The impact of physical activity on progression-free and overall survival in metastatic breast cancer based on molecular subtype by Philipp Ziegler, Andreas D. Hartkopf, Markus Wallwiener, Lothar Häberle, Hans-Christian Kolberg, Peyman Hadji, Hans Tesch, Johannes Ettl, Diana Lüftner, Volkmar Müller, Laura L. Michel, Erik Belleville, Pauline Wimberger, Carsten Hielscher, Hanna Huebner, Sabrina Uhrig, Lena A. Wurmthaler, Carolin C. Hack, Christoph Mundhenke, Christian Kurbacher, Peter A. Fasching, Rachel Wuerstlein, Michael Untch, Wolfgang Janni, Florin-Andrei Taran, Michael P. Lux, Diethelm Wallwiener, Sara Y. Brucker, Tanja N. Fehm, Andreas Schneeweiss, Chloë Goossens

“…Results Patient and tumor characteristics were equally distributed across IPAQ categories. HER2pos, HRpos and TNBC were present in 23.1%, 65.7% and 11.2% of patients, respectively. …”
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Differential circulating miRNA profiles identified miR-423-5p, miR-93-5p, and miR-4532 as potential biomarkers for cholangiocarcinoma diagnosis by Kittiya Supradit, Sattrachai Prasopdee, Teva Phanaksri, Sithichoke Tangphatsornruang, Montinee Pholhelm, Siraphatsorn Yusuk, Kritiya Butthongkomvong, Kanokpan Wongprasert, Jutharat Kulsantiwong, Amnat Chukan, Smarn Tesana, Veerachai Thitapakorn

“…Background Cholangiocarcinoma (CCA) is high in morbidity and mortality rates which may be due to asymptomatic and effective diagnostic methods not available. Therefore, an effective diagnosis is urgently needed. …”
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Postoperative Sore Throat After Tracheal Intubation: An Updated Narrative Review and Call for Action by Chen Z, Zuo Z, Zhang L, Gong M, Ye Y, Jin Y, Zhao X

“…Currently, effective prevention methods for POST consist of pharmacological interventions, non-pharmacological interventions, and traditional Chinese medicine (TCM) therapy. …”
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Comparative Ethics of Modern Payment Models by Jacob Riegler

“…As an example of misaligned interests, there is a clear financial incentive to deny prior authorization for a medication that is an expensive yet otherwise appropriate alternative for a patient’s condition. This could result in equal treatment, perhaps a generic version even, or an alternative that the provider and patient would not have chosen otherwise. …”
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Comparative Ethics of Modern Payment Models by Jacob Riegler

“…As an example of misaligned interests, there is a clear financial incentive to deny prior authorization for a medication that is an expensive yet otherwise appropriate alternative for a patient’s condition. This could result in equal treatment, perhaps a generic version even, or an alternative that the provider and patient would not have chosen otherwise. …”
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Longitudinal graphics of patient-reported physical function in patients treated for hematologic malignancies by Gita Thanarajasingam, Vishal Bhatnagar, Brie N. Noble, Ting-Yu Chen, Mallorie H. Fiero, Ron Hoffman, Molly Jeffery, Gina L. Mazza, John Mascarenhas, Ruben Mesa, Meena Murugappan, Joseph Ross, Surbhi Sidana, Rahma Warsame, Paul G. Kluetz, Amylou C. Dueck

“…The objectives of this study were to develop analytic methods and visualizations of patient-reported PF in patients with cancer. …”
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Assessment of the effectiveness of differential management of patients in the early postoperative period following the dental implant surgery by Yu. Yu. Yarov

“…The obtained results allow to recommend the proposed methods of differential medicamentous therapy in the early postoperative period following the dental implant surgery for a wide application in dental practice.…”
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A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children by Anna Nikula, Stefan Lundeberg, Malin Ryd Rinder, Mitja Lääperi, Katri Sandholm, Maaret Castrén, Lisa Kurland

