Cerebrospinal fluid (CSF) CD8+ T-cells that express interferon-gamma contribute to HIV associated neurocognitive disorders (HAND). by Rachel D Schrier, Suzi Hong, Melanie Crescini, Ronald Ellis, Josué Pérez-Santiago, Celsa Spina, Scott Letendre, HNRP Group

“…However, in the ART era, there is increasing evidence for the involvement of CD8+ T-cells in CNS pathogenesis.<h4>Methods</h4>To investigate the relationship between T-cell responses and neurocognitive impairment (NCI), cerebrospinal fluid (CSF) and peripheral blood CD4+ and CD8+ T-cell intracellular cytokine (IFNγ, IL-2, TNFα) and lytic marker (CD107a) expression were assessed in HIV infected subjects who underwent comprehensive neurocognitive (NC) evaluation and either initiated or changed ART.…”
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Efgartigimod Followed by Telitacicept in Adult Generalized Myasthenia Gravis: A Retrospective Case Series by Zhang Y, Fang Z, Liu Y, Wan B, Zhang Q, Qu X, Pan S, Zhang Y, Dai Y, Yang S, Li J, Zhang X

“…Yuan Zhang,1,&ast; Zheyu Fang,1,&ast; Yaping Liu,2,&ast; Bingbing Wan,1 Qiaoyi Zhang,1 Xi Qu,1 Shengli Pan,1 Yu Zhang,1 Yilin Dai,1 Shiyin Yang,1 Jia Li,1 Xu Zhang1 1Department of Neurology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, People’s Republic of China; 2Department of Neurology, Lianshui People’s Hospital, Huai’an, Jiangsu, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Jia Li, Email lijia@wzhospital.cn Xu Zhang, Email drzhangxu@live.cnBackground: The emergence of biologics for the treatment of generalized myasthenia gravis (gMG) has increased therapeutic options, but evidence on their flexible use remains limited.Purpose: This study retrospectively analyzed gMG patients treated with efgartigimod followed by telitacicept.Methods: A retrospective analysis was conducted on gMG patients treated with efgartigimod followed by telitacicept. …”
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Multi-platform integration of histopathological images and omics data predicts molecular features and prognosis of hepatocellular carcinoma by Linyan Chen, Yang Li, Zhiyuan Zhang, Tongshu Yang, Hao Zeng

“…This study extracted quantitative histopathological image features to predict molecular features, and combined them with omics data to predict prognosis of hepatocellular carcinoma (HCC) patients.MethodsTotally 334 patients from The Cancer Genome Atlas were divided equally into the training and testing sets. …”
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Bereaved parents’ perceptions of their cancer-ill child’s last month with or without palliative care - a nationwide study by Margaretha Stenmarker, Margaretha Stenmarker, Margaretha Stenmarker, Lilian Pohlkamp, Josefin Sveen, Ulrika Kreicbergs

“…In accordance with international standards, equal and early access to palliative care should be available to children and adults. …”
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A Composite Index for Distinguishing Benign and Malignant Obstructive Jaundice by Peng H, Li J, Zhou X, Nong Z, Zhang R, Lu P, Ye S, Lei L, Qin C, Li J

“…Hao Peng,1,2,&ast; Jixue Li,1,&ast; Xiaoru Zhou,1 Zhewen Nong,1 Ruiying Zhang,1 Pei Lu,1 Shasha Ye,1 Liping Lei,3 Chuang Qin,2 Jiangfa Li1,4,5 1Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical University, Guilin, 541001, People’s Republic of China; 2Department of Hepatobiliary and Pancreatic Surgery, Liuzhou People’s Hospital, Liuzhou, 545001, People’s Republic of China; 3Department of Geriatric Medicine, The Affiliated Hospital of Guilin Medical University, Guilin, 541001, People’s Republic of China; 4Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University), Ministry of Education, Nanning, 530021, People’s Republic of China; 5Guangxi Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor, Nanning, 530021, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Chuang Qin, Department of Hepatobiliary and Pancreatic Surgery, Liuzhou People’s Hospital, No. 8, Wenchang Road, Central District, Liuzhou, 545001, People’s Republic of China, Email 382944957@qq.com Jiangfa Li, Department of Hepatobiliary and Pancreatic Surgery, Affiliated Hospital of Guilin Medical University, No. 15, Lequn Road, Xiufen District, Guilin, Guangxi, 541001, People’s Republic of China, Email 247546160@qq.comObjective: To explore a more effective and practical comprehensive index for differentiating benign from malignant obstructive jaundice by analyzing the clinical data of patients with benign obstructive jaundice (BJ) group and malignant obstructive jaundice (MJ) group.Methods: A retrospective analysis was conducted on the clinical data of 339 patients with obstructive jaundice. …”
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Cellular Heterogeneity and IL-17 Pathway Dynamics Reveal Insights into the Transition from Ulcerative Colitis to Colorectal Cancer Through scRNA-Seq Analysis by Li Y, Sun R, Wang X, Ma M, Wang H, Yang B, Lu Y, Li Y

