Predictors of Severity in Hemorrhagic Fever with Renal Syndrome by Huang L, Wu J, Luo J, Gu W

“…Lihua Huang,1,* Jun Wu,2,* Jiao Luo,1 Wei Gu1 1Department of Infection Disease, The First Affiliated Hospital of Dali University, Dali, Yunnan, People’s Republic of China; 2Department of Ophthalmology, Dali Bai Autonomous Prefecture People’s Hospital, Dali, Yunnan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wei Gu, Department of Infection Disease, The First Affiliated Hospital of Dali University, 32 Jia Shi Bo Road, Dali, Yunnan, 671000, People’s Republic of China, Email gw777@163.comObjective: To explore the risk factors for the severity of hemorrhagic fever with renal syndrome (HFRS) and construct a nomogram model.Methods: A retrospective analysis was conducted on the data of 191 patients diagnosed with HFRS at the First Affiliated Hospital of Dali University between January 1, 2013, and September 30, 2024. …”
Get full text

The Distinct Ultrasound Characteristics and Prognostic Features of Insulin-Induced Lipohypertrophy: A Systematic Review by Yang H, Zhang L, Dong Q, She Y, Zhang Y, Cao M, Xu M, Chu S

“…This review aimed to systematically analyze the ultrasound characteristics and progression patterns of LH, and explore the relationship between different LH types and clinical outcomes.Methods: A systematic literature search was conducted from January 2000 to October 2024 in PubMed, Web of Science, Embase, and Cochrane Library following PRISMA guidelines. …”
Get full text

SARS-CoV-2 infection is associated with higher chance of diabetes remission among Veterans with incident diabetes. by Pandora L Wander, Elliott Lowy, Anna Korpak, Lauren A Beste, Steven E Kahn, Edward J Boyko

“…<h4>Research design and methods</h4>We conducted a retrospective inception cohort study using Veterans Health Administration data (March 1, 2020-May 31, 2022) among individuals with ≥ 1 positive nasal swab for SARS-CoV-2 and individuals with ≥ 1 laboratory test of any type but no positive swab. …”
Get full text

DWI-MRI: Single, Informative, and Noninvasive Technique for Prostate Cancer Diagnosis by Elhousseiny I. Ibrahiem, Tarek Mohsen, Adel M. Nabeeh, Yasser Osman, Ihab A. Hekal, Mohamed Abou El-Ghar

“…To evaluate diffusion weighted image-MRI (DWI) as a single diagnostic noninvasive MRI technique for prostate cancer (PCa) diagnosis. Material and Methods. A prospective study was conducted between July 2008 and July 2009. …”
Get full text

Retrospective Cross-Sectional Study of Quadratic-Linear Correlations Between Cephalometric Measurements and Profile Esthetics in Adult Orthodontic Patients by Visessan Pornsirianand, Janeta Chavanavesh, Pimsiri Kanpittaya, Anupap Somboonsavatdee

“…This study used quadratic and/or linear regression to identify cephalometric variables related to profile attractiveness, expanding on previous bivariate analyses. Methods: This retrospective cross-sectional study comprised 180 post-treatment lateral cephalograms of 18 to 37 year-old orthodontic patients, equally distributed among 3 profile types (concave, straight, and convex), each comprising 60 cases with balanced sex representation. …”
Get full text

Ameliorative effect of Naja haje venom against arthritic influence of Freund&apos;s complete adjuvant FCA in paw and ankle of male rats by Nabil A. Soliman, Amr A. Shalaby, Mayada R. Farag, Shimaa Kamal, Sara M. Abdelkarem Alashqar, Mohamed Ahmed Ammar, Suzan Attia Mawed

“…Aim: While there are a number of therapeutic options for arthritis, their side effects restrict their use and encourage the search for alternative, natural remedies. Methods: In male rats, we examined the anti-inflammatory and anti-arthritic properties of Naja haje venom (NHV). …”
Get full text

