Effect of <i>CTLA4</i> gene polymorphism on relapse probability among patients with acute leukemias after allogenic hematopoietic stem cells transplantation by D. S. Romaniuk, A. A. Khmelevskaya, M. Yu. Drokov, N. N. Popova, V. A. Vasilieva, L. A. Kuzmina, G. A. Efimov, E. N. Parovichnikova, V. G. Savchenko

“…The overall survival, the event-free survival and relapse probability were calculated using the Kaplan–Mayer method. A log-rank test was used to assess the statistical significance of group disparities. …”
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Carbon cycle and climate feedbacks under CO₂ and non-CO₂ overshoot pathways by I. Melnikova, I. Melnikova, P. Ciais, K. Tanaka, K. Tanaka, H. Shiogama, K. Tachiiri, K. Tachiiri, T. Yokohata, O. Boucher

“…We first present a method to recalibrate methane and nitrous oxide concentrations to align with published radiative forcings, ensuring accurate model performance. …”
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Biological Activity study of the <i>Melampyrum sylvaticum</i> Extract by E. E. Galishevskaya, E. N. Polyakova, T. V. Bombela, A. V. Agafontseva, A. G. Anisimova, O. A. Krotkova, T. A. Yagontseva, V. G. Luzhanin, E. R. Kurbatov

“…To investigate the in vivo acute toxicity, anticonvulsant and sedative activity of a dry alcohol extract from the aerial part of Melampyrum sylvaticum.Materials and methods. The extract was obtained by extracting substances from the aerial part of Melampyrum sylvaticum with 50 % ethanol, by the method of repercolation with an equal loading of raw materials, followed by evaporation to a dry residue. …”
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A Comparison of the Effects of Sevoflurane, Propofol, and Propofol Combined with Butorphanol in Suppressing Sufentanil-Induced cough&mdash;A Randomized Controlled Trial by Ji H, Zhang F, Yang M, Xu X, Sun Y, Xia X, Li Y

“…A total of 174 patients who underwent ENT surgery at Chaohu Hospital Affiliated with Anhui Medical University were enrolled and divided into groups S, C and B, with 58 patients in each group, according to the random number table method. General anesthesia was induced with 5% sevoflurane in Group S, 2.5 mg/kg of propofol and 30 μg/kg of butorphanol in Group B, and 2.5 mg/kg of propofol and 1 mL of normal saline in Group C. …”
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Effects of alginate oligosaccharides on depression-like behavior and gut microbiota in zebrafish induced by chronic unpredictable mild stress by LONG Yan, SHI Yanxia, QIU Yue, NONG Huiting, ZHU Wuchang, SU Hongmei, HE Naihuan, QIN Zhuwen, WEI Jinbin

“…Objective To investigate the effects of alginate oligosaccharides (AOS) on depression-like behavior and gut microbiota in zebrafish, a model of chronic unpredictable mild stress (CUMS). Methods Wild-type AB strain zebrafish were randomly divided into normal, model, positive control and AOS low, medium and high dose (AOS-L, AOS-M, AOS-H) groups, with 24 fish in each group. …”
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A eletropirexia no tratamento da neurossífilis by Iracy Doyle

“…If it is finally ascertained that short ware diathermy is of equal or superior efficiency to malariotherapy, there will be no further defense for the theory of the specific action of the Plasmodium; if this is true, as it would seem to be, we shall have to believe that therapeutic results depend on the fever factor alone. …”
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A New Strategy for the Treatment of Patients With Prolonged Impairment of Consciousness Using Xenon. Prospective Pilot Study by A. I. Shpichko, A. N. Kuzovlev, R. A. Cherpakov, N. P. Shpichko, O. A. Grebenchikov, A. K. Yevseyev, A. K. Shabanov, S. S. Petrikov

“…When comparing spastic activity on the 1st and 7th days, we did not obtain a statistically significant difference in any of the groups.CONCLUSION Our method of xenon inhalation made it possible to have a beneficial effect on the level of consciousness of patients after traumatic brain injury, but this did not affect the final level of spastic activity in any way.…”
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Development and Validation of an Interpretable Machine Learning Model for Prediction of the Risk of Clinically Ineffective Reperfusion in Patients Following Thrombectomy for Ischem... by Hu X, Qi D, Li S, Ye S, Chen Y, Cao W, Du M, Zheng T, Li P, Fang Y

