CXCR2 Activated JAK3/STAT3 Signaling Pathway Exacerbating Hepatotoxicity Associated with Tacrolimus by Chen X, Hu K, Zhang Y, He SM, Wang DD

“…The aim of this study was to investigate the mechanism of tacrolimus-induced hepatotoxicity and provide reference for drug development target.Methods: In this study, biochemical analysis, pathological staining, immunofluorescent staining, immunohistochemical staining, transcriptomic analysis, Western blotting was used to investigate the mechanism of tacrolimus-induced hepatotoxicity in gene knockout mice and Wistar rats.Results: In gene knockout mice, compared to wild-type mice, CXCR2-deficiency alleviated tacrolimus-induced hepatotoxicity (P…”
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Thriving in golden years: Promoting psychological well-being for healthy ageing in India by Dhananjay W Bansod, Raghunath Mandi

“…Therefore, present study examines the relationship between psychological well-being and healthy ageing among the elderly in India aged 60 years and above. Methods: We created composite score of healthy ageing using Principal Component Analysis based on LASI (wave-1) data 2017–18 in accordance with the WHO framework of healthy ageing based on the functional ability of an individual. …”
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Follicular mycosis fungoides - A report of four Indian cases by Rajalakshmi T, Inchara Y, Antony Meryl

“…<b> Aims:</b> To describe the clinical and pathological features of FMF. <b> Materials and Methods:</b> All cases of FMF between January and December 2007 were retrieved. …”
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Protective Effect of Fenugreek Supplementation against Mercury Toxicity on Sperm Parameters, Serum Testosterone and Testicular Tissue in the Rat by Jalal A. Karim, Karim R. Hamad

“…Background and objectives:The purpose of the current study was to investigate the effects of fenugreek supplementation against toxic effect of mercuric chloride (HgCl2)on Body weight (B.W), testis and epididymis weight, some sperm parameters, serum testosterone, serum MDA, and testis histology in the rat.Methods: Twenty eight male albino rats weights ranging from 254 to 302 gm and were divided randomly and equally into 4 groups. …”
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Effects of macrolide antibiotics on blood inflammatory mediators and organ damage markers in lipopolysaccharide-induced pulmonary damage rats by Ayşe Er, Enver Yazar

“…<p> <b>Materials and Methods:</b> Total 198 Sprague-Dawley rats were used. …”
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Fear of negative evaluation biases social evaluation inference: evidence from a probabilistic learning task. by Katherine S Button, Daphne Kounali, Lexine Stapinski, Ronald M Rapee, Glyn Lewis, Marcus R Munafò

“…We developed an instrumental learning task to model social evaluation learning, predicting that FNE would specifically bias learning about the self but not others.<h4>Methods</h4>During six test blocks (3 self-referential, 3 other-referential), participants (n = 100) met six personas and selected a word from a positive/negative pair to finish their social evaluation sentences "I think [you are / George is]…". …”
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503 A novel approach to developing and validating a predictive model of functional recovery for adults with stroke in post-acute rehabilitation by Alison Cogan, Dongze Ye, Dingyi Nie, Mary Lawlor, Nicolas Schweighofer

“…Objectives/Goals: To use patient-level Center for Medicare and Medicaid Services (CMS) mandated quality metrics for inpatient rehabilitation facilities (IRFs) to develop and validate predictive models of functional recovery and interactions of baseline characteristics with therapy time. Methods/Study Population: Retrospective cohort study of a national US sample of ~40,000 adults with a primary diagnosis of stroke admitted to IRFs in 2023. …”
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Microscopic evaluation of the effect of low-level laser therapy on platelet-rich fibrin: An in vitro study by Sruthi Kallayil Suresh, Girija Venkatesh Arishinagodi, Mallanagouda B. Patil

“…Aim: The study aimed to evaluate the effect of LLLT on PRF architectural changes and platelet concentrate values. Materials and Methods: Thirty-four samples from seventeen subjects were included in the study, with 20 mL of blood collected from each participant. …”
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Descriptive transcriptome analysis of tendon derived fibroblasts following in-vitro exposure to advanced glycation end products. by Shivam H Patel, Christopher L Mendias, Chad C Carroll

