Pharmacoeconomic analysis of fixed-duration targeted therapy regimens for chronic lymphocytic leukemia compared with therapy used until progression or intolerable toxicity by A. R. Kasimova, A. S. Kolbin, M. A. Proskurin, Yu. E. Balykina

“…To perform a pharmacoeconomic analysis of the feasibility of fixed therapy regimens based on venetoclax in comparison with other targeted drugs registered in Russia, from the class of bruton kinase inhibitors, used until CLL progression or unacceptable toxicity.Materials and methods. A list of direct costs in the health care system was compiled. …”
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Integrating Sustainability in Aircraft Component Design: Towards a Transition from Eco-Driven to Sustainability-Driven Design by Angelos Filippatos, Dionysios Markatos, Athina Theochari, Spiros Pantelakis

“…To efficiently prioritize different variables, methods such as multi-criteria decision-making (MCDM) are employed, and a sustainability index is developed in this framework to assess the overall sustainability of each design alternative. …”
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Flexural Properties, Impact Strength, and Hardness of Nanodiamond-Modified PMMA Denture Base Resin by Shaimaa M. Fouda, Mohammed M. Gad, Passent Ellakany, Maram A. Al Ghamdi, Soban Q. Khan, Sultan Akhtar, Mohamed S. Ali, Fahad A. Al-Harbi

“…Investigate the effect of low nanodiamond (ND) addition and autoclave polymerization on the flexural strength, impact strength, and hardness of polymethylmethacrylate (PMMA) denture base. Methods. A total of 240 heat polymerized PMMA were fabricated with low ND concentrations of 0.1%, 0.25%, and 0.5%, and unmodified as control. …”
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Abstract 275: Hypothesizing After Results are Known (HARKing) in Neurovascular Research Induced by Meeting Abstract Preparation Guidelines by Venya Vaddi, Jesse W. Hou, Neal M. Rao, Jeffrey L. Saver

“…Meeting abstract instructions may affect the frequency of HARKing. Methods We tested the hypothesis that, compared with abstract instructions NOT indicating a "hypothesis" should be stated, instructions indicating THAT a "hypothesis" should be stated would increase the proportion of abstracts judged by field content experts to exhibit HARKing. …”
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The peculiarities of using and reading of hydrogen breath test results with lactose load in young children and their mothers by S. I. Ilchenko, S. M. Nedelska, T. V. Mozheiko

“…Purpose of the work is to evaluate efficacy of using hydrogen breath test with nutritional lactose load among young children and their mothers and correlation of the test results with manifestation of functional gastrointestinal disorders in children. Materials and methods. Hydrogen breath test with nutritional lactose load, genetic marker C (-13910)T of the gene MCM6 investigation by buccal scraping, microbiological investigation of stool were carried out in 32 young children between 1 month and 2 years of age with different manifestations of functional gastrointestinal disorders. …”
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Saudi native chicken response to embryonic thermal manipulation: Comparative morphometric analysis of myofiber diameter of the pectoral and thigh muscles by Ibrahim Albokhadaim

“…Aim: This study assessed the impact of temperature modulation on the hatchability, body weight, and myofiber diameter of pectoral and thigh muscles in native Saudi chickens. Methods: In this study, 300 viable eggs were equally divided and at random into three groups. …”
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Tomatidine Alleviates Intervertebral Disc Degeneration by Activating the Nrf2/HO-1/GPX4 Signaling Pathway by Li Z, Cheng P, Xi H, Jiang T, Zheng X, Qiu J, Gong Y, Wu X, Mi S, Hong Y, Hong Z, Zhou W

“…The aim of this study is to investigate the effects and mechanisms of tomatidine in ameliorating lumbar IDD.Methods: Nucleus pulposus cells (NPCs) exposed to lipopolysaccharides were used as an in vitro model to investigate changes in the expression of extracellular matrix components and associated signaling pathway molecules. …”
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Analysis of clinical and pathological prognostic factors of survival in rectal adenocarcinoma treated with preoperative radiochemotherapy by Sarhan Sydney Saad, Nora Forones, Gaspar Lopes Filho, Jaques Waisberg, Elesiario Caetano Júnior, Ricardo Artigiani-Neto, Delcio Matos

