Classification of the LC4 Primarily-like Cell Line—Recapitulating a CDK4 Overexpressing Immune Evasive HIV-HCV-Induced HCC by Janine Kah, Lisa Staffeldt, Tassilo Volz, Kornelius Schulze, Asmus Heumann, Götz Rövenstrunk, Meike Goebel, Sven Peine, Maura Dandri, Stefan Lüth

“…Therefore, we classify a primary-like cell line derived from the core region of an HCC with underlying HIV-HCV co-infection employing deep analysis on the pathway regulation level. Methods: We employed DEG analysis, followed by pathway analysis, to characterize the preservation level of the LC4 cells and the level of adoption. …”
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GRaNIE and GRaNPA: inference and evaluation of enhancer‐mediated gene regulatory networks by Aryan Kamal, Christian Arnold, Annique Claringbould, Rim Moussa, Nila H Servaas, Maksim Kholmatov, Neha Daga, Daria Nogina, Sophia Mueller‐Dott, Armando Reyes‐Palomares, Giovanni Palla, Olga Sigalova, Daria Bunina, Caroline Pabst, Judith B Zaugg

“…We demonstrate their power by investigating gene regulatory mechanisms underlying the response of macrophages to infection, cancer and common genetic traits including autoimmune diseases. Finally, our methods identify the TF PURA as a putative regulator of pro‐inflammatory macrophage polarisation.…”
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The changing demographics and severity in hospitalized patients across COVID-19 variants: A national cohort study by Priyanka Parajuli, Lara A.C. Phipps, Roy Sabo, Rasha Alsaadawi, Amanda Robinson, Evan French, Richard K. Sterling, N3C. consortium

“… Abstract Introduction: The respiratory syndrome coronavirus (SARS-CoV-2) has undergone genetic evolution and led to variants of concern that vary in transmissibility and clinical severity. Methods: This retrospective cohort analysis studied 232,364 hospitalized COVID-19-positive patients in the National COVID Cohort Collaborative [April 27, 2020 and June 25, 2022]. …”
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A CLINICAL AND ECONOMICAL ANALYSIS OF THE RESULTS PRODUCED BY THE PROGRAM OF RSV-INFECTION PROPHYLAXIS DURING THE EPIDEMIOLOGICAL SEASON OF 2012/2013 IN MOSCOW by V. I. Ignat'eva, D. U. Ovsannikov, M. V. Avksentyeva, O. U. Rebrova, K. V. Gerasimova, I. G. Soldatova, G. A. Asmolova, L. L. Pankratyeva, E. A. Degtareva

“…Immune prevention expenses in the group under study equaled to 33,518,514.60 rubles, whereas the estimated expenses in the absence of immune prevention equaled to 1,698,103.90 rubles. …”
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Comparison of hair steroid levels among Wistar rats exposed to different environmental enrichment settings by Alberto Elmi, Niccolò I. Vannetti, Viola Galligioni, Nadia Govoni, Camilla Aniballi, José M. Sánchez-Morgado, Maria L. Bacci, Domenico Ventrella

“…This study aimed to compare the hair steroid profiles, specifically corticosterone, cortisol, and dehydroepiandrosterone (DHEA), of Wistar rats exposed to two different EE settings. Materials and Methods: Twenty (n = 20) outbred Wistar rats were enrolled in this study. …”
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Mechanical injuries of the eye: Incidence, structure and possibilities for prevention by Jovanović Miloš, Stefanović Ivan

“…The aim of this study was to analyze factors leading to occurrence of mechanical injuries of the eye. Methods. Mechanic injuries of the eye in patients treated at the Institute for Eye Diseases of the Clinical Center of Serbia in Belgrade, in an eight-year period were analyzed. …”
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Analysis of control arms in oncology randomised trials in Brazil: a cross-sectional study by Ana Elisa Boracini Sanches, Luiza Aleixo Barros Leite Fadul, Debora Aparecida Pires de Campos Zuccari, Beatriz de Menezes Dobbert, Lorena Forner, Júlia Belone Lopes, Daniel Vilarim Araujo

