Activity of imipenem/relebactam against KPC-producing Klebsiella pneumoniae and the possible role of Ompk36 mutation in determining resistance: an Italian retrospective analysis by Emanuele Palomba, Agnese Comelli, Francesca Saluzzo, Federico Di Marco, Elisa Matarazzo, Noemi Lo Re, Alessandra Bielli, Chiara Silvia Vismara, Antonio Muscatello, Marianna Rossi, Daniela Maria Cirillo, Alessandra Bandera, Andrea Gori

“…Our study aimed to analyse the in vitro activity of imipenem/cilastatin/relebactam (IMI/REL) against KPC-producing Klebsiella pneumoniae (KPC-Kp) and investigate the genetic determinants of resistance to this agent. Methods A total of 603 KPC-Kp strains, which were randomly collected during a multicentre study in northern Italy in the period 2016–2018, were analysed retrospectively. …”
Get full text

Diarrhea Prevalence and Sociodemographic Factors among Under-Five Children in Rural Areas of North Gondar Zone, Northwest Ethiopia by Atalay Getachew, Tadesse Guadu, Alebachew Tadie, Zemichael Gizaw, Mulat Gebrehiwot, Daniel Haile Cherkos, Martha Alemayehu Menberu, Teklay Gebrecherkos

“…Thus, the aim of this study was to assess diarrhea prevalence and sociodemographic factors among under-five children in rural areas of North Gondar Zone. Methods. A community-based cross-sectional study was conducted from April to June 2016 among 736 randomly selected households with one child under five years old. …”
Get full text

ANALYSIS OF SAFETY OF NEOADJUVANT CHEMORADIOTHERAPY IN PATIENTS WITH LOCALLY ADVANCED GASTRIC CANCER (RESULTS OF A MULTICENTER RANDOMIZED TRIAL) by V. Yu. Skoropad, S. G. Afanasyev, S. V. Gamayunov, P. V. Sokolov, V. A. Karov, L. N. Titova, N. K. Silanteva, S. A. Ivanov, A. D. Kaprin

“…The purpose of the study was to immediate results of neoadjuvant chemoradiotherapy in patients with locally advanced gastric cancer were analyzed in a multicenter randomized trial. Material and Methods. The comparative analysis of neoadjuvant chemotherapy regimens, toxicity and postoperative complications was carried out. …”
Get full text

Improving outcomes in acute coronary syndrome: A meta-analysis of home-based compared to hospital-based cardiac rehabilitation and usual care by Eva Marti, Anggoro Budi Hartopo, Haryani, Margareta Hesti Rahayu, Riris Diana, Ninik Yunitri

“…Aim: To assess the effectiveness of home-based cardiac rehabilitation (HBCR) in improving health-related quality of life (HRQoL) and other outcomes in patients with acute coronary syndrome (ACS), compared to hospital-based cardiac rehabilitation (CR) and usual care. Methods: This systematic review followed PRISMA guidelines and included a comprehensive search across MEDLINE, CINAHL, ProQuest, Cochrane Library, Clinical Key, PubMed, Embase, and ClinicalTrials.gov up to June 2023. …”
Get full text

The Effect of Pupil Size on Cone Contrast Sensitivity by Ali Almustanyir, Meznah S. Almutairi, Amal Aldrwish, Nabeela Hasrod, Bader A. Alqhtani, Tahani Alqahtani, Muteb Alanazi, Mansour Alghamdi, Essam Almutleb, Balsam Alabdulkader, Faisal Fakhouri, Mosaad Alhassan

“…This study examined how pupil size affects cone contrast sensitivity (CCS). Methods: This study included 50 participants of equal gender. …”
Get full text

ZnCl2 Precipitation-Assisted Sample Preparation for Proteomic Analysis by Qiqing He, Qingjing Chen, Dongxue Wang, Fuchu He

“…Additionally, ZASP outperformed other common sample preparation methods such as sodium deoxycholate (SDC)-based in-solution digestion, acetone precipitation, filter-aided sample preparation (FASP), and single-pot, solid-phase-enhanced sample preparation (SP3). …”
Get full text

Oxidative Distress in Patients with Polytrauma by M. Sh. Khubutia, A. K. Shabanov, G. V. Bulava, A. G. Dorfman, Z. M. Zainudinov, M. V. Skulachev, A. N. Kuzovlev, O. A. Grebenchikov, A. A. Sergeev, M. I. Shpitonkov, G. Yu. Maltsev

“…At the same time, the risk of lifethreatening infectious complications increases.Objective: to study oxidative distress over time and its association with early pulmonary infectious complications in patients with polytrauma.Subjects and methods. The authors examined 35 patients with polytrauma in the first 6—12 and 12—24 hours and 3, 5—7, and 10 days after injury and 25 healthy volunteers. …”
Get full text