Efficacy of Topical Azithromycin versus Systemic Doxycycline in Treatment of Meibomian Gland Dysfunction by Marwa Aly Zaky, Adel Galal Zaky, Moataz Fayez Elsawy, Kareem Fatehy Shehata, Mohamed Samy Abd Elaziz

“…The aim of this work was to compare the efficacy of azithromycin topical eye drops versus oral doxycycline in MGD individuals. Methods. This prospective comparative cohort research was carried out on 56 patients of both sexes of any age with symptomatic MGD. …”
Get full text

Comparing recommended doses of angiotensin receptor blockers and ACE inhibitors (CORD Study) by J. Spinar, J. Vftovec, M. Soucek, L. Dusek, T. Pavlik

“…Losartan and ramipril demonstrated equal antihypertensive effectiveness and a tendency to improve metabolic parameters. …”
Get full text

Deep Learning and Radiomics in Triple-Negative Breast Cancer: Predicting Long-Term Prognosis and Clinical Outcomes by Cheng C, Wang Y, Zhao J, Wu D, Li H, Zhao H

“…They are extensions of conventional imaging diagnostic methods and have demonstrated tremendous potential in image segmentation, reconstruction, recognition, and classification. …”
Get full text

SPP1 as a Prognostic and Immunotherapeutic Biomarker in Gliomas and Other Cancer Types: A Pan-Cancer Study by Wang K, Wan J, Zheng R, Xiao Y, Lv F, Ge H, Yang G, Cheng Y

“…This study investigates the role of Secreted Phosphoprotein 1 (SPP1) as a prognostic and immunotherapeutic biomarker in gliomas and other cancers through pan-cancer analysis.Methods: A comprehensive pan-cancer analysis was conducted using datasets from UCSC TCGA Pan-Cancer, TCGA-GBM, UALCAN, and single-cell sequencing data from GEO and TISCH. …”
Get full text

Different patterns of pre-excitation in a large Italian cohort of asymptomatic non-competitive athletes evaluated by telecardiology screening: Prevalence and ECG features by Martina Molinari, Sergio Setti, Natale Daniele Brunetti, Nicola Di Nunno, Maria Alberta Cattabiani, Giuseppe Molinari

“…The highest incidence (29 WPW patterns) was observed in the 10–15 year group with an equal sex ratio (M/F:16/13).Intermittent pre-excitation was found in 8 NCAs. …”
Get full text

Disruption of Gut Microbiota and Associated Fecal Metabolites in Collagen-Induced Arthritis Mice During the Early Stage by Wu D, Yin M, Cao D, Zhang X, Zhu Y, Wei Y, Li Y, Wen C, Zhou J

“…Further revealing the microbiota and related metabolic disorders in the preclinical stage of RA (pre-RA) is of great significance for exploration of disease mechanisms.Methods: DBA/1 mice were injected with type II collagen on days 0 and 21 to establish collagen-induced arthritis (CIA) mouse model. …”
Get full text

L-shaped correlation between serum alpha-1-acid glycoprotein concentration and urinary albumin creatinine ratio in females: a cross-sectional survey by Junjie Wang, Junjie Wang, Li Xiao, Yuxuan Zhang, Zhou Li

“…We divided all participants equally into three groups based on their serum AGP concentration. …”
Get full text

Gender disparities in literacy: an analysis of regional and age-group variations in Somalia by Mukhtaar Axmed Cumar, Abdisalan Hassan Muse, Befekadu Zeleke Kidane, Jibril Abdikadir Ali

“…Further studies employing qualitative methods and longitudinal designs are recommended to deepen understanding of the dynamics underlying these disparities.…”
Get full text

Identification and Quantification of the Component Composition of the Active Substance Gentamicin Sulfate by ¹Н and ¹³С NMR Spectroscopy by S. V. Moiseev, N. E. Kuz’mina, E. Yu. Severinova, E. P. Simonova, V. V. Kosenko

“…These characteristic signals provided spectral markers indicative of the gentamicins of interest in the sample, with normalised integrated intensities equal to the mole fractions of the analytes. The authors compared NMR and HPLC measurements of the active substance composition.Conclusions. …”
Get full text

