A Simplified Immune-Dysregulation Index (IL-6/LY) as a Robust Predictor of 28-Day In-Hospital Mortality and MODS in Patients with Sepsis by Liu M, You T, Li S, Hao Y, Wang Z, Huang F, Wang J

“…Meili Liu,1,2,* Tao You,3,* Shifeng Li,1,* Yan Hao,1,* Zhiyang Wang,1 Fang Huang,1 Jun Wang1 1Department of Critical Care Medicine, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 2Department of Cardiology, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China; 3Department of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jun Wang; Fang Huang, Department of Critical Care Medicine, The First Affiliated Hospital of Soochow University, No. 188 Shizi Street, Suzhou, 215006, People’s Republic of China, Email dr_wangjun@suda.edu.cn; blue-virus@163.comObjective: To evaluate the prognosis significance of a newly simplified immune-dysregulation index, interleukin-6-to-lymphocyte ratio (IL-6/LY), in individuals diagnosed with sepsis.Methods: This was a retrospective cohort study enrolling consecutive patients diagnosed with sepsis who qualified the inclusion criteria and were admitted to the intensive care unit of the First Affiliated Hospital of Soochow University between March 2017 and January 2023. …”
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Fitness profile and training of Special Operation Forces: a comparison with sports athletes by Alain Dössegger, Alain Dössegger, Thomas Gsponer, Martin Flück, Martin Flück, Christian Protte, Christian Protte, Thomas Wyss, Eric Häusler, Markus Gerber, Oliver Faude

“…Evidence for a group effect was quantified by the Bayes Factor and Probability of direction, where >90% is considered equal to an alpha level of 0.05, thus a non-negligible effect.ResultsWeekly training volume averaged 8.5 h for operators, 6.9 h for candidates, and 9.5 h for athletes. …”
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Trichoscopic evaluation in oral tofacitinib and oral betamethasone in the treatment of moderate to severe alopecia areata by Soumi Biswas, Arun Achar

“…However, most were retrospective studies and often lacked of thorough dermoscopic evaluation of the therapeutic response.2–6 Thus, we evaluated and compared the dermoscopic changes associated with oral tofacitinib and oral betamethasone mini-pulse therapy in alopecia areata patients.Materials and Method: This was an institution-based open-label randomised controlled parallel-group comparative trial. …”
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STYLISTIC MEANS OF IMPLEMENTING THE IDEA OF THE WORLD’S IRIDESCENCE IN PH.K. DICK’S “UBIK” IN THE CONTEXT OF TRANSLATION TRANSFORMATIONS by Svitlana F. Aleksenko, Larysa I. Taranenko

“…Among the typical translation methods, instrumental in the rel- evant textual sequences in “Ubik”, a share of lexical and semantic transformations equals 60.2% of the re- searched sets of translation counterparts, with modulation and specification being the dominant ones and logical synonymy, calquing and lexical compensation trailing behind. …”
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Prediction of Ki-67 Expression in HIV-Associated Lung Adenocarcinoma Patients Using Multiple Machine Learning Models Based on CT Imaging Radiomics by Song C, Chen J, Zhao C, Song S, Yang T, Huang A, Liu R, Pan Y, Xu C, Chen C, Zhu Q

“…Therefore, developing a non-invasive and accurate method for Ki-67 prediction holds significant clinical importance. …”
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The Median Effective Dose of Ciprofol Combined with Sufentanil for Inhibiting Responses to Gastroscope Insertion in Obese Patients: A Prospective, Single-Center Study by Xue Z, Liu X, Qian W, Yang N, Pan Y, Zhou Y, Jiang W, Li F, Qian B

“…All patients received 0.1 μg/kg of sufentanil, and the ciprofol dose was determined by the modified Dixon sequential method with an initial dose of 0.4 mg/kg and a dose gradient of 0.01 mg/kg. …”
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Multimodal Imaging of Brain Metastasis-Derived Extracellular Vesicles Using Superparamagnetic Iron Oxide Nanoparticle Labeling by Feginn Berle B, Juliussen S, Castilho Á, Solel E, Sdik Saed H, Vanderpoorten O, Lunavat TR, Thorsen F, Rigg E

