Polyethylenimine-Conjugated Au-NPs as an Efficient Vehicle for in vitro and in vivo DNA Vaccine Delivery by Kartouzian A, Heiz A, Shameli K, Moeini H

“…Aras Kartouzian,1 Alexandra Heiz,1 Kamyar Shameli,2,* Hassan Moeini3,* 1Catalysis Research Center, School of Natural Sciences, Technical University of Munich, Munich, Germany; 2Institute of Virology, School of Medicine, Technical University of Munich, Munich, Germany; 3Iguana Biotechnology GmbH, Munich, Germany*These authors contributed equally to this workCorrespondence: Kamyar Shameli; Hassan Moeini, Email kamyarshameli@gmail.com; moeini82@yahoo.comPurpose: This study aimed to develop green-synthesized gold nanoparticles (Au-NPs) conjugated with polyethyleneimine (PEI) to overcome challenges in intracellular DNA vaccine delivery, focusing on enhancing cellular uptake and immune responses against the human norovirus (HuNoV) GII.4 variants.Methods: Au-NPs were synthesized using a citrate-ion-mediated green approach, with size and morphology analyzed via UV-vis spectroscopy and transmission electron microscopy (TEM). …”
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Impact of Jordanian Pharmacists’ Knowledge of the Human Microbiome: Has the Practice of Antibiotics and Probiotics Dispensing Been Affected? A Cross-Sectional Study by Sawan HM, Shroukh W, Abutaima R, Al Omari SM, Abdel-Qader DH, Binsuwaidan R

“…Statistical significance was considered at p < 0.05.Results: Of the 333 respondents, around 75% (n=250) had a high level of general knowledge regarding the human gut microbiome. Almost equal proportions of participants had either intermediate or high levels of knowledge about the role of gut bacteria in health (n=164, 49.2%) (n=166, 49.8%), respectively, while almost two-thirds had an intermediate level of knowledge of the role of gut bacteria in disease (n=197, 59.2%). …”
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Association of Six Complex Inflammatory Indicators with Prognosis in Patients with Intravenous Thrombolysis Stroke by Li Y, Xi L, Sun H, Yu F, Liang Q, Qie T, Dai B

“…Yinglei Li,1,&ast; Lingyun Xi,2,&ast; Haichuan Sun,1 Feifei Yu,1 Qing Liang,1 Tao Qie,1 Bing Dai1 1Department of Emergency Medicine, Baoding NO.1 Central Hospital, Baoding, People’s Republic of China; 2Department of Laboratory and Pathology, The Hospital of 82nd Group Army PLA, Baoding, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Bing Dai, Department of Emergency Medicine, Baoding NO.1 Central Hospital, Baoding, People’s Republic of China, Email 447023235@qq.comObjective: The objective of this study is to examine the correlation between neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), lymphocyte-to-monocyte ratio (LMR), systemic immune inflammation index (SII), systemic inflammation response index (SIRI) and pan-immune-inflammation value (PIV) with the outcome following 3 months of thrombolysis in individuals diagnosed with acute ischemic stroke.Methods: A retrospective analysis was conducted on a cohort of 762 patients who received intravenous thrombolysis between January 2019 and December 2022. …”
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Nudging Health Behavior Change Among Home-Based Cardiac Rehabilitation Patients: A Scoping Review by Yang Z, Jin D, Huang H, Zheng X, Liu S, Wang A

“…The literature on nudging strategy is fragmented and lacks comprehensive reviews.Objective: This study aimed to identify nudging interventions to promote health behavior change among patients undergoing home-based cardiac rehabilitation, focusing on the scope, characteristics and delivery.Methods: A scoping review was conducted from July to September 2023, during which databases including PubMed, Web of Science, and OVID (Embase, Cochrane Library, JBI) were searched. …”
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The Dose-Dependent Effects of Fluorocitrate on the Metabolism and Activity of Astrocytes and Neurons by Huiling Zhuang, Deliang Yuan, Fuxiu Shi, Xujun Wu, Zhen Luo, Wenbiao Gan

“…Whether FC at such concentrations may affect neuronal metabolism and function <i>in vivo</i> remains unclear. Methods: We examined the effects of FC on the ATP levels and Ca²⁺ activity of the astrocytes and neurons in the motor cortices of living mice using two-photon microscopy. …”
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Acupuncture Ameliorates Alzheimer&rsquo;s-Like Cognitive Impairment and Pathological Changes via Regulating the Intestinal Fungal Community in APP/PS1 Mice by Hao X, Ding N, Zhang Y, Wu M, Tao Y, Li Z

