Assessing Pharmacokinetics and Safety of Therapeutic Alpha-1-Microglobulin in First-in-Human Kidney Transplantation: A Noncomparative Open-Label Multiple-Dose Phase 1b Study by Johan E. A. Nordström, MD, Lars M. Wennberg, PhD, MD, Greg Nowak, PhD, MD, Tobias E. Larsson, PhD, MD, Sara J. Thuresson, MSc, Michael Reusch, MD

“…This first-in-human study aimed to evaluate the pharmacokinetics and safety of RMC-035 in kidney transplant recipients. Methods. Eight living-donor kidney transplant recipients were included in 2 dose cohorts. …”
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Telemedicine in Times of COVID-19 Pandemic: A Prospective Outcome Study by Ranit Bag, Malabika Mondal, Soumik Mukherjee

“…Telemedicine technologies will continue to grow and be adopted by more healthcare practitioners and patients in a wide variety of forms, and these practice guidelines will be a key factor for handling emergency health conditions in the future. Materials and methods: It was a record-based, cross-sectional study done in the Telemedicine Center at IPGMER, Kolkata, from 1st January to 31st January, 2022. …”
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Drivers of Food Decision Making and Aspirations for the Future of the School Food Environment among Junior High School Students in Cape Coast, Ghana: a Photovoice Study by Elise C Reynolds, Christiana Nsiah-Asamoah, Harriet Okronipa, Nicholas F Russell, Madina Habib, Christine P Stewart

“…Secondarily, we sought to elicit adolescent ideas for the future of their school food environment. Methods: Forty adolescents were purposively selected equally across 4 JHSs in Cape Coast, Ghana. …”
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An evaluation of male learners’ knowledge, attitudes and practices regarding sexual and reproductive health in rural northern KwaZulu-Natal province by Mampho Mochaoa Rogers, Gloria Mfeka-Nkabinde, Andrew Ross

“…The aim of this research was to assess the knowledge, attitudes and practices regarding sexual and reproductive health among young men in the Bethesda Hospital catchment area of northern KwaZulu-Natal province. Methods: This observational, descriptive cross-sectional study was conducted at six randomly selected high schools within the uMkhanyakude district. …”
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Efficacy of Selective Nerve Root Block for Different Types of Lumbar Disc Herniation: Study Protocol for a Single-Blind, Prospective Cohort Study by Tan H, Zhou J, Pu Y, He L, Wang L

“…This study aims to evaluate the clinical efficacy of SNRB in treating various LDH subtypes, classified according to the Michigan State University (MSU) classification system, and to explore its potential as a safe and minimally invasive percutaneous treatment option.Methods: This is a single-blind, Prospective Cohort Study. …”
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<i>Lactuca racemosa</i> Willd., Source of Antioxidants with Diverse Chemical Structures by Klaudia Michalska, Danuta Jantas, Janusz Malarz, Klaudia Jakubowska, Wojciech Paul, Anna Stojakowska

“…In addition, HPLC-PAD chromatographic methods were used to estimate the deacetylmatricarin derivatives, luteolin 7-<i>O</i>-glucoside, and caffeic acid derivatives contents in the analyzed plant material. …”
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Terminological collocations in different types of medical discourse by Oksana O. Lyamova

“…Purpose – to analyze the lexical content of well-known courses of medical English, authentic dictionaries and textbooks on medicine to identify and classify the main models of terminological collocations in different types of medical discourse. Materials and methods. Contemporary courses of medical English: «Check Your English Vocabulary for Medicine» (A&C Black); «Medicine 1 / 2» (S. …”
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STUDY OF CEREBROTROPIC DOSE-DEPENDENT EFFECT OF PYRIMIDINE DERIVATIVE UNDER PIR-9 CODE AGAINST THE BACKGROUND OF EXPERIMENTAL CEREBRAL ISCHEMIA IN RATS by A. V. Voronkov, N. B. Shabanova, M. P. Voronkova, T. A. Lysenko

“…In this connection, there is an obvious need for new compounds exhibiting cerebroprotropic properties, as well as those able of improving the prognosis of the course of ischemic genesis pathologies.The aim of the article is to study the dose-dependent cerebrotropic effect of a pyrimidine derivative under PIR-9 code against the background of experimental cerebral ischemia in rats.Materials and methods. The experiment was conducted on 140 male Wistar rats (m=170–190 g) divided into 7 equal groups. …”
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Best Practices for Chronic Pancreatitis Pain Management: A Comprehensive Evidence-Based Review by Huang PY, Xiao AF, Ren ZQ, Chen L, Ding L, Li C

