MUC1 and glycan probing of CA19-9 captured biomarkers from cyst fluids and serum provides enhanced recognition of ovarian cancer by Shamima Afrin Ruma, Rufus Vinod, Shruti Jain, Kaisa Huhtinen, Johanna Hynninen, Janne Leivo, Kim Pettersson, Karin Sundfeldt, Kamlesh Gidwani

“…Abstract Glycosylation changes of circulating proteins carrying the CA19-9 antigen may offer new targets for detection methods to be explored for the diagnosis of epithelial ovarian cancer (EOC). …”
Get full text

Global, regional, and national burden of cutaneous malignant melanoma from 1990 to 2021 and prediction to 2045 by Chengling Liu, Xingchen Liu, Li Hu, Xin Li, Haiming Xin, Sailin Zhu

“…To address this, we analyzed epidemiological patterns and investigated risk factors for CMM-related mortality.MethodsThis study analyzed CMM using data from the 2021 Global Burden of Diseases survey, covering 204 countries and territories. …”
Get full text

Protective effect of erythropoietin preconditioning on kidney ischemia-reperfusion injury by ZHANG Jiong, WANG Jia, WANG Fang, LI Gui-sen

“…Objective To explore the protective effect of erythropoietin(EPO)on renal ischemia-reperfusion injury(IRI)in rats.Methods Thirty male SD rats were randomly divided into sham operation group(Sham),renal IRI group(IRI)and EPO pretreatment group(EPO),10 rats in each group.The renal IRI model was constructed by clamping the left renal pedicle for 1h,removing the right kidney,and reperfusion for 24 h.In EPO group,EPO(1 000U/kg)was intraperitoneally injected at 1hbefore operation,while Sham group and IRI group were intraperitoneally injected with equal volume of normal saline.The left renal pedicle was clamped for 45 min in EPO and IRI groups,but not in Sham group.Renal perfusion was restored for 24 h,and then kidneys and serum were obtained.Enzyme linked immunosorbent assay(ELISA)was used to detect serum creatinine(SCr),blood urea nitrogen(BUN),pro-inflammatory cytokines [interleukin-6(IL-6);interferon gamma(IFN-γ)and tumor necrosis factor alpha(TNF-α)]and anti-inflammatory cytokine(IL-10 and TGF-β).The reverse transcriptase polymerase chain reaction(RT-PCR)was used to detect renal pro-inflammatory cytokines(IL-6,IFN-γand TNF-α)and anti-inflammatory cytokines[IL-10 and transforming growth factor beta(TGF-β)]mRNA expression levels.Western blotting was used to detect EPO receptor(EPOR),phosphorylated EPOR(p-EPOR),tyrosine kinase-2(JAK2),signal transducer and activator of transcription 3(STAT3),phosphorylated JAK2(p-JAK2),phosphorylated STAT3(pSTAT3)protein expression levels.Periodic acid Schiff staining(PAS)was used to examine the pathological changes of renal tissues.Results As compared with Sham group,the expression levels of pEPOR,p-JAK2,p-STAT3,SCr,BUN,IL-6,TNF-αand IFN-γwere significantly increased,pathological changes of renal tissues obviously alleviated,and expression levels of IL-10 and TGF-βwere markedly reduced in IRI group.There was no significant difference in EPOR,JAK2 and STAT3levels between Sham group and IRI group.As compared with IRI group,the expression levels of p-EPOR,p-JAK2,p-STAT3,IL-10 and TGF-βwere significantly increased,the levels of SCr,BUN,IL-6,TNF-αand IFN-γwere significantly reduced,and the pathological changes of renal tissues were significantly alleviated in EPO group,but there was no significant difference in EPOR,JAK2 and STAT3expression between IRI group and EPO group.Conclusions EPO preconditioning can alleviate inflammation by inhibiting renal IRI,which may be related with the activation of EPOR/JAK2/STAT3 signaling pathway.…”
Get full text

Global Burden of Alzheimer’s Disease Attributable to High Fasting Plasma Glucose: Epidemiological Trends and Machine Learning Insights by Ma Y, Huang S, Dong Y, Jin Q

“…This study aims to analyze global trends in AD death rates and disability-adjusted life years (DALYs) rates attributable to HFPG from 1990 to 2021 and assess the potential of glucose-related biomarkers in predicting cognitive impairment.Methods: Data from the Global Burden of Disease 2021 database were used to analyze AD death rates and DALY rates due to HFPG across 204 countries. …”
Get full text

Comparison of Percutaneous Transforaminal Endoscopic Surgery (PTES) With MIS-TLIF for Treating Lumbar Degenerative Disease in Obese Patients by Fan W, Chen Y, Zhou T, Xu Y, Gu Y

