Ultrasound-Guided Sural Nerve and Tibial Nerve Block Provides Comparable Analgesia to Popliteal Sciatic Nerve Block Following Calcaneal Surgery: A Single Center Randomized Controll... by Yao J, Cai J, Lu Q, Huang X

“…This study compared the efficacy of ultrasound-guided sural and tibial nerve blocks (ST) with popliteal sciatic nerve block (PS) for operative and postoperative analgesia.Methods: A total of 80 patients (40 per group) undergoing calcaneal surgery were randomized to receive either ST or PS nerve blocks. …”
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CITED2 Mediates Metabolic Reprogramming in Renal Tubular Epithelial Cells via the AKT Signaling Pathway to Induce Sepsis-Associated Acute Kidney Injury by Deng R, Yang H, Zhong W, Zhou J, Huang G, Zeng K

“…The aim of this study was to investigate the role of CITED2 in the metabolic reprogramming of TECs and its effects on inflammation and kidney injury in S-AKI.Material and Methods: The C57BL/6 mouse model of S-AKI was established using cecal ligation and puncture (CLP). …”
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Distance between implants has a potential impact of crestal bone resorption by Matteo Danza, Ilaria Zollino, Anna Avantaggiato, Alessandra Lucchese, Francesco Carinci

“…Implant length was shorter than 13 mm, equal to 13 mm and 16 mm in 23 (39%), 23 (39%) and 13 (22%) SFIs. …”
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The Prevalence of Potential Drug-Drug-Gene Interactions: A Descriptive Study Using Swiss Claims Data by Wittwer NL, Meier CR, Huber CA, Moser JD, Meyer zu Schwabedissen HE, Allemann SS, Schneider C

“…Nina L Wittwer,1,2 Christoph R Meier,1– 3 Carola A Huber,4 Julie D Moser,1 Henriette E Meyer zu Schwabedissen,5 Samuel S Allemann,6,* Cornelia Schneider1,2,* 1Basel Pharmacoepidemiology Unit, Division of Clinical Pharmacy and Epidemiology, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland; 2Hospital Pharmacy, University Hospital Basel, Basel, Switzerland; 3Boston Collaborative Drug Surveillance Program, Lexington, MA, USA; 4Department of Health Sciences, Helsana Group, Zürich, Switzerland; 5Biopharmacy, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland; 6Pharmaceutical Care, Department of Pharmaceutical Sciences, University of Basel, Basel, Switzerland*These authors contributed equally to this workCorrespondence: Samuel S Allemann, Pharmaceutical Care Research Group, University of Basel Department of Pharmaceutical Sciences Klingelbergstrasse 504056 Basel, Switzerland, Email s.allemann@unibas.chPurpose: We aimed to determine the prevalence of interactions between PGx drugs metabolized by CYP2C9, CYP2C19, and CYP2D6 and drugs that act as inhibitors or inducers of those enzymes in the Swiss population.Patients and Methods: We defined concomitant use of PGx drugs and inhibitors/inducers as instances where a claim of a PGx drug and a claim of an inducer or inhibitor concerning the same enzyme were made within a specified temporal window, either ± 5 days or ± 30 days. …”
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Effect of Different Doses of Esketamine on Postoperative Recovery in Patients Undergoing Gynecologic Laparoscopic Surgery, a Randomized, Double-Blind, Single-Center Clinical Study by Li T, Han L, Wu Z, Chen Y, Wang Y

“…Tingting Li,1,* Liuhu Han,2,3,* Zhen Wu,1 Yanfang Chen,1 Yiqiao Wang1 1Department of Anesthesiology, Anhui No.2 Provincial People’s Hospital, Hefei, People’s Republic of China; 2Department of Anesthesiology, The First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China; 3Department of Anesthesiology, Anhui Medical University, Hefei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yiqiao Wang, Department of Anesthesiology, Anhui No.2 Provincial People’s Hospital, North Second Ring, Yaohai District, Hefei, Anhui, People’s Republic of China, Tel +86 158 5694 0528, Email wyq20188@163.comPurpose: This study aimed to explore the effect of preoperative different doses of esketamine on postoperative recovery in patients undergoing gynecologic laparoscopic surgery.Methods: A total of 99 women scheduled for gynecologic laparoscopic surgery under general anesthesia were enrolled and randomized. …”
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Evaluating the Relationship Between Occupational Exposure to Polycyclic Aromatic Hydrocarbons (PAHs) and Urinary Metabolite Levels in Built-Up Roofing Asphalt Workers in Ilam City by Hossein Ali Rangkooy, Behzad Fouladi Dehaghi, Maedeh Kamalvandi, Hojatollah Kakaei

