Internal-External Homologous Drug-Loaded Exosome-Like Nanovesicles Released from Semi-IPN Hydrogel Enhancing Wound Healing of Chemoradiotherapy-Induced Oral Mucositis by Wei X, Wang M, Dong X, He Y, Nan W, Ji S, Zhao M, Chang H, Wei H, Ding D, Chen H

“…This study aimed to develop a novel therapeutic approach.Methods: We fabricated internally-externally homologous drug-loaded exosome-like nanovesicles (ORI/ENs) derived from Rabdosia rubescens and encapsulated them in a semi-interpenetrating network hydrogel system (ORI/ENs/Gel) to repair chemoradiotherapy-induced OM. …”
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Endometriosis and Mortality Risk in US Women: Findings From NHANES 1999–2006 by Liu L, Shao C, Li L, Wu N

“…We assessed the association between endometriosis and all-cause and cause-specific mortality using a retrospective cohort study design based on data from the National Health and Nutrition Examination Survey (NHANES) 1999– 2006.Materials and Methods: Both crude and multivariable-adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) for endometriosis and age at endometriosis with all-cause mortality were estimated using weighted Cox proportional hazards regression. …”
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Comparison of Effects of ACEIs and ARBs on Albuminuria and Hyperkalemia in Indonesian Hypertensive Type 2 Diabetes Mellitus Patients by Putri S. Agustina, Em Yunir, Pukovisa Prawiroharjo, Johanda Damanik, Rani Sauriasari

“…Therefore, it necessitates a detailed evaluation of the effects of ACEIs and ARBs on albuminuria and their side effect, hyperkalemia, specific to Indonesian T2DM patients. Methods. This cross-sectional study involved 134 T2DM patients whose treatment was restricted to either ACEIs (n = 57) or ARBs (n = 77) for at least two months before the study during May–October 2018. …”
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Exploring safety aspects of maternity care through the lens of midwifery students’ clinical experiences in Belgium, Czech republic, Estonia, Norway, Slovakia: A qualitative study by Daniela Javornická, Synnøve Mari Eidsvik Folkvord, Annelies Jaeken, Terézia Krčméryová, Helena Kisvetrová, Mary Steen

“…This paper explores aspects of maternity care services impacting patient safety as identified by midwifery students in five European countries. Methods A 2-stage qualitative design employed an interpretivist approach. …”
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Generación Z y gamificación: el dibujo pedagógico de una nueva sociedad educativa / Generation Z and gamification: the pedagogical drawing of a new educational society by Juan Carlos Manzanares Triquet

“…Furthermore, it contextualizes the role of technology and digital tools within current teaching methods. Lastly, this work examines in detail gamification as an innovation technique by scrutinizing the elements who shape it, their typology and the different phases that link their process in order to enable a learning experience in line with the particularities of nowadays students.…”
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Mediators affecting the higher risk of stillbirth among foreign‐born women in Sweden: A nationwide cohort study by Minna Lundén, Ingela Hulthén Varli, Helena Kopp Kallner, Hanna Åmark

“…In this nationwide cohort of more than 2 million births, we assessed the risk factors for stillbirth among foreign‐born women with the aim of understanding which mediators have the largest impact on the elevated risk of stillbirth. Material and Methods This was a nationwide cohort study in Sweden including 2 300 391 births between 2000 and 2021. …”
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Evaluation of the federal hospital atlas in the context of the hospital reform 2024: a critical analysis of the healthcare provision in German hospitals by Jonas Roos, Theresa Isabelle Wilhelm, Ron Martin, Kristian Welle, Elio Assaf, Robert Kaczmarczyk

“…Understanding regional differences in hospital characteristics—such as ownership type, staffing levels, emergency care provision, and specialization—is essential to assess the current state of healthcare and inform policy decisions. Methods We conducted a cross-sectional analysis of 1,628 hospitals using data from the Federal Hospital Atlas (as of April 2025). …”
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Predicting Drug Resistance: The Use of Novel Inflammatory Markers in Identifying ESBL-Producing Klebsiella pneumoniae by Ma X, Yuan J, Tang L, Chen X, Zhou Y, Wang N, Sun H

“…Xin Ma,1,2,* Jing Yuan,1,* Lihong Tang,1,* Xue Chen,1,* Yan Zhou,3 Ningna Wang,1 Hong Sun1 1Department of Clinical Laboratory, Urumqi Friendship Hospital, Urumqi City, Xinjiang Uygur Autonomous Region, People’s Republic of China; 2School of Basic Medicine, Xinjiang Medical University, Urumqi City, Xinjiang Uygur Autonomous Region, People’s Republic of China; 3The second Medical College, Xinjiang Medical University, Laboratory Class, Karamay City, Xinjiang Uygur Autonomous Region, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hong Sun, Urumqi Friendship Hospital, Tianshan District, Urumqi City, Xinjiang Uygur Autonomous Region, 830049, People’s Republic of China, Tel +86-13899816208, Email 632598426@qq.comPurpose: To explore the association of the Systemic Inflammatory Response Index (SIRI) and Systemic Inflammatory Immunity Index (SII) with extended-spectrum β-lactamase (ESBL)-producing Klebsiella pneumoniae (K. pneumoniae) and its resistance prediction.Methods: A total of 425 patients with K. pneumoniae infections were included in the study. …”
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Study on the Mechanism of UMI-77 in the Treatment of Sepsis-Induced Acute Lung Injury Based on Transcriptomics and Metabolomics by Zhang J, Xia Z, Dong C, Zhu J, Ni H, Xu Y, Xu Y

