Study on the spatial and temporal differences and influencing factors of out-of-pocket payments as a share of total health expenditure in China by Xiaoyu Dong, Huaizhi Cheng, Ruotong Tian, Lingxiao Gao, Wenpei Lyu, Jiaqi Zhang, Doudou Huang, Bin Guo

“…However, in China, research in this area is relatively scarce, and few studies have been conducted from a macro perspective and space-time dimension. Methods Based on the panel data of 31 provinces in China, the spatiotemporal distribution characteristics of the proportion of OOP payments in China from 2013 to 2022 were analyzed using spatial autocorrelation. …”
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Correlational Analysis of Resistant Hypertension with Diabetes Mellitus, Chronic Kidney Disease, and the Interplay of Sodium, Calcium, Magnesium, and Phosphorus by Feng XD, Wang SF, Qiao SY, Huang JY, Ma ZL, Zhou D, Tang JY, Wei YH

“…Xin-Di Feng,1,* Shao-Feng Wang,2,* Si-Yu Qiao,1 Jia-Ying Huang,3 Zi-Lin Ma,1 Duan Zhou,1 Jing-Yi Tang,3 Yi-Hong Wei1 1Department of Cardiovascular, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China; 2Department of Traditional Chinese Medicine, Chuansha Huaxia Community Health Service Center, Shanghai, People’s Republic of China; 3Department of Industry-university Cooperative Research Center, Shanghai University of Traditional Chinese Medicine, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jing-Yi Tang, Department of Industry-university cooperative research Center, Shanghai University of Traditional Chinese Medicine, No. 1200, Cailun Road, Pudong New District, Shanghai, 201203, People’s Republic of China, Tel +86-13601815342, Email dr_tang@163.com Yi-Hong Wei, Department of Cardiovascular, Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, No. 725, Wanping South Road, Xuhui District, Shanghai, 200032, People’s Republic of China, Tel +86-13801686228, Email tcmwyhdoc@163.comObjective: To analyze the relationship between resistant hypertension (RH) and hypertension, diabetes mellitus, chronic kidney disease, sodium, calcium, magnesium, phosphorus.Methods: A total of 475 patients with hypertension admitted to Longhua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine from January 2021 to December 2023 were divided into hypertension group (HT group) and resistant hypertension group (RH group). …”
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Comparison of the Dural Puncture Epidural and Conventional Epidural Analgesia Maintained Using Programmed Epidural Boluses for Labor Analgesia by Mo X, Yu J, Qin Z, Ma J, Chen Y, Chen X

“…We hypothesized that DPE, when combined with PIEB, not only speeds up analgesia onset but also improves neuraxial analgesia maintenance over EP.Patients and Methods: A total of 126 term nulliparous women with singleton pregnancies with a VAS pain score > 50 mm and cervical dilation < 5 cm were randomized to receive EP+PIEB or DPE+PIEB for labor analgesia, initiated with 15 mL of 0.0625% ropivacaine with 0.4 μg/mL of sufentanil using the EP or DPE technique (using 25-gauge Whitacre needle) technique and both maintained with the same solution for PIEB (fixed volume 10 mL, intervals 45 minutes, lockout interval 15 minutes) with labor analgesia. …”
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Determining the 90% Effective Dose of Remimazolam to Prevent Physical Movement in Surgical Abortions: A Biased-Coin Up-and-Down Sequential Allocation Trial by Fang F, Li H, Li L, Yan B, Yin P, Hu B, Zhu S, Kang X

“…However, its dosing references from clinical studies such as gastrointestinal and bronchoscopic anesthesia have resulted in high incidence of physical movement.Purpose: Determining the optimal dosage (the 90% effective dose [ED90]) for preventing physical movement during surgical abortions.Patients and Methods: Fifty-seven individuals aged 18 to 45 undergoing surgical abortion were included. …”
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Prognostic Value of Red Blood Cell Width Distribution-to-Platelet Ratio in Patients with Snakebite-Associated Multiple Organ Dysfunction Syndrome: A Retrospective Observational Stu... by Liang X, Xing D, Zhuang Z, Feng H, Li S, Fang X, Wang F, Qiu L, Chen XL