“…The objective of this study was to evaluate whether intranasal dexmedetomidine could provide more effective analgesia and sedation during a procedure than intranasal esketamine. Methods This was a double-blind equally randomized (1:1) superiority trial of 30 children aged 1–3 years presenting to the Emergency Department with a laceration or a burn and requiring procedural sedation and analgesia. …”
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Parameters of radical resection in laparoscopic and open colon and rectal cancer surgery by Krdžić Igor, Kenić Marko, Šćepanović Milena, Soldatović Ivan, Ilić-Živojinović Jelena, Radovanović Dragan

“…The aim of this study was to determine whether laparoscopic approach provides all parameters of oncological radicality as open surgery of colorectal cancer. Methods. The study included 122 patients with carcinoma of colon and rectum, divided into two equal groups: patients operated on by laparoscopic and those operated on by open approach. …”
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Folate-Modified Smart Responsive Nanosystems for Enhancing Anti-Tumor Therapy Through Calcium Overload and Chemotherapy by Tang Y, Huang J, Cui C, Yang F, Li K, Gao B, Fu S, Yang X

“…Precise drug delivery via folate-modified nanomaterials is an important measure to improve efficacy and reduce toxicity.Methods: CaCO3 nanoparticles served as the carrier for loading DOX and 5-Fu, followed by encapsulation with folic acid-modified polydopamine (PDA) to form a smart dual drug-carrying nanosystem called FA-DCFP. …”
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Real-World Analysis of the Efficacy and Adverse Events of T-DM1 in Chinese Patients With HER2-Positive Breast Cancer by Gu H, Zhu T, Ding J, Yang Z, Qi S, Guo G

“…Huayan Gu,1,* Teng Zhu,2,* JiaLing Ding,1 Zhi Yang,1 Shuangyi Qi,1 Guilong Guo1 1Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China; 2Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guilong Guo, Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang Street, Wenzhou City, Zhejiang Province, People’s Republic of China, Email guoguilong@sina.comPurpose: This study efforts to explore the association of adverse events (AEs) with efficacy in HER2-positive breast cancer patients treated with TDM1.Methods and Materials: This retrospective study included women diagnosed with HER2+ BC treated with TDM1 from January 2012 to December 2023. …”
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CEREBROPROTECTIVE ACTIVITY OF NEW DERIVATIVES OF PIRIMIDINE4 1H ONE PIR9 AND PIR10 IN IRREVERSIBLE OCCLUSION OF THE COMMON CAROTID ARTERY by A. V. Voronkov, N. B. Shabanova, I. P. Kodonidi, I. S. Shatalov

“…The aim of this work is to study the cerebroprotective activity of the new derivatives of Pirimidine-4-(1H)-OHA PIR-9 and PIR-10 in irreversible occlusion of the common carotid artery. Materials and methods. The study was carried out on 120 male rats of the Wistar line, weighing 200-220 g, divided into 6 equal groups. …”
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Nerve Block Extends Nerve Function Recovery in Patients with Diabetic Foot Ulcers by Wei Q, Rong H, Zhang G, Xie Y, Dai W

“…The aim of this study is to investigate the minimum stimulation thresholds of the femoral and sciatic nerves, as well as the duration of nerve block, in patients diagnosed with diabetic foot.Methods: From July 2020 to March 2022, a prospective study was conducted involving patients aged 50– 80 scheduled for distal lower limb surgery. …”
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Clinical and Antibiotic Resistance Features for Extended-Spectrum Betalactamase-Producing Escherichia coli and Klebsiella pneumoniae Bloodstream Infections and Predictors of Poor P... by Yan W, Liang J, Liu M, Hu X, Zhang H, Guo J, Li L

