Association of Recreational Physical Activity with Gut Microbiota Diversity and Composition, and Symptom Burden in Crohn’s Disease: A Cross-Sectional Study by Sun S, Chen Y, Zheng M, Zhou M, Weng C, Fan Y, Lv B

“…Shaopeng Sun,* Yifei Chen,* Mingxu Zheng, Mi Zhou, Chunyan Weng, Yihong Fan, Bin Lv Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Bin Lv, Department of Gastroenterology, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54, Youdian Road, Shangcheng District, Hangzhou, Zhejiang Province, 310003, People’s Republic of China, Email lvbin@medmail.com.cnObjective: This study aimed to investigate the potential benefits of physical activity (PA) on patient-reported outcomes (PROs) in individuals with Crohn’s disease (CD) and to examine whether these benefits are associated with gut microbiota.Methods: This cross-sectional study included 251 patients with CD from two inflammatory bowel disease centers in China. …”
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Predictive Value of Inflammation Markers for Frailty in Older Patients with CVD by Hu S, Lai X, Shi Y, Chai H, Guo Z, Liu D, Cui C

“…This study aimed to investigate the relationship between SIRI and frailty in older patients with CVD, and to develop a nomogram for predicting the risk of frailty in this population.Methods: A total of 234 older patients with CVD were included. …”
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Role of hydrops MRI in differentiating between Menière’s disease and vestibular migraine: a prospective study by Anja Bernaerts, Morgana Sluydts, Vincent Liégeois, Catherine Blaivie, Floris L. Wuyts, Floris L. Wuyts, Joost van Dinther, Andrzej Zarowski, Filip Deckers, Bert De Foer

“…ObjectiveWe investigated the effectiveness of delayed post-gadolinium (Gd) three-dimensional (3D) sampling perfection with application-optimized contrasts using different flip angle evolution (SPACE) fluid-attenuated inversion recovery (FLAIR) sequence to differentiate between Menière’s disease (MD) and vestibular migraine (VM) in a prospective study.MethodsA total of 31 patients—15 with MD (10 with definite MD and 5 with probable MD) and 16 with VM (9 with definite VM, 7 with probable VM)—were prospectively enrolled between January 2019 and December 2022. …”
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Dosimetric comparison of the carotid arteries in patients of T1 and T2 N0 M0 carcinoma glottis by three-dimensional conformal radiotherapy versus carotid sparing intensity-modulate... by Sathya SB, Sathiyan K, Harish Karthick R, Vijayasree TN

“…Aims and Objectives: This study aimed to compare the dosimetric impact of three-dimensional conformal RT (3DCRT) and Cs-IMRT on carotid artery exposure in patients with T1 and T2 N0 M0 carcinoma of the glottis. Materials and Methods: This prospective comparative study included 30 patients equally divided into 3DCRT and Cs-IMRT treatment arms. …”
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Urinary Ferritin as an Early Indicator of Tubular Injury in Diabetic Kidney Disease: Insights from NHANES and Clinical Cohorts by Huang B, Ding X, Wen W, Ye S

“…Bin Huang,1,* Xiangyu Ding,2,* Wenjie Wen,3 Shandong Ye1 1Department of Endocrinology, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People’s Republic of China; 2First Clinical Medical College, Anhui Medical University, Hefei, Anhui, 230001, People’s Republic of China; 3School of Stomatology, Wannan Medical College, Wuhu, Anhui, 241002, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shandong Ye, Department of Endocrinology, The First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People’s Republic of China, Email 981257013@qq.comObjective: To investigate the association between iron metabolism disorders and diabetic kidney disease (DKD) and to evaluate the potential of urinary ferritin as an early marker of tubular injury in diabetic patients.Methods: This study utilized data from 1,306 diabetic patients and 1,306 propensity score-matched non-diabetic controls from the NHANES (2017–March 2020) dataset. …”
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Factors Associated with Successful Treatment of Carbapenem-Resistant Gram-Negative Bacilli Infections Using Intravenous Colistin Sulfate in China: A Real-World Retrospective Study by Gao W, Li W, Liu H, Xu D, Tian L, Zhang J, Liu D, He Y

“…Weixi Gao,1,2,* Wei Li,1,* Huali Liu,3,* Dong Xu,4 Lei Tian,5 Jinwen Zhang,1 Dong Liu,1 Yan He1 1Department of Pharmacy, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 2Department of Pharmacy, Renmin Hospital of Wuhan University, Wuhan, 430060, People’s Republic of China; 3Cancer Center, Renmin Hospital of Wuhan University, Wuhan, 430060, People’s Republic of China; 4Department of Infection Disease, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China; 5Clinical Microbiology Laboratory, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yan He, Email heyan_may@hotmail.com Jinwen Zhang, Email jinwen_zhang0308@126.comObjective: To evaluate the efficacy of intravenous colistin sulfate (CS) in the treatment of carbapenem-resistant Gram-negative bacilli (CR-GNB) infections in real-world clinical settings and to identify factors influencing its therapeutic outcomes, with the aim of promoting the rational use of CS.Methods: A retrospective analysis was conducted on the clinical characteristics and treatment outcomes of 174 patients diagnosed with CR-GNB infection who received intravenous CS at our center between January 2021 and December 2023. …”
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Microcirculatory and functional changes in the retina and visual channels in multiple sclerosis by E. P. Lantukh, M. V. Zueva, I. V. Tsapenko, O. V. Zaitseva, M. N. Zakharova, N. M. Maglakelidze, T. O. Simaniv