“…This study aims to explore the prognostic value of red blood cell distribution width (RDW) to platelet ratio (RPR) on multi-organ dysfunction (MODS) in patients with snake bites.Methods: A retrospective study included 637 patients with snakebite between 2015 and 2020 from two hospitals in Anhui province, China. …”
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Assessment of Dual Rinse Combined with Sodium Hypochlorite Irrigating Solution on Post-Instrumentation Pain and Bacterial Load Reduction: A Randomized Clinical Trial by Laila Zakaria Ismail Abdel-Hamid, Randa Mohamed El Boghdadi, Shaimaa Ismail Gawdat, Sherifa Tarek Salem, Noha Salah Soliman

“… Objective: The study compared the efficacy of Dual Rinse combined with sodium hypochlorite in comparison to sodium hypochlorite irrigating solution on post instrumentation pain incidence, reduction of the load of intracanal bacteria and periapical MMP-9 expression in patients with pulp necrosis. Material and Methods: Thirty-four patients diagnosed with a necrotic mandibular premolar having a single root canal were included. …”
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Tranexamic acid and tourniquet versus tourniquet for controlling blood loss during open abdominal myomectomy: a double-blind placebo-controlled randomised trial by George U Eleje, Kingsley E Ekwuazi, Victor I Amulu, Joseph T Enebe, Cyril C Dim, David M Aqua, Chidinma C Okafor, Chigozie G Okafor

“…Objectives To compare blood loss in reproductive-age women who received intravenous tranexamic acid plus tourniquet versus tourniquet and placebo during an open abdominal myomectomy.Methods This is a prospective three-centre double-blind randomised placebo-controlled trial of consenting eligible 114 women with uterine fibroids scheduled for open abdominal myomectomy. …”
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LncRNA PVT1 Promotes the Progress of Hypertrophic Scar via Regulating the Proliferation and Migration of Myofibroblasts Through Targeting miR-29a-3p/STAT3 by Han P, Liu R, Guan X

“…This research was aimed at exploring the clinical value of lncRNA PVT1 in HS formation and its potential mechanisms in human hyperplastic scar myofibroblasts (HSFs).Patients and Methods: Fifty-seven HS patients were enrolled. RT-qPCR was conducted to examine the RNA levels of lncRNA PVT1, miR-29a-3p and STAT3. …”
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Vaccarin Ameliorates Renal Fibrosis by Inhibiting Ferroptosis via Nrf2/SLC7A11/GPX4 Signaling Pathway by Cui M, Xu Q, Duan L, Lu J, Hu J

“…This study aimed to investigate the effects of vaccarin on RF and its molecular mechanisms.Methods: Network pharmacology was used to analyze the effect of vaccarin on RF, and molecular docking and molecular dynamics simulations were performed to assess the binding of nuclear factor erythroid 2-related factor 2 (Nrf2) to vaccarin. …”
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Development of Hybrid District Heating Systems by A. V. Sednin, K. M. Dyussenov

“…It is indicated that in order to ensure the required maneuverable properties of heat supply systems, it is necessary to develop and apply new methods of planning and managing heat supply systems, excluding a single-purpose approach in the organization of hybrid systems, which manifests a synergistic effect with new possibilities for finding optimal solutions aimed at reducing fuel consumption. …”
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The significance of the expression of cell proliferation and inflammation markers in the development of acquired middle ear cholesteatoma by Erdoglija Milan, Grgurević Uglješa, Cerović Snežana, Jović Milena, Baletić Nenad, Sotirović Jelena

“…This research should influence further studying of etiology and development of acquired middle ear cholesteatoma. Methods. We investigated clinical, histological and immunohistochemical characteristics of cholesteatoma in 50 samples from operated patients with acquired middle ear cholesteatomas. …”
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Runoff Variations and Quantitative Analysis in the Qinghai Lake Basin Under Changing Environments by Li Mo, Xinxiao Yu, Yonghan Feng, Tao Jiang