“…Wenshuai Fan,1,2,* Yuheng Chen,1,* Tianyao Zhou,1 Yun Xu,3,4 Yutong Gu1,4 1Department of Orthopaedic Surgery, Zhongshan Hospital Fudan University, Shanghai, People’s Republic of China; 2Department of Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, People’s Republic of China; 3Centre for Rehabilitation Medicine, Department of Pain Management, Zhejiang Provincial People’s Hospital, Zhejiang, People’s Republic of China; 4Shanghai Southwest Spine Surgery Center, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yutong Gu, Zhongshan Hospital Fudan University, 180 Fenglin Road, Shanghai, 200032, People’s Republic of China, Email 447574313@qq.com Yun Xu, Zhejiang Provincial People’s Hospital, Hangzhou Medical College, Hangzhou, 310014, People’s Republic of China, Email xuyun65204@163.comPurpose: The purpose of this study is to compare clinical outcomes of obese patients with lumbar degenerative disease (LDD) receiving either percutaneous transforaminal endoscopic surgery (PTES) or minimally invasive surgery-transforaminal lumbar interbody fusion (MIS-TLIF).Methods: There were 26 patients underwent PTES, and 29 patients were treated with MIS-TLIF between June 2014 and June 2019. …”
Get full text

Evaluation of the tubular penetration of two different types of nanoparticle root canal sealers over apically separated files: a scanning electron microscopic study (in vitro study... by Alaa H. Nagdi, Nayera A. Mokhless, Mahmoud R. Aboelseoud

“…Aim of the study This study aimed to evaluate tubular penetration of two nanoparticles modified root canal sealers compared to conventional sealers using ultrasonic activation over an apically separated file analyzed by scanning electron microscopy (SEM). Materials and methods Forty extracted single canaled mandibular premolar teeth were decoronated and prepared using M-Pro (IMD, Shanghai, China) nickel titanium rotary files which were intentionally separated at apical third. …”
Get full text

Distribution of Angle Alpha in a Large Population in Eastern China: An Analysis of the 30705 Eyes Using the Ray Tracing Aberrometer by Hua Z, Zeng Q, Zhang L, Shen J, Yang J

“…Zhixiang Hua,1– 5,* Qiulin Zeng,6,* Limei Zhang,7 Jiying Shen,7,* Jin Yang1– 5,* 1Department of Ophthalmology and the Eye Institute, Eye and Ear, Nose, and Throat Hospital, Fudan University, Shanghai, People’s Republic of China; 2The Key Laboratory of Myopia, Ministry of Health, Shanghai, People’s Republic of China; 3Shanghai Key Laboratory of Visual Impairment and Restoration, Shanghai, People’s Republic of China; 4Key National Health Committee of the Key Laboratory of Myopia, Fudan University, Shanghai, People’s Republic of China; 5The Key Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, People’s Republic of China; 6Department of Ophthalmology, Shanghai Xinshijie Dongqu Eye Hospital, Shanghai, People’s Republic of China; 7Department of Ophthalmology, Shanghai Heping Eye Hospital, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jin Yang, Department of Ophthalmology, Eye, Ear, Nose, and Throat Hospital of Fudan University, Shanghai, People’s Republic of China, Tel +008613671632525, Email jin_er76@hotmail.com Jiying Shen, Department of Ophthalmology, Shanghai Heping Eye Hospital, Shanghai, People’s Republic of China, Tel +008613817505149, Email susu22yoyo@163.comPurpose: To describe the distribution of angle alpha orientation and magnitude in a large population and to analyze the impact of eye laterality, gender, and age on angle alpha.Setting: EENT Hospital of Fudan University and Shanghai Heping Eye Hospital, 2017– 2023.Design: A retrospective analysis utilizing the iTrace system to examine preoperative angle alpha in patients undergoing cataract surgery.Methods: Angle alpha orientation and magnitude were collected from 30,705 individuals. …”
Get full text

Exploring Melasma Patients’ Needs Through Social Media: A Qualitative Study by Liu X, Liu X, Han Y, Cheng Y, Luo H, Liu Y, Li D, Guo W, Jiang H, Guo L, Jiang X