“…However, the potential regulatory effects of acupuncture on the fungal microbiota have been largely overlooked.Methods: APP/PS1 mice were used as AD animal model and randomly divided into the AD model (AD) group, the acupuncture (Ac) group, and the probiotics (Pr) group. …”
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Screening results correlating to personality disorder traits in a new employee population of People&amp;#39;s Republic of China by Tan Y, Liu Y, Wu L

“…To understand the current mental status and further improve the mental health level of the new employee population of People&amp;rsquo;s Republic of China, we conducted a cross-sectional study to screen the prevalence and correlates of personality disorder (PD) traits in this population.Methods: This study included all male participants who were new employees (those who had started working in approximately the last three months) from 12 machinery factories in People&amp;rsquo;s Republic of China. …”
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Identifying Key Prognostic Indicators for Relapse and Chronic Epilepsy in Autoimmune Encephalitis: Insights from a Multicenter Retrospective Study by Lai Q, Chen Y, Wang W, Lian Z, Liu T, Wen C

“…Qingwei Lai,1,&ast; Yue Chen,1,&ast; Wei Wang,2,&ast; Zhangxu Lian,3,&ast; Tengfei Liu,4 Chunmei Wen5 1Department of Neurology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People’s Republic of China; 2Department of Neurology, Yancheng First People’s Hospital, Yancheng, People’s Republic of China; 3Department of Neurology, Xuzhou Central Hospital, Xuzhou, People’s Republic of China; 4Department of Neurology, Xuzhou Mining Group General Hospital, Xuzhou, People’s Republic of China; 5Department of Neurology, Yancheng Third People’s Hospital, Yancheng, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Qingwei Lai, Department of Neurology, Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou, Jiangsu, 221002, People’s Republic of China, Tel +8651685802193, Email lqw8696@163.comObjective: The aims of this study were to investigate clinical factors associated with encephalitis relapse and chronic epilepsy development, and to evaluate the effectiveness of immunotherapy on encephalitis relapse.Methods: Patients with autoimmune encephalitis diagnosed as positive for neuronal surface antibodies in five general hospitals were included. …”
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Strategic Optimization of Nanoparticle Characteristics to Enhance Tumor Targeting and Doxorubicin Delivery by Lee YJ, Hong J, Seo BY, Lee BH, Sarangthem V, Park RW

“…To improve its specificity and therapeutic efficacy, multivalent targeting strategies are being developed.Methods: A chimeric polypeptide consisting of an elastin-like polypeptides (ELP) copolymer with a repeating IL-4 receptor-specific targeting peptide, AP-1, and a (GGCGSCGSC)2 sequence encoding 6 cysteine residues (C6) at the carboxyl-terminus for Dox conjugation was designed. …”
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Comparison Between Norepinephrine Alone Versus Norepinephrine/Vasopressin Combination for Resuscitation in Septic Shock by Rania M. Hussien, Hanaa A. El-Gendy, Mohamed I. Elsaidy, Mostafa S. Abdelhamid, Tarek S. Shabana

“…They were randomly divided into two equal groups; NE group (received NE infusion) and VP/NE group (received NE and VP infusion). …”
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Malassezia Globosa Aggravates Atopic Dermatitis by Influencing the Th1/Th2 Related Cytokines in Mouse Models by Wu Z, Yu H, Chen Z, Liu W, Xia P

“…Zhuoxuan Wu,1– 3,&ast; Huiyuan Yu,1– 3,&ast; Zunyi Chen,1– 3 Wei Liu,1– 3 Ping Xia1– 3 1Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2Department of Dermatology, Wuhan No.1 hospital, Wuhan, 430022, People’s Republic of China; 3Hubei Province and Key Laboratory of Skin Infection and Immunity, Wuhan, 430022, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Ping Xia, Department of Dermatology, Wuhan No.1 hospital, Wuhan, 430022, People’s Republic of China, Tel +86 13886130960, Email alicexiaping@gmail.comPurpose: To establish atopic dermatitis (AD) mouse models infected with Malassezia globosa and study its effects and potential mechanisms.Methods: Twenty - four male BALB/c mice were randomly allocated into four groups: control, AD, M (normal mice treated with olive oil fungus suspension), and AD + M (AD mice treated with the same suspension). …”
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The efficacy of training on the four quadrant brain processes on cognitive functions of students with mathematical disorders by zohreh sadat moeini, farnaz Keshavarzi Arshadi, Masoud Gholam Ali Lavasani, SAEED hasanzadeh