“…Abrupt changes were detected using the Mann–Kendall and cumulative anomaly methods, while the Budyko framework attributed runoff variations to dominant factors. …”
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Effects of Different Blood Flow Restriction Training Modes on Body Composition and Maximal Strength of Untrained Individuals by Hualong Chang, Xudong Yang, Biao Chen, Jianli Zhang

“…Additionally, we aimed to compare these effects with those observed in high-load resistance training (HL-RT). Methods: Thirty-three adults without prior professional sports or resistance training experience were recruited and randomly assigned to three groups (<i>n</i> = 11 per group) for an 8-week training program, held three times weekly. …”
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Effects of Aerobic Versus Resisted Intradialytic Exercises on Quality of Life, Pain, and Physiological Outcomes in Chronic Kidney Disease by Rania Nagy Karkousha, Amira Hussin Draz, Nesreen Gharib ElNahas, Efrem Kentiba, Mohamed Magdy ElMeligie

“…This aimed to comparatively assess the impact of intradialytic resistance and aerobic exercises on urea reduction rate concentration and various quality of life dimensions in chronic kidney disease patients. Methods: In this single-blinded, randomized controlled trial with a pre-and post-test design, 30 patients (both sexes, aged 25-35 years, BMI 18-25 kg/m²) diagnosed with stage 4 chronic kidney disease  and stable on dialysis for a minimum of 2 months were enrolled. …”
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Succinate Facilitates CD4+ T Cell Infiltration and CCL1 Production to Promote Myofibroblast Activation and Renal Fibrosis in UUO Mice by Tao Y, Zhang W, Liu D, Cao H, Yi X, Deng X, Li P, Shen X, Zhou H

“…However, the precise pathogenic mechanisms of succinate in obstructive nephropathy remain to be elucidated.Methods: Succinate was supplemented in the drinking water to study its impact on the pathogenesis of obstructive nephropathy induced by unilateral ureteral obstruction (UUO) in mice. …”
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Predictors of Cervical Cancer Screening Uptake among Healthcare Providers in Siaya County, Kenya by Zilper Imbuye, Damaris Ochanda, John Arudo

“…Methods: The study was conducted in Siaya County hospitals and adopted analytical cross-sectional study design. …”
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General practitioners’ familiarity, attitudes and practices with regard to Attention Deficit Hyperactivity Disorder (ADHD) in children and adults by Charmaine Louw, Marietjie M. Oswald, Mariechen D. Perold

“…The study also briefly explored the training models of GPs in South Africa. Methods: The research questions were addressed by means of a survey approach, using quantitative measures. …”
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Combining Dual Biologics Therapy for Severe Asthma: A Series of Ten Cases by Chen Y, Wang L, Xie J

“…Dual biologic therapy has emerged as a promising strategy, but its efficacy and safety are not yet fully understood.Objective: To describe the characteristics, endotyping features, decision-making process and therapeutic response of patients with severe asthma on dual biologic therapy in a real-world setting.Methods: We present ten patients on dual biologics for severe asthma. …”
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Causal Pathways Between Breast Cancer and Cardiovascular Disease Through Mediator Factors: A Two-Step Mendelian Randomization Analysis by Lu W, Li K, Wu H, Li J, Ding Y, Li X, Liu Z, Xu H, Zhu Y

“…Our study endeavors to investigate the causal association between BC and CVD, with a focus on identifying potential metabolic mediators and elucidating their mediation effects in this causality.Methods: In this study, we conducted two-sample Mendelian randomization (MR) to estimate the causal effect of BC (overall BC, ER+ BC, ER- BC) from the Breast Cancer Association Consortium (BCAC) on CVD including coronary heart disease (CHD), hypertensive heart disease (HHD), ischaemic heart disease (IHD), and heart failure (HF) from the FinnGen consortium. …”
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Clinical Characteristics and Prognostic Factors of Severe COVID-19 by Yang Y, Huang Z, Pei Y, Huang Y, Chen C, Zhou T

“…We aimed to identify the severe cases in early stages to improve the prognosis and mortality.Patients and Methods: We collected the clinical data of 98 patients with severe COVID-19, who were admitted to the Second Affiliated Hospital of Soochow University (Jiangsu, China) from December 2022 to November 2023. …”
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