“…Xinjin Liu,1,2,* Xu Liu,1,2,* Yanbing Han,1,2 Yifei Cheng,1,2 Hongjie Luo,1,2 Yichen Liu,1,2 Dingling Li,1,2 Weihong Guo,1,2 Haoyu Jiang,1,2 Linghong Guo,1,2 Xian Jiang1,2 1Department of Dermatology, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China; 2Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, People’s Republic of China*These authors contributed equally to this workCorrespondence: Xian Jiang, Department of Dermatology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, People’s Republic of China, Tel +86 189 8060 1693, Email jiangxian@scu.edu.cn Linghong Guo, Department of Dermatology, West China Hospital, Sichuan University, No. 37 Guoxue Xiang, Chengdu, 610041, People’s Republic of China, +86 18380131660, Email Linhom.guo@foxmail.comPurpose: To identify the primary concerns and unmet needs of patients with melasma on social media using qualitative analysis and AI-based keyword extraction.Patients and Methods: We conducted a qualitative study of melasma patient discussions using publicly available posts on Facebook and Baidu. …”
Get full text

Parents’ perspective on children’s access to healthcare services and associated factors: a cross-sectional study by Nona Salimi, Javad Javan-Noughabi, Vahid Ghavami, Reza Matinfar, Fatemeh Kokabisaghi

“…This research aimed to explore parents’ perspective on children’s access to healthcare services and its associated factors. Methods In this cross-sectional study, 317 parents of children aged ≤ 18, chosen by two-stage cluster sampling participated. …”
Get full text

NOSOLOGICAL DIAGNOSIS OF JUVENILE ARTHRITIS AT DIFFERENT FOLLOW-UP STAGES by Svetlana Olegovna Salugina

“…Objective: to define the nosological category of juvenile arthritis (JA) in patients of different ages with different disease stages and follow-up periods. Subjects and methods. Group 1 included 135 children, mainly girls (60.7%), aged 1 to 16 years (range 7.9±5.0 years) with early-onset JA, the duration of which was 2 weeks to 6 months (range 2.9±1.6 months) who were further followed up for 2 years. …”
Get full text

MHR Was Associated with Hyperuricemia Risk in Patients with Type 2 Diabetes Mellitus: The Mediating Effect of Body Mass Index by Huang B, Li X, Zhang XX, Li SW, Wang M, Chen Q, Cao YD, Cui JQ

“…Therefore, our study specifically investigates the relationship between MHR and HUA in a T2DM population.Methods: This cross-sectional study enrolled 1,261 T2DM patients. …”
Get full text

Varicella-zoster virus vasculopathy: a rare complication of Ramsay Hunt Syndrome: a literature review by Di Wu, Mian Song

“…The aim of this review was to analyze clinical and neuroimaging findings, laboratory findings, treatment and outcome of these patients.MethodsWe report a literature review that includes all case reports identified via PubMed on RHSII complicated by VZV Vasculopathy. …”
Get full text

“It’s the Time they Take to Give Feedback; it has Become a Problem” Exploring Barriers and Facilitators for Research Supervision in Postgraduate Medical Education... by Abeid M, Mbekenga C, Jusabani AM, Kassamali SA, Mgonja ML, Sibuma M, Sirili N, Noorani M

“…We aimed to explore the barriers and facilitators for research supervision in postgraduate medical education in Tanzania.Methods: We adopted an exploratory qualitative case study and conducted key informant interviews with three purposively selected faculty in leadership and four focus group discussions with 14 postgraduate trainees and 10 faculty members. …”
Get full text

Huanglian Ejiao Decoction Alleviates Ulcerative Colitis in Mice Through Regulating the Gut Microbiota and Inhibiting the Ratio of Th1 and Th2 Cells by Tang J, Hu Y, Fang J, Zhu W, Xu W, Yu D, Zheng Z, Zhou Q, Fu H, Zhang W

“…Therefore, this study aimed to investigate whether HED could exert anti-inflammatory effects on 2,4,6-Trinitrobenzenesulfonic acid (TNBS)-induced colitis (UC) model through the regulation of CD4+T subsets and gut microbiota.Methods: Fifty-eight major compounds in HED were identified by UPLC-Q-TOF/MS. …”
Get full text

Combination of Diane-35 and Cangfu Daotan Wan Effectively Ameliorates Inflammatory Response, Stress State, and Hormone Levels in Patients with Polycystic Ovary Syndrome (PCOS), Lea... by Chen L, Fang CP, Chen Y, Gu WH, Wang SL, Niu N, Zhang QH

“…Li Chen,1,* Cai-Ping Fang,1,* Yan Chen,1 Wei-Hua Gu,1 Sai-Li Wang,1 Ning Niu,1 Qin-Hua Zhang2 1Department of Gynecology, Taizhou Hospital of Traditional Chinese Medicine, Taizhou, People’s Republic of China; 2Department of Gynecology, Shanghai Shuguang Hospital, Shanghai, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qin-Hua Zhang, Email bzie564@163.comObjective: To assess the impact of combining Diane-35 with Cangfu Daotan Wan on inflammatory response, stress response, and hormone levels in patients with polycystic ovary syndrome (PCOS), and to offer insights for clinical management.Methods: A retrospective analysis was conducted from January 2022 to March 2024, encompassing PCOS patients treated at our hospital who fulfilled the inclusion criteria. …”
Get full text