“…Purpose: to compare subtle changes in retinal and optic disk morphology and microcirculation and the functional activity of visual channels in patients with multiple sclerosis (MS) and optical neuritis (ON) in the medical history. Material and methods: 19 patients with remitting MS (duration of about four years) and ON developed about six months ago were tested by standard neurologic and ophthalmologic techniques, optical coherent tomography (OCT) with the angio OCT (RTVue XR 100 Avanti) protocol. …”
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Combined Transcriptomic and Mendelian Randomisation Explores the Diagnostic Value of Ubiquitination-Related Genes in Sepsis by Bai X, Liu R, Tang Y, Yang L, Niu Z, Hu Y, Zhang L, Chen M

“…This study combined bioinformatics and Mendelian randomization (MR) analyses to identify ubiquitin-related genes (UbRGs) with unique roles in sepsis.Methods: Relevant genes were obtained from the GSE28750 dataset and GSE95233, weighted gene co-expression network analyses were performed to identify gene modules, and differentially expressed UBRGs (DE-UBRGs) were generated by differentially expressed genes (DEGs) crossover with key modular genes and UBRGs in sepsis and normal samples. …”
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Pharmaceutico Analytical and Clinical Evaluation of Modified Dosage Forms (Lepa guti) of Varun Twak Lepa and Krushnatiladi Lepa in Vyanga (Melasma): A Research Protocol for Randomi... by Pratiksha Mahure, Bharat Rathi

“…Aim: To conduct a pharmaceutical and analytical evaluation of modified dosage forms (Lepa guti) of Krushnatiladi Lepa and Varun Twak Lepa, as well as, to assess their clinical efficacy in managing Vyanga (melasma). Materials and Methods: A randomised double-blind, controlled clinical trial will be conducted Department of Rasa Shastra and Bhaishajya Kalpana, Mahatma Gandhi Ayurved College and Research Centre (MGACH and RC), Salod (H), Wardha, Maharashtra, India, from August 2024 to August 2025. …”
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Comparison between sulcus-implanted three-piece hydrophobic intraocular lens and bagal-implanted single-piece intraocular lens in combined diabetic phacoemulsification and pars pla... by Mohsen Abou Shousha, Mohamed H. Said

“…Objective The current study aimed to compare the sulcus-implanted three-piece hydrophobic IOL and the bagal-implanted single-piece hydrophobic IOL in combined diabetic phacoemulsification with pars plana vitrectomy in diabetic eyes. Patients and methods This is a prospective interventional comparative study of the eyes for which phaco-vitrectomy was performed for the complications of DR. …”
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Serum miR-130a-3p and miR-326: Correlation with Airway Inflammation and Prognostic Implications in Pediatric Bronchial Asthma by Liu D, Liao F, Wang H

“…Danhong Liu,* Fanda Liao,* Hongbing Wang Department of Pediatrics, Suizhou Hospital, Hubei University of Medicine, Suizhou, Hubei, 441300, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongbing Wang, Department of Pediatrics, Suizhou Hospital, Hubei University of Medicine, No. 60 Long Men Street, Zengdu District, Suizhou, Hubei, 441300, People’s Republic of China, Email wanghongbingwhb@21cn.comObjective: To investigate the relationship between serum microRNA (miR)-130a-3p, miR-326 and airway inflammation in children suffering from bronchial asthma.Methods: A retrospective study was conducted on 122 children suffering from bronchial asthma. …”
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Lactate Arterial-Central Venous Gradient among COVID-19 Patients in ICU: A Potential Tool in the Clinical Practice by Giuseppe Nardi, Gianfranco Sanson, Lucia Tassinari, Giovanna Guiotto, Antonella Potalivo, Jonathan Montomoli, Fernando Schiraldi

“…In physiological conditions, arterial blood lactate concentration is equal to or lower than central venous blood lactate concentration. …”
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Predictive Laboratory Markers for Gastrointestinal Complications in Children with Henoch-Schönlein Purpura by Guo Q, Xia S, Ding Y, Liu F

“…Identifying reliable predictive markers for GIS complications is crucial for early intervention and improved patient outcomes.Objective: This study aims to identify laboratory markers predictive of GIS complications in children with HSP using a machine learning approach.Methods: This retrospective study included children diagnosed with HSP and a control group from May 2020 to January 2024. …”
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COST-EFFECTIVENESS OF APIXABAN AS COMPARED WITH WARFARIN AND ACETYLSALICYLIC ACID IN PATIENTS WITH NON-VALVULAR ATRIAL FIBRILLATION IN THE RUSSIAN FEDERATION by A. V. Rudakova, V. A. Parfenov

