The most effective combination of pharmacological therapy for heart failure with reduced ejection fraction: a network meta-analysis of randomized controlled trials by Huilin Tang, Kimberly Germinal, Alexandra Milfort, Wei-Han Chen, Shao-Hsuan Chang, Wenxi Huang, Yujia Li, Ying Lu, Mustafa M. Ahmed, Stephen E. Kimmel, Jiang Bian, Jingchuan Guo

“…This study aimed to evaluate the most effective combination of pharmacological therapy in patients with HFrEF. Methods We systematically searched Medline, Embase, and CENTRAL up to Feb 2022, to include randomized controlled trials (RCTs) that evaluated the efficacy of pharmacological treatment among adults (≥ 18 years) with a diagnosis of HFrEF (defined by a left ventricular ejection fraction ≤ 45%). …”
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General Practice-led urgent care practice vs. emergency room – satisfaction of ambulatory patients with low urgency medical problems by Katharina Schmalstieg-Bahr, Bastian Bessert, Penelope-Sophie Peters, Johanna Sophie Bobardt, Ulrich Mayer-Runge, Martin Scherer, Jan Oltrogge-Abiry

“…However, patients may perceive themselves as ER-cases and expect ER-treatment including extensive diagnostics.Objectives To assess UCP-patients’ satisfaction compared to ambulatory ER-patients.Methods Sub-analysis (11/2019–01/2020) of a prospective, monocentric observational study at the University Medical Centre Hamburg-Eppendorf ER and co-located UCP focusing on patient survey data including demographics, waiting time and diagnoses. …”
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Linking Diet and Homocysteine to complexity of coronary artery disease using SYNTAX score – A cross sectional study by Sowndarya Kollampare, Anupama Hegde, Arpit Jain, Padmanabh Kamath, Ramya Shenoy, Poornima A. Manjrekar

“…Influence of diet on Hcy and its relation to SYNTAX score was evaluated in newly diagnosed CAD. Methods: A cross-sectional analytical study was conducted in 160 patients aged 40–59 years diagnosed as CAD by the Cardiologist at a tertiary healthcare center. …”
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Association between the difference in estimated GFR based on cystatin C versus creatinine in coronary artery diseases by Zechen Liu, Wangying Jiang, Yanjun Song, Kefei Dou, Weihua Song

“…However, primary prevention of the risk of coronary artery disease (CAD) is equally important but there is a lack of studies specifically investigating this implication.Methods This prospective cohort study utilized data from the UK Biobank, including 437,536 participants without CAD at baseline. …”
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The effectiveness of David procedure for aneurysm of the root and ascending part of the aorta by O.V. Zelenchuk, B.M. Todurov, I.O. Stetsiuk, V.B. Demyanchuk, D.O. Loskutov, N.O. Yashchenko, N.V. Ponych

“…The aim – comparison of the results of David and Bentall operations in patients with aneurysms of the root and ascending aorta. Materials and methods. The one-centre study included 85 patients who underwent planned and urgent surgical treatment from 2019 to 2022. …”
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Use of Injection of Hemostatic Gelfoam Mixture During Percutaneous Core Biopsy for Renal Tumors: A Comparative Retrospective Study of Outcomes Regarding Bleeding Complications, Hos... by Antonios Michailidis, Georgia Mingou, Eleni Tsakirmpaloglou, Panagiotis Kosmoliaptsis, Danae Makri, Ioannis Papadimitriou, George Dimou, Christos Giankoulof, Evangelos Petsatodis

“…This study aimed to determine whether injecting a hemostatic Gelfoam mixture into the biopsy tract reduces post-procedural bleeding while maintaining diagnostic accuracy. <b>Methods:</b> This retrospective study included 500 patients who underwent PKB at our hospital between 2019 and 2024. …”
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Effectiveness and Safety of Dual Versus Triple Antibiotic Therapy for Treating Brucellosis Infection: A Retrospective Cohort Study by Yazed Saleh Alsowaida, Shuroug A. Alowais, Rema A. Aldugiem, Hussah N. Albahlal, Khalid Bin Saleh, Bader Alshoumr, Alia Alshammari, Kareemah Alshurtan, Thamer A. Almangour