“…We propose to complete a descriptive approach to pathway profiling to broaden our mechanistic understanding of cell signaling events that may contribute to the development of tendon pathology.<h4>Methods</h4>Rat Achilles tendon fibroblasts were treated with glycolaldehyde-derived AGEs (200μg/ml) for 48 hours in normal glucose (5.5mM) conditions. …”
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The effect of angle between the graft and coronary artery on volumetric flow rate through the anastomosis by S.S. Galych, A.V. Rudenko, E.A. Nastenko, Yu.S. Starodub

“…The aim – to determine the optimal value of the angle between the graft and the coronary artery, which can ensure maximum volumetric blood flow through the created coronary anastomosis. Materials and methods. The study was carried out with porcine vessels. …”
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Palliative care in policy documents for adults with cancer and non-cancer diseases with potential palliative care needs: a document analysis by Anna O’Sullivan, Linnéa Carling, Joakim Öhlén, Stina Nyblom, Anneli Ozanne, Ragnhild Hedman, Carl-Johan Fürst, Cecilia Larsdotter

“…Design: Document analysis. Methods: A document analysis of Swedish policy documents for different disease-specific groups with severe chronic conditions, cancer and non-cancer, was performed. …”
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Evaluation of the Proximity of Root Apices of Maxillary Posterior Teeth to the Maxillary Sinus Floor using CBCT among Different Age Groups: A Retrospective Study by Nadia Rasool, S. Vidhyadhara Shetty, Sajad A. Buch, Prathap MS Nair, S Kalaichelvan, Nishi Jayasheelan

“…Therefore, knowing that a thorough understanding of the anatomical correlation between maxillary sinus floor (MSF) and maxillary teeth is indispensable for the management of cases; this research was undertaken to evaluate the proximity of root apices of the maxillary posterior (RAMP) teeth to the MSF using cone-beam computed tomography (CBCT) among different age groups of the Indian population. Methods: CBCT scans of 150 patients were obtained from the institute’s database based on strict inclusion and exclusion criteria; such that an equal number of samples were obtained in the following three age groups: Group 1 – Young group (20–44 years), Group 2 – Middle age (45–59 years), Group 3 – Elderly (60–70 years). …”
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The influence of orthodontist change on treatment duration and outcomes in patients treated with Clark’s twin block appliance followed by non-extraction fixed mechanotherapy – a re... by Rizwan Khalil, Rashna Hoshang Sukhia, Mubassar Fida

“…This retrospective cohort study aimed to compare the duration and quality of treatment outcomes between two patient groups: the transfer group, who underwent orthodontic care from multiple residents, and the non-transfer group, whose entire treatment was overseen by a single resident. Methods Sixty-six patients were enrolled and equally divided into transfer and non-transfer groups. …”
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THE PROBLEMS AND CHALLENGES OF CHILDREN FROM MULTICULTURAL FAMILIES IN SOUTH KOREA by Kim Jang Gyem

“…The data obtained are described and analyzed and then presented with descriptive methods. The problems faced by the children of multicultural families are generally more to the Indonesian culture. …”
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The Frequency Of Hematological Abnormalities in Children (Age 1 Month To 12 Years) Presenting With Sars-Cov-2 Infection At Shifa International Hospital by Sidra Tul Muntaha, Hammad Ayaz, Huma Mahmood, Afifa Kulsoom, Muhammad Tayyab, Arslan Farooq

“… Objective: To determine the frequency of haematological abnormalities in pediatric patients presenting with COVID-19 infection. Methods: A Cross-Sectional analytical study was conducted at the paediatric department of Shifa International Hospital Islamabad, over a period of six months from December 2021 to June 2022. …”
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Success rate of three capping materials used in pulpotomy of primary molars: A randomized clinical trial by Randa Youssef Abd Al Gawad, Rasha Mohamed Hatem Hanafy

