Natural killer T cell immunotherapy combined with IL-15-expressing oncolytic virotherapy and PD-1 blockade mediates pancreatic tumor regression by Simon Gebremeskel, Adam Nelson, Brent Johnston, Brian D Lichty

“…It is likely that novel and combined therapies will be needed to achieve clinical benefits.Methods Using experimental mouse models of pancreatic ductal adenocarcinoma, we examined natural killer T (NKT) cell activation therapy in combination with a recombinant oncolytic vesicular stomatitis virus (VSVΔM51) engineered to express the cytokine IL-15 (VSV-IL-15). …”
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Cholesterol-Rich Antibiotic-Loaded Liposomes as Efficient Antimicrobial Therapeutics by Natsaridis E, Gkartziou F, Mouzoura P, Mourtas S, Papadia K, Kolonitsiou F, Klepetsanis P, Dermon CR, Spiliopoulou I, Antimisiaris SG

“…In this study, we investigated the effects of cholesterol (Chol) content of liposomes, liposome concentration, and surface coating with polyethylene glycol (PEG) on the antimicrobial activity of moxifloxacin (MOX) liposomes against Staphylococcus epidermidis (ATCC 35984) (S.e).Methods: MOX-liposome compositions with increasing Chol content were evaluated for their susceptibility to planktonic S.e (growth inhibition, killing, and live-dead staining), as well as against pre-formed biofilms (crystal violet, MTT assay, and confocal microscopy). …”
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A formal notation of legal rules applicable in the local space by Anna M. Barańska, Konrad Eckes

“…This approach to law allows for space management using IT methods. The notation of the spatial structure and of legal relationships related to time enable the definition of rules of conduct for diverse groups of local societies. …”
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A comparative study of student performance in all-ceramic crown preparation by clinical-phase students by Abdulkarim H. Alshehri, Mohammed M. Al Moaleem, Abdullah Ahmed Meshni, Thrya S. Gadah, Nasser M. Alahmari, Nassreen H. Albar, Hafiz Ahmed A. Adawi, Bandar M. A. AL-Makramani, Mosa A. Shubayr, Kulashekar Reddy Nandalur

“…Abstract Background Given ongoing discussions about potential gender disparities in clinical skill assessments within dental education, this study aimed to evaluate whether an analytic rubric could provide objective, equitable evaluation of all-ceramic crown preparations among male and female dental students. Materials and methods An analytical rubric for the evaluation of all-ceramic preparation steps was utilized in a clinical course study with two evaluators. …”
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Alterations in White Matter Structure in Sleep-Related Epilepsies: A TBSS-Based Diffusion Tensor Imaging Study by Wang Z, Liu W, Feng X, Wang Q, Ning X, Xing W

“…Ziyun Wang,1,2,* Weiping Liu,3,* Ximei Feng,4 Qian Wang,1,2 Xun Ning,1,2 Wu Xing1,2 1Department of Radiology, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 2National Clinical Research Centre for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 3Department of Neurology, Xiangya Hospital, Central South University, Changsha, People’s Republic of China; 4Department of Radiology, Changsha Central Hospital, University of South China, Changsha, People’s Republic of China*These authors contributed equally to this workCorrespondence: Wu Xing, Department of Radiology, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Changsha, Hunan, 410008, People’s Republic of China, Email xingwu@csu.edu.cnPurpose: The study aims to further investigate the relationship between the Sleep-related epilepsies (SRE) and alterations in the White Matter (WM) microstructure, as well as to explore the clinical value of diffusion tensor imaging (DTI) in patients with SRE.Methods: DTI data were acquired for 52 patients with SRE and 74 Healthy Controls (HC), all of whom were matched for sex and age. …”
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Development and validation of BCG vaccine‐induced novel granulomatous liver injury preclinical animal model by Swati Sharma, Abhishek Moudgil, Jyoti Grewal, Pankaj Khatri, Vishal Sharma, Madhumita Premkumar, Amanjit Bal, Dibyajyoti Banerjee, Amol N. Patil

“…The present study aimed to establish a preclinical model of granulomatous hepatitis by using the BCG (Bacillus Calmette‐Guérin) vaccine, further studying it in the presence of ATT dosing, and analyze the pharmacokinetics of isoniazid, rifampicin, and their respective primary metabolites. Methods We used 56 rats in seven equal groups. Group I functioned as a normal control (NC) receiving normal saline only. …”
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Clinical and hardware evaluation of moisturizing properties and tolerability of a emollient cream with filagrinol (“Admera”) in atopic dermatitis in children by S. S. Masalskiy, Yu. S. Smolkin, O. Yu. Smolkina