“…This study aimed to investigate the factors contributing to clinically ineffective reperfusion (CIR), develop and validate a machine-learning model to predict CIR, and provide guidance for future clinical treatments.Methods: We collected data from patients undergoing thrombectomy at Shanghai Fourth People’s Hospital between December 2021 and June 2024. …”
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Clinical Characteristics of Auditory Mismatch Negativity in Patients with Chronic Disorders of Consciousness Following Intracerebral Haemorrhage: A Prognostic Prediction Study by Lv X, Yang N, Lv J, Li L, Gao Y, Xiang Z, Li Z, Lang X, Tao D, Zhao Y, Duan H, Li H

“…Xuehai Lv,1,&amp;ast; Nuan Yang,2,&amp;ast; Jingwei Lv,3 Linxi Li,4 Yuemin Gao,5 Zhengmao Xiang,6 Zhengfan Li,4 Xiaoguang Lang,5 Dan Tao,7 Yuqin Zhao,5 Haili Duan,5 Hongling Li1 1Second Department of Rehabilitation Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050000, People’s Republic of China; 2Graduate School, Hebei Medical University, Shijiazhuang, Hebei Province, 050017, People’s Republic of China; 3School of Basic Medicine, Hebei Medical University, Shijiazhuang, Hebei Province, 050017, People’s Republic of China; 4Graduate school, Hebei North University, Zhangjiakou, Hebei Province, 075000, People’s Republic of China; 5Department of Clinical Rehabilitation Medicine, Handan Central Hospital, Handan, Hebei Province, 056001, People’s Republic of China; 6Graduate school, Chengde Medical University, Chengde, Hebei Province, 067000, People’s Republic of China; 7Academy of Geography, Sociology, and International Studies, Hong Kong Baptist University, Hong Kong, 519000, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Hongling Li, Second Department of Rehabilitation Medicine, The Second Hospital of Hebei Medical University, No. 215 of Hepingxi Road, Xinhua District, Shijiazhuang, Hebei Province, 050000, People’s Republic of China, Tel +86 15803210622, Email lihongling_lhl@163.comObjective: To examine the clinical features of auditory mismatch negativity (MMN) and its potential utility in prognostic prediction in patients with chronic disorders of consciousness (DOC) following intracerebral haemorrhage (ICH).Methods: Between September 2023 and July 2024, 24 patients with chronic DOC following ICH were recruited. …”
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Comparative Cost-Effectiveness of Two Artificial Liver Therapies in Early-Stage Hepatitis B Virus-Related Acute-on-Chronic Liver Failure: A Retrospective Cohort Study by Chen J, Luo Q, Wang L, Zheng L, Zhang Y, Liu Y, Peng L, Xu W

“…Jia Chen,1,&amp;ast; Qiumin Luo,1,&amp;ast; Lu Wang,2,&amp;ast; Lihua Zheng,1 Yeqiong Zhang,1 Ying Liu,1 Liang Peng,1,3 Wenxiong Xu1 1Department of Infectious Diseases and Guangdong Key Laboratory of Liver Disease Research, Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, People’s Republic of China; 2Department of Diagnostics, second School of Clinical Medicine, Binzhou Medical University, Yantai, Shandong, People’s Republic of China; 3Key Laboratory of Tropical Disease Control, Ministry of Education, Sun Yat-sen University, Guangzhou, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Wenxiong Xu, Department of Infectious Disease, Third Affiliated Hospital of Sun Yat-sen University, 600&amp;num; Tianhe Road, Tianhe District, Guangzhou, Guangdong province, 510630, People’s Republic of China, Tel +8613760783281, Email xuwenx@mail.sysu.edu.cn Liang Peng, Department of Infectious Disease, Third Affiliated Hospital of Sun Yat-sen University, 600&amp;num; Tianhe Road, Tianhe District, Guangzhou, Guangdong province, 510630, People’s Republic of China, Tel +8613533978874, Email pliang@mail.sysu.edu.cnPurpose: This study aimed to compare the cost-effectiveness of the double plasma molecular adsorption system sequential low-volume plasma exchange (DPMAS+LPE) versus conventional plasma exchange (PE) in treating early-stage hepatitis B virus-related acute-on-chronic liver failure (HBV-ACLF).Patients and Methods: A total of 215 early-stage HBV-ACLF patients were assigned to either DPMAS+LPE or conventional PE groups. …”
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Antimicrobial Effects of Thonningianin a (TA)-Loaded Chitosan Nanoparticles Encapsulated by a PF-127&nbsp;hydrogel in Diabetic Wound Healing by Lin Q, Zhu F, Shiye A, Liu R, Wang X, Ye Z, Ding Y, Sun X, Ma Y