“…Although UMI-77 has demonstrated efficacy in mitigating lung injury in sepsis, the molecular mechanisms underlying its action have not yet been fully elucidated.Methods: This study aimed to delineate the mechanism by which UMI-77 counteracts sepsis-induced ALI using comprehensive transcriptomic and metabolomic analyses.Results: UMI-77 significantly ameliorated histopathological changes in the lungs of mice with sepsis-induced ALI Transcriptomic analysis revealed that 124 differentially expressed genes were modulated by UMI-77 and were predominantly implicated in chemokine-mediated signaling pathways, apoptosis regulation, and inflammatory responses. …”
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Exploration of Key Brain Regions Involved in Acupuncture and Moxibustion Analgesia: An Imaging-Based Study by He L, Zhou R, Hou S, Huang D, Zhao X, Wang M, Huang M, Yin T, Yin H, Yu S

“…Advancements in neuroimaging techniques have opened a novel pathway for investigating alterations in brain function resulting from acupuncture and moxibustion analgesia.Purpose: The purpose of this study was to investigate the brain regions activated during acupuncture and moxibustion treatment for pathological pain using neuroimaging, to better understand the underlying analgesic mechanisms.Patients and Methods: An electronic search of PubMed was conducted using the keywords “acupuncture”, “moxibustion”, “analgesia”, and “neuroimaging”. …”
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Synthesis of Zinc Oxide-Doped Carbon Dots for Treatment of Triple-Negative Breast Cancer by Wang M, Lan S, Song M, Zhang R, Zhang W, Sun X, Liu G

“…Mengqi Wang,1,* Shuting Lan,2,* Mingjun Song,3 Rongrong Zhang,2 Wenqi Zhang,2 Xiaomei Sun,2 Gang Liu2 1College of Life Science and Oceanography, Weifang University, Weifang, Shandong, People’s Republic of China; 2Key Laboratory of Medical Cell Biology, Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, People’s Republic of China; 3College of Chemical Engineering and Environmental Chemistry, Weifang University, Weifang, Shandong, People’s Republic of China*These authors contributed equally to this workCorrespondence: Mengqi Wang; Gang Liu, Email wangmengqi@tju.edu.cn; 20190043@immu.edu.cnIntroduction: The anti-cancer properties of zinc oxide-doped carbon dots (CDs/ZnO) in inhibiting triple-negative breast cancer (TNBC) progression merit more investigation.Methods: With citric acid as the carbon source, urea applied as the nitrogen source, and zinc oxide (ZnO) used as a reactive dopant, CDs/ZnO were synthesized by microwave heating in the current study, followed by the characterization and biocompatibility assessments. …”
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Biliary Microbial Community and Metabolic Potential in Patients with Multiple Common Bile Duct Stones by Xia T, Feng S, Zou Z, Zhou J, Cai X, Ye J, Dai C

“…In this study, we aimed to investigate the characteristics and metabolic potential of biliary microbiota in patients with multiple CBDS.Methods: Eligible patients were prospectively enrolled in this study at First Affiliated Hospital of Soochow University between December 2022 and October 2023. …”
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The Prognostic Significance of the CALLY Index in Ampullary Carcinoma: An Inflammation-Nutrition Retrospective Analysis by Xi P, Huang G, Huang K, Qin D, Yao Z, Jiang L, Zhu Q, He C

“…This study aims to investigate the relationship between the CALLY index and the prognosis of patients with AC.Methods: We retrospectively analyzed data from 201 patients with AC at Sun Yat-sen University Cancer Center. …”
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Comparison of the Efficacy of Polyvinyl Alcohol Colorless Embolic Microspheres (8Spheres) and Gelatin Embolic Microspheres (Embosphere) in Uterine Artery Embolization for Symptomat... by Gao S, Li F, Song F, Zhang X, Wang Y, Wang J

“…Songkun Gao,1,* Fengshuang Li,1,* Fang Song,1 Xiaofeng Zhang,2 Yan Wang,1 Jiandong Wang1 1Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100026, People’s Republic of China; 2Department of Radiology,Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, 100026, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan Wang, Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Qihelou Street, Dongcheng District, Beijing, 100006, People’s Republic of China, Email wwyy3196@ccmu.edu.cn Jiandong Wang, Department of Gynecologic Oncology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Qihelou Street, Dongcheng District, Beijing, 100006, People’s Republic of China, Email wangjiandongxy@ccmu.edu.cnObjective: To evaluate the differences in efficacy between polyvinyl alcohol colorless embolic microspheres (8Spheres®) and gelatin embolic microspheres (Embosphere®) in uterine artery embolization for symptomatic uterine fibroids.Methods: We included 259 patients from 12 hospitals who underwent uterine artery embolization for symptomatic uterine fibroids. …”
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A Graphene-Based Lipid Modulation Nanoplatform for Synergetic Lipid Starvation/Chemo/Photothermal Therapy of Oral Squamous Cell Carcinoma by Li R, Li Y, Song Z, Gu Y, Jiao X, Wan C, Liu T, Zhang R, Gao R, Wang X