“…The aim of this study was to investigate the relationship between exposure to PAHs and urinary metabolites among built-up roofing installers. Material and Methods: The current case-control study, conducted in 2021 in Ilam City, involved 35 built-up roofing workers as the case group and 15 non-exposed workers as the control group. …”
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Indicators of cellular metabolism alterationsin patients with traumatic disease due to hypoxia, depending on a management regimen of intensive care by M. S. Matvieienko, Y. V. Volkova, I. V. Belozorov, K. E. Shamoun, O. V. Riabov, V. O. Pronin

“…The aim of this study was to evaluate changes in the level of erythrocyte metabolism under conditions of hypoxia in patients with traumatic disease in polytrauma depending on the components of intensive care (IC). Materials and methods. A prospective study was carried out in 88 patients suffering from polytrauma in the period from 2015 to 2017. …”
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Unveiling the Therapeutic Potential of Baicalin in Intervertebral Disc Degeneration: Integrative Bulk and Single-Cell Transcriptome Analysis with Experimental Validation of PANopto... by Wang X, Gao S, Zhou D, Cai W, Lv J, Wei Z, Song C, Shan X, Liu Z

“…PANoptosis, a recently identified form of PCD integrating pyroptosis, apoptosis, and necroptosis, may represent a more comprehensive target for therapeutic intervention in IVDD.Objective: To explore the role of PANoptosis in IVDD and investigate the therapeutic potential and underlying mechanism of baicalin in regulating PANoptosis to alleviate disc degeneration.Methods: We performed integrative analyses of bulk transcriptomic datasets (GSE167199, GSE245147, GSE266883) and a single-cell RNA-seq dataset (GSE244889) to identify PANoptosis-related genes involved in IVDD. …”
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Intermedin1-53 Improves Atherosclerosis by Reducing Local Endothelial Damage via AMPK Signaling Pathway in Obese apoE-Deficient Mice by Zhu HX, Ren JL, Cao WJ, Wang R, Chen LL, Gao Q, Zhou YB

“…In the present study, the role and mechanism of intermedin (IMD), a potent active peptide, in endothelial damage in AS in obese apolipoprotein E-deficient (apoE−/−) mice were investigated.Methods and Results: In vivo, IMD1-53 was infused via Alzet mini-osmotic pump in apoE−/− mice with high-fat diet (HFD) for 4 weeks. …”
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Healthy lifestyle and life expectancy in people with multimorbidity in the UK Biobank: A longitudinal cohort study. by Yogini V Chudasama, Kamlesh Khunti, Clare L Gillies, Nafeesa N Dhalwani, Melanie J Davies, Thomas Yates, Francesco Zaccardi

“…We investigated the associations between healthy lifestyle and life expectancy in people with and without multimorbidity.<h4>Methods and findings</h4>A total of 480,940 middle-aged adults (median age of 58 years [range 38-73], 46% male, 95% white) were analysed in the UK Biobank; this longitudinal study collected data between 2006 and 2010, and participants were followed up until 2016. …”
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Circulation of Fungi of the Genus Candida in Children's and Adult Multi Purpose Hospitals by M. I. Petrukhina, A. M. Martynova2, N. G. Politova, N. V. Starostina, A. N. Cairo

“…The aim of the work is to study the circulation of fungi of the genus Candida in children's and adult multi purpose hospitals.Materials and methods. A total of 61,226 studies of material obtained from patients in the children's hospital were performed. …”
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Increased Co-Expression of PD-L1 and CTLA-4 Predicts Poor Overall Survival in Patients with Acute Myeloid Leukemia Following Allogeneic Hematopoietic Stem Cell Transplantation by Chen C, Qiu K, Chen J, Wang S, Zhang Y, Wang C, Li Y

“…This study aims to investigate the significance of the alteration of IC co-expression for evaluating the prognosis of AML patients following allogeneic hematopoietic stem cell transplantation (allo-HSCT).Patients and Methods: Quantitative real-time PCR (qRT-PCR) data of bone marrow (BM) samples from 62 de novo AML patients, including 37 patients who received allo-HSCT and 25 patients who received chemotherapy only, were used for prognostic analysis.Results: High expression of PD-1, PD-L1, PD-L2, CTLA-4, and LAG-3 was associated with poor overall survival (OS) in AML patients receiving allo-HSCT, while the expression levels of PD-1, PD-L2, CTLA-4, and LAG-3, other than PD-L1, were not significantly correlated with OS in AML patients receiving chemotherapy. …”
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Retrospective cohort study on cumulative live birth rate of in vitro fertilization/intracytoplasmic sperm injection after multiple complete cycles in patients with diminished ovari... by Sisi Xi, Xiuli Yang, Jing Shang, Qing Xue