Effect of concurrent chemoradiation with cisplatin versus concurrent chemoradiation with carboplatin in locally advanced carcinoma cervix: A quasi-experimental study by Syed Md. Asadul Hoque, Uday Kumar Sarkar, Mohammad Rahamatullah, Newton Kumar Sarker, Md Jamal Uddin, Md Abdul Bari

“…This study was aimed at comparing the treatment response and toxicity of carboplatin-based versus cisplatin-based concurrent chemoradiation in locally advanced carcinoma of the cervix. Methods: This quasi-experimental study was conducted from September 2022 to August 2023 on 80 patients with locally advanced carcinoma cervix. …”
Get full text

Socio-economic disparities in the appropriateness of diabetes care in an Italian region: findings of AEQUITAS study by Rosaria Gesuita, Francesca Piraccini, Edlira Skrami, Italo Paolini, Giuliano Sebastianelli, Carlo Stramenga, Dario Bartolucci, Alberico Marcobelli, Fabio Romagnoli, Giulia Silvestrini, Walter Ricciardi, Gianfranco Damiani, Flavia Carle

“…Background: To evaluate socio-economic disparities in diabetes prevalence and care in Marches (a region of central Italy) in 2003-2010 through a cross-sectional study. Methods: The databases of 52 general practitioners were mined for people with diabetes (age ≥20 years). …”
Get full text

Effect of icatibant on sweating-induced dermal pain by Shunsuke Takahagi, Shunsuke Takahagi, Daiki Matsubara, Emi Murakami, Yumi Aoyama, Shinya Imamura, Atsushi Fukunaga, Atsushi Fukunaga, Yoshiko Oda, Hiroyuki Murota, Michihiro Hide, Michihiro Hide

“…This study aimed to evaluate the analgesic effect of icatibant, a bradykinin B2 receptor antagonist, for the dermal pain induced by sweating stimuli and explored the role of bradykinin in its pathomechanism.MethodsThis single-blind, randomized, crossover study enrolled adult patients who had experienced severe sweating-induced dermal pain. …”
Get full text

Can the Methotrexate Therapy Prevent the Development of Uveitis in Patients with Juvenile Idiopathic Arthritis: Results of a Retrospective Study by M. M. Kostik, E. V. Gaydar, M. F. Dubko, V. V. Masalova, L. S. Snegireva, I. A. Chikova, E. A. Isupova, T. N. Nikitina, E. D. Serogodskaya, O. V. Kalashnikova, A. Ravelli, V. G. Chasnyk

“…Currently, the possibility of reducing the risk of uveitis in children with JIA by using methotrexate has been studied.Objective: Our aim was to analyze the results of treatment of children with JIA by studying the relation between the use of methotrexate and the risk of uveitis.Methods: A retrospective uncontrolled study. The case histories of patients with JIA who were treated for at least 2 years after the onset of the disease were studied. …”
Get full text

Effects of a 6-Week Concurrent Training Program Combining Resistance and Various Modalities of Aerobic Exercise in Obese Women with Prehypertension: A Randomized Controlled Trial by Jinhyuk Yu, Eunjoo Lee, Jae-Ho Choi, Yerin Sun, Seungyeon Woo, Sohyang Cho, Deunsol Hwang, Sung-Woo Kim, Jisu Kim, Kiwon Lim, Hun-Young Park

“…<b>Background/Objectives</b>: Our study aimed to verify the effects of 6 weeks of concurrent training composed of resistance training (RT) and different modalities of aerobic exercise (moderate-intensity continuous training (MICT) or high-intensity interval training (HIIT)) on body composition, blood pressure, vascular function, autonomic nervous system (ANS) function, blood lipid levels, cardiometabolic index (CMI), and health-related fitness in obese middle-aged women with prehypertension. <b>Methods</b>: We selected 26 middle-aged women with obesity and prehypertension and divided them equally into the RT + MICT (n = 13) and RT + HIIT (n = 13) groups. …”
Get full text

Pregabalin produces analgesia in males but not females in an animal model of chronic widespread muscle pain by Ashley N. Plumb, Kazuhiro Hayashi, Adam Janowski, Angela Smith, Lynn Rasmussen, Kathleen A. Sluka, Joseph B. Lesnak

“…The purpose of our study was to investigate potential sex differences in the analgesic efficacy of pregabalin that may contribute to disparities in human outcomes. Methods:. We used a mouse model of chronic widespread muscle pain (CWP) to test the effects of pregabalin on muscle hyperalgesia, nonreflexive pain, and motor behaviors. …”
Get full text

Strategies for men’s engagement and its effectiveness in improving child health and immunization—a rapid review by Sarah Nabia, Myra Betron, Elizabeth Arlotti-Parish, Amanda Varnauskas, Chinelo Cynthia Nduka, Angioha Pius, Jean Munro, Katharine Bagshaw, Chizoba Barbara Wonodi

