A PROSPECTIVE, OBSERVATIONAL STUDY OF ADVERSE REACTIONS TO DRUG REGIME FOR MULTI-DRUG RESISTANT PULMONARY TUBERCULOSIS IN CENTRAL INDIA. by Dr. Rohan C. Hire, Dr. A. S. Kale, Dr. G. N. Dakhale, Dr. Nilesh N. Gaikwad

“…Abstract Objective: 1) To assess the adverse drug reactions of second line anti-tubercular drugs used to treat Multi-drug resistant Tuberculosis (MDR TB) in central India on the basis of causality, severity and avoidability scales. 2) To study the relationship of type of MDR TB (primary or secondary) and presence of diabetes mellitus (DM) with mean smear conversion time. Material and Methods: A prospective, observational study was carried out on diagnosed multidrug resistant tuberculosis patients enrolled for DOTS‑Plus regimen at TB and Chest Disease Department from January to December 2012. …”
Get full text

Persistent oral health inequality in children—repeated cross-sectional studies in 2010 and 2019 by Caroline Blomma, Thomas Davidson, Elisabeth Wärnberg Gerdin, Mats Bågesund, Johan Lyth

“…The aim was therefore to analyse the association between 6-year-olds´ caries prevalence and socioeconomic variables at family and residential area levels in 2010 and 2019 as well as potential differences in the association between 2010 and 2019. Methods The study design is an epidemiological registry-based, repeated cross-sectional study based on caries data (grouped as 0, 1–3 and > 3 dmft) for the population of 6-year-olds in 2010 (n = 4,408, 95% coverage) and 2019 (n = 5,199, 94% coverage) in a Swedish region. …”
Get full text

Application of the 2021 AAPOS Guidelines in Clinics with Revision and Validation of SPOT Referral Criteria by Li R, Yan Q, Lin X, Wu Z, Zhu H, Guo W, Zhang P, Zuo F, Wu Z, Liu H, Huang D

“…Rui Li,1,* Qi Yan,2,* Xiao Lin,3,* Zhujian Wu,4 Hui Zhu,4 Wei Guo,4 Peibin Zhang,4 Feidi Zuo,5 Ziyan Wu,5 Hu Liu,4 Dan Huang4 1Department of Ophthalmology, Nanjing First Hospital, Nanjing Medical University, Nanjing, People’s Republic of China; 2Department of Ophthalmology, Children’s Hospital of Soochow University, Suzhou, People’s Republic of China; 3Department of Ophthalmology, Baylor College of Medicine, Houston, TX, USA; 4Department of Ophthalmology, the First Affiliated Hospital with Nanjing Medical University, Nanjing, People’s Republic of China; 5The Fourth School of Clinical Medicine of Nanjing Medical University, Nanjing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hu Liu; Dan Huang, Department of Ophthalmology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, 210029, People’s Republic of China, Tel +86 (25) 68136470, Fax +86 (25) 83275171, Email liuhu@njmu.edu.cn; huangdan@njmu.edu.cnPurpose: This study aims to validate and revise the Spot Vision Screener referral criteria for detecting amblyopia risk factors (ARFs), visually significant refractive error (VSRE), and amblyopia.Methods: In clinics, we gathered data from children aged 12 months to 7 years. …”
Get full text

Immunoglobulin G N-Glycosylation and Inflammatory Factors: Analysis of Biomarkers for the Diagnosis of Moyamoya Disease by Zan X, Liu C, Wang X, Sun S, Li Z, Zhang W, Sun T, Hao J, Zhang L

“…This research aimed to evaluate the diagnostic efficacy of IgG N-glycosylation for MMD.Methods: Ultra-high-performance liquid chromatography (UPLC) was employed to examine the properties of IgG N-glycans in blood samples from 116 patients with MMD and 126 controls, resulting in the quantitative determination of 24 initial glycan peaks (GP). …”
Get full text

Reversing Pathology in an Aggravated Fabry Mouse Model Using Low-Dose Engineered Human Alpha-Galactosidase A AAV Gene Therapy by Wanida Ruangsiriluk, Mugdha Deshpande, Natalia Boukharov, Girija Rajarshi, Shreya Mukherji, Shipeng Yuan, Jennifer Wiseman, Nancy Chen, Eric Park, Hyelim Cho, Rizwana Islam

“…Efficacy of the Eng-C AVV GT was equal to or greater than the efficacy of the higher doses of the AAV GT with native α-GAL. …”
Get full text

Hypotensive Effects of Statins: A Rapid Review by Smruti Besekar, Sangita Jogdand, Satyawan Singh Patel