“…This study aims to evaluate the effectiveness and safety of dual and triple antibiotic therapy for treating brucellosis. <b>Methods:</b> This is a retrospective cohort study for patients with confirmed Brucellosis infection from 2015 to 2024. …”
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Use of GetCheckedOnline and testing through healthcare providers among repeat users of British Columbia's digital testing service for sexually transmitted and blood-borne infection... by Mark Gilbert, Aidan Ablona, Hsiu-Ju Chang, Ihoghosa Iyamu, Rodrigo Sierra-Rosales, Heather Pedersen, Paul Flowers, Nathan Lachowsky, Daniel Grace, Catherine Worthington

“…To explore this further, we described patterns of provider-based testing among repeat users of a digital STBBI testing service, and their association with access barriers. Methods We conducted a cross-sectional survey in November 2022 of repeat GetCheckedOnline.com users (≥2 tests, with 1 test between April and October 2022). …”
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Three-year prognoses after low-dose oral food challenge for cow's milk by Mai Tokunaga, Ken-ichi Nagakura, Kyohei Takahashi, Sakura Sato, Motohiro Ebisawa, Noriyuki Yanagida

“…We investigated the long-term prognoses after an LD-OFC for CMA. Methods: Children with immediate CMA symptoms after consuming <25 mL of CM within 2 years of a baseline LD-OFC were retrospectively analyzed. …”
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The impact of pathogen reduction on ABO isoagglutinin titers in apheresis platelets by Mikayel Yeghiazaryan, Yembur Ahmad, Jessie Singer, Vaanush Nazaryan, Craig Fletcher, Yamac Akgun

“…Pathogen reduction technologies have been widely adopted to enhance the safety of blood products, however, the impact of such treatments on ABO isoagglutinin titers in platelet products remains unclear. Methods: This study analyzed 60 apheresis platelet donations, including type O, A, and B donors, using the INTERCEPT® Blood System for pathogen reduction. …”
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Reproducibility of Breech Progression Angle: Standardization of Transperineal Measurements and Development of Image-Based Checklist for Quality Control by Ana M. Fidalgo, Adriana Aquise, Francisca S. Molina, Aly Youssef, Otilia González-Vanegas, Elena Brunelli, Ilaria Cataneo, Maria Segata, Marcos J. Cuerva, Valeria Rolle, Maria M. Gil

“…<b>Objectives:</b> To evaluate the reproducibility of measurements of breech progression angle (BPA) by transperineal ultrasound (US) before and after its standardization by applying an image-based checklist. <b>Methods:</b> Eighteen 3-dimensional (3D) volumes of transperineal US from women at 36–40 weeks of gestation with a singleton fetus in breech presentation were provided to eight operators from four maternity units in Spain and Italy. …”
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Association between protein intake and sources in mid-pregnancy and the risk of gestational diabetes mellitus by Rui Wang, Xingyi Jin, Jian Zhu, Xiaocheng Li, Jian Chen, Chunyan Yuan, Xiaoli Wang, Yufeng Zheng, Shaokang Wang, Guiju Sun

“…Abstract Objectives This study aimed to investigate the relationship between dietary protein intake and sources in the second trimester of pregnancy and the risk of gestational diabetes mellitus (GDM) and to further investigate the effects of total protein and animal protein intake on the risk of GDM. Methods A case-control study was conducted, which involved 947 pregnant women in the second trimester from three hospitals in Jiangsu, China. …”
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A cross-sectional study evaluating insulin injection techniques and the impact of instructions from various healthcare professionals on insulin users in the southern region of Saud... by Sirajudeen Shaik Alavudeen, Md Sayeed Akhtar, Sultan Mohammed Alshahrani, Vigneshwaran Easwaran, Asif Ansari Shaik Mohammad, Noohu Abdulla Khan, Abubakr Taha Hussein, Salem Salman Almujri, Abdulrahman Saeed Alshaiban, Khalid Orayj

“…This study aims to investigate the knowledge, practices, and challenges faced by insulin users regarding IIT, as well as the impact of healthcare professionals’ education on it. Methods We conducted a questionnaire-based cross-sectional study using a validated online questionnaire to gather demographic and clinical data, as well as the participants’ knowledge, practices, and challenges related to insulin therapy. …”
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Effect of supervised exercise training on objectively measured physical activity in patients during anthracycline therapyKey points by Caroline Schneider, Laura Stuetz, Annika Dierks, Kristin L. Campbell, Matthias Wilhelm, Prisca Eser

