ATP6V1A deletion leads to impaired clearance of septic cardiac resident macrophages by YANG Shunxin, ZHOU Yuanqun, XIANG Xinming

“…Objective To investigate the clearance capacity of cardiac resident macrophages in post-sepsis and its underlying mechanism. Methods A mouse model of sepsis was established using cecum perforation ligation. …”
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Identifying KL-6-Associated Immune Cell Signatures and Key Genes in Emphysematous COPD by Xiao X, Guo W, Li N, Chen N, Zhang Q

“…Xinru Xiao,1,* Wenwen Guo,1,* Na Li,1 Nuo Chen,1 Qian Zhang1,2 1Department of Respiratory and Critical Care Medicine, The Second People’s Hospital of Changzhou, The Third Affiliated Hospital of Nanjing Medical University, Changzhou, 213003, People’s Republic of China; 2Changzhou Medical Center, Nanjing Medical University, Changzhou, 213003, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qian Zhang, Email qianzhang@njmu.edu.cnBackground: This study aimed to evaluate the potential of Krebs von den lungen-6 (KL-6) as a biomarker for distinguishing emphysematous chronic obstructive pulmonary disease (COPD-E) from non-emphysematous COPD (COPD-NE), and to explore the underlying mechanisms associated with KL-6 expression.Methods: We enrolled 154 patients with COPD and 170 healthy controls to assess serum KL-6 levels. …”
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Ambivalent User Needs as a Challenge and Chance for the Design of a Web-Based Intervention for Gaming Disorder: Qualitative Interview Study With Adolescents and Young Adults by Birte Linny Geisler, Kay Uwe Petersen, Sara Hanke, Simon Schurer, Anne Schreiber, Christine Lämmle, Anil Batra, Tobias Renner, Isabel Brandhorst

“…ObjectiveThe aim of this study was to explore the treatment needs of young people with GD in Germany and derive implications for the development of a self-guided WBI for GD. MethodsUsing a qualitative study design, we conducted a focus group with 3 young male adults and semistructured individual interviews with 3 male adolescents. …”
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Beliefs about COVID-19 testing and treatment: A national survey of Black and White adults by Laura A. Siminoff, K. Laura Barker, Ryan Blunt, Diana Litsas, Gerard P. Alolod, Jay S. Patel

“…Study design: Cross-sectional structured survey. Methods: Respondents were randomly selected from an opt-in national panel in December 2022. …”
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TRIB3 Is a Hub Gene in Steatohepatitis and Aggravates Lipid Deposition and Inflammation in Hepatocytes by Xia W, Xiao L, Cheng H, Feng Y

“…Wen Xia,1,* Li Xiao,1,* Huan Cheng,1 Yuwei Feng2 1Department of Cardiovascular Medicine, Wuhan No.1 Hospital, Wuhan, Hubei, People’s Republic of China; 2Department of Hepatology with Integrated Traditional Chinese and Western Medicine, Hubei No.3 People’s Hospital of Jianghan University, Wuhan, Hubei, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuwei Feng, Department of Hepatology with Integrated Traditional Chinese and Western Medicine, Hubei No.3 People’s Hospital of Jianghan University, #26 Zhongshan Avenue, Wuhan, 430022, People’s Republic of China, Tel +86-27-85332356, Email fengyw92@163.comBackground: Non-alcoholic fatty liver disease (NAFLD), also known as Metabolic dysfunction–associated fatty liver disease (MASLD), has become one of the most common chronic liver diseases worldwide, approximately 30% of adults and 70%~80% of patients with obesity and diabetes suffer from NAFLD.Objective: We attempted to find a potential hub gene in NAFLD hepatocyte cell model induced by palmitic acid and oil acid (PAOA), and investigated the function of the hub–gene.Methods: We searched and downloaded the GSE122660 dataset from GEO-DataSets, and differentially expressed genes (DEGs) were analyzed using R software. …”
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Apixaban versus enoxaparin to prevent venous thromboembolism in post-operative patients with gynecologic cancers at an urban academic medical center by Victoria Diamond, Katherine Gerber, Geno Merli, Rebecca Mercier, Aaron Shafer, Norman Rosenblum

