A randomized double-blind trial of intranasal dexmedetomidine versus intranasal esketamine for procedural sedation and analgesia in young children by Anna Nikula, Stefan Lundeberg, Malin Ryd Rinder, Mitja Lääperi, Katri Sandholm, Maaret Castrén, Lisa Kurland

“…The objective of this study was to evaluate whether intranasal dexmedetomidine could provide more effective analgesia and sedation during a procedure than intranasal esketamine. Methods This was a double-blind equally randomized (1:1) superiority trial of 30 children aged 1–3 years presenting to the Emergency Department with a laceration or a burn and requiring procedural sedation and analgesia. …”
Get full text

Parameters of radical resection in laparoscopic and open colon and rectal cancer surgery by Krdžić Igor, Kenić Marko, Šćepanović Milena, Soldatović Ivan, Ilić-Živojinović Jelena, Radovanović Dragan

“…The aim of this study was to determine whether laparoscopic approach provides all parameters of oncological radicality as open surgery of colorectal cancer. Methods. The study included 122 patients with carcinoma of colon and rectum, divided into two equal groups: patients operated on by laparoscopic and those operated on by open approach. …”
Get full text

Folate-Modified Smart Responsive Nanosystems for Enhancing Anti-Tumor Therapy Through Calcium Overload and Chemotherapy by Tang Y, Huang J, Cui C, Yang F, Li K, Gao B, Fu S, Yang X

“…Precise drug delivery via folate-modified nanomaterials is an important measure to improve efficacy and reduce toxicity.Methods: CaCO3 nanoparticles served as the carrier for loading DOX and 5-Fu, followed by encapsulation with folic acid-modified polydopamine (PDA) to form a smart dual drug-carrying nanosystem called FA-DCFP. …”
Get full text

Real-World Analysis of the Efficacy and Adverse Events of T-DM1 in Chinese Patients With HER2-Positive Breast Cancer by Gu H, Zhu T, Ding J, Yang Z, Qi S, Guo G

“…Huayan Gu,1,* Teng Zhu,2,* JiaLing Ding,1 Zhi Yang,1 Shuangyi Qi,1 Guilong Guo1 1Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China; 2Department of Gastrointestinal Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Guilong Guo, Department of Breast Surgery, The First Affiliated Hospital of Wenzhou Medical University, Nanbaixiang Street, Wenzhou City, Zhejiang Province, People’s Republic of China, Email guoguilong@sina.comPurpose: This study efforts to explore the association of adverse events (AEs) with efficacy in HER2-positive breast cancer patients treated with TDM1.Methods and Materials: This retrospective study included women diagnosed with HER2+ BC treated with TDM1 from January 2012 to December 2023. …”
Get full text

CEREBROPROTECTIVE ACTIVITY OF NEW DERIVATIVES OF PIRIMIDINE4 1H ONE PIR9 AND PIR10 IN IRREVERSIBLE OCCLUSION OF THE COMMON CAROTID ARTERY by A. V. Voronkov, N. B. Shabanova, I. P. Kodonidi, I. S. Shatalov

“…The aim of this work is to study the cerebroprotective activity of the new derivatives of Pirimidine-4-(1H)-OHA PIR-9 and PIR-10 in irreversible occlusion of the common carotid artery. Materials and methods. The study was carried out on 120 male rats of the Wistar line, weighing 200-220 g, divided into 6 equal groups. …”
Get full text

Nerve Block Extends Nerve Function Recovery in Patients with Diabetic Foot Ulcers by Wei Q, Rong H, Zhang G, Xie Y, Dai W

“…The aim of this study is to investigate the minimum stimulation thresholds of the femoral and sciatic nerves, as well as the duration of nerve block, in patients diagnosed with diabetic foot.Methods: From July 2020 to March 2022, a prospective study was conducted involving patients aged 50– 80 scheduled for distal lower limb surgery. …”
Get full text

