Study on the comparison between Bosentan and Macitentan in the treatment of persistent pulmonary hypertension of the newborns, simultaneously on sildenafil: A randomized double-bli... by Mandana Kashaki, Arash Mohazzab, Mohammad Radgoudarzi, Arash Bordbar, Sama Dabbagh

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Metformin Activation of Sirtuin 3 Signaling Regulates Mitochondrial Function Improves Diabetes-Associated Cognitive Impairment by An JF, Su H, Zhang CQ, Wang XT, Zhang GQ, Fu LY, Xu YN, Tao L, Shen XC

“…While metformin has demonstrated a significant impact on mitigating DACD, the precise mechanisms underlying its therapeutic effects remain inadequately understood.Objective: This study aims to examine the protective effects of metformin (MET) on DACD and to elucidate the underlying mechanisms involved.Materials and Methods: C57BL/6J male mice from in vivo animal experiments established DACD by high-fat diet (HFD) for 12 weeks, combined with intraperitoneal injection of low-dose streptozotocin (STZ, 40 mg/kg). …”
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An updated comparison of standard and novel FEV1 indices' association with all-cause mortality. by Stephen T Russell, Mohleen Kang, Jordan A Kempker

“…<h4>Objective</h4>This study evaluates the association between FEV1 value and mortality in six FEV1 indices in a large, U.S based cohort.<h4>Methods</h4>This is a cohort of 2007-2012 National Health and Nutrition Examination Study (NHANES) participants with spirometry and linked mortality data through 2019. …”
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Which men change in intimate partner violence prevention interventions? A trajectory analysis in Rwanda and South Africa by Rachel Jewkes, Nicola J Christofides, Andrew Gibbs, Esnat Chirwa, Kristin Dunkle, Shibe Mhlongo, Abigail Hatcher

“…However, it is unknown whether all men benefit equally, or whether different groups of men respond differentially to interventions.Methods We conducted trajectory modelling using longitudinal data from men enrolled in intervention arms of three IPV trials in South Africa and Rwanda to identify trajectories of IPV perpetration. …”
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Characterizing Patient Perceptions of Living with Geographic Atrophy: The Global Geographic Atrophy Insights Survey by Bakri SJ, Brinkmann CK, Mulvey A, Steinberg K, Katz R, Vatsyayan P, Sarda SP, Holekamp NM

“…Sophie J Bakri,1,&ast; Christian K Brinkmann,2,&ast; Amy Mulvey,3 Kathy Steinberg,3 Roz Katz,4 Pooja Vatsyayan,4 Sujata P Sarda,5 Nancy M Holekamp6 1Department of Ophthalmology, Mayo Clinic, Rochester, MN, USA; 2Department of Ophthalmology, Dietrich-Bonhoeffer Hospital, Neubrandenburg, MV, Germany; 3Media and Communications Research, The Harris Poll, Chicago, IL, USA; 4Global Commercial Strategy, Ophthalmology, Apellis Pharmaceuticals Inc, Waltham, MA, USA; 5Health Economics and Outcomes Research, Apellis Pharmaceuticals Inc, Waltham, MA, USA; 6Retina Services, Pepose Vision Institute, Chesterfield, MO, USA&ast;These authors contributed equally to this workCorrespondence: Sophie J Bakri, Department of Ophthalmology, Mayo Clinic, Rochester, MN, 55905, USA, Tel +1 507-284-3614, Email Bakri.Sophie@mayo.eduBackground: Geographic atrophy (GA) is an advanced form of age-related macular degeneration leading to irreversible vision loss and negative impacts on quality of life.Methods: To assess the experiences of living with GA, the Geographic Atrophy Insights Survey (GAINS) was conducted between October 12, 2021, and December 10, 2021, captured the responses of individuals ≥ 60 years with a self-reported GA diagnosis residing in the United States, Canada, Australia, and six European countries. …”
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High-Mobility Group Box-1 as a Predictor for Malignant Brain Edema Following Mechanical Thrombectomy in Acute Ischemic Stroke Patients by Chen X, E Y, Wang W, Huang Y, Xin X, Chen G