“…ABSTRACT Purpose: To identify the prognostic variables related to the survival of patients operated on for adenocarcinoma of the rectum who underwent preoperative radiochemotherapy (RCT). Methods: We studied 70 patients from the Discipline of Surgical Gastroenterology at Escola Paulista de Medicina from 2000 to 2019, with rectal cancer located up to 10 cm from the anal verge and with stages II or III, submitted to preoperative RCT and curative surgery (R0) and with follow-up of at least 12 months. …”
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Endoscopic Treatment of Zenker’s Diverticulum: Comparable Treatment Outcomes in Treatment-Naïve and Pretreated Patients by Johannes Manzeneder, Christoph Römmele, Carolin Manzeneder, Alanna Ebigbo, Helmut Messmann, Stefan Karl Goelder

“…This study analyzes long-term symptom control and the rate of adverse events in treatment-naïve patients and patients with recurrence, using the stag beetle knife junior (sb knife jr). Methods. From August 2013 to May 2019, 100 patients with symptomatic ZD were treated with flexible endoscopy using the sb knife jr. …”
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Escherichia coli in the T11-12 Thoracic Vertebrae: A Case Report by Weng D, Zhou H, Huang G, Cao Q, Wang H, Cao Z, Xie Q

“…Early diagnosis and precise management are essential for improving outcomes, given the limitations of traditional microbiology detection methods in identifying the causative pathogens.Case Presentation: A 68-year-old immunocompetent male presented with recurrent fever, fatigue, loss of appetite and initial evidence of sepsis and AKI upon admission. …”
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Clinical and functional evaluation of patients with acute low back pain and radiculopathy treated with different energy doses of low level laser therapy by Jovičić Milica, Konstantinović Ljubica, Lazović Milica, Jovičić Vladimir

“…The aim of this study was to investigate the effects of three different energy doses of LLLT in patients with acute LBP and radiculopathy. Methods. The study included 66 patients with acute LBP and radiculopathy who had been randomly divided into three groups (22 patients each) received three different doses of LLLT. …”
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Correlation Between Bone Metabolism Indices and Osteoporotic Thoracolumbar Vertebrae Fracture in Postmenopausal Women by Jing P, Kong F, Meng B, Yang S

“…Pengrui Jing,* Fanqi Kong,* Bin Meng, Shaofeng Yang Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, Suzhou, 215006, People’s Republic of China*These authors contributed equally to this workCorrespondence: Shaofeng Yang; Bin Meng, Department of Orthopaedic Surgery, The First Affiliated Hospital of Soochow University, No. 899 Pinghai Road, Suzhou, Jiangsu, 215006, People’s Republic of China, Email shaofengyang1014@163.com; mengbinspine@163.comBackground: This study aims to explore the correlation between bone metabolism indices and osteoporotic thoracolumbar vertebrae fracture (OTVF) in postmenopausal women.Methods: A total of 447 female patients with postmenopause and underwent OTVF in our hospital were selected as group A. …”
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Comparison of Canal Transportation, Separation Rate, and Preparation Time between One Shape and Neoniti (Neolix): An In Vitro CBCT Study by Maryam Kuzekanani, Faranak Sadeghi, Nima Hatami, Maryam Rad, Mansoureh Darijani, Laurence James Walsh

“…This in vitro study compared root canal preparation in curved mesiobuccal canals of molar teeth using either the One Shape™ or the Neoniti (Neolix) rotary NiTi single-file systems, assessing canal transportation, instrument separation and time required for preparation. Methods. Extracted maxillary and mandibular human molar teeth with mesiobuccal canals having apical angles of curvature between 25 and 35o were selected and embedded in acrylic resin blocks, and an initial CBCT was taken. …”
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Taxus chinensis-Derived Nanovesicles Alleviate Mouse Colitis by Inhibiting Inflammatory Cytokines and Restoring Gut Microbiota by Gong Q, Hu J, Pu C, Zhao Z, Guo Y

“…Among these, plant-derived nanovesicles (NVs) have garnered significant attention for their potential in treating colitis.Methods: In this study, we extracted NVs from the leaves (LNVs) and stems (SNVs) of Taxus, a well-known natural anti-cancer plant. …”
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Intratumoral and Peritumoral Radiomics Based on DCE-MRI for Prediction of Microvascular Invasion Grading in Solitary Hepatocellular Carcinoma (≤3 cm) by Li Y, Li H, Feng Y, Lu L, Zhang J, Jia N