“…This study aimed to describe the clinical characteristics, profiles of antibiotic susceptibility, and risk factors associated with BSIs caused by E. coli (ESBL-EC) and K. pneumoniae (ESBL-KP), and identify risk factors for poor prognosis in neonatal patients with E. coli or K. pneumoniae BSIs.Methods: In the period from January 2017 to December 2023, a retrospective case-control study was conducted at Guangxi Children’s Hospital in China. …”
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Usability Evaluation of Foods with Function Claims Labelling as Health Information in Japan: A User-Testing Study by Yamamoto M, Yamamoto K, Takano-Ohmuro H, Yamamoto R, Saruwatari J

“…It is important to explore ways to evaluate and improve labelling usability from the consumers’ perspective to ensure safe usage.Patients and Methods: We conducted user testing from the consumers’ perspective on labels of five different FFCs, utilizing semi-structured interviews with 50 participants of diverse ages and sexes. …”
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Dysbiosis and Metabolic Dysregulation of Salivary Microbiota in Schizophrenia by Wang J, Lu L, Ren L, Zhu R, Jiang Y, Qiao Y, Li Y

“…However, fewer studies have directly investigated the potential links between oral microbiota and SZ.Purpose: This study aimed to explore the relationship between salivary microbiota dysbiosis and SZ, examining microbial and metabolic alterations that may contribute to SZ pathophysiology.Methods: Salivary samples from 30 hospitalized patients diagnosed with SZ and 10 healthy controls were collected. …”
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Patients’ perception of quality of care in health facilities empanelled under Sehat-Card-Plus programme, in Khyber-Pakhtunkhwa, Pakistan by Kiran Sohail Azeemi, Shifa Salman Habib, Waqas Hameed, Junaid Ur Rehman Siddiqui, Ali Hussaini, Asma Altaf Hussain Merchant, Adil Haider, Sameen Siddiqi

“… Objective:This study aims to assess perceived quality of care among users of hospitals empanelled under SCP Programme, KP. Methods: The assumed satisfaction level was 80% among SCP users, and 10%-point lower satisfaction among SCP nonusers. …”
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Analysis of Pharmacokinetic Parameters of Acetylsalicylic Acid for Prediction of Potential Nephrotoxic Effects by L. M. Krasnykh, O. A. Goroshko, G. F. Vasilenko, G. I. Gorodetskaya, V. V. Smirnov, T. A. Rodina

“…The study of the pharmacokinetics of acetylsalicylic acid products will contribute to timely detection and correction of side effects caused by this medicinal product.The aim of the study was to evaluate potential nephrotoxic effects following a single oral administration of 75 mg of acetylsalicylic acid, based on the analysis of the pharmacokinetic parameters.Materials and methods: the study involved 24 healthy volunteers who received 75 mg of acetylsalicylic acid (tablets) once orally. …”
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Multidomain Cognitive Tele-Neurorehabilitation Training in Long-Term Post-Stroke Patients: An RCT Study by Marianna Contrada, Gennarina Arabia, Martina Vatrano, Caterina Pucci, Isabel Mantia, Federica Scarfone, Giusi Torchia, Maria Quintieri, Antonio Cerasa, Loris Pignolo

“…A randomized controlled trial (RCT) study was conducted to compare the effectiveness of a TNR multidomain cognitive approach to conventional face-to-face cognitive treatment. Methods: A total of 30 patients with stroke were equally enrolled and randomly assigned to the experimental and control groups. …”
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Prototyping neural networks to evaluate the risk of adverse cardiovascular outcomes in the population by L. A. Bogdanov, E. A. Komossky, V. V. Voronkova, D. E. Tolstosheev, G. V. Martsenyuk, A. S. Agienko, E. V. Indukaeva, A. G. Kutikhin, D. P. Tsygankova

“…To develop a neural network basis for the design of artificial intelligence software to predict adverse cardiovascular outcomes in the population.Materials and Methods. Neural networks were designed using the database of 1,525 participants of PURE (Prospective Urban Rural Epidemiology Study), an international, multi-center, prospective study investigating disease risk factors in the urban and rural areas. …”
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