Prevalence of Hyperuricemia and Rheumatoid Factor Positivity Among Patients Aged 35 and Above in Huye District, Southern Province of Rwanda by Umukundwa R, Akimana E, Nsanzimana V, Mapira HT, Musarurwa C

“…This study aimed to determine the prevalence of hyperuricemia and RF positivity in patients aged 35 and above in Huye district of Rwanda.Patients and Methods: We conducted a cross-sectional study from October 2023 to January 2024, enrolling 367 patients from Huye and Matyazo Health Centers. …”
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Evaluation of Very-High-Frequency Ultrasound Imaging Characteristics of Dermatofibroma by Dong B, Xia H, Liu Y, Tao H, Xia Y, Zhu F

“…Herein, we analyze the sonographic features and application value of VHF ultrasound in the diagnosis of DF.Methods: Clinical data from 153 patients with pathologically confirmed DF from January 2019 to December 2023 were retrospectively analyzed using high-resolution VHF ultrasound, including size, location, shape, edge, boundary, interior echo, blood supply and so on.Results: The VHF sonographic features of DF showed that the maximum diameter of the lesions was about 7.29 ± 2.85 mm (mean ± standard deviation). …”
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Magnitude and determinants of intimate partner violence against women in Somalia: evidence from the SDHS survey 2020 dataset by Abdirizak Hassan Abokor, Omer Adam Farih, Mustafe Abdillahi Ali, Christophe Chesneau, Abdisalam Hassan Muse

“…Purpose This study aims to identify the prevalence and key determinants of IPV in Somalia, including age groups, administrative regions, place of residence, educational level, household size, husband/partner’s education and work, respondent’s work, and total children ever born. Methods Data from the Somali Demographic and Health Survey (SDHS) 2020 were analyzed. …”
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Molecular Mechanisms in Idiopathic Mitral Valve Chordae Tendineae Rupture: Insights from Transcriptome Analysis and Inflammation Evaluation by Wang Q, Zhong L, Hua L, Pang S, Li Y, Zhang Z, Zhao J, Huang H

“…Qiuji Wang,1– 3,* Lishan Zhong,1,2,* Linbin Hua,1– 3 Shanwen Pang,1– 3 Yuxin Li,1,2 Zhaolong Zhang,1,2 Junfei Zhao,1,2 Huanlei Huang1– 3 1Department of Cardiac Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, 510080, People’s Republic of China; 2Guangdong Cardiovascular Institute, Guangzhou, 510030, People’s Republic of China; 3Guangdong Provincial Key Laboratory of South China Structural Heart Disease, Guangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Huanlei Huang, Department of Cardiac Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Second Road, Yuexiu District, Guangzhou, Guangdong, People’s Republic of China, Email hhuanlei@hotmail.com Junfei Zhao, Department of Cardiac Surgery, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, 106 Zhongshan Second Road, Yuexiu District, Guangzhou, Guangdong, People’s Republic of China, Email zhaojunfei@gdph.org.cnObjective: This study investigates the molecular mechanisms and hub genes in idiopathic rupture of mitral valve chordae tendineae (iRCT).Methods: Histological changes were assessed via pathological staining, and transcriptome sequencing was performed on samples from 8 iRCT patients and 6 controls. …”
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Cubosomes as Delivery System to Repositioning Nitrofurantoin in Breast Cancer Management by Louis D, Rizkalla CMZ, Rashad A

“…This activation mechanism has led to its exploration for repositioning applications in controlling and treating breast cancer, which express a Nitro reductase gene.Methods: NITRO Cubosomes were developed using hot homogenization according to 23-full factorial design. …”
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Effect of transdermal immunomodulation on liver regeneration by E. G. Kuznetsova, O. M. Kuryleva, L. A. Salomatina, L. A. Kirsanova, Z. Z. Gonikova, A. O. Nikolskaya, N. P. Shmerko, V. I Sevastianov

“…Objective: to study the effect of transdermal administration of immunomodulator sodium aminodihydrophthalazinedione on early recovery processes in the liver after EHR in in vivo experiments.Materials and methods. Sodium aminodihydrophthalazinedione was used as an active substance in TTS in the form of powder for preparation of intramuscular injection solution (Galavit®, SELVIM LLC). …”
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Immune Dysregulation and Cellular Composition in Lichen Sclerosus Revealed by Integrative Epigenetic Analysis with Cell Type Deconvolution by Wang J, Fan H, Bao Z, Li G, Wang L, Zhang D

