Validation of an AI-Powered Smart Dry Powder Inhaler (RS01X) for Asthma and COPD in a Clinical Setting by Chamaon D, Sportel E, Elferink ECM, van der Palen J

“…The objective was to validate the smart DPI compared to an external inhalation profile recorder (IPR).Methods: This monocenter cross-sectional study with 97 participants comprises patients with COPD, asthma and healthy participants. …”
Get full text

Targeting AGE-RAGE Signaling Pathway with Hujin Decoction Ameliorates MAFLD in HepG2 Cells by Zhang Z, Shi J, Liu F, Zhou J, Shen Q, Shi X

“…Zixuan Zhang,1,* Jiaxi Shi,2,* Fuxuan Liu,1 Jing Zhou,1 Qi Shen,3 Xuguang Shi1 1School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, 510006, People’s Republic of China; 2The First School of Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People’s Republic of China; 3Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xuguang Shi, School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, People’s Republic of China, Tel +8613602740975, Email sxg6902@126.comPurpose: To explore the mechanism and substance basis of HJD for the treatment of MAFLD based on system pharmacology.Patients and Methods: The ingredients of HJD in vitro and in vivo were detected by UPLC-MS/MS, then network pharmacology and molecular docking technology were used to predict the mechanism and substance basis, then the establishment of in vitro MAFLD model was confirmed by oil red O staining and ELISA technology, and finally the mechanism was verified by PCR, WB and flow cell technology.Results: System pharmacology determined that succinic acid, Ginsenoside Rh4, Caffeic acid, 7-Methoxycoumarin, 5-Acetylsalicylic acid and other ingredients were the basis of pharmacodynamic substances, while RAGE[Advanced glycosylation end product-specific receptor (RAGE)], BCL2[Apoptosis regulator Bcl-2 (BCL2)], and CASP3[Caspase-3 (CASP3)] were predicted as the core targets, and AGE-RAGE was the key pathway. …”
Get full text

Comprehensive Analysis of Metabolic Changes in Mice Exposed to Corilagin Based on GC-MS Analysis by Xu B, Wang C, Zhu X, Zhu L, Han G, Cui C

“…The aim of this study was to explore the pharmacological mechanism of Corilagin.Methods: This study utilized gas chromatography-mass spectrometry (GC-MS) to analyze central target tissues, comprehensively exploring the pharmacological mechanism of Corilagin in mouse models. …”
Get full text

Evaluation of Iron Overload Between Age Groups Using Magnetic Resonance Imaging and Its Correlation with Iron Profile in Transfusion-dependent Thalassemia by Pustika Amalia Wahidiyat, Stephen Diah Iskandar, Damayanti Sekarsari

“…The number of subjects between children and adults was almost equal. Most of subjects had normal cardiac iron deposition. …”
Get full text

A measure of the difference between test sets for generating controlled random tests by V. N. Yarmolik, V. V. Petrovskaya, I. Mrozek

“…The limitations of using the Hamming and Damerau – Levenshtein distances to obtain a measure of the difference between test sets are shown.Methods . Based on the characteristic of the interval used in the theory of the chain of successive events, a new measure of the difference between two symbolic test sets is determined. …”
Get full text

Analysis of Tumor and Tumor-Like Entities Tested on the Orthopaedic In-Training Examination From 2012 to 2023 by Sean Kelly, MD, Braden Goldberg, MD, Eli Bryk, MD, FAAOS, FAOA, FACS, Vincent Vigorita, MD

“…Tumor-related questions constituted 10–16% of each OITE, with an equal number of questions concerning benign and malignant entities. …”
Get full text

Symbiotic anti-oxidant, anti-glycation, and anti-inflammatory qualities of a combination of thiamine and niacin protected type-2 diabetic male rats against both macro and micro-vas... by Sina Mahdavifard, Hamid Reza Malekzadeh

“…Therefore, we aimed to study the impact of the combination of thiamine and niacin on hepatic NF-kβ signaling, metabolic profile, and Glo-I activity in male rats with type-2 diabetes (T2DM).Materials and Methods: Forty male rats were divided equally into five groups: control, diabetic, diabetic treated with thiamine (180 mg/l in drinking water), niacin (180 mg/l), and a combination of both. …”
Get full text

Combining Supervised and Reinforcement Learning to Build a Generic Defensive Cyber Agent by Muhammad Omer Farooq, Thomas Kunz

“…Sophisticated mechanisms for attacking computer networks are emerging, making it crucial to have equally advanced mechanisms in place to defend against these malicious attacks. …”
Get full text

User experience with pregnancy tracker mobile apps: Findings from comment-based qualitative study. by Md Alamgir Hossain, Janet Perkins, Md Tanvir Hasan, Sharon Low Bee Lian, Ribica Chowdhury, Md Tanzirul Alam, Anisuddin Ahmed, Mohammad Sohel Shomik, Shams El Arifeen, Ahmed Ehsanur Rahman, Aniqa Tasnim Hossain, M Shafiqur Rahman

“…While most of the apps are user-friendly, not all of them are equally appealing. This study aimed to explore the user experience (UX) of pregnancy tracker mobile apps used by pregnant women.…”
Get full text

Periconception glycemic control and congenital anomalies in women with pregestational diabetes by Annie M Dude, Nevert Badreldin, Amanda Schieler, Lynn M Yee

“…Introduction To assess the relationship between periconception glycemic control and congenital anomalies in a contemporary, diverse population of women with pregestational diabetes.Research design and methods This is a retrospective cohort study of all pregnant women with pregestational diabetes at a single institution (2003–2017) in the USA. …”
Get full text