“…In this study, we developed a graphene-based lipid modulation nanoplatform (NSD) that carries SB-204990, a small molecule inhibitor specific for ATP citrate lyase (ACLY), and doxorubicin (DOX), a chemotherapeutic agent, and the trio enables synergistic treatment of OSCC with lipid starvation, chemotherapy, and photothermal therapy.Methods: We first determined whether ACLY expression was upregulated in OSCC, and then assessed the growth inhibitory effects of SB-204990 on SCC-15 cells and changes in lipid (acetyl coenzyme A, free fatty acids, and cholesterol) levels. …”
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Trends and Dynamics of Respiratory Viruses in Hospitalized Children of Fuzhou: Insights Into the Impact of COVID-19 Pandemic Control Measures by Wu K, Huang H, Chen L, Wu Y

“…Kunhai Wu,1,* Huifang Huang,2,* Lufei Chen,1 Yanan Wu3 1Blood Transfusion Department, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 2Int Care Unit, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China; 3Department of Clinical Laboratory, Fujian Provincial Hospital, Fuzhou, Fujian, People’s Republic of China*These authors contributed equally to this workCorrespondence: Huifang Huang, Intensive Care Unit, Fujian Maternity and Child Health Hospital College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, Fujian, People’s Republic of China, Tel +8613906913057, Email 190596715@qq.comPurpose: This study aimed to investigate the prevalence of common respiratory viruses among children with acute respiratory infections in Fuzhou from 2017 to 2023, considering the varying Corona Virus Disease 2019 (COVID-19) epidemic control measures in place.Patients and Methods: This study retrospectively analyzed the detection of respiratory viruses in children diagnosed with acute respiratory infections at a tertiary hospital in Fuzhou during the study period. …”
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Ultrasound-Guided the Prevertebral Fascia Incise and the C5 Root Hydrodissection for the Treatment of Neurogenic Thoracic Outlet Syndrome: an Application Study by Liao Z, Zhou Y, Cao W

“…Zhenlan Liao,1,* Yajing Zhou,2,* Wen Cao3 1Department of Ultrasound, The First People’s Hospital of Neijiang, Neijiang, People’s Republic of China; 2Department of Ultrasound Medicine, TongRen Hospital, Capital Medical University, Beijing, People’s Republic of China; 3Department of Ultrasound Medicine, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wen Cao, The Department of Ultrasound Medicine, Beijing Chao-Yang Hospital, Capital Medical University, No. 8 Gongren Tiyuchang Nanlu, Chaoyang District, Beijing, 100020, People’s Republic of China, Tel +86 (010) 85231030, Email caowenemail@126.comObjective: The aim of this retrospective study was to evaluate the effectiveness of ultrasound-guided hydrodissection of the C5 nerve root, in combination with prevertebral fascia incision, as a treatment for neurogenic thoracic outlet syndrome (NTOS).Methods: Between January 2023 and January 2024, a total of 34 patients diagnosed with NTOS were enrolled in the treatment group, all of whom underwent ultrasound-guided hydrodissection of the C5 nerve root and prevertebral fascia incision. …”
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Kisspeptin-10: A Predictor for Fetal Growth Restriction among Preeclamptic Women that Discriminated Early Onset Cases by Manal Madany Abdalqader, Shatha Sami Hussein, Huda Fadhil Jadi, Wassan Nori

“…The current study aimed to examine Kisspeptin’s-10 role in predicting FGR in PE pregnancies and to verify whether it can predict its onset as early or late FGR. Methods: An observational case-control study enrolled 120 eligible cases at matched gestational age (28–40 weeks) and body mass index (BMI); they were divided into 2-groups: (60) healthy controls and (60) PE cases. …”
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Identification and Validation of Feature Genes Related to Mitochondrial Dysfunction and Oxidative Stress in Ulcerative Colitis by Wu Y, Tan Z, Lan Q, Liu Y, Liu C, He H, Zhang J, Dong W

“…Given their close association, it is crucial to clarify the molecular characteristics and biological functions of MD and OS-related genes in UC.Methods: Gene expression profiles, mitochondrial-related genes, and OS-related genes were obtained from the corresponding databases. …”
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Inequalities in early childhood care and development in low/middle-income countries: 2010–2018 by Kai Liu, Günther Fink, Bernadette Daelmans, Zhihui Li, Linda Richter, Chunling Lu, Jorge Cuartas, Dana McCoy

“…Improving and applying population-level measurements on ECD in more countries over time are important for ensuring equal opportunities for young children globally.…”
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