“…Evaluate the possibility of using a cream with 5 % filagrinol ("Admera") in children (0-18 years old) as an emollient in atopic dermatitis (AtD) and receive hardware measurements of skin hydration.Materials and methods. Open interventional study in parallel groups of children with AtD 0-18 years old (n = 72, median age 6 [3.75; 7.0] years). 2 equal groups: group 1 received methylprednisolone cream 1 time daily on lesions for 14 days + Admera emollient on the other skin; group 2 received the same treatment + cream with filagrinol 5 % applied from day 5 on the lesions.Results. …”
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Global Trends in the Incidence and Primary Causes of Femoral Fractures, Excluding Femoral Neck Fractures: A Global Epidemiological Study by Fu F, Liu B, Pu H, Wang Y, Zhang P, Wei S, Gu H, Zhang Q, Ye H

“…This study aims to analyze global patterns in the incidence and primary causes of femoral shaft fractures.Methods: Data from the Global Burden of Disease database were analyzed for femoral fractures (excluding femoral neck fractures) by age, gender, and socio-demographic index regions. …”
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The Effects of Trade Names on the Misuse of Some Over-The-Counter Drugs and Assessment of Community Knowledge and Attitudes in Alkarak, Jordan by Shaqfeh MI, Alsayed AR, Hasoun LZ, Khader HA, Zihlif MA

“…The Cronbach’s alpha was within the accepted range for all questionnaire items (0.7– 0.9).Results: Most participants were male (60.3%), with an average age equal to 38 ± 11.06 years, having a bachelor’s degree (61.0%) from humanity colleges (43.6%). …”
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Deep-EFNet: An Optimized EfficientNetB0 Architecture With Dual Regularization for Scalable Multi-Class Brain Tumor Classification in MRI by Hussein Alshaari, Saeed Alqahtani

“…Additionally, many current methods lack robust performance validation across multiple evaluation metrics. …”
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Glymphatic System Dysfunction in Thyroid Eye Disease Associated with Disease Activity and Duration by Zhang H, Jiang M, Liu Y, Lee XN, Fang Z, Li J, Li Y, Sun J, Tao X, Song X, Zhou H, Fan X

“…Haiyang Zhang,1,* Mengda Jiang,2,* Yuting Liu,1,* Xin Ning Lee,1 Zilin Fang,1 Jipeng Li,1 Yinwei Li,1 Jing Sun,1 Xiaofeng Tao,2 Xuefei Song,1 Huifang Zhou,1 Xianqun Fan1 1State Key Laboratory of Eye Health, Department of Ophthalmology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 2Department of Radiology, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xianqun Fan, Email fanxq@sjtu.edu.cn Huifang Zhou, Email fangzzfang@sjtu.edu.cnPurpose: To investigate the alterations in the glymphatic system in patients with thyroid eye disease (TED) using diffusion tensor imaging (DTI) analysis along the perivascular space (ALPS) and to explore the correlation between the glymphatic system and clinical features of TED.Methods: The study included 47 patients with TED, including 20 active TED patients (AP) and 27 inactive TED patients (IP), along with 24 healthy controls (HC). …”
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Manipulative Treatment of Myofascial Pain Syndrome: A Network Meta-Analysis Based on Randomized Controlled Trials by Chen J, Yin L, Hu Q, Liu S, Zeng L

“…We here conducted a comprehensive search of randomized controlled trial studies related to manipulative therapy for MPS and conducted a network meta-analysis to provide a basis for clinical applications and experimental studies.Methods: Reports on randomized controlled trials of noninvasive therapy for MPS deposited in the China National Knowledge Infrastructure database, Chinese Science Citation Database(CSCD), Chinese Citation Database(CCD), Chinese Biomedical Database, PubMed, Embase, Cochrane Library, and Web of Science from their respective inception dates until November 10, 2024, were retrieved. …”
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Mental Health Literacy and Professional Psychological Help-Seeking Attitudes Among Primary Healthcare Workers: The Mediating Role of Social Support and Mental Illness Stigma by He X, Chen S, Zhang Q, He S, Yang L, Ma J

