A Super-Assembled Synergistically Nanoplatform AP@ZIF-8Pt for Hepatocarcinoma Therapy by Luo Z, Wang D, Lin L, Zhou R, Su Y, Zhang Z, Hu J, Dai Y, Wu J, Huang X, Zhou Y, Gong L

“…Herein, a three-step intelligent biodegradable drug delivery nanoplatform was designed.Methods: First, a hollow ZIF-8 was synthesized, embedded with platinum nanoparticle to form ZIF-8Pt, and then loaded with AP, and lastly formed AP@ZIF-8Pt, which possess pH-responsive drug release and cancer-targeted ability.Results: As expected, both in vitro and in vivo experiment demonstrated that AP@ZIF-8Pt performed treatment effects in hepatocarcinoma through relieving tumor-hypoxic microenvironment, inhibiting cell proliferation and promoting cell apoptosis. …”
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Economic burden of hypertension in Iran: a prevalence-based cost of illness study by Ali Akbarisari, Rajabali Daroudi, Zahra Shahali, Mahmoud Zamandi

“…Additional data, such as population, employment rates, household activity rates, wage rates and GDP per capita, were obtained from the Statistical Centre of Iran and the World Bank.Participants and methods A prevalence-based cost of illness study was used to estimate the economic burden of hypertension. …”
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PROFESSIONAL AND PEDAGOGICAL COMMUNICATION OF TEACHERS OF HIGHER EDUCATION INSTITUTIONS: CHALLENGES OF WAR by Nataliia P. Volkova, Olha V. Lebid

“…The essence of the concepts «personality-oriented communication of the teacher», «emotional-supportive communication of the teacher» is revealed; the principles of emotional and supportive communication of a teacher of a higher education institution are determined; the importance of reflexive (active) listening during the professional and pedagogical communication of the teacher in the conditions of war is substantiated; effective methods of reflexive listening (clarification, paraphrasing, reflection of feelings, summarizing) are revealed; the characteristics of pedagogical facilitation are distinguished (cooperation, own position, individuality and equality, self-disclosure, involvement of everyone in joint activities, organization of space). …”
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Correlation Between Serum Inflammatory Factor Level Changes and Disease Severity in Patients with Chronic Obstructive Pulmonary Disease Complicated by Tuberculosis by Di Y, Yang F, Che C, Xu S, Qi Y

“…The correlation between serum inflammatory factors and disease severity and prognosis in COPD patients with TB remains unclear.Methods: This retrospective study included 200 participants treated at the Affiliated Hospital of Hebei University from December 2020 to December 2022: 80 patients with COPD and TB, 40 with COPD alone, 40 with TB alone, and 40 healthy controls. …”
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Characteristics of Older Individuals with Asthma Being Treated with Biologics by Aetou M, Kiskinov Y, Ratsimba SFN, Barth M, Pizarro C, Bergs I, Spiesshoefer J, Skowasch D, Dreher M

“…Therefore, this study reports the characteristics of older individuals receiving biologic therapy for severe asthma.Patients and Methods: This study was a retrospective data analysis conducted at two centers in Germany.Results: Eighty-eight patients were included (52 aged 50– 59 years and 36 aged ≥ 60 years). …”
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Systemic Immunomodulatory Therapy in Uveitis Related to Behçet’s Disease: A 10-year Profile by Almeida M, Ferreira AM, Araújo JR, Figueira L

“…This study aims to determine the efficacy and safety of systemic immunomodulatory therapy (IMT) in Behçet’s disease and the optimal timing for its discontinuation in patients who are in remission.Patients and Methods: A retrospective single center longitudinal study was performed at the Centro Hospitalar Universitário São João (Porto, Portugal). …”
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Health-oriented leadership in specialized outpatient palliative care teams in Germany: a qualitative study with palliative care professionals by Friederike Hess, André Klussmann, Volker Harth, Stefanie Mache

“…Furthermore, the perceived advantages of this approach in the given context will be discussed, and the challenges inherent to its implementation will be presented. Methods In this qualitative study, a total of 30 semi-structured interviews were conducted with palliative care professionals working in Northern Germany. …”
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Efficacy of low-dose hypobaric anesthetics in spinal anesthesia for cesarean delivery: systematic review and meta-analysis by Min Li, Guohao Xie, Lihua Chu, Yan Li

