naval Medical University, Shanghai, People’s Republic of China, Email hongliyan@smmu.edu.cnBackground: It has been shown that the Basal cell carcinoma (BCC) is associated with chronic inflammation of skin conditions, the circulating inflammatory protein levels may be a more intuitive index in response to inflammation, however, the cause-and-effect relationship between circulating inflammatory proteins and BCC is currently unknown.Methods: This study performed a Mendelian randomization (MR) analysis using the plasma inflammatory protein levels from a large genome-wide protein quantitative trait loci study as the exposure data, and the outcome data from a GWAS for BCC. …”
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The Value of Common Laboratory Markers in Predicting the Severity of COVID-19 Patients by Chen L, Jiang YH, Li MY, Huang B, Yuan L, Wan JH, Qin TY, Zeng TT, Chen QG

“…Lian Chen,1,* Yu-Huan Jiang,2,* Mei-Yong Li,3 Bo Huang,3 Lei Yuan,2 Jin-Hua Wan,2 Ting-Yu Qin,2 Ting-Ting Zeng,2 Qing-Gen Chen2 1Department of Ultrasound Medicine, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China; 2Department of Clinical Laboratory, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China; 3Department of Clinical Laboratory, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China*These authors contributed equally to this studyCorrespondence: Qing-Gen Chen, Department of Clinical Laboratory, the First Affiliated Hospital of Nanchang University, Nanchang, 330006, People’s Republic of China, Tel/Fax +86 0791-86319420, Email 272880243@qq.comPurpose: The aim of the present study was to identify more effective laboratory markers to assess the severity of corona virus disease 2019 and predict the progression of the disease by collecting more laboratory markers and variables.Patients and Methods: In this study, most risk factors, including epidemiological characteristics, blood cell counts, cytokines, and infection markers, were collected from 126 patients with COVID-19 to assess their predictive value.Results: The area under curve (AUC) of Albumin (Alb) to fibrinogen (Fib) ratio (AFR) (0.791), Lactate dehydrogenase (LDH) (0.792), myoglobin (MYO) (0.795), C-reactive protein (CRP) (0.801) and lymphocyte count (0.859) were higher than other markers to distinguish severe from non-severe patients in receiver operating characteristic (ROC) analysis. …”
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Mexiletine in the Treatment of LQT2, LQT3, and Acquired LQTS: A Meta-Analysis by Dhiya Ihsan, Mohammad Iqbal, Charlotte Johanna Cool, Chaerul Achmad, Miftah Pramudyo, Hawani Sasmaya Prameswari, Mohammad Rizki Akbar

“…Methods: A meta-analysis was conducted using systematic electronic searches of PubMed, Embase, and Cochrane Library. …”
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Patterns of prescription antihypertensive drug utilization and adherence to treatment guidelines in the city of Novi Sad by Tomas Ana, Tomić Zdenko, Milijašević Boris, Ban Milica, Horvat Olga, Vukmirović Saša, Sabo Ana

“…The use of more expensive ACEi was observed, despite the guidelines deeming all the drugs of these class equally effective in treatment of hypertension. …”
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Impact of 30-minute and 90-minute Naps on Aerobic and Anaerobic Intermittent Performance in Collegiate Soccer Players by Xu A, Wang N, Gao Y, Li X

“…Anran Xu,1,* Ning Wang,1,* Yang Gao,1 Xiaotian Li1,2 1Department of Physical Education and Research, Central South University, Changsha, 410083, People’s Republic of China; 2School of Sports Training, Wuhan Sport University, Wuhan, 430079, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yang Gao, Department of Physical Education and Research, Central South University, Changsha, 410083, People’s Republic of China, Email 1062065203@qq.com Xiaotian Li, Department of Physical Education and Research, Central South University, Changsha, 410083, People’s Republic of China, Email xiaotianli@csu.edu.cnPurpose: This study aims to investigate the effects of 30-minute and 90-minute naps on collegiate soccer players’ aerobic and anaerobic performance following a normal night of sleep, and to compare the performance differences between the two nap durations.Patients and Methods: A total of 25 male collegiate soccer players (age: 20 ± 1 years, height: 180.4 ± 5.6 cm, weight: 72.1 ± 4.2 kg, BMI: 22.1 ± 2.2 kg·m⁻²) participated in the RAST and 30– 15. …”
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