“…Introduction: It is unknown what the benefits of cardio-oncologic rehabilitation programmes on cardiorespiratory fitness and cancer fatigue during anthracycline-based chemotherapies (AC) are with supervised exercise training (ET), compared to PA advice and tracking only. Methods: Patients with breast cancer or lymphoma were recruited from four cancer centres and randomly assigned to three months supervised ET during (EXduringAC) or after (EXpostAC) AC. …”
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The impact of probiotics on pulmonary, gastrointestinal, and growth outcomes in pediatric cystic fibrosis: a randomized controlled trial by Parisa Rahmani, Pejman Rohani, Arian Kariman, Farzaneh Motamed, Mohammad Reza Modaresi, Kambiz Eftekhari, Mehri Ayati, Mohammad Hassan Sohouli

“…The present study was conducted with the aim of investigating the effects of probiotic consumption in improving pulmonary, gastrointestinal, and growth symptoms in patients with CF. Materials and methods In this double-blind randomized clinical trial, 110 CF patients were examined. …”
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Bridging research integrity and global health epidemiology (BRIDGE) statement: guidelines for good epidemiological practice by Daniel Weibel, Walter Mendoza, Kristien Verdonck, Annick Lenglet, Sandra Alba, Sanjay Juvekar, Susan F Rumisha, Martijn Wienia, Imre Teunissen, Masja Straetemans, Daniel Jeannetot, Harriet Mayanja-Kizza

“…Research integrity and research fairness principles should be equally nurtured to produce high-quality impactful research—but bridging the two can lead to practical and ethical dilemmas. …”
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Excess mortality in young cancer survivors compared with the general population in Italy: a retrospective study from the Italian population-based cohort of adolescents and young ad... by Paolo Giorgi Rossi, Francesco Marinelli, Pamela Mancuso, Lucia Mangone, Massimo Vicentini, Isabella Bisceglia, Alice Bernasconi, Laura Botta, Annalisa Trama, Ada Working Group

“…We aim to calculate all-causes cancer and non-cancer excess mortality of young cancer survivors compared to the general population.MethodsThe AYA cohort includes cancer patients diagnosed between 1976 and 2013 and alive at 5 years after diagnosis in 30 population-based Cancer Registries and followed up until 31 December 2019. …”
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Grid-based analysis of three-dimensional choroidal Sattler’s and Haller’s layer vascularity volume index and its relation to age and axial length in adults by ultra-widefield swept... by Yuyao Qu, Jixian Ma, Rong Di, Yue Bian, Yuchen Li, Hanze Zhang, Yazhou Qin, Qiuping Liu, Jianqin Lei, Jingming Li

“…Abstract Background This study was to evaluate the features of choroidal Sattler’s and Haller’s layer (CSHL) vessels in adults and explore its relationship with factors such as age, axial length (AL) and body mass index (BMI) by using ultra-widefield swept-source optical coherence tomography angiography (ultra-widefield SS-OCTA). Methods 24mm × 20mm fovea centered rectangular SS-OCTA scans were acquired. …”
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Early Flap Reconstruction and Infection Rates in Open Lower Extremity Fractures: A Systematic Review and Meta-analysis by Rafael Felix P. Tiongco, BA, Siam K. Rezwan, BA, Sami Alahmadi, MSc, Matthew J. Heron, BS, Scott A. Sylvester, MD, Stella M. Seal, MLS, Tim de Jong, MD, PhD, Ala Elhelali, PhD, MSc, Lily R. Mundy, MD

“…We aimed to synthesize the literature and determine if time to flap is associated with reduced infection rates following traumatic lower extremity injuries. Methods:. We searched 5 databases for articles published before March 2023. …”
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Acupoint catgut embedding advantage in treating gastro-oesophageal reflux disease (ACE-GERD): study protocol for a randomised controlled trial by Xiaofeng Lin, Shuting Wen, Xiying Zhao, Zhaoli Fu, Shumin Qin, Qimou Pan, Fengbin Liu, Wenfang He, Tianwen Liu

“…This study will investigate the effects of ACE on anxiety, depression, acid reflux and heartburn in patients with GERD.Methods The ACE-GERD trial is a single-centre, prospective randomised controlled trial. 62 patients will be randomly assigned equally to the experimental and control groups. …”
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