Institutional priorities and student engagement: a multi-stakeholder analysis of physical education in Israel by Ali Alayan, Ahmad Salhab, Paz Carmel, Ronit Ahdut HaCohen

“…This study investigates the perceptions of students, PE teachers, and school administrators in Israel regarding PE value, participation, and institutional support.MethodsA cross-sectional survey was conducted with 150 participants from six East Jerusalem secondary schools, including students (70%), PE teachers (20%), and administrators or other staff (10%). …”
Get full text

Psychiatrists’ experiences with the implementation of safewards and other quality improvement work: an explorative, qualitative interview study by Martin Lindow, Mårten J. Tyrberg, Veikko Pelto-Piri, Anna Björkdahl

“…This study aimed to identify key facilitators and barriers to psychiatrists’ engagement in implementing Safewards and other quality improvement work. Methods In this qualitative exploratory study, semi-structured interviews and inductive content analysis were utilized. …”
Get full text

Non-menstrual pelvic symptoms and women's quality of life: a cross-sectional observational study. by Marlon de Freitas Fonseca, Felipe Ventura Sessa, Claudio Peixoto Crispi, Nilton de Nadai Filho, Bruna Rafaela Santos de Oliveira, Rafael Ferreira Garcia, Claudio Peixoto Crispi

“…This study aimed to compare the relative burdens of 4 different non-menstrual pelvic symptoms on HQoLife: Deep dyspareunia (DDyspareunia), non-menstrual pelvic pain (NMPelvicPain), non-menstrual dyschezia (NMDyschezia) and non-menstrual dysuria (NMDysuria).<h4>Subjects and methods</h4>This is a pre-planned cross-sectional interdisciplinary retrospective observational study. …”
Get full text

Views on patient portal use for adolescents in mental health care - a qualitative study by Martine Stecher Hornum, Aslak Steinsbekk, Torunn Hatlen Nøst

“…Most informants thought that healthcare providers should have the autonomy to determine which information should be shared with whom, but also requested guidelines to ensure equal practice and support in difficult situations. …”
Get full text

A Prospective Tumour Marker for Breast Cancer: YWHAB and Its Role in Promoting Oncogenic Phenotypes by Gopaul VL, Winstone L, Gatien BG, Nault BD, Maiti S, Opperman RM, Majumder M

“…The potential of YWHAB as a therapeutic target or biomarker for BRCA is investigated here.Methods: After YWHAB was knocked down with siRNA, BRCA cell lines were used for in vitro assays (proliferation, migration, epithelial-to-mesenchymal transition). …”
Get full text

Enhanced phoxim biodegradation by immobilizing Novosphingobium sp. RL4 on attapulgite-sodium alginate by Tong Peng, Tong Peng, Yining Huang, Tao Yang, Tao Yang, Yinquan Wang, Ling Jin

“…The immobilization of degrading strains on natural adsorbent materials is a common strategy to enhance the degradation of target compounds in the environment by the strains.MethodsA phoxim-degrading bacterial strain was isolated from the rhizosphere soil of rhubarb (Rheum palmatum L.), which had been exposed to long-term phoxim contamination. …”
Get full text

CLINICAL EFFICACY OF A GEL BASED ON BIO SUBSTANTIATION FROM THE PRODUCTS OF ANTLER MARAL BREEDING IN THE TREATMENT OF GINGIVITIS by Светлана Ивановна Токмакова, Юлия Васильевна Луницына, Ольга Владимировна Бондаренко, Вера Феопеновна Турецкова, Любовь Габдулбариевна Дворникова, Виктория Анатольевна Кузикова, Алёна Олеговна Шевякина

“…Two numerically equal groups have been formed. In the main one, complex treatment was carried out with the use of a developed gel containing dry maral blood. …”
Get full text

Artificial Intelligence-Based Classification of Anatomical Sites in Esophagogastroduodenoscopy Images by Yuan P, Ma ZH, Yan Y, Li SJ, Wang J, Wu Q

“…This study aimed to evaluate the effectiveness of artificial intelligence in identifying gastric anatomy sites by analyzing esophagogastroduodenoscopy images.Methods: Using endoscopic images, we proposed a system called the Artificial Intelligence of Medicine (AIMED) through convolutional neural networks and MobileNetV3-large. …”
Get full text

The Relationship Between Intolerance of Uncertainty and Treatment Adherence: The Moderating Effect of Self-Compassion on the Chain Mediation Model by Shi X, Wang Y, Jia Q, Peng S, Liu X, Pei Y

“…Existing research indicates that intolerance of uncertainty is closely associated with patients’ follow-up compliance; however, further in-depth investigation into its influencing mechanisms and potential improvement strategies is required.Patients and Methods: This study conducted a questionnaire survey among 319 young and middle-aged patients newly diagnosed with pulmonary nodules, examining the moderating effect of self-compassion on follow-up compliance and investigating the chain intermediary role of negative interpretation bias and trust in linking intolerance of uncertainty to follow-up compliance.Results: The study found that women, urban residents, and patients over 50 years old demonstrated relatively higher follow-up compliance. …”
Get full text

Impact of a single non-sex-related stroke risk factor on atrial fibrillation and oral anticoagulant outcomes: a systematic review and meta-analysis by An De Sutter, Lies Lahousse, Stephane Steurbaut, Maxim Grymonprez

“…A critical appraisal of the role of OACs and the benefit–risk profile of non-vitamin K antagonist oral anticoagulants (NOACs) compared with vitamin K antagonists (VKAs) in this patient subgroup are needed.Methods and results This systematic review provides an overview of literature on the effectiveness and safety of OACs in AF patients with a single non-sex-related stroke risk factor after searching Medline and Embase. …”
Get full text