“…To promote diabetic wound healing, a composite of thonningianin A (TA)-loaded chitosan nanoparticles (CNPS) encapsulated by a Pluronic F-127 (PF-127) hydrogel (TA-CNPS-PF) was developed in this study.Methods: TA-CNPS was prepared by ionic gelation method and TA-CNPS was thoroughly dispersed into PF-127 hydrogel to prepare TA-CNPS-PF. …”
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Construction of Cationic Carbon Dots Carrying Survivin siRNA Delivery System and Its Active Targeting Therapy for Liver Cancer by Xue W, Du J, Wei Y, Zhou S, Wang S, Yang Y, Chen L, Yu S

“…Wenqiang Xue,1,&amp;ast; Jinglei Du,2,&amp;ast; Yingying Wei,2 Shizhao Zhou,2 Shicai Wang,4 Yongzhen Yang,3 Lin Chen,3 Shiping Yu2 1Department of Interventional Therapy, Shanxi Provincial People’s Hospital, Taiyuan, 030001, People’s Republic of China; 2Department of Interventional Therapy, Shanxi Province Cancer Hospital/ Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences/ Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, 030001, People’s Republic of China; 3Key Laboratory of Interface Science and Engineering in Advanced Materials, Ministry of Education, Taiyuan University of Technology, Taiyuan, 030024, People’s Republic of China; 4Department of Interventional Therapy, Taiyuan Central Hospital, Taiyuan, 030001, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Yongzhen Yang, Key Laboratory of Interface Science and Engineering in Advanced Materials, Ministry of Education, Taiyuan University of Technology, Taiyuan, 030024, People’s Republic of China, Email yangyongzhen@tyut.edu.cn Shiping Yu, Department of Interventional Therapy, Shanxi Province Cancer Hospital, Shanxi Hospital Affiliated to Cancer Hospital, Chinese Academy of Medical Sciences, Cancer Hospital Affiliated to Shanxi Medical University, Taiyuan, 030001, People’s Republic of China, Email yushiping@sxmu.edu.cnBackground: Small interfering RNA (siRNA) provides a new method for anti-tumor therapy by targeting Survivin gene in liver cancer. …”
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Hyper-Relapse Disease is a Special Pattern of Relapse of Hepatocellular Carcinoma After Curative Hepatectomy: A Retrospective Cohort Study by Yang ZL, Gan YX, Xu JX, Tang YH, Ouyang LY, Qi LN, Xu L

“…Hyper-relapse disease (HRD) is defined as tumor relapse within 6 months from surgery, multiple intrahepatic lesions, as well as macrovascular invasion and/or extrahepatic metastasis. Kaplan–Meier method and Cox regression model were used to analyze overall survival (OS). …”
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Epidemiologia de 118 casos de esclerose múltipla com seguimento de 15 anos no centro de referência do Hospital da Restauração de Pernambuco Epidemiology of 118 cases of multiple sc... by Maria Lúcia Brito Ferreira, Maria Íris Moraes Machado, Maria Lúcia Vilela, Maria José Guedes, Luis Ataíde Jr, Silvana Santos, Sílvia Gomes Laurentino