Machine Learning-Based Prediction Model for Multidrug-Resistant Organisms Infections: Performance Evaluation and Interpretability Analysis by Zhao W, Sun P, Li W, Shang L

“…This study evaluated an interpretable machine learning model incorporating SHapley Additive exPlanations (SHAP) to predict MDRO infections in ICU patients.Methods: A retrospective cohort study was conducted on 888 ICU patients (2020– 2022) from a tertiary hospital in China. …”
Get full text

Evaluation of Medical Device Aging and Replacement Decisions within Hospital Environments: A User-Centered Approach by Park S, Seo G, Park Y, Kim EJ, Lee H, Lee M, Jakovljevic M

“…We seek to prioritize criteria for medical device replacement and develop feasible strategies applicable to real-world healthcare settings.Methods: This analysis was conducted by reviewing previous studies to identify the key factors in medical device replacements. …”
Get full text

The Accuracy of Dynamic Parameters for Prediction of Fluid Responsiveness in Elderly Patients with Septic Shock by Paphawin S, Theerawit P, Junhasavasdikul D, Sutherasan Y

“…Sittikorn Paphawin,1,* Pongdhep Theerawit,2,* Detajin Junhasavasdikul,3 Yuda Sutherasan3 1Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 2Division of Critical Care Medicine, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand; 3Division of Pulmonary and Pulmonary Critical Care Medicine, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, Mahidol University, Bangkok, Thailand*These authors contributed equally to this workCorrespondence: Yuda Sutherasan, Division of Pulmonary and Pulmonary Critical Care Medicine, Department of Medicine, Faculty of Medicine Ramathibodi Hospital, 270 Rama VI Road, Ratchathewi, Bangkok, 10400, Thailand, Tel +6622011619, Fax +6622011629 Ext 2, Email Sutherasan_yuda@yahoo.comPurpose: Assessed the accuracy of stroke volume variation (SVV), pulse pressure variation (PPV), and dynamic arterial elastance (Eadyn) in predicting fluid responsiveness (FR) and mean arterial pressure (MAP) response in elderly patients with septic shock.Patients and Methods: Mechanically ventilated patients aged over 65 with septic shock were enrolled. …”
Get full text

The Advances in Utilizing Right Ventricular Function as a Predictor of Peripartum Cardiomyopathy Recovery: A Single Centre Prospective Cohort Study by Akbar MR, Sakasasmita S, Achmad C, Dewi TI, Hasan M, Prameswari HS

“…One of the contemporary predictors studied in cardiomyopathy is right ventricular (RV) function during initial presentation.Purpose: This study aimed to determine the role of RV systolic function based on the various RV function parameters by two-dimensional transthoracic echocardiography (2DE) to predict PPCM recovery within 6 months of follow-up and identify the most accurate parameter among them.Patients and Methods: This was a prospective cohort study that include all patients registered in the “Long Term Registry on Patients with Peripartum Cardiomyopathy” at Dr. …”
Get full text

CLSI-derived hematology and biochemistry reference intervals for healthy adults in eastern and southern Africa. by Etienne Karita, Nzeera Ketter, Matt A Price, Kayitesi Kayitenkore, Pontiano Kaleebu, Annet Nanvubya, Omu Anzala, Walter Jaoko, Gaudensia Mutua, Eugene Ruzagira, Joseph Mulenga, Eduard J Sanders, Mary Mwangome, Susan Allen, Agnes Bwanika, Ubaldo Bahemuka, Ken Awuondo, Gloria Omosa, Bashir Farah, Pauli Amornkul, Josephine Birungi, Sarah Yates, Lisa Stoll-Johnson, Jill Gilmour, Gwynn Stevens, Erin Shutes, Olivier Manigart, Peter Hughes, Len Dally, Janet Scott, Wendy Stevens, Pat Fast, Anatoli Kamali

“…The objective of this study was to establish clinical laboratory reference intervals for 25 hematology, immunology and biochemistry values among healthy African adults typical of those who might join a clinical trial.<h4>Methods and findings</h4>Equal proportions of men and women were invited to participate in a cross sectional study at seven clinical centers (Kigali, Rwanda; Masaka and Entebbe, Uganda; two in Nairobi and one in Kilifi, Kenya; and Lusaka, Zambia). …”
Get full text