“…Both boys and girls are equally affected by mathematical disorders, and they usually start displaying problematic behaviors as soon as they begin math classes in school. …”
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Exploring Potential Gender-Based Disparities in Referral for Transplant, Activation on the Waitlist and Kidney Transplantation in a Canadian Cohort by Amanda J. Vinson, Aran Thanamayooran, Karthik K. Tennankore, Bethany J. Foster

“…Conclusion: Gender-based barriers to any of (or in this case each of) referral, activation, or transplantation result in inequities in access; identification of disparities at these critical decision points is an important first step toward ensuring equal access for all.…”
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Association Between 10 Autoimmune Diseases and Risk of Pulmonary Tuberculosis: A Mendelian Randomization Study by Chen YE, Zhao GL, Liu FH

“…We performed a Mendelian randomization (MR) study to determine the causal genetic connections between liability to autoimmune diseases (AIDs) and PTB.Methods: After rigorous assessment, potential candidate SNPs for 10 AIDs and PTB were extracted from GWAS datasets. …”
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Dihydrosanguinarine enhances tryptophan metabolism and intestinal immune function via AhR pathway activation in broilers by Yue Su, Miaomiao Wang, Zhiyong Wu, Peng Huang, Jianguo Zeng

“…Subsequently, equal concentrations of sanguinarine and its metabolites were separately added to the diets. …”
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Prevalence of Onchocerciasis and Associated Factors among Adults Aged ≥ 15 Years in Semen Bench District, Bench Maji Zone, Southwest Ethiopia: Community Based Cross-Sectional Study... by Bedilu Kifle, Kifle Woldemichael, Mamo Nigatu

“…Methods. Community based cross-sectional study was conducted on 553 study participants selected by multistage sampling in April 2018. …”
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Final-Year Dental Students’ Perceived Confidence: Competencies in General Dentistry by Navodika Yaparathna, Iresha Udayamalee, Megan Gray, Cheree He, Rachel Wu, Chelsea Taing, Menaka Abuzar

“…Both in-house training and outplacement equally improve the levels of competency development. …”
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Time to Occurrence of&nbsp;Incontinence-Associated Dermatitis: An Experimental Animal Study by Duan J, Zhang Y, Yuan D, Wang X, Peng J, Wang J, Liang X, Xu C

“…Junfang Duan,1,&ast; Yan Zhang,2,&ast; Dajiang Yuan,3 Xiaoru Wang,1 Jian Peng,4 Junli Wang,1 Xiaojuan Liang,1 Chenli Xu1 1Department of Critical Care Medicine, The Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 2General Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 3Shanxi Cardiovascular Hospital, Taiyuan, 030024, People’s Republic of China; 4Anhui Institute of Pediatric Research, Anhui Provincial Children’s Hospital, Anhui, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chenli Xu, Department of Critical Care Medicine, Second Hospital of Shanxi Medical University, No. 382 of Wuyi Road, Xinghualing District, Taiyuan, 030001, People’s Republic of China, Tel +8619834513692, Email xuchenli0531@163.comObjective: To establish an animal model of Incontinence-Associated Dermatitis (IAD) and investigate inflammatory factor changes to determine the time frame for IAD onset.Methods: Twenty-eight male SPF mice were randomly assigned to four groups. …”
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The Effect of Drug&amp;ndash;Drug Interactions on the Pharmacokinetics of Isavuconazole: A Comprehensive Review by Sang Y, Xu Q, Gao A, Zhao Q

“…Additionally, we aimed to evaluate whether the duration of combination therapy modulates the magnitude of DDIs and provide references for clinical medication.Methods: The literature concerning the interactions of isavuconazole was systematically retrieved from three retrieval platforms, PUBMED, EMBASE, and the Cochrane Library, using the search terms: “isavuconazole” or “isavuconazonium” or “Cresemba” and “interact&amp;ast;”, or “cotreatment”, or “coadministration”, or “combination”, or “concomitant”. …”
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Exploring the Kidney-Brain Crosstalk: Biomarkers for Early Detection of Kidney Injury-Related Alzheimer&rsquo;s Disease by Cai Y, Huang G, Ren M, Chai Y, Fu Y, Yan T, Zhu L

“…The primary goal of this study was to investigate the link between KI and AD, with a specific focus on identifying diagnostic biomarkers for KI-related AD.Methods: The first step of the present study was to use Mendelian randomization (MR) analysis to investigate the link between KI and AD, followed by verification of in vivo and in vitro experiments. …”
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