“…The goal of this rapid review is to identify and summarize effective and promising strategies for men’s engagement in child health and immunization in low-and-middle-income countries (LMICs) and further categorize the strategies into its potential for gender transformative outcomes.MethodsWe searched PubMed, Embase and CINAHL databases for peer-reviewed literature and identified grey literature sources through key informant interviews. …”
Get full text

Analysis of modified sitting positions for subarachnoid block: A prospective observational study by Nousheen Chowdhary, Ajaiz Rasool, Raja Suhail Shounthoo, Majid Jehangir, Rohey Jan, Showkat Ahmad Gurcoo

“…Aims and Objectives: Comparison of three different sitting positions including classical sitting position (CSP), hamstring stretch position (HSP), and riders sitting position (RSP), for SAB. Materials and Methods: A total of 207 patients, divided equally into three groups (CSP, HSP and RSP) with 69 patients in each group. …”
Get full text

Three-Dimensional Printed Model of the Mediastinum for Cardiothoracic Surgery Resident Education by Catherine T. Byrd, MD, Winston L. Trope, BE, H. Henry Guo, MD, PhD, Kyle Gifford, BA, Prasha Bhandari, MPH, Jalen Benson, AB, Douglas Z. Liou, MD, Leah M. Backhus, MD, MPH, Mark F. Berry, MD, Joseph B. Shrager, MD, Natalie S. Lui, MD, MAS

“…We hypothesized that a 3-dimensional printed model of the mediastinum would be an effective tool for teaching residents the anatomy and techniques for mediastinoscopy. Methods: A color model of the mediastinum was 3-dimensionally printed based on segmented computed tomographic images. …”
Get full text

Comparison of analytical sensitivity of automated microbiological blood culture systems by Lyamin A.V., Ismatullin D.D., Kozlov A.V., Alekseev D.V., Kayumov K.A., Bochkareva P.V., Antipov V.A.

“…To compare analytical parameters and sensitivity between BACT/ALERT® 3D 60 and Yunon® Labstar 50. Materials and Methods. The study included 20 species of clinically significant microorganisms isolated from blood (20 strains for each facultative anaerobic species and 10 strains for each aerobic species). …”
Get full text

Bleaching efficacy of in-office bleaching with violet light using low-concentration hydrogen peroxide nanoparticulate photocatalyst gel: A randomized controlled trial by Gustavo Garcia Castro, Palena Araújo Pinto, Michael Willian Favoreto, Alessandra Reis, Maria Viviana-Mora, Rita de Cássia Mendonça de Miranda, Andres Felipe Milan Cardenas, Alessandro D. Loguercio, Rudys Rodolfo de Jesus Tavarez

“…Objective: This randomized controlled trial aimed to evaluate the bleaching efficacy and tooth sensitivity (TS) of participants submitted to different application protocols of in-office bleaching with violet light using 6 % hydrogen peroxide (HP) nanoparticulate photocatalyst gel. Materials and methods: Sixty-six participants were randomized and bleached using either a 6 % HP (Nano White, DMC), and/or violet light (Bright Max Whitening, MMOptics), according to the following protocols: 1) only violet light (VIOL); 2) only bleaching gel application (BG) and; 3) combined bleaching gel application + violet light (BG+VIOL). …”
Get full text

Enhanced levels of IL-6 and PAI-1 and decreased levels of MMP-3 in cytomegalovirus seropositive patients with prior myocardial infarction by Xinling Xu, Angela Silveira, Pia Lundman, Afsar Rahbar, Cecilia Söderberg-Nauclér

“…While CMV seroprevalence was equal, the CMV-IgG levels were higher in controls. …”
Get full text

Development and evaluation of a web-based diet quality screener for vegans (VEGANScreener): a cross-sectional, observational, multicenter, clinical study by Tooba Asif, Anna Ouřadová, Ainara Martínez Tabar, Vanessa Bullón-Vela, Sandra Müller, Joelina Dietrich, Vanessa Keller, Marina Heniková, Eliška Selinger, Isabelle Herter-Aeberli, Maria Wakolbinger, Willem De Keyzer, Willem De Keyzer, Wendy Van Lippevelde, Monika Cahová, Leonie H. Bogl, Leonie H. Bogl, Marek Kuzma, Maira Bes-Rastrollo, Maira Bes-Rastrollo, Stefaan De Henauw, Markus Keller, Selma Kronsteiner-Gicevic, Selma Kronsteiner-Gicevic, Eva Schernhammer, Eva Schernhammer, Jan Gojda

“…To provide a standardized tool for public use, a clinical study will be conducted to evaluate the VEGANScreener against a reference dietary assessment method and nutritional biomarkers. An observational study is set to include 600 participants across five European sites – Belgium, Czech Republic, Germany, Spain, and Switzerland. …”
Get full text