“…However, tracking their distribution and interactions in vivo remains challenging.Objective: To develop and validate a method for labeling BM-derived EVs using superparamagnetic iron oxide nanoparticles (SPIONs) that enables their visualization and tracking through magnetic resonance imaging (MRI).Methods: Three SPION variants with different coatings and sizes were evaluated using two patient-derived BM cell lines. …”
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FACTORS OD DENTURES’ MALADJUSTMENT, ITS PREVENTION AND TREATMENT by E. Diasamidze, M. Diasamidze, K. Zhukov, S. Schneider

“…Modern medicine has a significant, rapidly replenished arsenal of painkillers and methods, most of which are aimed at the suppression of the nociceptive system. …”
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A Machine Learning Model for Predicting Prognosis in HCC Patients With Diabetes After TACE by Wu L, Chen L, Zhang L, Liu Y, Ouyang D, Wu W, Lei Y, Han P, Zhao H, Zheng C

“…Lastly, the SHapley Additive exPlanations (SHAP) method was used to interpret the final ML model.Results: A total of 636 patients were included. …”
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EC50 and EC95 of Remifentanil for Inhibiting Bronchoscopy Responses in Elderly Patients During Fiberoptic Bronchoscopy Under Ciprofol Sedation: An Up-and-Down Sequential Allocation... by Lan H, Liu S, Liao Y, Xu B, Lin Y, Wu X, Chen Q, Chen H, Guan X

“…The EC50 and EC95 values of remifentanil required to alleviate the responses to FOB were calculated using Dixon’s up-and-down method for both male and female groups. Probit analysis was used to generate a dose-response curve.Results: Thirty-nine patients (19 males and 20 females) were enrolled. …”
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Exploring the Role of Allergenic Components in Children with House Dust Mite-Induced Allergic Diseases by Xu Q, Shang Y, Li X, Ran S, Lu M, Cheng L

“…Qiuyan Xu,1,* Yunxia Shang,1,* Xiang Li,1 Shuangqin Ran,1 Min Lu,1 Lei Cheng2,3 1Department of Pediatrics, Suzhou Research Center of Medical School, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, Suzhou, People’s Republic of China; 2Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, Nanjing, People’s Republic of China; 3International Centre for Allergy Research, Nanjing Medical University, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Lei Cheng, Department of Otorhinolaryngology & Clinical Allergy Center, The First Affiliated Hospital, Nanjing Medical University, 300 Guangzhou Road, Nanjing, 210029, People’s Republic of China, Email chenglei@jsph.org.cn Min Lu, Department of Pediatrics, Suzhou Research Center of Medical School, Suzhou Hospital, Affiliated Hospital of Medical School, Nanjing University, 1 Lijiang Road, Suzhou, 215153, People’s Republic of China, Email samy_lm@163.comPurpose: To investigate the main characteristics of HDM-induced allergic diseases in children and to explore allergen component-specific sensitization patterns, features, and correlations with clinical symptoms.Methods: Serum samples were collected from children with HDM-induced allergic diseases. …”
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Protective Effects of Gynostemma pentaphyllum Saponins on Liver Injury in Guinea Pigs of Hyperlipemia Based on Oxidative Stress by Tianyi DAI, Donglian LIU, Xingmin QIN, Chengling GAO, Jiayi LI, Hailing KUANG

“…Objective: To observe the protective effects of Gynostemma pentaphyllum saponins (GPs) on liver injury in guinea pigs of hyperlipemia based on oxidative stress. Methods: A total of 32 guinea pigs were randomly divided into a model group, a low dose GPs group (85 mg/kg), a high dose GPs group (170 mg/kg), and a simvastatin group (1.5 mg/kg), with 8 animals in each group. …”
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Assessment of The Factors Affecting Management of Gender and Sexual Violence Against Women in Rural Communities: A Case Study of Kyanamira Sub County Kabale District. by Tumuheki, Timothy

“…The researcher employed a content analysis method to analyze the data. The emerging themes and opinions were properly analyzed, and compared with the information that was obtained in the literature review. …”
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Study on the Therapeutic Effects of Bisdemethoxycurcumin on a Cerebral Amyloid Angiopathy Mouse Model Established via Chronic Treatment With Five Vascular Risk Factors by Shudong Lin, Guanghua Zhu, Juan Xie, Xuanwei Wen, Limin Deng, Sijing Li, Guozhi Liu, Feiyan Wang, Shuangxi Chen, Zijian Xiao