“…Its etiology is unknown, possibly involving immune dysregulation and inflammation.Methods: Study used DNA methylation (DNAme) and single-cell RNA sequencing (scRNA-seq) to compare LS with normal skin. …”
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Research on the Developmental Trajectory of Movement-Evoked Pain and Its Potential Predictors in Patients After Knee Arthroplasty by Ai S, Zhao S, Yan L, Hu H, Niu P, Zhu Y, Zheng M

“…Shanshan Ai,1,* Sumin Zhao,1,* Lihui Yan,1 Hangying Hu,1 Pengli Niu,2 Yueli Zhu,1,* Meifang Zheng1,* 1Department of Nursing, Integrated Traditional Chinese and Western Medicine of Linping District Hospital, Hangzhou, Zhejiang, People’s Republic of China; 2Department of Nursing, The First Hospital of Dalian Medical University, Dalian, Liaoning, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yueli Zhu, Department of Nursing, Integrated Traditional Chinese and Western Medicine of Linping District Hospital, No. 15, Baojian Road, Linping District, Hangzhou, Zhejiang, 311100, People’s Republic of China, Tel +86 189 0681 1351, Email 2582840555@qq.comPurpose: This study aimed to investigate the developmental trajectory of movement-evoked pain after knee arthroplasty and analyze the predictors of different developmental trajectory categories.Patients and Methods: In this study, a total of 178 patients undergoing knee arthroplasty were recruited from the Department of Joint Surgery at a tertiary care hospital in China. …”
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Controlled Nitric Oxide-Releasing Nanovehicles for Enhanced Infected Wound Healing: A Study on PDA@BNN6 Encapsulated in GelMA Hydrogel by Yang J, Jia D, Qiao J, Peng X, Zhou C, Yang Y

“…This dual action promotes the healing of full-thickness skin wounds that are infected.Methods: Gel/PDA@BNN6 was developed, and both in vitro and in vivo experiments were carried out to evaluate its structure, physicochemical properties, antibacterial effects, effectiveness in promoting infected wound healing, and biocompatibility.Results: Gel/PDA@BNN6 was successfully synthesized, exhibiting a porous three-dimensional lattice structure and excellent mechanical properties. …”
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Extraperitoneal Open Radical Cystectomy: A New Standard in Frail Patients with Muscle-Invasive Bladder Cancer? by Daniel Porav-Hodade, Silvestru-Alexandru Big, Vlad-Ilie Barbos, Bogdan Gherle, Ernő Jerzicska, Victor Ona, Bogdan-Ovidiu Feciche

“…The purpose of this study was to evaluate the feasibility and the safety of extraperitoneal open RC in our experience; <b>Methods</b>: We retrospectively collected the data of 75 frail patients who underwent an extraperitoneal open RC, performed by a single experienced surgeon. …”
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Association Between Systemic Immune-Inflammation Index and Stress Urinary Incontinence in Adult Women: A Population-Based Study by Jiang M, Yao X, Jiang H

“…This study aims to explore the association between SII and SUI in women.Methods: Adult participants from the 2007– 2018 NHANES were included. …”
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Toxicity of treatment regimens for drugresistant tuberculosis. by G. N. Mozhokina, Yu. R. Zyuzya, L. Yu. Petrova, A. G. Samoilova, I. A. Vasilyeva

“…Combinations of fluoroquinolones, bedaquiline, and linezolid with traditional anti-tuberculosis drugs are used in new regimens for the treatment of patients with multidrug- and extensively drug-resistant tuberculosis, but the safety of new regimens has yet to be sufficiently studied.The aim was to study the features of toxic effect manifestations of the 5-component antimycobacterial drug complexes in an experiment on rats.Methods. The study was carried out on 64 non-pedigree rats, old females, divided equally into 3 experimental groups and 1 control. …”
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Integrating Machine Learning Algorithms to Construct a Triaptosis-Related Prognostic Model in Melanoma by Xie J, Zhang M, Qi M