“…This study aimed to evaluate the cumulative live birth rate of in vitro fertilization / intracytoplasmic sperm injection after multiple complete cycles in patients with diminished ovarian reserve. Methods We performed a retrospective cohort study in female patients with diminished ovarian reserve undergoing in vitro fertilization / intracytoplasmic sperm injection cycle during the period from January 2016 to December 2020. …”
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Allopurinol in the complex therapy of acute decompensation of heart failure by Laura H. Sarieva, Marina D. Muksinova, Svetlana N. Nasonova, Igor V. Zhirov, Sergey N. Tereshchenko

“…To evaluate the efficacy of allopurinol in patients with ADHF, hyperuricemia, and reduced glomerular filtration rate compared with standard of care for 6 months. Materials and methods. We present the results of a 6-month follow-up for 72 patients with ADHF, hyperuricemia, and reduced filtration function of the kidneys, calculated using the CKD-EPI formula, divided equally into two groups: group 1 received standard of care for HF combined with a xanthine oxidase inhibitor – allopurinol, and group 2 received standard of care only. …”
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Integrated Fast Reactor Analysis and Calculation of Neutronics-thermal Coupling by LI Haotian, WU Mingyu, WU Zongyun, ZHOU Zhiwei, HUO Xingkai, XIAO Yubai

“…Through multi-physical coupling and refined computations, conducting high-precision numerical simulations of the reactor, and reducing various simplifications and approximations in traditional calculation methods, the actual operation of the reactor can be better reflected, providing verification for the reactor design scheme. …”
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Assessment of aortic elasticity parameters in obese and overweight children by Noor Mohammad Noori, Maryam Nakhaei-Moghadam, Alireza Teimouri

“…The aim of the study was to evaluate the aortic stiffness in obese and overweight children compared to healthy ones. Methods. The study evaluated 98 sex matched children aged 4 to 16 years that were equally distributed in asymptomatic obese or overweight and healthy children groups. …”
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Effectiveness of Microwave Therapy Combined with Berberine /GelMA via COX-2/IL-1&beta; Pathway to Treat Skeletal Muscle Injury: An in vivo Study in Rats by Du T, Zhou L, Liu J, Wang X, Xie H, Yang X, Yang Y

“…Berberine (BBR) has several pharmacological effects, including anti-inflammatory, anti-tumor, and anti-arrhythmic properties.Methods: In order to treat skeletal muscle injuries, a safe and non-toxic nanogel (BBR/GelMA) was developed for efficient berberine delivery. …”
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LBP-CD155 Liposome Nanovaccine Efficiently Resist Colorectal Cancer and Enhance ICB Therapy by Yan Y, Duan T, Xue X, Yang X, Liu M, Ma B, Duan X, Su C

“…Therefore, to improve the current prophylaxis and treatment scheme, offering a favorable strategy efficient against CRC is urgently needed.Methods: Here, we developed a nanovaccine (LBP-CD155L NVs) loaded with CD155 gene in liposome, which was modified by Lycium barbarum polysaccharides (LBP) through electrostatic interaction. …”
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Investigating Remedial Strategies for Missed or Delayed Dose of Sertraline in Chinese Adolescent Patients with Depressive Disorders via Population Pharmacokinetics Modeling and Sim... by Xia H, Deng G, Liang F, Zhang Z, Huang W, Guo Z, Song Q, Wen Y, Shang D, Tan Y

“…Hence, we designed the remedial strategies of different missed dosage scenarios based on population pharmacokinetics (PPK) model simulation, aiming to provide medication guidance to Chinese adolescent depressive patients.Methods: A total of 221 sertraline concentration monitoring data were collected from 103 sertraline-treated adolescent patients with depression. …”
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Relation of oncogenic microRNA-10b and microRNA-21 to glioblastoma size and localization by Nikitović Marina, Stepanović Aleksandar, Arsenijević Tatjana, Petrović Nina

“…Our study aimed to investigate whether there is a link between miR-10b and miR-21 expression levels and tumor size and tumor localization. Methods. The research involved 43 patients diagnosed with glioblastoma. …”
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