Clinical and Antibiotic Resistance Features for Extended-Spectrum Betalactamase-Producing Escherichia coli and Klebsiella pneumoniae Bloodstream Infections and Predictors of Poor P... by Yan W, Liang J, Liu M, Hu X, Zhang H, Guo J, Li L

“…This study aimed to describe the clinical characteristics, profiles of antibiotic susceptibility, and risk factors associated with BSIs caused by E. coli (ESBL-EC) and K. pneumoniae (ESBL-KP), and identify risk factors for poor prognosis in neonatal patients with E. coli or K. pneumoniae BSIs.Methods: In the period from January 2017 to December 2023, a retrospective case-control study was conducted at Guangxi Children’s Hospital in China. …”
Get full text

Usability Evaluation of Foods with Function Claims Labelling as Health Information in Japan: A User-Testing Study by Yamamoto M, Yamamoto K, Takano-Ohmuro H, Yamamoto R, Saruwatari J

“…It is important to explore ways to evaluate and improve labelling usability from the consumers’ perspective to ensure safe usage.Patients and Methods: We conducted user testing from the consumers’ perspective on labels of five different FFCs, utilizing semi-structured interviews with 50 participants of diverse ages and sexes. …”
Get full text

Dysbiosis and Metabolic Dysregulation of Salivary Microbiota in Schizophrenia by Wang J, Lu L, Ren L, Zhu R, Jiang Y, Qiao Y, Li Y

“…However, fewer studies have directly investigated the potential links between oral microbiota and SZ.Purpose: This study aimed to explore the relationship between salivary microbiota dysbiosis and SZ, examining microbial and metabolic alterations that may contribute to SZ pathophysiology.Methods: Salivary samples from 30 hospitalized patients diagnosed with SZ and 10 healthy controls were collected. …”
Get full text

Patients’ perception of quality of care in health facilities empanelled under Sehat-Card-Plus programme, in Khyber-Pakhtunkhwa, Pakistan by Kiran Sohail Azeemi, Shifa Salman Habib, Waqas Hameed, Junaid Ur Rehman Siddiqui, Ali Hussaini, Asma Altaf Hussain Merchant, Adil Haider, Sameen Siddiqi

“… Objective:This study aims to assess perceived quality of care among users of hospitals empanelled under SCP Programme, KP. Methods: The assumed satisfaction level was 80% among SCP users, and 10%-point lower satisfaction among SCP nonusers. …”
Get full text

Analysis of Pharmacokinetic Parameters of Acetylsalicylic Acid for Prediction of Potential Nephrotoxic Effects by L. M. Krasnykh, O. A. Goroshko, G. F. Vasilenko, G. I. Gorodetskaya, V. V. Smirnov, T. A. Rodina

“…The study of the pharmacokinetics of acetylsalicylic acid products will contribute to timely detection and correction of side effects caused by this medicinal product.The aim of the study was to evaluate potential nephrotoxic effects following a single oral administration of 75 mg of acetylsalicylic acid, based on the analysis of the pharmacokinetic parameters.Materials and methods: the study involved 24 healthy volunteers who received 75 mg of acetylsalicylic acid (tablets) once orally. …”
Get full text

Multidomain Cognitive Tele-Neurorehabilitation Training in Long-Term Post-Stroke Patients: An RCT Study by Marianna Contrada, Gennarina Arabia, Martina Vatrano, Caterina Pucci, Isabel Mantia, Federica Scarfone, Giusi Torchia, Maria Quintieri, Antonio Cerasa, Loris Pignolo

“…A randomized controlled trial (RCT) study was conducted to compare the effectiveness of a TNR multidomain cognitive approach to conventional face-to-face cognitive treatment. Methods: A total of 30 patients with stroke were equally enrolled and randomly assigned to the experimental and control groups. …”
Get full text

Prototyping neural networks to evaluate the risk of adverse cardiovascular outcomes in the population by L. A. Bogdanov, E. A. Komossky, V. V. Voronkova, D. E. Tolstosheev, G. V. Martsenyuk, A. S. Agienko, E. V. Indukaeva, A. G. Kutikhin, D. P. Tsygankova