“…We have identified: predominance of mulattoes (110,93.2%), 82 (82.2%) cases clinically defined, 15 (12.7%) cases laboratorial defined and 6 (5.1%) cases clinically probable; a number of maximum bouts equal to 46; more frequent mild EDSS for patients with 1 to 10 years of MS of remittent-recurrent (RR) form. …”
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Opioid-Free Anesthesia Improved the Quality of Recovery After Thyroidectomy Through Pre-Emptive and Preventive Analgesia: A Randomized Controlled Trial by Zhang Y, Xian X, Wang F, Zhou B, Wang Y, Wang P, Li Y, Wu Y

“…However, a prolonged emergence recovery was observed when patients receiving OFA strategy, warranting further investigation to optimize agent design and monitoring method to balance the intraoperative anesthesia depth.Name of Trial Registry: Chinese Clinical Trial Registry.Registration Number: ChiCTR2300070794; URL: https://www.chictr.org.cn/showproj.html?…”
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Development of Solid Self-Nanoemulsifying Drug Delivery System of Rhein to Improve Biopharmaceutical Performance: Physiochemical Characterization, and Pharmacokinetic Evaluation by More SM, Rashid MA, Kharwade RS, Taha M, Alhamhoom Y, Elhassan GO, Gangane P, Asar TO, Pise A, Kaleem M, Mujtaba MA

“…Thus, this study aimed to develop a rhein-loaded self-nano emulsifying drug delivery system (RL-SNEDDS) to improve solubility and bioavailability.Methods: The RL-SNEDDS was prepared by aqueous titration method with eucalyptus oil (oil phase), tween 80 (surfactant), and PEG 400 (co-surfactant) and optimization was performed by 32 factorial design. …”
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Healthcare Providers’ Adherence to COVID-19 Prevention and Control Practices in Health Records and Information Management, Ghana by Richard Okyere Boadu, Kwame Adu Okyere Boadu, Nathan Kumasenu Mensah, Godwin Adzakpah, Fortune Afaglo, Rosemary Bermaa Abrefa, Emmanuella Aryee, Nancy Gyamena Botwe, Dinah Baiden-Amissah, Dennis Bless Ashiavor, Larry Lee Mensah, Lovemond Kojo Asamoah, Judith Obiri-Yeboah

“…This study assesses healthcare providers’ perceived adherence to COVID-19 PCP in Health Records and Information Management. Subjects and Method. A cross-sectional survey was conducted to collect data from 1268 HCPs working in eight randomly selected hospitals across five regions in Ghana. …”
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Comparison of Lesser galangal, Alpinia officinarum extract and Letrozole in masculinization of Nile tilapia, Oreochromis niloticus by Seyed Mohammad Reza Taheri, Sakineh Yeganeh, Homayon Hoseinzadeh Sahafi

“…So, the purpose of the present study was to investigate the effects of different doses of the rhizome extract of A. officinarum on the sex reversal of Nile tilapia fry and compare it with the chemical drug, letrozole. Materials and Methods: The number of 2760 pieces of Nile tilapia larvae seven days after fertilization with an average weight of 0.026 ± 0.002 g distributed in 24 aquaria (200-L in volume) equipped with aeration and filtration systems in equal and completely random released. …”
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Association Between Weight-Adjusted Waist Circumference Index and Metabolic Disease-Associated Fatty Liver Disease: A Retrospective Study by Tang T, Fan H, Yu Q, Rao X, Shi Y, Tong X, Feng L, Xu Z, Fu X, Chen J, Zhang X, Tang J, Wang H, Wang M

“…There is a need for a straightforward and effective method to screen for metabolic disease-associated fatty liver disease. …”
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MAGICAL REALISM IN THE CONTEXT OF POSTMODERN AESTHETICS: HERMANN KASACK’S “THE CITY BEYOND THE RIVER” AND MAX KIDRUK’S “DON’T LOOK BACK AND STAY QUIET” INTER- TEXTUAL CONNECTIONS... by Tetiana V. Bykova, Nina D. Osmak

“…To achieve the stated aim and solve the set tasks, historical-literary, hermeneutic, mythopoetic methods, as well as the method of intertextual analysis, were used. …”
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