“…Aim: To explore the hypotensive effects of statins on BP and to determine whether they can serve as an adjunct to antihypertensive drugs. Materials and Methods: This study was conducted in compliance with the Preferred Reporting Items for Systematic Reviews and Meta-analysis Statement (PRISMA-S) guidelines. …”
Get full text

Neutrophils in Rheumatoid Arthritis Synovium: Implications on Disease Activity and Inflammation State by Deng Y, Li J, Wu R

“…This finding suggests that neutrophil involvement in RA pathogenesis is not universal but subtype-specific, potentially linked to distinct clinical phenotypes.Methods: We performed a retrospective analysis of synovial pathology and clinical data from 55 RA patients collected during 2023. …”
Get full text

Serum Glucose-Phosphate Ratio on Admission as a Potential Biomarker for Severity, Functional Outcome, and Recurrence in Acute Ischemic Stroke by Li J, Ma W, Tang W, Yang K, Gu H, Shi J, Chen F, Xu C, Gu S, Wang Y

“…Therefore, this prospective study aimed to investigate the association between admission serum glucose-phosphate ratio and the severity and 1-year clinical outcome of AIS.Methods: All the patients with AIS were enrolled from the Third China National Stroke Registry III. …”
Get full text

Effect of Jian-Pi-Zhi-Dong Decoction on striatal glutamate and γ-aminobutyric acid levels detected using microdialysis in a rat model of Tourette syndrome by Zhang W, Wei L, Yu W, Cui X, Liu X, Wang Q, Wang S

“…This study evaluated the effect of JPZDD on glutamate (Glu) and γ-aminobutyric acid (GABA) and their receptors in a TS rat model.Materials and methods: Rats were divided into four groups (n=12 each). …”
Get full text

Exosomes from Adipose-Derived Mesenchymal Stromal Cells Prevent Medication-Related Osteonecrosis of the Jaw by Inhibiting Macrophage M1 Polarization and Pyroptosis by Zheng Y, Wang X, He Y, Chen S, He L, Zhang Y

“…In this study, our aim was to explore the mechanisms of exosomes derived from adipose-derived mesenchymal stromal cells (ADSCs) in preventing MRONJ by focusing on macrophage M1 polarization and pyroptosis.Methods: The MRONJ model was established by the administration of zoledronate and tooth extraction. …”
Get full text

Fumarate Hydratase Restrains mtDNA Attenuates LPS-Induced Acute Lung Injury Through cGAS-STING Pathways by Jiang Z, He R, Zhong Y, Liu B, He Z

“…Fumarate hydratase (FH), a key enzyme catalyzing fumarate-to-malate conversion in the TCA cycle, is implicated in macrophage inflammatory responses, but its specific role in ALI remains unclear.Methods: We employed FHIN1 to assess its regulatory effects in LPS-induced ALI models. …”
Get full text

Modulation Effects of Formulated Topical Nifedipine Ointment on IL- 6 and C-Reactive Protein During Facial Skin Wound Healing in Rabbits by Wasan J. Al-Dabbagh, Faehaa A. Al-Mashhadane, Ayad A. Al-Sarraj, Saba I. Thanoon, Nenuphar N. Ibrahim

“…The current study aimed to assess the modulation effect of 1% and 2% topical nifedipine ointment on IL-6 and CRP during facial skin wound healing in rabbits. Materials and Methods: Nifedipine ointments of 1% and 2% were prepared. …”
Get full text

Patient-reported outcome was close to the Danish background population 6 months after non-surgical treatment of Neer 2-part surgical neck fractures: a prospective cohort study in p... by Stig Brorson, Signe A Borg, Line L Houkjær, Kenneth B Holtz, Zaid Issa

“…We aimed to evaluate patient-reported outcome in a consecutive series of older people receiving nonoperative treatment. Methods: This is a single-center prospective cohort study. …”
Get full text

Qualitative and Quantitative Assessment of T2-Weighted Imaging Signal Variations in Prostate MRI Following Different Abstinence Periods: A Study in Young Healthy Men by Ma W, Ren B, Gao Y, Bai W