“…This study sought to investigate the potential association between circulating HMGB-1 levels and the risk of malignant brain edema (MBE) in patients undergoing mechanical thrombectomy (MT).Methods: This study prospectively recruited patients presenting with large vessel occlusive stroke in the anterior circulation and receiving MT treatment. …”
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Morphometric parameters of pelvic lymph nodes in experimental metastatic prostate cancer by V. V. Astashov, N. G. Kulchenko

“…Identification of structural and functional changes in pelvic lymph nodes in experimental metastatic prostate cancer.Materials and methods. The study included 30 male mice aged 3 months. …”
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Is High-Intensity Interval Training an Option for Post-Kidney Transplant Physical Rehabilitation Programmes? A Scoping Review by Lovatto V, Sousa BDS, Marães VRFDS

“…Viviane Lovatto,1,2,&ast; Bruna da Silva Sousa,1,&ast; Vera Regina Fernandes da Silva Marães1,3 1Postgraduate Programme in Health Sciences and Technologies, University of Brasília, Ceilândia, Brazil; 2Faculty of Physiotherapy, University of Rio Verde, Rio Verde, Brazil; 3Postgraduate Programme in Biomedical Engineering, University of Brasilia, Gama, Brazil&ast;These authors contributed equally to this workCorrespondence: Viviane Lovatto, Faculty of Physiotherapy, University of Rio Verde, Fazenda Fontes Do Saber - Campus UniversitáRio, Mailbox: 104 - Zip Code 75901-970, Rio Verde, Brazil, Email vivianelovatto@unirv.edu.brPurpose: To systematically and broadly review the literature to show the available information on high-intensity interval training for kidney transplant recipients as an adjunct to physical rehabilitation.Methods: A scoping review of high-intensity interval training for post-kidney transplant patients was conducted by searching the PubMed, EMBASE (Elsevier), Scopus (Elsevier), Web of Science, and PEDro databases. …”
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How do people with multimorbidity prioritise healthcare when faced with tighter financial constraints? A national survey with a choice experiment component by James Larkin, Louise Foley, Shane Timmons, Tony Hickey, Barbara Clyne, Patricia Harrington, Susan M. Smith

“…The aim of this study was to understand how people with multimorbidity prioritise different healthcare services when faced with tighter budget constraints and how they experience cost-related non-adherence. Methods A national cross-sectional online survey incorporating a choice experiment was conducted. …”
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Local Effect of Insulin on Healing of Extraction Socket (Experimental Study) by Waqass S. Thanoon, Omar W. Majid, Ali Khalil Marie

“…Evaluating oral mucosa healing and bone regeneration of the healing process during three intervals 3-, 10- and 30-days post-extraction. Materials and Methods: Twelve male albino rabbits were used in this study, randomly subdivided into three sub-groups (N=4) for the histological and immunohistochemistry evaluation at 3, 10, and 30 days post-extraction and compared to the controls. …”
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A Transcriptomic Biomarker for Predicting the Response to TACE Correlates with the Tumor Microenvironment and Radiomics Features in Hepatocellular Carcinoma by Wang C, Leng B, You R, Yu Z, Lu Y, Diao L, Jiang H, Cheng Y, Yin G, Xu Q

“…This study aimed to identify a biomarker for predicting TACE response in HCC patients and to investigate its correlations with the tumor microenvironment and pre-TACE radiomics features.Patients and Methods: GSE104580 data were obtained from the Gene Expression Omnibus (GEO) database. …”
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Comparing Liposomal Bupivacaine and Ropivacaine in Serratus Anterior Plane Block for Thoracoscopic Lobectomy: A Randomized Controlled Trial by Zhang Y, Li W, Wei A, Chen S, Wang X

“…We aimed to examine whether ultrasound-guided serratus anterior plane block (SAPB) with liposomal bupivacaine could provide continuous and effective analgesic effects for lung cancer patients undergoing VATS.Methods: A total of 64 patients were randomly allocated to receive either the liposomal bupivacaine (LB group) or the ropivacaine (RO group). …”
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Scoring System for the Japanese Version of the ICECAP-A by Sado M, Nagashima K, Koreki A