“…Therefore, a meta-analysis of these trials is warranted.Methods Systematic review and meta-analysis of eligible randomized controlled trials comparing the efficacy of low-dose spinal hypobaric anesthetics (Bupivacaine < 10 mg, levobupivacaine < 10 mg, ropivacaine < 15 mg) with conventional dose (Bupivacaine/Levobupivacaine ≥ 10 mg, ropivacaine ≥ 15 mg) in elective and subemergency Cesarean sections in data sources (PubMed, Embase, Web of Science, and Cochrane Central) from inception to February 2025.Results We obtained data from 1,280 patients from 17 published trials. …”
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Evaluation of different safety-engineered protection mechanisms of port access needles using a lifelike model of vascular access routes by Feline Gabler, Pierre Heiden, Peter Deibert, Daniel Steinmann

“…Therefore, we evaluated differences in product characteristics and user preferences of safety-engineered protection mechanisms of port access needles.MethodsPort puncture was performed using port access needles with four different safety mechanisms: (a) EZ Huber™ PFM Medical, (b) Gripstick® Safety OMT, (c) Gripper Micro® Smiths Medical and (d) pps ct® Vygon. …”
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Analysis of influencing factors and equity in health education for mobile populations based on random forest model: evidence from the China migrants dynamic survey by Meng Han Jiang, Shan Yan Lei, Fang Yang

“…Furthermore, the contribution of these important factors to health education equity is analyzed to inform differentiated intervention strategies, thereby providing a reference for enhancing mobile populations’ health level and achieving equal access to basic public health services.MethodsThis study utilized data from the 2018 China Migrants Dynamic Survey (CMDS), with a final sample of 103,910 participants after data cleaning. …”
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CYTOKINE PROFILE IN PATIENTS WITH SYSTEMIC LUPUS ERYTHEMATOSUS by Maria Eduardovna Tsanyan, S K Solovyev, A A Novikov, E N Aleksandrova, S I Glukhova, E L Nasonov

“…Objective: to investigate the levels of cytokines in patients with systemic lupus erythematous (SLE) and to determine their correlation with SLE activity and organ damage, as well as their changes during rituximab (RTM) therapy.Subjects and methods. The trial enrolled 26 patients (5 men and 21 women) with a median (Me) age of 27 [range 23-40] years and a SLE duration of 9 to 300 months (Me 72 [range 36-108] months and 30 healthy donors marched withthe examinees for gender and age. …”
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The Effect of PNF Stretching and Lower Extremity Strengthening Programs on Knee Joint Range of Before and After Local Fatigue of the Quadriceps Muscle in Male Athletes with Patello... by F Rostamizalani, M Sahebozamani, A.H Daneshjoo, M Zarei

“…The aim of this study was to investigate the effect of PNF stretching exercises and lower extremity strengthening on knee range of motion and quadriceps muscle strength before and after local quadriceps fatigue in male athletes with PFPS.Methods:24 male athletes (20-30 years age range) with PFPS from Tehran were randomly divided into two equal groups of PNF stretching exercises and strengthening exercises. …”
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Ready, steady, who do we know? Internationalization intent among emerging market SMEs in Central Asia by Matevž (Matt) Rašković, Nurgul Daminova

“… Objective: The objective of our paper is to examine the determinants and moderators of managerial internationalization intent of not yet internationalized emerging market small and medium-sized enterprises (EMSMEs) from Kyrgyzstan, a country in Central Asia. Research Design & Methods: Analyzing a sample of 178 non-yet-internationalized SMEs in Kyrgyzstan collected through a survey questionnaire, which have indicated willingness to internationalize, we use an OLS regression model to analyze the impact of government support, international market outlook and various kinds of resources, as determinants of two types of internationalization intent: simple internationalization intent (i.e., establishing first contact) and sophisticated internationalization intent (i.e., corresponding to more intense resource commitments). …”
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Clinical Characteristics and Analysis of Risk Factors Associated with Rhabdomyolysis in Snakebite Victims by Wang FZ, Xiang SH, Lin SQ, Qian FQ, Zhang QX, Geng MH, Deng JX, Wu SC

“…Fu-zhen Wang,1,&ast; Shi-hong Xiang,1,2,&ast; Sen-qing Lin,1 Feng-qi Qian,1 Qiu-xia Zhang,1 Ming-hui Geng,1 Jin-xiu Deng,1 Sen-chao Wu1 1Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, Longyan, Fujian 364000, People’s Republic of China; 2Department of Nephrology, Xuanhan County People’s Hospital, Dazhou, Sichuan, 636150, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Sen-chao Wu; Jin-xiu Deng, Department of Nephrology, Longyan First Affiliated Hospital of Fujian Medical University, No.105 Jiuyi North Road, Longyan, Fujian, 364000, People’s Republic of China, Tel +86 13860217030 ; Tel +86 18159828598, Email wusenchaowsc@126.com; dengjinxiudjx@126.comObjective: To enhance the understanding of rhabdomyolysis (RM) caused by snakebites and to promptly identify and intervene in the risk factors associated with RM.Methods: A retrospective analysis involving 209 snakebite victims who visited our hospital for snakebite cases was conducted. …”
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Jiangzhi Granule Ameliorates JNK-Mediated Mitochondrial Dysfunction to Reduce Lipotoxic Liver Injury in NASH by Jiang Y, Xu J, Ding J, Liu T, Liu Y, Huang P, Wang Q, Zheng P, Song H, Yang L