“…This trial aims to describe the control arms of randomised oncology trials recruiting in Brazil, an LMIC where the majority of patients receive care through the public health system, the Unified Health System (SUS), which provides limited access to cancer treatments.Methods and analysis This cross-sectional study included randomised clinical trials recruiting in Brazil on 4 December 2023 (ClinicalTrials.gov). …”
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Treatment Efficacy of Open Kinetic Chain Combined with Closed Kinetic Chain Exercise Training on Patients after Anterior Cruciate Ligament Reconstruction by GAO Peng, JIANG Xin, WANG Junzhe, WANG Hongyu, LIU Chengyao

“…ObjectiveTo observe the effect of open kinetic chain (OKC) combined with closed kinetic chain (CKC) exercise training on motor function of knee or lower limb, balance function, quadriceps isokinetic muscle strength and atrophy degree after anterior cruciate ligament (ACL) reconstruction.MethodsA total of 84 patients who underwent knee ACL reconstruction in the Jinan Zhangqiu District People's Hospital from January 2020 to October 2021 were randomly divided into OKC group, CKC group, equal combination group and adjusted combination group, with 21 cases in each group. …”
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The Relationship Between Supply Environment, Supply Chain Integration and Performance Considering Opportunistic Behaviors by Abbas َAsadi, safanaz Heidari

“…From among the statistical population of 230 individuals, a sample of 140 participants was obtained using the Cochran sampling method. They were selected through random sampling. …”
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Automated Measurement of Coronary Artery Calcifications and Routine Perioperative Blood Tests Predict Survival in Resected Stage I Lung Cancer by Federica Sabia, MSc, Camilla Valsecchi, MSc, Roberta Eufrasia Ledda, MD, Giorgio Bogani, MD, Riccardo Orlandi, MD, Luigi Rolli, MD, Michele Ferrari, MD, Maurizio Balbi, MD, Alfonso Marchianò, MD, Ugo Pastorino, MD

“…This study aimed to evaluate the performance of a fully automated CAC scoring alone and combined with a prognostic index on the basis of perioperative routine blood tests in predicting 5-year survival of patients with stage I LC. Methods: This study included 536 consecutive patients with stage I LC who underwent preoperative chest computed tomography followed by surgical resection. …”
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The First Insight-HXMT Localization Catalog of Short-duration Gamma-Ray Bursts: The First Six Years by Shuo Xiao, Yan-Ting Zhang, Yue Wang, Yan-Qiu Zhang, Shao-Lin Xiong, Shuang-Nan Zhang, Shi-Jie Zheng, Jin-Peng Zhang, Peng Zhang, Cheng-Kui Li, Xiao-Bo Li, Shu-Xu Yi, Zhen Zhang, Bing Li, Hua Feng, Cong-Zhan Liu, Ming-Yu Ge, Xu-Fang Li, Zheng-Wei Li, Yu-Peng Xu, Xiang-Yang Wen, Jian-Chao Sun, Lian Tao, Qi-Bin Yi, Ce Cai, Yi Zhao, Wang-Chen Xue, Jia-Cong Liu, Chao Zheng, Chen-Wei Wang, Wen-Jun Tan, You-Li Tuo, Li-Ming Song, Fang-Jun Lu, Ti-Pei Li

“…The median and minimum of the joint localization area are 229 and 0.2 square degrees, respectively. We also propose a method to effectively locate those bursts (e.g., GRB 200415A) for which HE suffered from data saturation. …”
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Endotheliumprotectiv and antihypoxic properties of quercetin in elderly patients with metabolic syndrome by O. V. Korkushko, I. A. Antoniuk-Shcheglova, S. S. Naskalova, O. V. Bondarenko, O. M. Hryb, V. B. Shatylo, N. M. Koshel

“…Aim: To investigate the effectiveness of course quercetin in improving functional state of the microvascular endothelium and to determine the possibility of using quercetin to increase body resistance to hypoxia in the elderly. Materials and methods. The effectiveness of quercetin in improving the functional state of the endothelium and increasing body resistance to hypoxia was studied in 110 elderly patients with metabolic syndrome, who were divided equally into the main and control groups. …”
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The effect of three different acrylic intraocular lenses on the glistening formation by Todorović Dušan, Srećković Sunčica, Petrović Nenad, Resan Mirko, Damjanović Goran, Todorović Željko, Šarenac-Vulović Tatjana