“…Thus, the present study mainly focused on the potential therapeutic effects of BDMC on CAA. Method The 30 male C57BL/6 mice were subjected to chronic treatment with five vascular risk factors (lipopolysaccharide, social stress, streptozotocin, high‐cholesterol diet, and copper‐containing drinking water) for 35 weeks to establish a CAA mouse model. …”
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Modeling the relationship between the moral charter derived from Islamic teachings and performance with the mediating variable of employees' perception by leila jahantigh, Abbas Babaeenezhad, Mohsen Zayandehroudi, saeed sayadi

“…The collection tool in the current research includes the organizational equality perception questionnaire by Astron (2015). …”
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Detection of moderate to high antiphospholipid antibodies by chemiluminescence meets 2023 APS classification criteria by Haiyue Jiang, Yaqing Yang, Zihan Tang, Haoyu Pan, Honglei Liu, Xiaobing Cheng, Yutong Su, Junna Ye, Qiongyi Hu, Jianfen Meng, Huihui Chi, Zhuochao Zhou, Jinchao Jia, Hui Shi, Chengde Yang, Jialin Teng, Tingting Liu

“…However, enzyme-linked immunosorbent assay (ELISA) remains the sole specified method for antiphospholipid antibody detection. This study aims to establish moderate and high levels of anticardiolipin(aCL) and anti-β2-glycoprotein I antibodies (anti-β2GPI) using chemiluminescence assay (CIA) and to investigate the diagnostic efficiency and risk stratification capabilities of CIA in comparison to ELISA. …”
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Land instability Compounds the risk of sea level rise in Alexandria, Egypt by Rejoice Thomas, Sara Zouriq, Shahryar Fazli, Amr Fawzy, Nikolay Grisel Todorov, Surendra Maharjan, Wenzhao Li, Erik Linstead, Daniele Struppa, Hesham El-Askary

“…Moreover, in the absence of a recent, openly accessible Digital Elevation Model (DEM) with satisfactory resolution, we developed a novel approach to update DEM using the Small Baseline Subset method. This approach enabled us to generate a projected DEM for the year 2040, facilitating the creation of a stream network based on this “future DEM”. …”
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Quality of life assessment in patients treated due to chronic pancreatitis by Dragović Saša, Vulović Maja, Stamenković Dušica, Rančić Nemanja, Mitrović Miroslav, Bezmarević Mihailo, Jovanović Milan, Pantić Ivan, Rujanovski Zoran, Lepić Sanja, Milev Boško

“…According to the method of treatment, patients completed the questionnaire. …”
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Is 2 h of Hypothermic Machine Perfusion for Pancreas Preservation Effective in Improving Graft Reperfusion? by Benoit Mesnard, MD, Christophe Masset, MD, PhD, Etohan Ogbemudia, MD, PhD, Sarah Bruneau, PhD, Mohamed Elzawahry, MD, Stéphanie Le Bas-Bernardet, PhD, David Minault, Jeremy Hervouet, Diego Cantarovich, MD, PhD, Jérôme Rigaud, MD, PhD, Lionel Badet, MD, PhD, Peter Friend, MD, PhD, Rutger Ploeg, MD, PhD, Gilles Blancho, MD, PhD, James Hunter, MD, PhD, Thomas Prudhomme, MD, Julien Branchereau, MD, PhD

“…Static cold storage (SCS) remains the standard method for organ preservation. The development of parenchymal edema during prolonged hypothermic machine perfusion (HMP) was a major barrier to the introduction of this technique for the preservation of pancreases. …”
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Development and Validation of Models to Estimate the Incident Risk of Cognitive Impairment and Atherosclerotic Cardiovascular Disease in Older Adults by Michael G. Nanna, Daniel Wojdyla, Eric D. Peterson, Ann Marie Navar, Jeff D. Williamson, Lisandro D. Colantonio, Stephen Y. Wang, Yasser Jamil, Alain G. Bertoni, Musarrat Nahid, Abdulla A. Damluji, Parag Goyal, Sarwat I. Chaudhry, Thomas M. Gill, Karen P. Alexander

“…Variable selection, including functional status, was based on the least absolute shrinkage and selection operator method. The cognitive impairment (N=3466) and ASCVD (N=4403) model populations were split into derivation and validation cohorts with external validation, then performed in MESA (Multi‐Ethnic Study of Atherosclerosis). …”
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