“…It also explores the chain mediating roles of social support and mental illness stigma in this relationship.Methods: We conducted the study among primary healthcare workers in Shapingba District, Chongqing, China. …”
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The influence of acelysin and nimotop on the cellular response of the hippocampus during the dynamics of experimental subarachnoid hemorrhage by O. Yu. Polkovnikov, S. I. Tertyshnyi

“…Immunohistochemical study of rat hippocampal neurons and astrocytes at different time-points of experimental brain hemorrhage treated with acelysin and nimotop. Materials and methods. Subarachnoid hemorrhage (SAH) was modeled according to R. …”
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The Role of Fibrinogen in Mediating NGAL-Associated Neuronal Damage in Acute Ischemic Stroke: A Moderated Mediation Analysis by Zhao N, Chen Y, Lu Z, Han L, Song Y, Ding J, Zhu D, Guan Y

“…This study aimed to explore the association between NGAL, fibrinogen and neuronal damage in AIS.Methods: This study is a cross-section study. One hundred ninety-six successively hospitalized AIS patients in Renji Hospital in China between January 1, 2023, and May 31, 2023, were included. …”
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Healing of a skin wound when using Trigonella foenum‑graecum against the background of experimental steroid hyperglycemia by L. A. Balykova, V. I. Inchina, T. V. Tarasova, G. I. Myandina, D. A. Khaydar, E. A. Korovyakova, L. M. Mosina, I. V. Saushev, R. S. Tarasov, G. A. Bayburina, D. E. Bayburina, I. E. Trubitsyna

“…To evaluate the intensity of healing of an infected skin wound in rats using Trigonella foenum- graecum (Fenugreek) against the background of experimental steroid hyperglycemia.Materials and methods. The rats included in the study (n = 20) were divided into two equal groups. …”
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Correlation Between Monocyte Count, Monocyte–Lymphocyte Ratio, and Other Inflammatory Cells With Sleep and Psychiatric Symptoms in First-Episode Schizophrenia Patients by Hu C, Du N, Li J, Chen L, Meng X, Yao L, Yu T, Shi L, Zhang X

“…This study aimed to explore the correlation between inflammatory cell counts, sleep quality, and psychiatric symptoms in first-episode schizophrenia patients.Methods: A total of 103 first-episode schizophrenia patients (patient group) admitted to the Anhui Provincial Mental Health Center from November 2021 to August 2022 were included in the study, while 57 healthy individuals (control group) who met the criteria were recruited as the study subjects. …”
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Comprehensive Analysis of the Biomechanical Research of Pelvic Organ Prolapse: A Scientometric Approach by Du H, Yang M, Qi X, Yang L, Wang Z, Yang T, Xu S, Fu L

“…Despite the considerable number of biomechanical studies reported on POP, there remains a lack of a systematic approach to summarize and synthesize all existing research.Methods: The Web of Science Core Collection (WoSCC) database was used as the data source to select literature published from 2003 to 2023 related to biomechanical research of POP. …”
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Dynamics of free radical processes in the oral fluid of patients with chronic recurrent aphthous stomatitis at the first stage of therapy by O. V. Tarasova, A. V. Shumsky, O. N. Pavlova, O. N. Gulenko

“…In order to achieve the set objective we had to solve the following tasks: to evaluate the functional activity of free radical processes in the oral liquid of patients with CPAS on the background of antiseptics (chlorhexidine, octenisept, furacilin, myramistine) and anaesthetic (Camistad gel) application for 7 days.Materials and Methods. During the study the oral fluid of 120 people diagnosed with CPPS was studied, divided into 4 groups equally: Group 1 – control, patients used the antiseptic chlorhexidine for gargling; Group 2 – patients with CPPS therapy with octenisept; Group 3 – patients with CPPS therapy with furacilin; Group 4 – patients with CPPS therapy with miramistine. …”
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Temporal Trends of Polycystic Ovary Syndrome Burden in the East and Southeast Asia from 1990 to 2021: An Analysis from the Global Burden of Disease Study 2021 by Chen Q, Zhao J, Wu X, Xie X, Liu M

“…This study aims to assess the current burden of PCOS in East and Southeast Asia and analyze its spatiotemporal trends over the past three decades.Patients and Methods: Data on the prevalence, incidence, and years lived with disability (YLDs) due to PCOS from 1990 to 2021 were extracted from the GBD 2021. …”
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