Identifying Key Prognostic Indicators for Relapse and Chronic Epilepsy in Autoimmune Encephalitis: Insights from a Multicenter Retrospective Study by Lai Q, Chen Y, Wang W, Lian Z, Liu T, Wen C

“…Qingwei Lai,1,* Yue Chen,1,* Wei Wang,2,* Zhangxu Lian,3,* Tengfei Liu,4 Chunmei Wen5 1Department of Neurology, Affiliated Hospital of Xuzhou Medical University, Xuzhou, People’s Republic of China; 2Department of Neurology, Yancheng First People’s Hospital, Yancheng, People’s Republic of China; 3Department of Neurology, Xuzhou Central Hospital, Xuzhou, People’s Republic of China; 4Department of Neurology, Xuzhou Mining Group General Hospital, Xuzhou, People’s Republic of China; 5Department of Neurology, Yancheng Third People’s Hospital, Yancheng, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qingwei Lai, Department of Neurology, Affiliated Hospital of Xuzhou Medical University, 99 West Huaihai Road, Xuzhou, Jiangsu, 221002, People’s Republic of China, Tel +8651685802193, Email lqw8696@163.comObjective: The aims of this study were to investigate clinical factors associated with encephalitis relapse and chronic epilepsy development, and to evaluate the effectiveness of immunotherapy on encephalitis relapse.Methods: Patients with autoimmune encephalitis diagnosed as positive for neuronal surface antibodies in five general hospitals were included. …”
Get full text

Strategic Optimization of Nanoparticle Characteristics to Enhance Tumor Targeting and Doxorubicin Delivery by Lee YJ, Hong J, Seo BY, Lee BH, Sarangthem V, Park RW

“…To improve its specificity and therapeutic efficacy, multivalent targeting strategies are being developed.Methods: A chimeric polypeptide consisting of an elastin-like polypeptides (ELP) copolymer with a repeating IL-4 receptor-specific targeting peptide, AP-1, and a (GGCGSCGSC)2 sequence encoding 6 cysteine residues (C6) at the carboxyl-terminus for Dox conjugation was designed. …”
Get full text

Comparison Between Norepinephrine Alone Versus Norepinephrine/Vasopressin Combination for Resuscitation in Septic Shock by Rania M. Hussien, Hanaa A. El-Gendy, Mohamed I. Elsaidy, Mostafa S. Abdelhamid, Tarek S. Shabana

“…This study aimed to compare the effect of norepinephrine (NE) alone versus early NE/vasopressin (VP) combination on tissue perfusion and renal function in septic shock patients. Materials and methods The study enrolled 90 adult ICU patients who developed septic shock. …”
Get full text

Malassezia Globosa Aggravates Atopic Dermatitis by Influencing the Th1/Th2 Related Cytokines in Mouse Models by Wu Z, Yu H, Chen Z, Liu W, Xia P

“…Zhuoxuan Wu,1– 3,* Huiyuan Yu,1– 3,* Zunyi Chen,1– 3 Wei Liu,1– 3 Ping Xia1– 3 1Department of Dermatology, Traditional Chinese and Western Medicine Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2Department of Dermatology, Wuhan No.1 hospital, Wuhan, 430022, People’s Republic of China; 3Hubei Province and Key Laboratory of Skin Infection and Immunity, Wuhan, 430022, People’s Republic of China*These authors contributed equally to this workCorrespondence: Ping Xia, Department of Dermatology, Wuhan No.1 hospital, Wuhan, 430022, People’s Republic of China, Tel +86 13886130960, Email alicexiaping@gmail.comPurpose: To establish atopic dermatitis (AD) mouse models infected with Malassezia globosa and study its effects and potential mechanisms.Methods: Twenty - four male BALB/c mice were randomly allocated into four groups: control, AD, M (normal mice treated with olive oil fungus suspension), and AD + M (AD mice treated with the same suspension). …”
Get full text

The efficacy of training on the four quadrant brain processes on cognitive functions of students with mathematical disorders by zohreh sadat moeini, farnaz Keshavarzi Arshadi, Masoud Gholam Ali Lavasani, SAEED hasanzadeh

“…Aims: This research aims to investigate the effectiveness of training on the four quadrant brain processes on the cognitive functions of students with mathematical learning disorders. Methods: This study falls into the category of semi-experimental research with a pre-test-post-test design and follow-up, using a matched group. …”
Get full text