“…Pei-Yu Huang,1,&ast; Ai-Fang Xiao,1,&ast; Zhen-Qing Ren,2 Lu Chen,2 Li Ding,1 Cong Li1 1Department of Emergency, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, People’s Republic of China; 2Department of Nursing, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, Taizhou, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Lu Chen, Department of Nursing, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, No. 366 Taihu Road, Pharmaceutical High-tech Zone, Taizhou, 225300, People’s Republic of China, Tel +8613641589385, Email chenlucll01@126.com Zhen-Qing Ren, Department of Nursing, The Affiliated Taizhou People’s Hospital of Nanjing Medical University, No. 366 Taihu Road, Pharmaceutical High-tech Zone, Taizhou, 225300, People’s Republic of China, Tel +8613515157666, Email renzhenqingrzq69@126.comPurpose: This study aimed to identify and synthesize high-quality evidence regarding pain management in individuals with chronic pancreatitis (CP) to serve as a reference for clinical practice interventions.Methods: A thorough review encompassing databases, clinical guidelines, and information platforms, such as UpToDate, Guidelines International Network (GIN), National Institute for Health and Clinical Excellence (NICE), guide.medlive.cn, PubMed, Embase, Chinese Biomedical Literature Service System, China National Knowledge Infrastructure (CNKI), and Wanfang Data, was conducted to gather relevant evidence on pain management in CP. …”
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Research Hotspots and Trends in Workplace Violence Among Healthcare Professionals: A Bibliometric and Visualization Analysis Based on Web of Science by Lin Q, Liu L, Fu M, Chen K, Li L, Jiang M, Wu J

“…Despite growing concerns, a comprehensive understanding of the research landscape remains limited.Objective: This study aims to analyze the research hotspots and trends in workplace violence among healthcare professionals through bibliometric and visualization analysis, providing insights into the current state of research and identifying future directions.Methods: We conducted a comprehensive search of the Web of Science database from inception to August 10, 2024, identifying relevant studies on workplace violence among healthcare professionals. …”
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Secondary Analysis of PSA and BCR-Free Survival in Asian Prostate Cancer Patients by Gao X, Fu Y, Mo Z, Ruan Y

“…This study aimed to investigate the relationship between preoperative PSA levels and BCR-free survival in Asian populations.Methods: We conducted a retrospective cohort study of 3,092 prostate cancer patients who underwent radical prostatectomy at Yonsei University College of Medicine, Korea (1992– 2014). …”
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Somatic characteristics of 9-year-old boys with different levels of physical fitness Budowa somatyczna 9-letnich chłopców o różnym poziomie sprawności fizycznej by Paweł Tomaszewski, Piotr Żmijewski, Jan Gajewski, Katarzyna Milde, Beata Szczepańska

“…Aim of the study: Somatic characteristics of 9-year-old boys with different levels of physical fitness Material and methods: Somatic traits and physical fitness were assessed in 9-year-old boys (n=308) attending to public elementary schools in Warsaw. …”
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Associations between exposure to the U=U message and perceived HIV stigma among both the HIV and non-HIV adult populations in South Africa by Sibongile Kubheka, Rickesh Patel, Pholokgolo Ramothwala, Michelle Moorhouse, Perry Mohammed, Andres Doblado-Maldonado, Chinyere Okoli

“…The educational message ‘Undetectable Equals Untransmittable’ (U=U) may mitigate stigma. …”
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Epigenetic Regulation of Sorbitol Dehydrogenase in Diabetic Retinopathy Patients: DNA Methylation, Histone Acetylation and microRNA-320 by Amin R, Permana H, Kartasasmita AS, Hilmanto D, Hidayat R

“…Ramzi Amin,1,&ast; Hikmat Permana,2,&ast; Arief Sjamsulaksan Kartasasmita,3,&ast; Dany Hilmanto,4,&ast; Rachmat Hidayat5,&ast; 1Department of Ophthalmology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia; 2Department of Internal Medicine, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; 3Department of Ophthalmology, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; 4Department of Pediatrics, Faculty of Medicine, Universitas Padjadjaran, Bandung, Indonesia; 5Department of Medical Biology, Faculty of Medicine, Universitas Sriwijaya, Palembang, Indonesia&ast;These authors contributed equally to this workCorrespondence: Ramzi Amin, Department of Ophthalmology, Faculty of Medicine, Universitas Sriwijaya, Jl Dr Moh Ali KM 3.5, Palembang, South Sumatera, 30126, Indonesia, Tel +62 882 2505 3819, Email ramziamin20@gmail.comPurpose: This study aimed to investigate the correlation between epigenetic markers and sorbitol dehydrogenase (SDH) levels in patients with type 2 diabetes and diabetic retinopathy (DR).Patients and Methods: We conducted a case control study on 40 patients with type 2 diabetes and DR and 40 patients with type 2 diabetes without DR. …”
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Comparison of microscopic vs. endoscopic technique in revision stapes surgery: a systematic literature review by Federico Maria Gioacchini, Massimo Ralli, Massimo Re, Giannicola Iannella, Alfonso Scarpa, Valerio Di Pasquale Fiasca, Giovanni Motta, Arianna Di Stadio

