Digital outdoor exercise program for obese patients with type 2 diabetes mellitus: a non-inferiority randomized controlled trial by Jian Cui, Qiang Liu, Lihua Huang, Haoyan Yu

“…Adherence and cost-effectiveness were also assessed.MethodsWe conducted a randomized controlled noninferiority trial at a single tertiary center. …”
Get full text

Factors associated with malaria in pregnancy among antenatal care mothers at Gulu Regional Referral Hospital in northern Uganda by Solomon Oguta, Brian Serumaga, Lameck Odongo, Donald Otika, Jackline Ayikoru, Raymond Otim, Jimmyy Opee, Baifa Arwinyo, Francis Pebolo Pebalo, Vincentina Achora, Sande Ojara, Benard Abola, Silvia Awor

“…This study aimed to assess the factors associated with malaria in pregnancy among antenatal care mothers at Gulu Regional Referral Hospital. Methods This was a cross-sectional study at Gulu Regional Referral Hospital antenatal clinic from July to August 2023. …”
Get full text

Seroprevalence and Clinical Insights of Ocular Herpesvirus Infections: A Cross-Sectional Study Evaluating ELISA as a Diagnostic Tool by Chen S, Peng Q, Wang H, Xie J, Cao H, Xu X

“…This study aimed to investigate the seroprevalence of HSV and VZV infections in patients with suspected ocular infections and to evaluate associated risk factors.Methods: We conducted a cross-sectional study using enzyme-linked immunosorbent assay (ELISA) to detect antibodies against HSV and VZV in patients with ocular symptoms. …”
Get full text

Gait Characteristics and Neuroanatomical Alterations in Obstructive Sleep Apnea–Hypopnea Syndrome by Jiang J, Mo Y, Abuduwaili Z, Mao C, Fang S, Ke Z, Hu Z, Huang L, Xu S, Yang D, Xiong R, Xie P, Zhu X, Xu Y

“…Recently, it has been found to contribute to gait disorders, but there is limited information regarding how various indicators of OSAHS affect gait patterns.Methods: A total of 136 subjects recruited from Nanjing Drum Tower Hospital were categorized based on apnea hypopnea index (AHI) and oxygen saturation (SpO2), respectively. …”
Get full text

Open donor nephrectomy via singular pararectal extraperitoneal mini-incision: single-center experience with 425 consecutive cases by Philipp Tessmer, Oliver Beetz, Anna Meyer, Clara A. Weigle, Simon Stoerzer, Gunilla Einecke, Wilfried Gwinner, Florian W. R. Vondran, Felix Oldhafer, Moritz Schmelzle, Nicolas Richter

“…Conclusions Unlike the endoscopic technique, SPEM is equally suitable for right- and left-sided nephrectomy. …”
Get full text

Innovative Cardiac Rehabilitation: Effects of Adaptive Postural Balance Exercise on Coronary Artery Disease and Type 2 Diabetes by Qin D, Liu G, Zhang J, Lin S, Liu X, Zhao J, Zhang Q, Ma M, Wang S

“…Specifically, we compared the efficacy of APBCRE with aerobic exercise (AE) alone and irregular exercise (IE).Patients and Methods: This randomized controlled trial included 348 patients with CAD, comprising 261 patients with T2DM and 87 non-diabetic CAD patients as a control group. …”
Get full text

The Effect of Minimal-Dose S-Ketamine Administration Post-Surgery on Opioids Consumption and Functional Rehabilitation Exercises in Patients Undergoing Minimally Invasive Radical R... by Xie J, Shen F, Wang X, Yao J, Zhou L, Huang L, Sun J

“…Jue Xie,1 Fangming Shen,1 Xingming Wang,2 Juan Yao,1 Lingzhen Zhou,3 Luxin Huang,1 Jie Sun1 1Department of Anesthesiology, Surgery and Pain Management & Key Laboratory of Clinical Science and Research, Zhongda Hospital Southeast University, Southeast University School of Medicine, Nanjing, Jiangsu, People’s Republic of China; 2Department of Anesthesiology, Pain and Perioperative Medicine, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, 450052, People’s Republic of China; 3Department of Thoracic Surgery, Zhongda Hospital Southeast University, Southeast University School of Medicine, Nanjing, Jiangsu, People’s Republic of ChinaCorrespondence: Jie Sun, Email dgsunjie@hotmail.comStudy Objective: To examine the impact of minimal-dose S-ketamine on postoperative analgesia in patients undergoing minimally invasive radical resection for esophageal cancer, with a focus on reducing opioid consumption, enhancing analgesic quality, and facilitating postoperative recovery.Methods: A total of 216 patients undergoing minimally invasive radical resection of esophageal cancer under general anesthesia were randomly assigned into two groups (S-ketamine and control group), receiving intravenous S-ketamine (0.015 mg/kg/h) or an equal volume of saline for 48 h postoperatively. …”
Get full text