Exploring Potential Gender-Based Disparities in Referral for Transplant, Activation on the Waitlist and Kidney Transplantation in a Canadian Cohort by Amanda J. Vinson, Aran Thanamayooran, Karthik K. Tennankore, Bethany J. Foster

“…Introduction: In the United States, women are less likely to be referred, activated on the waitlist, or undergo kidney transplant (KT) than men; contemporary Canadian data regarding access to transplant for women are lacking. Methods: Among patients initiating dialysis in Nova Scotia (NS), Canada from 2010 to 2020, we examined the association of candidate gender with overall access to KT, including the following: (i) odds of transplant referral within 1 year of dialysis initiation, (ii) odds of activation on the transplant waitlist (if referred), and (iii) time-to-transplantation (if activated) using logistic regression or Cox proportional hazards models as appropriate. …”
Get full text

Association Between 10 Autoimmune Diseases and Risk of Pulmonary Tuberculosis: A Mendelian Randomization Study by Chen YE, Zhao GL, Liu FH

“…We performed a Mendelian randomization (MR) study to determine the causal genetic connections between liability to autoimmune diseases (AIDs) and PTB.Methods: After rigorous assessment, potential candidate SNPs for 10 AIDs and PTB were extracted from GWAS datasets. …”
Get full text

Dihydrosanguinarine enhances tryptophan metabolism and intestinal immune function via AhR pathway activation in broilers by Yue Su, Miaomiao Wang, Zhiyong Wu, Peng Huang, Jianguo Zeng

“…This study aimed to decode the mechanisms by which sanguinarine enhances intestinal immune function in broilers. Methods Liquid chromatography-tandem mass spectrometry (LC-MS/MS) was employed to identify the main metabolites of sanguinarine in the intestine. …”
Get full text

Prevalence of Onchocerciasis and Associated Factors among Adults Aged ≥ 15 Years in Semen Bench District, Bench Maji Zone, Southwest Ethiopia: Community Based Cross-Sectional Study... by Bedilu Kifle, Kifle Woldemichael, Mamo Nigatu

“…Methods. Community based cross-sectional study was conducted on 553 study participants selected by multistage sampling in April 2018. …”
Get full text

Final-Year Dental Students’ Perceived Confidence: Competencies in General Dentistry by Navodika Yaparathna, Iresha Udayamalee, Megan Gray, Cheree He, Rachel Wu, Chelsea Taing, Menaka Abuzar

“…Both in-house training and outplacement equally improve the levels of competency development. …”
Get full text

Time to Occurrence of Incontinence-Associated Dermatitis: An Experimental Animal Study by Duan J, Zhang Y, Yuan D, Wang X, Peng J, Wang J, Liang X, Xu C

“…Junfang Duan,1,* Yan Zhang,2,* Dajiang Yuan,3 Xiaoru Wang,1 Jian Peng,4 Junli Wang,1 Xiaojuan Liang,1 Chenli Xu1 1Department of Critical Care Medicine, The Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 2General Surgery, The Second Hospital of Shanxi Medical University, Taiyuan, People’s Republic of China; 3Shanxi Cardiovascular Hospital, Taiyuan, 030024, People’s Republic of China; 4Anhui Institute of Pediatric Research, Anhui Provincial Children’s Hospital, Anhui, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chenli Xu, Department of Critical Care Medicine, Second Hospital of Shanxi Medical University, No. 382 of Wuyi Road, Xinghualing District, Taiyuan, 030001, People’s Republic of China, Tel +8619834513692, Email xuchenli0531@163.comObjective: To establish an animal model of Incontinence-Associated Dermatitis (IAD) and investigate inflammatory factor changes to determine the time frame for IAD onset.Methods: Twenty-eight male SPF mice were randomly assigned to four groups. …”
Get full text

The Effect of Drug–Drug Interactions on the Pharmacokinetics of Isavuconazole: A Comprehensive Review by Sang Y, Xu Q, Gao A, Zhao Q

“…Additionally, we aimed to evaluate whether the duration of combination therapy modulates the magnitude of DDIs and provide references for clinical medication.Methods: The literature concerning the interactions of isavuconazole was systematically retrieved from three retrieval platforms, PUBMED, EMBASE, and the Cochrane Library, using the search terms: “isavuconazole” or “isavuconazonium” or “Cresemba” and “interact*”, or “cotreatment”, or “coadministration”, or “combination”, or “concomitant”. …”
Get full text