“…Yinqiao Li,* Helin Li,* Yayuan Feng, Lun Lu, Juan Zhang, Ningyang Jia Department of Radiology, Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital of Naval Medical University, Shanghai, 200438, People’s Republic of China*These authors contributed equally to this workCorrespondence: Juan Zhang; Ningyang Jia, Department of Radiology, Eastern Hepatobiliary Surgery Hospital, Third Affiliated Hospital of Naval Medical University, Shanghai, 200438, People’s Republic of China, Email zhangjuan0801@126.com; ningyangjia@163.comPurpose: To explore the application value of clinical indicators, radiological features, and magnetic resonance imaging (MRI) radiomics to predict the grading of MVI in nodular hepatocellular carcinoma (≤ 3cm).Methods: A total of 131 patients with hepatocellular carcinoma (HCC) and confirmed microvascular invasion (MVI) who underwent surgical resection between January 2016 and December 2022 were retrospectively analyzed. …”
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HGH1 Promotes Breast Cancer Progression Through the PI3K/AKT/NF-κB Signaling Pathway: Potential Role for Prognosis and Targeted Therapy by Hu W, Si D, Liu C, Tie D, Xu D, Li N

“…Wenyu Hu,1,* Dikun Si,1,* Chenxi Liu,2,* Danchen Tie,1 Dongdong Xu,1 Nanlin Li1 1Department of Thyroid, Breast and Vascular Surgery, Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi, People’s Republic of China; 2Department of Obstetrics and Gynecology, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China*These authors contributed equally to this workCorrespondence: Nanlin Li, Email nanlin-74@163.comIntroduction: Previous studies have shown that the HGH1 gene is associated with poor prognosis in a variety of cancers, but its specific function and molecular mechanism in the pathological process of breast cancer remain unclear.Methods: The relationship between expression of HGH1 and overall survival in BC patients was analyzed. …”
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Physiological adaptations and myocellular stress in short-term, high-frequency blood flow restriction training: A scoping review. by Victor Sabino de Queiros, Nicholas Rolnick, Phelipe Wilde de Alcântara Varela, Breno Guilherme de Araújo Tinôco Cabral, Paulo Moreira Silva Dantas

“…<h4>Objectives</h4>To provide a comprehensive overview of short-term, high-frequency blood flow restriction training, including main adaptations, myocellular stress, limitations in the literature, and future perspectives.<h4>Methods</h4>A systematic search of electronic databases (Scopus, PubMed®, and Web of Science) was performed from the earliest record to April 23, 2022. …”
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Comparison between Bolus Intracoronary versus Bolus Intravenous Injection Regimens of Eptifibatide during Primary Percutaneous Coronary Intervention in Patients with Anterior ST-Se... by Mohamed Hassan Nab, Shaimaa Mostafa, Khaled Elrabat, Hamza Kabil, Neama Elmelegy

“…The current study aimed to examine the safety and efficacy of I/C vs I/V bolus regimen dose of eptifibatide during primary percutaneous coronary intervention (PPCI).Material and methods. Prospective, controlled, randomized study enrolled 100 patients with acute anterior ST-segment elevation myocardial infarction (STEMI) eligible for PPCI equally divided into 2 groups (group A received bolus I/C eptifibatide and group B received it I/V) followed by 12-hour continuous I/V infusion. …”
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Cluster Set Resistance Training Reduces Autonomic Perturbations Compared to Traditional Protocols in Trained Healthy Young Individuals: A Clinical Study by Bianca de Souza Soares, Maria Clara Gomes Alves, Carlos Eduardo Cantelmo, Bruna Cristina de Oliveira Barros, Gustavo Vieira de Oliveira

“…Objectives: This study investigates the effects of cluster set resistance training (RT) on heart rate variability (HRV) parameters in young, healthy individuals. Methods: This trial was registered in the Brazilian Clinical Trials Registry (ReBEC) under the identification number RBR-9857xj3 on 7 December 2024. …”
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Study on the Mechanism of Artesunate in Modulating AR Epithelial Injury and Th2-Type Inflammatory Status by Bao Y, Zhang Z, Shi B, Chen Q, Zhang Y, Zhu X

“…Youwei Bao,&ast; Zhiqiang Zhang,&ast; Binbin Shi, Qi Chen, Ying Zhang, Xinhua Zhu Department of Otorhinolaryngology Head and Neck Surgery, The second Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China&ast;These authors contributed equally to this workCorrespondence: Xinhua Zhu, Department of Otorhinolaryngology Head and Neck Surgery, The second Affiliated Hospital of Nanchang University, Jiangxi Medical College, Nanchang University, Nanchang, Jiangxi, 330006, People’s Republic of China, Email entzxh@126.comObjective: To evaluate the therapeutic efficacy of Artesunate (ART) in a mouse model of allergic rhinitis (AR) induced by house dust mite (HDM) and explore its underlying mechanism.Experimental Methods: Transcriptome sequencing (RNA-seq) analysis identified differentially expressed genes (DEGs) in nasal mucosa between healthy and allergic mice, with Gene Set Enrichment Analysis (GSEA) revealing STING pathway activation. …”
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