“…For “enjoyment” and “attachment”, the differences between levels 1 and 2 and between levels 2 and 3 were equally large. In contrast, for all other attributes, the greatest differences were observed between levels 1 and 2. …”
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Metformin's impact on asprosin and FBN1 expression: Potential mechanisms beyond insulin sensitivity in type 2 diabetes in rats by Ali Dashtkar, Mansour Karajibani, Mohsen Saravani, Roya zanganeh, Hamed Fanaei

“…The objective of this study is to investigate the effects of metformin on serum asprosin levels and FBN1 gene expression in white adipose tissue in male rats. Methods: Thirty-two male Wistar rats were randomly and equally divided into four groups (n = 8): 1. …”
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Epidemiological and etiological characteristics of community-acquired pneumonia in conscripts in the modern period. Comparative evaluation of the effectiveness of pneumococcal vacc... by P. V. Kulikov, S. D. Zhogolev, R. M. Aminev, K. D. Zhogolev, A. A. Kuzin, S. R. Rubova, A. N. Gorenchuk, E. A. Mikheeva

“…The purpose of the study is to analyze morbidity and to determine etiology of community-acquired pneumonia of conscripts, to examine the epidemiological effectiveness of pneumococcal conjugate and non-conjugate polysaccharide vaccines for the prevention of community-acquired pneumonia in soldiers.Materials and methods. The incidence of communityacquired pneumonia of conscripts in the period from 2008 to 2017 was examined. …”
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Impact of health intervention coverage on reducing maternal mortality in 126 low- and middle-income countries: a Lives Saved Tool modelling study by Xi-Ru Guo, Jue Liu, Hai-Jun Wang

“…We aimed to assess the impact of scaling up health intervention coverage on reducing MMR under four scenarios for 126 LMICs. Methods We conducted the modelling study to estimate MMR and additional maternal lives saved by intervention by 2030 for 126 LMICs using the Lives Saved Tool (LiST). …”
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The treatment characteristics of oral antipsychotics in treatment of adolescents with schizophrenia in China by Huaning Wang, Yongjing Zhang, Tao Wu, Sijia Dong, Rui Chi, Kun Jiang, Hong Qiu, Wentian Dong, Tianmei Si

“…Understanding the current practice of antipsychotics utilization is imperative to inform appropriate use in this population. Methods This retrospective cohort study used electronic medical records (2018–2022) from two hospitals in China. …”
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DYNAMICS OF HEART RATE VARIABILITY AND VENTRICULAR ECTOPIC ACTIVITY IN IVABRADINE-TREATED PATIENTS WITH CHRONIC HEART FAILURE by M. V. Surovtseva, N. A. Koziolova, A. I. Chernyavina

“…In patients with chronic heart failure (CHF) of ischemic aetiology, to assess the dynamics of heart rate variability (HRV) and ventricular ectopic activity during the complex, ivabradine-including therapy. Material and methods. In total, 90 patients with CHF and stable angina pectoris were examined. …”
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A comparative perception and impact of pictorial warnings on cigarette packaging among Malaysian smokers and non-smokers by Nurul Asyikin Yahya, Nur Aqilah Mohamed Kutty, Nurul Afira Saleh

“…This study aimed to assess the effectiveness of pictorial warnings on cigarette packaging among smokers and non-smokers. Methods A cross-sectional study using a self-administered questionnaire was conducted in Kuala Lumpur. …”
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Clinical Characteristics, Prognostic Risk Factors, and Primary Treatment for Elderly Patients with Primary Central Nervous System Lymphoma: A Seer Database-Based Research by Zhang M, Yang R, Du Y, Feng H, Liu Y, Liu H, Wu D, Niu F, He P

“…Moreover, there is currently no specific prognostic model for elderly PCNSL patients.Methods: This study retrospectively selected patients diagnosed with PCNSL between 1975 and 2016 from the National Cancer Institute Surveillance, Epidemiology, and End Results Database (SEER NCI). …”
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