Exploring the Kidney-Brain Crosstalk: Biomarkers for Early Detection of Kidney Injury-Related Alzheimer’s Disease by Cai Y, Huang G, Ren M, Chai Y, Fu Y, Yan T, Zhu L

“…The primary goal of this study was to investigate the link between KI and AD, with a specific focus on identifying diagnostic biomarkers for KI-related AD.Methods: The first step of the present study was to use Mendelian randomization (MR) analysis to investigate the link between KI and AD, followed by verification of in vivo and in vitro experiments. …”
Get full text

Trends and factors associated with immediate postnatal care utilisation in Ethiopia: analysis of the demographic and health surveys, 2011-2019 by Abdulaziz M Hussen, Aline Semaan, Binyam Tilahun, Özge Tunçalp, Diederick E Grobbee, Joyce L Browne

“…This study aimed to examine the trends of immediate postnatal care utilisation from the year 2011 to 2019 and to identify factors associated with immediate postnatal care utilisation using nationwide demographic and health survey data. # Methods The study was conducted using secondary data from Ethiopia Demographic and Health Survey (EDHS) in 2011 (n=4268), 2016 (n=4081), and 2019 (n=2159). …”
Get full text

Addressing the Сompetence of Experts and Specialists in the Light of Provisions of ISO/IEC 17025:2017 and International Experience in Applying Specialized Knowledge by E. V. Chesnokova, R. S. DuVal

“…International standards for forensic examination and comments thereto, foreign expert practice, publications on domestic forensic expertise and the procedural codes of the Russian Federation have served as materials for the research. The methods of the general theory of forensic examination have been used in the process of research, which are comparative analysis, abstraction and modeling and legal analysis. …”
Get full text

Informant accuracy of IQCODE, AD8 and GPCOGi for diagnosis of dementia: does your friend know best? by Jasmine Chingono, Samuel Thomas Creavin, Mark Fish, Sarah Cullum, Antony Bayer, Sarah Purdy, Yoav Ben-Shlomo

“…However, research on the accuracy of informant questionnaires in primary care remains limited. Methods This study assessed the diagnostic accuracy of IQCODE, AD8, and GPCOGi based on the informant’s relationship to the patient. …”
Get full text

Serum glutathione reductase level as a disease activity biomarker in systemic lupus erythematosus: a single-centre preliminary study by Yan Sun, Leixi Xue, Zhichun Liu, Mengxue Yan, Siping Li

“…Objectives This study aimed to investigate serum glutathione reductase (GR) levels in patients with SLE and to assess its association with disease activity.Methods The retrospective study collected clinical data, including serum GR, complement (C) 3 and C4 levels, among patients with SLE. …”
Get full text

Suboptimal Immune Reconstitution among HIV-Infected Saudi Patients following Successful Antiretroviral Treatment by Fahad Al-Majid, Zahid Shakoor, Mazin Barry

“…This study aims at assessing immune reconstitution after successful ART among HIV-infected Saudi patients. Methods. This retrospective study of 240 HIV-infected patients was performed between May 2010 and June 2015 in the HIV center at King Saud Hospital, Riyadh. …”
Get full text

Pituitary-Thyroid Hormones and Related Indices in Euthyroid Type 2 Diabetes: Association With Thyroid Nodules by Ji B, Shi S, Zhao H, Ma X, Sheng J, Ban B, Gao G

“…We aimed to explore the correlates of TNs in euthyroid type 2 diabetes (T2D) patients.Methods: This cross-sectional study included 1965 euthyroid adults with T2D. …”
Get full text

Maternal dietary diversity and associated factors with a focus on the food environment in the Tigray region, Northern Ethiopia by Shewit Engdashet Berhe, Gina Kennedy, Selamawit Asfaw Beyene, Freweini Gebrearegay Tela, Mestawet Gebru, Kebede Haile Misgina

“…Therefore, this study aimed to assess diet diversity and associated factors, with a special focus on the food environment, among pregnant women in the Kilteawlaelo district, Tigray, northern Ethiopia. Methods A mixed cross-sectional study design was used. …”
Get full text