“…Wenjun Ma,1,* Baoming Ren,1,* Yanjun Gao,2 Weixian Bai2 1Department of Urology, XI’an No.3 hospital, The Affiliated Hospital of Northwest University, Xi’an, Shaanxi Province, 710018, People’s Republic of China; 2Department of Medical Imaging, XI’an No.3 hospital, The Affiliated Hospital of Northwest University, Xi’an, Shaanxi Province, 710018, People’s Republic of China*These authors contributed equally to this workCorrespondence: Weixian Bai, Department of Medical Imaging, Xi’an No.3 hospital, The Affiliated Hospital of Northwest University, No. 10 East Section, Fengcheng 3rd Road, Weiyang District, Xi’an, Shaanxi Province, 710018, People’s Republic of China, Tel +86 17749010935, Email bai_weixianbwx@126.comObjective: This study evaluates the impact of an abstinence period on the image quality of high-field prostate magnetic resonance imaging (MRI).Methods: Male patients who underwent prostate MRI at Xi’an No.3 hospital between November 2021 and November 2022 were included in this study. …”
Get full text

Lactobacillus Protects Against Chronic Suppurative Otitis Media via Modulating RFTN1/ Lipid Raft /TLR4-Mediated Inflammation by Liu Z, Zhang F, Jia F, Li S, Jiang C, Ruan B, Long R

“…This study aimed to investigate the antipathogenic effects and underlying mechanism of Lactobacillus on CSOM.Methods: RNA sequencing of granulation of middle ear cavity from CSOM patients and lavage fluid of middle ear from normal volunteer was conducted. …”
Get full text

Image Recognition Performance of GPT-4V(ision) and GPT-4o in Ophthalmology: Use of Images in Clinical Questions by Tomita K, Nishida T, Kitaguchi Y, Kitazawa K, Miyake M

“…Kosei Tomita,1 Takashi Nishida,2 Yoshiyuki Kitaguchi,3 Koji Kitazawa,4,* Masahiro Miyake5,* 1Department of Ophthalmology, Kawasaki Medical School, Okayama, Japan; 2Hamilton Glaucoma Center, Shiley Eye Institute, Viterbi Family Department of Ophthalmology, University of California, San Diego, La Jolla, CA, USA; 3Department of Ophthalmology, Osaka University Graduate School of Medicine, Osaka, Japan; 4Department of Ophthalmology, Kyoto Prefectural University of Medicine, Kyoto, Japan; 5Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan*These authors contributed equally to this workCorrespondence: Takashi Nishida, University of California, 9415 Campus Point Drive, San Diego, La Jolla, CA, 92093-0946, USA, Email t.nishida.opt@gmail.comPurpose: To compare the diagnostic accuracy of Generative Pre-trained Transformer with Vision (GPT)-4, GPT-4 with Vision (GPT-4V), and GPT-4o for clinical questions in ophthalmology.Patients and Methods: The questions were collected from the “Diagnosis This” section on the American Academy of Ophthalmology website. …”
Get full text

The Effects of Home Quarantine Duration, Parental Emotional Intelligence, and Family Socioeconomic Status on Children’s Anxiety During the Pandemic: A Survey of 29,550 Parent... by Xiang J, Wu J, Lian C, Lin X

“…This study investigated the role of the length of the quarantine period, parents’ emotional intelligence, and family socioeconomic status (SES) in influencing children’s anxiety.Objective: This study aims to examine the relationship between quarantine duration and children’s anxiety and to explore the mediating role of parents’ emotional intelligence and the moderating role of family socioeconomic status in this relationship.Methods: An online questionnaire surveyed 29,550 parents in Guangdong, Hubei, Henan, and Guangxi provinces of China. …”
Get full text

NeuroFuzzXAI: A Hybrid Artificial Intelligence Framework for Epileptic Seizure Detection by Flavia COSTI, Emanuel COVACI, Ovidiu ROMAN, Darian ONCHIS

“…The objective is to enhance transparency in decision-making by identifying key EEG features and providing an interpretable risk assessment. Materials and Methods: This study utilizes the publicly available Epileptic Seizure Recognition dataset [i], which consists of EEG recordings from 500 subjects, segmented into 11,500 one-second windows, each described by 178 features. …”
Get full text

Effects of hypertensive heart disease on the quality of life of military personnel under the conditions of the Far north by A. S. Dybin, L. I. Menshikova

“…Aim: To assess the relationship between the presence of hypertension and the quality of life of contracted military personnel in the Far North, as well as to establish a correlation between the military rank and body mass index.Materials and methods. A medical and sociological study was conducted using a questionnaire survey of 613 military personnel serving on a contract basis in the Far North. …”
Get full text

Exploration of the Gaps in the Enactment and Implementation of the Domestic Violence Act of South Africa by Sabelinah M. Tshoane, Paul O. Bello, Jacob T. Mofokeng, Adewale A. Olutola

“…The study explored the existence of domestic abuse against men and the gender neutrality of the Domestic Violence Act of South Africa using a mixed-methods research strategy. The Gauteng, Limpopo, and KwaZulu-Natal provinces in South Africa were used for data collection. …”
Get full text