“…The aim of this study was to determine the incidence of glistening formation after the implantation of three different acrylic IOLs during the two-year follow-up period. Methods. Cataract surgery was performed in 93 patients (93 eyes) with developed senile cataracts. …”
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Efficacy of perioperative intravenous lidocaine infusion on postoperative pulmonary complications in patients undergoing video-assisted thoracoscopic lung resection surgery: protoc... by Li Liu, Fei Wang, Yanxia He, Miyi Zhou, Qingyong Luo, Zuojia Zeng, Si Zeng, Qian Lei

“…This study is designed to investigate whether intraoperative intravenous lidocaine infusion can reduce the incidence of PPCs in adult patients undergoing video-assisted thoracoscopic lung resection surgery.Methods and analysis This single-centre, double-blinded study will enrol 366 patients scheduled for video-assisted thoracoscopic lung resection surgery. …”
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Effect of Ruiyun procedure for hemorrhoids (RPH-4) for treating mixed hemorrhoids by Yao Qixian, Wang jinglin, Di Yan, Tang Lingjiao, An Xiaohai, He yu, Xu Jun

“…[Objectives] To investigate the effect of Ruiyun procedure for hemorrhoids (RPH-4) for treating mixed hemorrhoids. [Methods] Sixty-two patients with mixed hemorrhoids treated at the People’s Hospital of Suzhou New District between December 2018 and January 2020 were randomly assigned to the treatment group (n=31) and the control group (n=31). …”
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TNFα–308G/A Polymorphism as a Risk Factor for HPV Associated Cervical Cancer in Indian Population by Indu Kohaar, Nisha Thakur, Sudha Salhan, Swaraj Batra, Veena Singh, Anita Sharma, Pushpa Sodhani, B. C. Das, Debi P. Sarkar, Mausumi Bharadwaj

“…Background: Investigation of the potential association of single nucleotide polymorphisms (SNPs) at –308 G/A and –238 G/A of Tumor necrosis factor α (TNFα) with susceptibility to HPV-16 associated cervical cancer in Indian women. Methods: The study included 165 histologically confirmed cases with 45 precancer and 120 cancer patients and an equal number (165) of healthy controls with normal cervical cytology. …”
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The role of plant oils/lipids as innovative fat replacers in various food products: A review by Kok Jia-Wei, Ming Fu, Abu Bakar Asyrul-Izhar, Lilis Suryaningsih, Dicky Tri Utama, Kazem Alirezalu, Mohammad Rashedi Ismail-Fitry

“…This work reviews the methods of structuring plant oils into fat replacers and the functionality of these fat replacers, including emulsions and liquid oils, based on their recent applications in meat, bakery, and dairy products. …”
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What about the donor site morbidity – how invasive is the free latissimus dorsi flap? by Nikolaus Wachtel, Riccardo E. Giunta, Marc Hellweg, Maximilian Hirschmann, Constanze Kuhlmann, Nicholas Moellhoff, Denis Ehrl

“…The aim of this prospective study was therefore to objectively investigate the morbidity of a free LDM flap. Methods: A control group (n = 100) without surgery was recruited to assess the differences in strength and range of motion (ROM) in the shoulder joint with regard to handedness of patients. …”
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Involvement of the mouth and jaw area in dermatological diseases by Ramiah, Vasudevi, Sankar, Shenbaga Lalitha, Shunmugavelu, Karthik, Hussain, Sajid Tajamul, Sadasivam, Manju Palanisamy, Behura, Shyam Sundar

“…Oral mucosal lesions can be early manifestations of the disease or the only symptom of dermatological diseases; therefore no symptom or sign in the oral cavity should be neglected. Materials and methods: 1,131 patients who came to the Oral and Maxillofacial Pathology department for various dermatological treatments were included. …”
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Laser vs bur for bone cutting in impacted mandibular third molar surgery: A randomized controlled trial by Deepak Passi, Uma Shankar Pal, Shadab Mohammad, Rakesh Kumar Singh, Divya Mehrotra, Geeta Singh, Manoj Kumar, Arul A.L. Chellappa, Chandan Gupta

“…Background: The aim of this study was to assess the feasibility of Er: YAG laser in bone cutting for removal of impacted lower third molar teeth and compare its outcomes with that of surgical bur. Materials & methods: The study comprised 40 subjects requiring removal of impacted mandibular third molar, randomly categorized into two equal groups of 20 each, who had their impacted third molar removed either using Er: YAG laser or surgical bur as per their group, using standard methodology of extraction of impacted teeth. …”
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