“…A deeper understanding of these changes is essential for identifying potential therapeutic targets and improving disease outcomes.Methods: We performed scRNA-seq on tissue samples from a patient with coexisting UC and CACRC lesions, including normal colon, UC-affected tissue, and CACRC. …”
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Antibiotics consumption in the Eastern Region Of Libya 2012-2013 by A Khalifa, S Bukhatwa, M Elfakhri

“…The aim of this study is to assess the trend of antimicrobial consumption in the Eastern region of Libya during 2012 – 2013. Methods: Antimicrobial consumption data from the years 2012 and 2013 were obtained mainly from Benghazi office, Medical Supply Organization (MSO; the only official drug-importing body in Libya). …”
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Electromechanical Regulation Underlying Protein Nanoparticle-Induced Osmotic Pressure in Neurotoxic Edema by Zheng Z, Nie A, Wu X, Chen S, Zhang L, Yang D, Shi Y, Xiong X, Guo J

“…This study has investigated how PNs control the neuronal swelling through electromechanical activity.Methods: The fluorescence resonance energy transfer (FRET)-based Vimentin force probe was used to real-time monitor the osmotic tension in neurons. …”
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Inequalities and factors associated with maternal healthcare services utilisation in Mozambique: evidence from the Demographic and Health Survey 2022−2023 by Sergio Chicumbe, Nazeem Muhajarine, Fernanda Andre, Md Sabbir Ahmed, Nahin Shakurun

“…A key strategy for reducing maternal and child mortality is to promote adequate access to and utilisation of maternal healthcare services.Methods We used the population-based, nationwide, cross-sectional Mozambique Demographic and Health Survey 2022–2023 data (n=3808). …”
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Impact of Simulation-Based Surgical Training in Laparoscopy on Satisfaction Level and Proficiency in Surgical Skills by Mukhtar F, Shaheen MF, Alhabeeb AY, Zafar M, Alkattan K

“…This study aims to assess GS residents’ satisfaction with their laparoscopic training, self-appraise their proficiency, and objectively evaluate their skills using the Fundamentals of Laparoscopic Surgery (FLS) test.Methods: This cross-sectional study, approved by the Institutional Review Board and funded by Alfaisal University, took place between October 2021 and May 2023. …”
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Prognosis of Patients with Hepatocellular Carcinoma Treated with TACE: A New Score Combining Alpha-Fetoprotein and Des-&gamma;-Carboxy Prothrombin by Lu SY, Sun HY, Zhou Y, Luo X, Liu S, Zhou WZ, Shi HB, Yang W, Tian W

“…This study aimed to develop a new risk prediction score, called AD score, based on the serum markers alpha-fetoprotein (AFP) and des-γ-carboxy prothrombin (DCP), to offer an objective and accurate preoperative assessment of HCC in patients undergoing transarterial chemoembolization (TACE).Patients and Methods: This was a retrospective study that included 295 HCC patients who were subjected to TACE (training set, n=147; testing set, n=148). …”
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Changes in Respiratory Sensitivity Status of Patients in a Hospital in Shanxi Province Before and After the COVID-19 Epidemic by Dong C, Hu F, Ma Z, Ma X, Zhang L, Li Y, Du X, Feng L, Huo R, Xing Y, Li P, Dong Y, Cheng E, Tian X, Huang M

“…And the high allergy season from July to September each year.Purpose: To investigate the effect of the COVID-19 epidemic on the respiratory sensitivity status of the population, to provide a scientific and effective basis for the prevention, diagnosis, condition assessment, and treatment of allergic respiratory diseases.Methods: We collected 500 outpatient cases from Shanxi Medical University Second Hospital during the period from July to September 2022 and 500 cases during the period from July to September 2023 and divided them into the pre-COVID-19 epidemic group (the 2022 group) and the post-COVID-19 epidemic group (the 2023 group). …”
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The Protective Effects of N-Carbamylglutamate on Changes in the Testicular Tissue Structure of Newborn Mice Induced by Monosodium Glutamate by Gh Akbari, D Kianifard, Y Panahi, M Babaei, M Doudkani Fard

“…The aim of this study was to investigate the protective effects of NCG on the changes in the testicular tissue structure of baby mice caused by MSG consumption. Methods: In this experimental study, 24 pregnant mice were randomly divided into four equal groups of six. …”
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Enablers and Barriers to an Experience‐Based Co‐Design Process to Develop Service Improvements in Enhanced Community Care in Ireland: A Qualitative Study by Fay O'Donoghue, Máire T O'Donnell, Tomás P. Griffin, Eileen Fahy, Elaine Newell, Ann‐Marie Creaven