“…To develop a neural network basis for the design of artificial intelligence software to predict adverse cardiovascular outcomes in the population.Materials and Methods. Neural networks were designed using the database of 1,525 participants of PURE (Prospective Urban Rural Epidemiology Study), an international, multi-center, prospective study investigating disease risk factors in the urban and rural areas. …”
Get full text

Adverse birth outcome and associated factors among mothers with antepartum hemorrhage in public hospitals Tigray, northern Ethiopia, 2020 by Tomas Amare Abraha, Gebremedhin Kinfe Gebremariam, Berhane Teklay Asfaha, Tensay Kahsay Weldegebreal, Desta Hailu Aregawi

“…Preterm birth, low birth weight and asphyxiated babies are at high risk for mortality, morbidity and developmental problems Thus, the aim of this study was to assess adverse birth outcomes and associated factors among mothers with antepartum hemorrhage in Tigray public hospitals, northern Ethiopia. Methods Institution based cross sectional study design was conducted from February to April 2020 among randomly selected 309 charts of mothers with chart completeness of 95.4%. …”
Get full text

The main trends of dynamics of incomes of Russians in times of economic crisis by O. L. Petryakova

“…The research is based on the analysis of statistical and sociological information, including results of polls of the population, in him the research of ranks of dynamics, graphic and tabular methods is applied. In article sources of the income of the population, first of all – the salary and social payments exerting the greatest impact on the level of the income in general are considered. …”
Get full text

An adapted smoking-cessation intervention for Turkish-speaking migrants in Switzerland: Predictors of smoking outcomes at one-year follow-up. by Raquel Paz Castro, Michael P Schaub, Corina Salis Gross

“…Among those migrant populations, Turkish- and Kurdish-speaking migrants are often overrepresented. Providing equal access to health services is one of the major challenges of our time. …”
Get full text

MINIMALLY-INVASIVE SURGERY FOR COLLORECTAL CANCER IN ELDERLY PATIENTS by I. L. Chernikovskiy, V. M. Gelfond, A. S. Zagryadskikh, S. A. Savchuk

“…The purpose of the study was to evaluate the experience of surgical treatment for elderly patients with colorectal cancer. material and methods. The treatment outcomes of 106 colorectal cancer patients aged 75 years or over, who underwent surgery between 2013 and 2015 were presented. …”
Get full text

Study on the mechanism of action of NGAL in renal anemia on iron metabolism and erythrocyte maturation by WU Xin-hong, ZHANG Yun

“…Objective To explore the potential mechanism and main influencing factors of neutrophil gelatinase-associated lipocalin(NGAL) in iron metabolism and erythrocyte maturation of renal anemia, and finding new therapeutic targets for renal anemia. Methods Forty-five SD rats were divided into control group and observation group. …”
Get full text

Identification and Validation of Oxidative Stress-Related Diagnostic Marker Genes and Immune Landscape in Ulcerative Interstitial Cystitis by Integrating Bioinformatics and Machine... by Fu C, Zhang Y, Zhao Y, Wang S, Zhou Y, Lv J, Jin S, Liu F, Feng N

“…This study aimed to identify oxidative stress-linked biomarkers and explore their relationship with immune cell infiltration to enhance diagnosis and treatment strategies.Patients and Methods: The GSE711783 dataset from GEO was analyzed to identify differentially expressed genes in ulcerative IC. …”
Get full text

A Bibliometric Study of Interleukin Cytokines in the Treatment of Intervertebral Disc Degeneration by Wang H, Li X, Wang S, Liu J, Xie N

“…Systematic analysis of interleukin family cytokines and intervertebral disc degeneration and summary of related mechanisms will help to further promote the progress of related clinical treatment.Methods: The related articles published in 1 January 2015– 1 December 2024 were all from network science (WOS), and charts were made and analyzed by using social science statistics software package and GraphPad Prism 8 software. …”
Get full text