Challenges in Thirst Management for Intubated Patients in the ICU: A Qualitative Study of Healthcare Provider and Patient Perspectives by Yuan Y, He LF, Luo Q, Zhang X, Chen F, Hu RJ

“…You Yuan,1,&amp;ast; Li-Feng He,1,&amp;ast; Qian Luo,1 Xia Zhang,1 Fang Chen,1 Ru-Jun Hu1– 3 1Department of Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 2Department of Nursing, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China; 3School of Nursing, Zunyi Medical University, Zunyi, Guizhou, 563000, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Ru-Jun Hu, Department of Nursing, Affiliated Hospital of Zunyi Medical University, No. 149 Dalian Road, Huichuan District, Zunyi, Guizhou Province, 563000, People’s Republic of China, Tel +86 15085060545, Email hurujunok@163.comObjective: This study aims to examine the challenges associated with thirst management among patients undergoing tracheal intubation in intensive care units (ICUs), and to inform the development of more effective clinical strategies.Methods: A qualitative research design was employed using semi-structured interviews with 32 participants, including healthcare professionals and patients who had experienced tracheal intubation and associated thirst in the ICU. …”
Get full text

A Ferritin-Based Eg95 Nanoparticle Vaccine Adjuvanted with pCpG Eliciting Robust Immune Responses Against Cystic Echinococcosis in Mice Model by Gao X, Zhu X, Liu X, Zhou C, Shang Y, Wu T, Jia H, Zhang Z, Li Y, Xin T

“…The commercial Quil-A-adjuvanted Eg95 vaccine was empirically effective for CE control; however, it is expensive and has side effects and insufficient immunity.Purpose: This study aimed to employ a novel adjuvant consisting of a delivery system and an immune potentiator and assess its adjuvanticity to Eg95 antigen, thereby developing a safe and cost-effective novel vaccine against the disease.Methods: A ferritin-based Eg95 nanoparticle antigen was prepared and then mixed with a plasmid containing the TLR9 agonist CpG to formulate a novel nanovaccine. …”
Get full text

CURRENT APPROACH TO DEVELOPMENT OF BIOSIMILAR PRODUCTS CONTAINING MONOCLONAL ANTIBODIES AS AN ACTIVE SUBSTANCE – NON-CLINICAL AND CLINICAL STUDIES OF THE FIRST RUSSIAN RITUXIMAB BI... by S. M. Alekseev, K. D. Kaplanov, R. A. Ivanov, E. V. Chernyaeva

“…Within the whole study period  the frequency of AEs, including severe AEs (grade 3-4), associated with the use of monotherapy, were equal in both arms without any significant differences. …”
Get full text

Comparison of Outcomes of Classical Lichtenstein and Modified Lichtenstein in Patients with Indirect Inguinal Hernia by Ghulam Fatima Komal Memon, Shahid Hussain Mirani, Sadia Saher Memon, Dharmoon Arija, Halar Habibullah, Meena Sadaf

“… Objective: This study aimed to compare the outcomes of classical Lichtenstein and modified Lichtenstein techniques in patients with indirect inguinal hernia. Methods: This prospective cross-sectional study was conducted at the Department of Surgery, Ghulam Muhammad Mahar Medical College, from September 2024 to February 2025. …”
Get full text

Tofacitinib in early active axial spondyloarthritis: protocol of a randomized double-blind, placebo-controlled, multicenter phase IV study, FASTLANE by Valeria Rios Rodriguez, Lidia Sánchez-Riera, Hildrun Haibel, Caroline Höppner, Murat Torgutalp, Fabian Proft, Judith Rademacher, Elke Binder, Annette Diehl, Ivana Vranic, Yuxi Zhao, Rajiv Mundayat, Arne Yndestad, Denis Poddubnyy

“…Recently, the Assessment in SpondyloArthritis International Society (ASAS) defined early axSpA as a diagnosis of axSpA with a duration of axial symptoms equal to or less than 2 years. Tofacitinib is a Janus kinase (JAK) inhibitor for the treatment of ankylosing spondylitis. …”
Get full text