“…Objective: A recent clinical trial demonstrated that the use of apixaban was safe and equal to enoxaparin (LMWH) in post-operative gynecologic oncology patients. …”
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Comprehensive Analysis of Multi-Omics Data on RNA Polymerase as an Adverse Factor in Head and Neck Squamous Cell Carcinoma by Gu YJ, Zhang J, Liu YJ, Zhang Q, Geng QF

“…While RNA polymerases (POLRs) have been implicated in various transcriptional mechanisms, their impact on the tumor microenvironment (TME) remains poorly understood.Methods: We analyzed publicly available pan-cancer cohorts to evaluate the expression and genomic alterations of POLRs. …”
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A Population Pharmacokinetics Study of Venetoclax Concomitant with Voriconazole in Patients with Hematologic Malignancies by Yang J, Wang H, Liu D, Cao W, Xing H, Wang P

“…This study aimed to develop a population pharmacokinetics (PopPK) model to characterize the PK properties of venetoclax when co-administered with voriconazole.Methods: Patients (≥ 18 years of age) treated with venetoclax for hematologic malignancies and concomitant with voriconazole were enrolled. …”
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Pressure makes diamonds? The impact of closed incision negative pressure wound therapy on complications following abdominoplasty in patients with massive weight loss—results from a... by Torsten Schulz, Toralf Kirsten, Katharina Theresa Vogel, Stefan Langer, Rima Nuwayhid

“…The objective of this research was to assess the influence of ciNPWT on post-operative wound complications in this demanding patient collective. Methods: We conducted a retrospective case-control study. …”
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Mechanical behavior of hybrid glenoid components compared to all‐PE components: a finite element analysis by Nicolas Bonnevialle, Julien Berhouet, Paul Pôtel, Jacobus Hendrik Müller, Shoulder Friends Institute, Arnaud Godenèche

“…The hypothesis was that, compared to all‐PE components, hybrid components yield lower bone and cement stresses with smaller micromotions. Methods Implant micromotions and cement and bone stresses were compared among 4 all PE (U‐PG, U‐KG, A‐KG, I‐KG) and 2 hybrid (E‐hCG, I‐hPG) virtually implanted glenoid components. …”
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Exploring Potential Causal Links: How Parkinson’s Disease Brain Damage Impacts Liver Health–A Mendelian Randomization and Transcriptomic Study by Liu T, Chen Q, Wu H, Li J, Xian M, Lu K, Zhu C, Wei J

“…Clinical studies have demonstrated a close association between PD and liver disease, but most research has focused on the impact of liver disorders on brain damage in PD, and further exploration is needed to understand the pathways and mechanisms underlying liver damage in patients with PD.Methods: This study employs Mendelian Randomization (MR) and transcriptomic analysis to investigate the causal impact of PD-related brain damage on liver health, identifying serum metabolites (eg, cysteine) and shared immune-inflammatory pathways as mediators.Results: The study indicates that PD-related brain damage does indeed have an impact on liver metabolic function. …”
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Application and Analysis of Random Forest and Support Vector Classification in Risk Prediction of Childhood Obesity and Hyperuricemia by Wang Y, Shi S, Wei X, Wu Y, Shi Y, Cai J

“…Machine learning (ML) offers an effective framework for constructing efficient risk prediction models in pediatric populations.Objective: This study aimed to develop and evaluate two ML models—Random Forest (RF) and Support Vector Classification (SVC)—to predict the risk of childhood obesity and hyperuricemia by integrating clinical and biochemical variables.Methods: A total of 101 children were enrolled, including 60 with obesity and 41 with obesity plus hyperuricemia. …”
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Effects of Xuefu Zhuyu Decoction on Inflammatory Factors and the NF-kappaB Signaling Pathway in Rats Model of Radicular Pain by Liu X, Jiang T, Lu B

“…The rats in the treatment groups received different doses of XFZYD via oral administration, while the control and model groups received an equal volume of normal saline once daily for 7 days. …”
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An online intervention relationship enhancement couple therapy program versus systematic desensitization on sexual performance anxiety in women undergoing infertility treatment wit... by Maryam Afzal Dehkordi, Tahmineh Farajkhoda, Mahdi Khanabadi, Farimah Shamsi