“…This included four co‐design working group sessions per site. Methods Transcripts from the co‐design working groups and from brief follow‐up interviews with individual participants were analysed. …”
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Modified Xi-Jiao-Di-Huang Decoction Alleviates Sepsis via Regulating Macrophage Polarization by Inhibiting the PIM2/NF-&kappa;B Pathway by Ge F, Tian F, Zhu Y, Yan Q, Sun Q, Lu J

“…The purpose of this study was to investigate the protective effects of MXJDH in septic mice and explore its mechanism of action.Methods: Utilizing UPLC-Q-TOF-MS, we identified the primary constituents of the compound MXJDH. …”
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Unexpected Efficacy of Albumin-Bound Glycerol Monolaurate Against Multidrug-Resistant Bacterial Isolates: A Time-Kill Assay Study by Alrabiah MA, Hassan AA, Mubaraki MA, Albarrag AM, Dkhil MA, Somily AM, Delic D, Hafiz TA

“…Glycerol monolaurate (GML) is known for its antimicrobial properties, primarily against Gram-positive bacteria, with limited evidence of efficacy against Gram-negative pathogens.Methods: This study evaluated the antibacterial activity of GML alone and in combination with human serum albumin (HSA) against clinical isolates of carbapenem-resistant and vancomycin-resistant bacteria using MIC and time-kill assays.Results: Contrary to previous reports, we demonstrate that GML exhibits significant antibacterial activity against Gram-negative bacteria, including strains resistant to conventional antibiotics. …”
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Isoliquiritigenin Alleviates Periodontitis by Suppressing Inflammation via NF-&amp;kappa;B Signaling Pathway of Immune Cell by Wang X, Zhao T, Liang B, Fang J, Dong Q, Chen Q

“…., Ltd, Hangzhou, 310051, People’s Republic of China; 5Centre for Bone, Joint and Sports Medicine, The First Affiliated Hospital of Jinan University, Guangzhou, 510000, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Qianqian Chen; Qiu Dong, Email 18221767137@163.com; dong1005@stu2019.jnu.edu.cnBackground: Periodontitis, a chronic infectious disease, presents significant treatment challenges due to antibiotic resistance and high recurrence rates, necessitating novel therapeutics.Methods: Network pharmacology identified ISL’s potential targets in periodontitis, focusing on NF-κB signaling pathway. …”
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Inhibition of Ovarian Cancer Growth, Metastasis and Reverse the Tumor Microenvironment by Dual Drug-Loaded Polymer Micelle Targeting Tumor Microenvironment by Zhang L, Guo R, Chen M, Liu M, Liu Y, Yu Y, Zang J, Kong L, Li X

“…Transforming the immune environment from an immunosuppressive state to an anti-tumor state through the phenotypic transformation of tumor-associated macrophages is crucial for inhibiting the growth, metastasis, and recurrence of ovarian cancer.Methods: A polymer micelle (RC-PH-Ms) containing paclitaxel (PTX) and honokiol (HNK) was designed based on high expression of reactive oxygen species in the tumor microenvironment. …”
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Enhancing Periodontal Ligament Regeneration via PDLSC Delivery Using Electrospun PCL/Collagen/Cellulose Acetate Scaffolds and Collagen Hydrogel Incorporated with Curcumin-Loaded ZI... by Lan X, Wang Y, Yin M

“…This study explores a tissue engineering strategy that combines polycaprolactone (PCL)/collagen/cellulose acetate electrospun scaffolds with collagen hydrogels to deliver curcumin-loaded ZIF-8 nanoparticles fand periodontal ligament stem cells (PDLSCs).Methods: Scaffolds were fabricated via electrospinningand collagen hydrogels incorporated PDLSCs and curcumin-loaded ZIF-8 nanoparticles (CURZIF-8) were developed using cross-linking. …”
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Intravenous Versus Oral Omadacycline or Linezolid for Acute Bacterial Skin and Skin Infections: A post hoc Analysis of the OASIS Trials by George D. Rodriguez, Nathan Warren, Roman Yashayev, Surya Chitra, Maria Amodio-Groton, Kelly Wright

“…Both linezolid and omadacycline are available as intravenous or bioequivalent oral formulations. Materials and methods This post hoc analysis of the OASIS-1 (ClinicalTrials.gov identifier NCT02378480) and OASIS-2 (ClinicalTrials.gov identifier NCT02877927) phase 3 trials assessed safety and clinical efficacy of intravenous (IV)-start versus oral (PO)-start therapy in patients treated with omadacycline or linezolid for ABSSSI. …”
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