The Predictive Value of Soluble Fms-Like Tyrosine Kinase-1 for Prognosis in COVID-19 Patients by Lai C, Wang Y, Shi F, Geng N, Liu Z, Pan W, Shi H, Ma Y, Liu B

“…This study aimed to investigate the prognostic value of soluble fms-like tyrosine kinase-1 (sFlt-1) in COVID-19 patients.Methods: A prospective cohort study was conducted involving 154 COVID-19 patients, with comprehensive clinical data and laboratory parameters analyzed to evaluate the effectiveness of sFlt-1 in determining disease severity and prognosis.Results: The results revealed that sFlt-1 levels correlated significantly with disease severity, showing higher levels in severe/critical cases compared to mild cases (P< 0.05). …”
Get full text

Assessing Sedation Depth with PSI in Elderly ERCP Patients: A Prospective Cohort Study by Huang L, Liu LL, Lu YD, Zhuang MY, Dou W, Liu H, Ji FH, Peng K

“…We aimed to assess the correlation between PSI and Modified Observer’s Assessment of Alertness/Sedation (MOAA/S) scores in elderly patients undergoing ERCP.Methods: This prospective cohort study included 57 elderly patients scheduled for ERCP procedures. …”
Get full text

Exploring the Potential Regulatory Mechanisms of Mitophagy in Ischemic Cardiomyopathy by Li Z, Kong J, Xi S, Jin Z, Yang F, Zhu Z, Liu L

“…However, it is still uncertain how mitophagy related genes (MRGs) may affect the diagnosis of ICM.Patients and Methods: Data were obtained from public databases. …”
Get full text

Bromocriptine for Idiopathic Intracranial Hypertension: A Retrospective Multicenter Cohort Study by Morsy MM, Azzam AY, Mirdad MT, Abadi AM, Alqahtani SAM, Abukhadijah HJ, Elamin O, Morsy MD, Altschul DJ

“…This study aims to evaluate the safety and efficacy of bromocriptine in IIH management through a retrospective cohort analysis.Methods: A retrospective analysis was conducted, focusing on patients with IIH. …”
Get full text

Efficacy and Safety of Kilohertz Frequency Alternating Current with Non-Invasive Electrodes for Treatment of Neuropathic Pain After Spinal Cord Injury: A Randomized, Single-Blind,... by Shuai N, Zhu Y, Xiao Y, Yu B

“…Niannian Shuai,1,&amp;ast; Yuyao Zhu,2,&amp;ast; Yao Xiao,3,&amp;ast; Bin Yu4 1Department of Anesthesiology, Ningbo University Affiliated People’s Hospital, Zhejiang, People’s Republic of China; 2Department of Anesthesiology, Shanghai Tongji Hospital, Shanghai, People’s Republic of China; 3Department of Rehabilitation, Shanghai Tongji Hospital, Shanghai, People’s Republic of China; 4Department of Pain Rehabilitation, Yangzhi Rehabilitation Hospital, Affiliated with Tongji University, Shanghai, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Bin Yu, Department of Pain Rehabilitation, Yangzhi Rehabilitation Hospital, Affiliated with Tongji University, 2209 Guangxing Road, Songjiang District, Shanghai, 201613, People’s Republic of China, Tel +86 139 1810 8880, Email yubin@tongji.edu.cnObjective: To evaluate the effectiveness and safety of noninvasive kilohertz frequency alternating current (KHFAC) therapy for neuropathic pain in patients following spinal cord injury.Methods: In this randomized, single-blind, sham-controlled trial conducted from June 1, 2023, to January 31, 2024, 50 patients suffering from neuropathic pain post-spinal cord injury were assigned to receive either KHFAC or sham stimulation for 7 days, complemented by twice-daily oral administration of 75 mg pregabalin. …”
Get full text

Hyodeoxycholic Acid Ameliorates Metabolic Syndrome Through Pathways of Primary Bile Acid Synthesis and Fatty Acid Degradation: Insights From a Rat Model by Chen M, Huang K, Luo W, Zhang F, Gan H, Yang Z

“…Hyodeoxycholic acid (HDCA) has shown potential effects in non-alcoholic fatty liver disease (NAFLD), yet its role in MS is unexplored.Aim: This study aims to assess whether HDCA is a characteristic BA of MS and to investigate its intervention effects and potential mechanisms.Methods: We employed 16S rDNA sequencing and UHPLC-MS/MS to investigate the dynamics of the gut microbiota and BA profiles in rats and conducted a correlation study between indices, identifying HDCA as the potential characteristic BA. …”
Get full text