“…Objective: This study aimed to compare the effectiveness of relationship enhancement couple therapy program (RECT) vs. systematic desensitization (SD) on sexual anxiety. Materials and Methods: A parallel randomized clinical trial was conducted on 68 women with infertility in Shahrekord, Iran, in January 2022. …”
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Age and Sex Differences in Carotid Intima-Media Thickness: A Systematic Review and Meta-Analysis by Veronika A. Myasoedova, Alessio L. Ravani, Beatrice Frigerio, Donato Moschetta, Vincenza Valerio, Ilaria Massaiu, Mauro Amato, Damiano Baldassarre, Paolo Poggio

“…For this purpose, we analyzed the differences in cIMT, the impact of patient characteristics, and the influence of age on cIMT in men and women. Methods: A systematic search related to cIMT measured by an ultrasound and gender-specific differences was conducted according to the PRISMA 2020 guidelines. …”
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Male sexuality and the risk of developing benign prostatic hyperplasia and prostate cancer: is there a connection? by M. I. Kogan, M. E. Efremov, V. L. Medvedev, A. D. Anosov, T. P. Agapova, T. G. Sinyavskaya

“…To assess male sexuality (sexual constitution) as a potential risk factor for BPH or PCa.Materials & methods. The study included 47 men (Group 1) aged 49 – 71 years with Lower Urinary Tract Symptoms (LUTS) caused by BPH, as well as 87 patients aged 47 – 70 years with a newly diagnosed PCa T 1c-3b N 0-1 M 0-1a. …”
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Network Pharmacology Combined With Metabolomics Reveals the Mechanism of Yangxuerongjin Pill Against Type 2 Diabetic Peripheral Neuropathy in Rats by Jin R, Pei H, Yue F, Zhang X, Zhang Z, Xu Y, Li J

“…Pharmaceutical Factory, Beijing, 100079, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yi Xu; Jinsheng Li, Beijing Tongrentang Technology Development Co., Ltd. …”
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Cardioprotective effects of CoQ10 in pediatric patients with lysosomal storage disorders by Yasmine Abuzaid, Ghada Abdul Moemn Suliman, Osama Abd Rab El Rasool Toulba, Ahmed Abd El Basset Abo Elezz, Alshimaa Badraldeen, Heba Dawoud

“…The aim of this study: was to study the possible effects of Coenzyme Q10 as a cardioprotective and an antioxidant drug in patients with LSDs. Methods This study was a prospective case-control study conducted on 30 patients with LSDs and an equal number of healthy subjects of matched age and sex served as a control group at the unit of Medical Genetics and inborn errors of metabolism at the Pediatric Department of Tanta University Hospital. …”
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Phantom-based training of ultrasound-guided breast biopsy in medical education: a randomized controlled trial comparing handheld and high-end ultrasound by Barbara Greiner, Michael Akers, Florian Zeman, Andrea Goetz, Moritz Brandenstein, Christian Stroszczynski, Ernst Michael Jung, Simone Hammer

“…The objective of this study was to investigate if guidance by HUD is on par with a cart-based high-end ultrasound scanner (HEUS) regarding performance times and success rates in video- and phantom-based training of novices in US-guided freehand breast biopsy. Methods 32 medical students without any experience in performing US-guided percutaneous biopsies, who had previously completed a standardized diagnostic US training program, were randomized into either a HUD-group (n = 16) or a HEUS-group (n = 16). …”
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Impact of climate change on the potential global prevalence of Macrophomina phaseolina (Tassi) Goid. under several climatological scenarios by Peter F. Farag, Dalal Hussien M. Alkhalifah, Shimaa K. Ali, Aya I. Tagyan, Wael N. Hozzein

“…Macrophomina phaseolina (Tassi) Goid. is one of the most pervasive and destructive soil-borne fungus that threatens food security, so predicting its current and future distribution will aid in following its emergence in new regions and taking precautionary measures to control it.MethodsThroughout this work, there are about 324 records of M. phaseolina were used to model its global prevalence using 19 environmental covariates under several climate change scenarios for analysis. …”
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