“…IntroductionIn this study, we aimed to evaluate the differences in hearing outcomes and surgical complications after revision stapes procedure using endoscopic and microscopic techniques.MethodsSystematic literature review was performed following the Preferred Reporting Items for Systematic reviews and Meta-Analyses (PRISMA) checklist. …”
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B Cell Activation, Differentiation, and Their Potential Molecular Mechanisms in Osteoarthritic Synovial Tissue by Lu P, Li Y, Yang S, Yao H, Tu B, Ning R

“…Peizhi Lu,1,2,&ast; Ya Li,1,2,&ast; Shuo Yang,2 Haoyu Yao,2 Bizhi Tu,2 Rende Ning1,2 1Graduate School, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China; 2Department of Orthopedics, the Third Affiliated Hospital of Anhui Medical University, the First People’s Hospital of Hefei, Hefei, Anhui, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Bizhi Tu, Department of Orthopedics, the Third Affiliated Hospital of Anhui Medical University, the First People’s Hospital of Hefei, Hefei, Anhui, People’s Republic of China, Tel +86 15357483840, Email 1301535636@qq.com Rende Ning, Graduate School, Bengbu Medical University, Bengbu, Anhui, People’s Republic of China, Tel +86 13956966305, Email nrd1972@outlook.comObjective: The objective of this study was to characterize the activation and differentiation of B cells in the synovium of osteoarthritis (OA) and to explore the underlying molecular mechanisms.Methods: Peripheral blood and synovial samples from OA patients at different stages were collected, and flow cytometry was employed to analyze the activation and differentiation of B cells. …”
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Long term survival analysis of cementless Spotorno femoral stem in young patients by Murat Mert, Cenk Ermutlu, Emrah Kovalak, Ethem Ünkar, Sibel Çağlar Okur

“…Objective: The aim of this study was to analyze the survivorship and clinical outcome of Cementless Spotorno (CLS) stem in young patients. Methods: A total of 99 consecutive hip arthroplasties using CLS stem were performed on 84 patients younger than 50 years of age between 1993 and 2001. 63 patients were available for final follow-up (mean age: 39 ± 7.8 (range: 22–50)). …”
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Novel Proteomic Insights into Hip Fractures in the Elderly: Unraveling Immunologic Biomarkers, Temporal Expression Patterns, and Clinical Correlations by Lu Y, Liu J, Chen W, Hu P, Pei Y, Gao Y, Lu H, Wang L, Zhang Y

“…Yining Lu,1,2,&amp;ast; Jiaoran Liu,3,&amp;ast; Wei Chen,1 Pan Hu,4 Yan Pei,2 Yiming Gao,2 Hairong Lu,5 Ling Wang,1,2 Yingze Zhang1 1Department of Orthopedic Research Center, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Orthopedic Oncology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 3Department of Ultrasound Diagnosis, Bethune International Peace Hospital, Shijiazhuang, Hebei, People’s Republic of China; 4Trauma Medicine Center, Peking University People’s hospital, Beijing, China; National Center for Trauma Medicine, Beijing, People’s Republic of China; 5Department of Geriatric orthopedics, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China&amp;ast;These authors contributed equally to this workCorrespondence: Yingze Zhang, Department of Orthopedic Research Center, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China, Email yzzhang@hebmu.edu.cn Ling Wang, Department of Orthopedic Oncology, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China, Email wangling2016uw@126.com; wangling2021@hebmu.edu.cnBackground: Hip fractures in the elderly triggers a severe inflammatory immune response.Methods: Peripheral blood samples from 16 elderly hip fracture patients and 16 healthy controls were analysed for 92 inflammatory biomarkers using proximity extension assay (PEA) at different stages after trauma.Results: Dynamic trends in inflammatory proteins after surgery were assessed. …”
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Resilience and Affiliate Stigma Among Parents of Children with Autism Spectrum Disorder: The Mediating Role of Life Satisfaction and the Moderating Role of Ostracism by Chen H, Ding Y, Xu D, Xiong Z

“…The present study aims to investigate the association between parental resilience and affiliate stigma, examine the mediating role of life satisfaction in this relationship, and assess the moderating effect of ostracism on these pathways.Methods: This study employed a cross-sectional design to examine the relationship between resilience and affiliate stigma among parents of children with ASD, as well as the underlying mechanism. …”
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How does head position affect laryngeal vision with a video laryngeal mask airway? by Caridad G. Castillo-Monzón, Hugo Antonio Marroquín-Valz, Tomasz Gaszynski, Manuel Cayuela, Javier Orozco, Pawel Ratajczyk

“…The objective of this study is to evaluate and compare the optimal position for placement of a video laryngeal mask airway.MethodsThis prospective, observational, transversal, and analytical study was performed in 72 consecutive patients. …”
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