“…This study aims to investigate the pharmacological mechanism of Jiangzhi Granule (JZG), a Chinese herbal formula against NASH, with a focus on its regulation of JNK signaling-mediated mitochondrial function.Methods: Hepatocytes were induced by palmitic acid (PA) for 24 h to establish an in vitro lipotoxic model, which was simultaneously treated with either JZG or vehicle control. …”
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HDAC1 Mediates Immunosuppression of the Tumor Microenvironment in Non-Small Cell Lung Cancer by Fan Y, Ji X, Yuan K, Wu Q, Lou M

“…However, there are no studies on the immunological aspects of HDAC1 in non-small cell lung cancer (NSCLC).Methods: In this research, we used the Cancer Genome Atlas (TCGA) public database combined with tissue microarray (TMA) to investigate HDAC1 expression and prognosis in NSCLC. …”
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Comparison of the effects of two types of resistance training on the serum levels of factors involved in muscular hypertrophy in healthy young men by Sadegh Cheragh-Birjandi, Mojtaba Farhadpoor

“…This study aimed to investigate the effects of two types of resistance training on the serum levels of myostatin and follistatin and the ratio of follistatin to myostatin in healthy young men.Materials and Methods: Twenty active young men were randomly divided into two equal groups of pyramid resistance exercises (, Mean±SD; age, 22.3±4.7 years; body mass index, 23.1±3.9 kg/m2; fat percentage, 27.6±10.7) and inverted pyramid resistance exercises (Mean±SD; age, 21.11±3.55 years; body mass index, 23.2±6.7 kg/m2; fat percentage, 26.3±13.8). …”
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Deciphering climate variability trends: unveiling the impact on household staple crop productivity in East Wallaga Zone, Ethiopia by Dereje Chimdessa Kumsa, Admassu Tesso, Dereje Tolera

“…The report also emphasizes how important it is to combine measures for adapting to climate change with initiatives to resolve political unrest and advance sustainable agricultural methods.It is recommended that policymakers give equal weight to measures aimed at mitigating and adapting to climate change in order to enhance agricultural productivity and guarantee food security in the area. …”
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Global Research Status of Maca (Lepidium Meyenii Walp.): A Bibliometric Analysis of Hotspots, Bursts, and Trends by Li K, Zhao C, Dang M, Ren R, Fu M, Bai Y, Wang J, Zhang Q, Luan F

“…Kangjie Li,1,&ast; Chongbo Zhao,1– 3,&ast; Ming Dang,1 Runxin Ren,1 Maomao Fu,1 Yaya Bai,1 Jing Wang,1,2 Qiao Zhang,1 Fei Luan1 1School of Pharmacy, Shaanxi University of Chinese Medicine, Xi’an, 712046, People’s Republic of China; 2Shaanxi Provincial Engineering Technology Research Center for Traditional Chinese Medicine Decoction Pieces, Xi’an, 712046, People’s Republic of China; 3Shaanxi Traditional Chinese Medicine Processing Technology Heritage Base, Shaanxi University of Chinese Medicine, Xi’an, 712046, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Fei Luan, School of Pharmacy, Shaanxi University of Chinese Medicine, No. 1, Shiji Avenue, Xi Xian New Distracts, Xi’an City, Shaanxi Province, 712046, People’s Republic of China, Email 2051145@sntcm.edu.cnPurpose: This bibliometric study aims to comprehensively analyze the research landscape of Maca (Lepidium meyenii Walp.) from 2003 to 2024, identifying key research areas, trends, and patterns, as well as the roles of major countries and institutions in advancing the field.Methods: A quantitative analysis of literature pertaining to Maca was performed utilizing the bibliometric tools VOSviewer, CiteSpace, and R Bibliometrix. …”
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Insulin resistance in drug naive patients with multiple sclerosis by Kostić Smiljana, Kolić Ivana, Raičević Ranko, Stojanović Zvezdana, Kostić Dejan, Dinčić Evica

“…Our hypothesis was that the metabolic disorder that characterizes state of the insulin resistance (IR) and reduced insulin sensitivity (IS) in untreated patients with MS could play a role in disease progression and degree of functional disability. Methods. The study included 31 patients with relapsing-remitting (RR) MS and 14 healthy controls from the same geographic area matched by age, ethnicity and number of smokers. …”
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