“…The present study was conducted to assess clinically and radiographically the success rate of three capping materials: Nanohydroxyapatite (NHA), Mineral Trioxide Aggregate (MTA), and Formocresol (FC) in pulpotomy of primary molars. Methods: A clinical trial was carried out on healthy, four to eight years old children, with 72- second primary molars indicated for pulpotomy. …”
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What is the most important determinant of cardiometabolic risk in 60–65-year-old subjects: physical activity-related behaviours, overall energy expenditure or occupational status?... by Bartłomiej Konrad Sołtysik, Joanna Kostka, Kamil Karolczak, Cezary Watała, Tomasz Kostka

“…Objectives The aim of the study was to determine whether cardiovascular risk factors may differ according to occupational status and whether physical activity related to total energy expenditure (PA-EE) and related to health-related behaviours (PA-HRB) is associated with common cardiovascular risk factors or metabolic syndrome in pre-elderly subjects.Methods Three hundred subjects aged 60–65 were recruited and divided into three equal groups of white-collar, blue-collar workers and unemployed subjects; 50% were women. …”
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Correlation between 24-h ambulatory systolic blood pressure and glomeruar filtration rate among the elder by ZHAO Hai-yan, LI Chun-hui, ZHAO Hua-ling, SONG Lu, YANG Jing, RUAN Chun-yu, CUI Kai, WEI Guo-qing, ZHENG Xiao-ming, WU Yun-tao

“…Objective To investigate the correlation between the 24 h ambulatory systolic blood pressure(SBP) and estimated glomeruar filtration rate(eGFR) in the elder.Methods A total of 2464 participants who were more than or equal to 60 years old were selected with random sampling in accordance with the inclusion criteria from the retired workers in Tangshan Kailuan Company.Finally,1405 participants were enrolled,and the correlation between SBP and eGFR was analyzed.Multiple linear regression analysis was used to analyze the correlation between the 24 h,daytime,nightime SBP and eGFR,respectively.Results The observation population was divided into three groups according to the tertiles of 24 h,daytime,nightime SBP,respectively.With the increases of SBP,eGFR had increasing trend,but there was no significant difference.Partial correlation analysis showed negative association between 24 h SBP and eGFR(r =-0.056,P = 0.035),and no significant difference was found between daytime,nightime SBP and eGFR.Multiple linear regression analysis showed that after adjusting for confounding factors,the 24 h,daytime,nightime SBP was not associated with eGFR significantly(B =-0.28,-0.14 and-0.34;P = 0.619,0.798 and 0.521).However,the clinic SBP was associated with eGFR negatively and linearly(P<0.05).Conclusions The 24 h,daytime,nightime SBP was not significantly associated with eGFR,but there was negative association between clinic SBP and GFR.Closely monitoring blood pressure and keeping it at a low and steady level is essential to prevent and delay renal function decline.…”
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Retrospective study of 100-day mortality in advanced solid malignancies: Real world experience in a tertiary cancer center from South India by Shashidhar V Karpurmath, Shubha Supriya Asaithambi, Chevireddy Praneetha, Geetika Dandamudi, Veerendra Angadi, Manjunath Nandennavar

“…The secondary objective was to identify associated predictive factors. Materials and Methods: This retrospective cohort study included adults (>18 years) with Stage IV solid malignancies, who were planned for palliative systemic therapy at the Medical Oncology department, from a tertiary cancer center in South India over a 6-month period. …”
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Religion and union dissolution: Effects of couple and municipal religiosity on divorce and separation by Willem R. J. Vermeulen, Mioara Zoutewelle-Terovan, Niels Kooiman, Aart C. Liefbroer

“…OBJECTIVE: We aim to understand the extent to which levels of couple and municipal religiosity, as well as their interplay, affect the union dissolution risk of married and cohabiting couples. METHODS: This study focuses on the Netherlands and links survey information from the Dutch Labor Force Surveys (2011–2015) and register data from Statistics Netherlands (<i>n</i>_couples = 145,461). …”
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