Effect of aloe vera and coconut in the management of xerostomia in patients with Sjogren’s syndrome: a crossover randomized clinical trial by Alaa Mahmoud, Basma Elsaadany, Mervat Eissa, Wesam Abd Elmoneim, Sherifa Tarek, Mai Zakaria

“…Aim: This study aimed to evaluate the efficacy of carboxymethyl cellulose (CMC)-based natural mixture of aloe vera gel and coconut oil as a salivary substitute in comparison to the conventional CMC for the management of xerostomia in a sample of patients with Sjogren’s syndrome (SS). Methods: This crossover randomized clinical trial included 24 patients diagnosed with SS. …”
Get full text

Red Blood Cell Distribution Width/Hematocrit Ratio: A New Predictor of 28 Days All-Cause Mortality of AECOPD Patients in ICU by Long Z, Zeng Q, Ou Y, Liu Y, Hu J, Wang Y, Wang Y

“…Furthermore, the utility of RDW/HCT in improving traditional ICU scoring systems remains unexplored.Patients and Methods: The optimal RDW/HCT ratio cutoff was identified via ROC curve analysis, guiding classification into high and low ratio groups. …”
Get full text

Establishment of a Novel in vitro Model of Sepsis-Induced Myocardial Injury Using Septic Serum: A Comprehensive Comparative Study by Yang H, Feng L, Jiang Z, Deng R, Wu X, Zeng K

“…This study aimed to systematically compare different in vitro models to determine the most appropriate model for studying the pathophysiological mechanisms of sepsis-induced myocardial injury.Materials and Methods: AC16 cardiomyocytes were treated with lipopolysaccharide (LPS), tumor necrosis factor-α (TNF-α), or septic serum for 24 hours to induce myocardial injury. …”
Get full text

Glomerular filtration rate dynamics in patients with diffuse large B-cell lymphoma during induction immunopolychemotherapy by A. S. Nozdricheva, I. B. Lysenko, N. K. Guskova, M. A. Konovalchik, A. A. Maslov, E. V. Shalashnaya

“…To study the glomerular filtration rate (GFR) dynamics during induction immunopolychemotherapy (PCT) in patients with newly diagnosed diffuse large B-cell lymphoma.   Materials and methods. The study included 39 patients with newly diagnosed diffuse large b-cell lymphoma who received specialized treatment in oncohematology department of national medical research centre for oncology (Rostov-on-Don). …”
Get full text

Availability and readiness of health facilities in Burkina Faso to provide antenatal care: trend analysis from 2012 to 2020 by Marie-Jeanne Offosse, Kadari Cissé, Désiré Somda, Anna Gage, Annie Haakenstad, Aduragbemi Banke-Thomas

“…Availability and readiness indices were calculated using the equal-weighted approach, and the domain-weighted approach was used for readiness only. …”
Get full text

Efficacy Assessment and Prognostic Value of Inflammatory Markers in Patients with Stage IV Acral and Cutaneous Melanoma Receiving PD-1 Inhibitors by Zhang Y, Qu Z, Xuan H, Lu L, Ding C, He Z, Gu K, Zhang Y

“…Few studies have examined the role of inflammatory markers in predicting the overall survival (OS) in stage IV acral melanoma (AM) and cutaneous melanoma (CM) patients receiving immunotherapy.Purpose: This study aimed to investigate the value of inflammatory markers in efficacy and prognosis for stage IV melanoma patients who underwent immunotherapy.Patients and Methods: This multicenter study reviewed the clinicopathological characteristics and inflammatory markers of 94 stage IV AM and CM patients receiving PD-1 inhibitors therapy. …”
Get full text

Predictive Value of TRUS and CEUS Parameters for Lymph Node Metastasis in Rectal Cancer: A Retrospective Study by Su S, Huang X, Li X, Meng J, Huang J

“…Shitao Su,&amp;ast; Xuanzhang Huang,&amp;ast; Xigui Li, Jun Meng, Jianyuan Huang Department of Medical Ultrasound, the First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Jianyuan Huang, Department of Medical Ultrasound, the First Affiliated Hospital of Guangxi Medical University, 6 Shuangyong Road, Nanning, Guangxi Zhuang Autonomous Region, 530001, People’s Republic of China, Tel +86 771 5356899, Email huangjianyuan@sr.gxmu.edu.cnPurpose: To assess the predictive value of transrectal ultrasound (TRUS) combined with qualitative and quantitative parameters of contrast-enhanced ultrasound (CEUS) for lymph node metastasis (LNM) in rectal cancer (RC).Patients and Methods: This retrospective study analyzed preoperative clinical data, qualitative and quantitative TRUS and CEUS parameters, and postoperative pathological data from 535 patients with RC confirmed by surgical pathology. …”
Get full text