“…However, its role in melanoma remains largely unexplored.Methods: We explored the role of triaptosis in melanoma by integrating single-cell and bulk RNA sequencing data. …”
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Motor development in premature infants: Study protocol for an interdisciplinary hospital-home intervention by Carolina Sandoval-Cuellar, Adriana Lucía Castellanos-Garrido, Angélica María Ospina Romero, Óscar Rafael Boude Figueredo, María Eugenia Serrano-Gómez, César Augusto Fuya Caro, Diana Carolina Molina Cárdenas, Erika Marlen Pinto Rosas

“…This study aimed to determine the effect of an interdisciplinary hospital-home intervention addressing motor development adaptation in premature infants in Colombia in comparison with traditional interventions. Methods: This study was based on a parallel design, with two groups, namely, experimental and control. …”
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Comparative Efficacy of Quadratus Lumborum Muscle Energy Technique with Gluteus Medius Strengthening Versus Gluteus Medius Strengthening Alone in Sacroiliac Joint Dysfunction: A Ra... by Rabail Rani Soomro, Hossein Karimi, Syed Amir Gilani

“…Gluteus medius exercises, along with conventional treatment, are routinely given to patients with sacroiliac joint dysfunction; however, the aim of this study is to explore the additional effects of the muscle energy technique (MET) on the quadratus lumborum along with strengthening of the gluteus medius on pain, disability and quality of life of patients with sacroiliac joint dysfunction. Methods: Using a computer-generated random number table, seventy patients with unilateral sacroiliac joint pain were divided equally and randomly into two groups. …”
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Spot Urine PCR as an Independent Predictor of Renal Disease in Patients with Essential Hypertension by Spoorthi P. Yadagudde, Jayannan Jayasenan, Anbarasu Duraisamy

“…Results: The majority of participants were aged 51–60 years (26.7%), with a near-equal gender distribution (50 males; 51 females). …”
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Thyroid Stimulating Hormone May Facilitates Adipose Tissue Insulin Resistance by Inducing M1 Macrophage Polarization by Fu M, Wang H, Zhang Y, Yang L, Chen Y, Chen X, Wang Z, Sun H

“…However, currently the regulatory mechanism of TSH on the adipose tissue is not fully investigated yet.Methods: We constructed a subclinical hypothyroidism (SCH) mouse model induced by methimazole with elevated TSH levels and then observed its metabolic profile, adipose tissue IR, and the adipose tissue macrophages (ATMs) phenotype. …”
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Risk factors precipitating exacerbations in adult asthma patients presenting at Kalafong Hospital, Pretoria by Maria M. Geyser, Paul Rheeder

“…Asthma is reported as taking up 1 to 2% of the total health budget in direct costs, with equally large indirect costs being incurred for time lost from work and reduced productivity. …”
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Evaluation of Olaparib Tablet Safety and Pharmacokinetics in Healthy Chinese Male Subjects by Dong R, Chen J, Guo N, Yang Y, Wu J, Wang X, Song Y, Zhang X

“…., Shijiazhuang, Hebei Province, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xueyuan Zhang, Clinical Department, CSPC Zhongqi Pharmaceutical Technology (SJZ) Co., LTD., Shijiazhuang, Hebei Province, 050035, People’s Republic of China, Tel +86-311-69085585, Email xueyuanzhang1987@163.comPurpose: To evaluate the safety and pharmacokinetics of olaparib tablet test formulation (T) and reference formulation (R) in healthy Chinese male subjects.Subjects and Methods: This was a single-dose, randomized-sequence, two-way crossover study including three parts: part A: a safety exploration design in lower dose (n = 14, 100 mg), part B: a pivotal comparative pharmacokinetic (PK) trial under fast condition (n = 44, 150 mg) and part C: a pivotal comparative PK trial under food condition (n = 44, 150 mg). …”
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Phthalate Metabolites Were Related to the Risk of High-Frequency Hearing Loss: A Cross-Sectional Study of National Health and Nutrition Examination Survey by You LM, Zhang DC, Lin CS, Lan Q

“…This study aimed to investigate the relationship between phthalate metabolites and hearing loss.Methods: We conducted a cross-sectional study with 1713 participants based on the National Health and Nutrition Examination Survey 2015– 2018. …”
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