“…To evaluate the cost-effectiveness ratio of apixaban compared with warfarin and acetylsalicylic acid in patients with NVAF from the Russian Federation national health care system perspective.Material and methods. This analysis used a Markov model that allowed estimation of the incremental cost-effectiveness ratio (ICER) for apixaban as compared with warfarin and acetylsalicylic acid over lifetime horizon in VKA suitable and VKA unsuitable patients with NVAF respectively. …”
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Age at diagnosis of autism spectrum disorders: is there an association with socioeconomic status and family self-education about autism? by Hrdlicka M, Vacova M, Oslejskova H, Gondžová V, Vadlejchova I, Kocourkova J, Koutek J, Dudova I

“…Mothers were significantly more active in seeking information on autism than fathers or both parents equally (80 vs 9 vs 28 cases, respectively; P<0.001). …”
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Utilizing Targeted Next-Generation Sequencing for Rapid, Accurate, and Cost-Effective Pathogen Detection in Lower Respiratory Tract Infections by Qin L, Liang M, Song J, Chen P, Zhang S, Zhou Y, Li H, Tang J, Ma Y, Yang B, Xu J, Zhang J

“…Lisha Qin,1,* Mengyuan Liang,1,2,* Jianping Song,1,* Ping Chen,1,* Shujing Zhang,3,* Yaya Zhou,1 Hui Li,1 Jian Tang,1 Yanling Ma,1 Bohan Yang,1 Juanjuan Xu,1 Jianchu Zhang1 1Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2Department of Respiratory and Critical Care Medicine, Zhengzhou University People’s Hospital, Henan Provincial People’s Hospital, Zhengzhou, People’s Republic of China; 3Department of Pediatrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China*These authors contributed equally to this workCorrespondence: Jianchu Zhang, Department of Respiratory and Critical Care Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China, Tel +86-13971445469, Email zsn0928@163.comObjective: To evaluate the diagnostic performance and clinical impact of targeted next-generation sequencing (tNGS) in patients with suspected lower respiratory tract infections.Methods: Following propensity score matching, we compared the diagnostic performances of tNGS and metagenomic next-generation sequencing (mNGS). …”
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Risk Factors for Depression and Nomogram Prediction Among Chinese Coronary Heart Disease Patients: A Multi-Center Study from 2016 to 2018 by Tong H, Zhang J, Jiang L, Dong L, Hu J

“…Hongxuan Tong,1,* Jiale Zhang,1,* Lijie Jiang,1 Lei Dong,2 Jiatong Hu3 1Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, Beijing, 100700, People’s Republic of China; 2Breast Department, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 3Acupuncture Department, Guang ‘anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongxuan Tong, Institute of Basic Theory for Chinese Medicine, China Academy of Chinese Medical Sciences, No. 16 Nanxiao Street of Dongzhimennei, Dongcheng District, Beijing, People’s Republic of China, Email Thongxuan1@163.com Jiatong Hu, Doctor, Acupuncture Department, Guang ‘anmen Hospital, China Academy of Chinese Medical Sciences, No. 5, Beixiangge Street, Xicheng District, Beijing, People’s Republic of China, Email 13716031300@163.comBackground: This study aimed to assess the prevalence and identify risk factors associated with depression among coronary heart disease (CHD) patients at different stages in China.Methods: Conducted as a hospital-based, cross-sectional study across 48 hospitals in 23 provinces, the research spanned from October 2016 to April 2018. …”
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The Utility of Synovial Fluid Interleukin-10 in Diagnosing Chronic Periprosthetic Joint Infection: A Prospective Cohort Study by Zou Y, Yang Y, Yang J, Zhang Y, Zhao C, Qin L, Hu N

“…However, limited research has explored the diagnostic potential of SF IL-10 in chronic PJI patients.Objective: The study aimed to investigate the relationship between SF IL-10 and incidence of chronic PIJ, and to evaluate its diagnostic reliability.Design and Methods: We analyzed data from 137 patients who underwent revision surgery for aseptic loosening or chronic PJI between 2017 and 2019 in our hospital. …”
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Evaluation of ChatGPT-4 in detecting referable diabetic retinopathy using single fundus images by Owais Aftab, Hamza Khan, Brian L. VanderBeek, Drew Scoles, Benjamin J. Kim, Jonathan C. Tsui

“…Design: A cross-sectional study comparing ChatGPT-4′s versus retina specialists’ identification of more than mild DR (mtmDR) and vision-threatening DR (VTDR). Methods: Images in equal proportions of normal, mild, moderate, and severe nonproliferative DR (NPDR), proliferative DR (PDR), and blurry images with and without suspected PDR were presented to a panel of blinded retina specialists who identified images as readable or unreadable, and potentially as mtmDR or VTDR. …”
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Ocular Manifestations of Perinatal HIV Infection in Kenyan Children on HAART: A Cross-Sectional Comparative Study by Alisi L, Armentano M, Visioli G, Mingaine MS, Albanese GM, Lucchino L, Bruscolini A

“…This study aims to report the prevalence of ocular involvement in a cohort of children with perinatally acquired HIV.Methods: This cross-sectional study recruited 73 HIV-positive and 59 HIV-negative age-matched children in Kenya. …”
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