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  1. 5181

    Plant Cell Culture-Derived Saponin Adjuvant Enhances Immune Response Against a Stabilized Human Metapneumovirus Pre-Fusion Vaccine Candidate by Maarten Swart, Jessica Allen, Brendan Reed, Ana Izquierdo Gil, Johan Verspuij, Sonja Schmit-Tillemans, Anish Chakkumkal, Mark Findeis, Angela V. Hafner, Chandresh Harjivan, Rebecca Kurnat, Harmjan Kuipers, Roland Zahn, Boerries Brandenburg

    Published 2024-12-01
    “…Objective: This study reports on an alternative plant cell culture system for the consistent production of highly pure QS-21. Method: We evaluated the efficacy of cultured plant cell (cpc)-produced QS-21 in a novel HMPV vaccine, formulating a recombinant pre-fusion stabilized HMPV F protein (preF) with cpcQS-21 and a synthetic toll-like receptor 4 (TLR4) agonist adjuvant formulation. …”
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  2. 5182

    Evaluating atherogenic index of plasma as a predictor for metabolic syndrome: a cross-sectional analysis from Northern Taiwan by Liang-Sien Chen, Liang-Sien Chen, Liang-Sien Chen, Liang-Sien Chen, Yu-Rui Chen, Yu-Rui Chen, Yi-Hsiu Lin, Yi-Hsiu Lin, Hung-Keng Wu, Hung-Keng Wu, Yan Wen Lee, Jau-Yuan Chen, Jau-Yuan Chen

    Published 2025-01-01
    “…Our study aimed to assess AIP), a ratio of triglycerides to high-density lipoprotein cholesterol, as a predictor of MetS.MethodBetween 2014 and 2018, our cross-sectional study collected and analyzed health examination data from 9,202 Northern Taiwan Medical Center employees without cardiovascular diseases, diabetes, and end-stage renal disease (ESRD). …”
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  3. 5183

    Cell-Based Therapies: Ferromagnetic Versus Superparamagnetic Cell Targeting by Tasneem Halhouli, Lisa Münchhalfen, Sarkawt Hamad, Larissa Schmitz-Ullrich, Frank Nitsche, Felix Gaedke, Astrid Schauss, Linlin Zhang, Quoc-Khanh Pham, Gang Bao, Kurt Paul Pfannkuche

    Published 2025-06-01
    “…Therefore, magnetic cell targeting can be discussed as a method for capturing superparamagnetic nanoparticle-labelled cells in the tissue. …”
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  4. 5184

    Did dingo control cause the elimination of kowaris through mesopredator release effects? A response to Wallach and O'Neill (2009) by B. L. Allen

    Published 2010-12-01
    “…As such, the study contributes little insight into the effect of dingo control on kowaris. The study sites, methods, and results presented in Wallach & O'Neill (2009) have also been used elsewhere (Wallach et al., 2009a, 2009b, 2010), and these criticisms equally apply to those reports, and others similar to them. …”
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  5. 5185

    The Impact of a 10% Tax Rate and Redistribution on Resource Concentration in Networks by Sarah Leutner, Illia Terpylo, Detlef Groth

    Published 2025-07-01
    “…Objectives This study investigates the effects of a 10% tax rate and redistribution on inequality and resource stability within two network models: the ‘Winner-Loser Model’ which intensifies hierarchies through competitive interactions, and the ‘Null Model’, simulating equal opportunity exchanges. Sample and Methods We used Monte Carlo simulations with agents starting at equal resource levels, interacting under the rules of each model. …”
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  6. 5186

    Evolution of treatment for children with esthesioneuroblastoma (1969–2019) by A. D. Rodina, A. S. Krylov, T. V. Gorbunova, V. A. Korolyov, O. A. Merkulov, N. V. Ivanova, V. G. Polyakov

    Published 2021-11-01
    “…The information on incidence, disease course, and treatment of esthesioneuroblastoma in children vary significantly and depend on the follow-up period and statistical methods.Objective – to assess risk factors for esthesioneuroblastoma and evaluate treatment strategies used in children and their prospects.Materials and methods. …”
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  7. 5187

    The effects of Baduanjin exercise on physical fitness and mental health of female college students by Xinmin Zhao, Kai Nan, Tongtong Xing

    Published 2024-06-01
    “…In the context of increasing stress and declining health among female college students, there is an urgent need for effective methods to enhance their physical and mental well-being. …”
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  8. 5188

    Expression pattern of Arc in the hippocampus of a rat model of epilepsy and depression comorbidity by Shiqian Yu, Hu Tuo, Baozhen Yao, Haiju Zhang, Fang Liu

    Published 2025-04-01
    “…Background: Two key factors associated with the comorbidity of epilepsy and depression (EAD), activity regulated cytoskeletal protein (Arc) and homer protein homolog 1 (Homer1), were previously identified by our group through bioinformatics methods (Yu et al., 2022). The expression of Arc and Homer1 were verified through animal experiments. …”
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  9. 5189

    The Impact of Stay-At-Home Mandates on Uncertainty and Sentiments: Quasi-Experimental Study by Carolina Biliotti, Nicolò Fraccaroli, Michelangelo Puliga, Falco J Bargagli-Stoffi, Massimo Riccaboni

    Published 2025-03-01
    “…Additionally, we applied dictionary-based methods to categorize tweets into 4 dimensions—economy, health, politics, and lockdown policy—to assess the corresponding emotional reactions. …”
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  10. 5190

    Evaluation of periodontal tissues condition in children with blood coagulability pathology by M. A. Gavrilenko

    Published 2013-12-01
    “…Hygiene index value was determined according to Fedorov and Volodkina, PMA index (papillary-marginal-alveolar index) was determined by standard methods. Visual presence of inflammation clinical signs and periodontal tissue condition was determined in each group. …”
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  11. 5191

    Transcriptome Sequencing Reveals the Molecular Mechanism of Heat Stroke-Induced Myocardial Injury by Xiang J, Shao S, Huang J, Yang N, Guo F, Tang B, Zhang L

    Published 2025-06-01
    “…Bioinformatics methods were used to analyze transcriptomics to reveal the pathophysiological mechanism of HS-induced myocardial injury. …”
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  12. 5192

    SOCIAL COMPETENCE FORMATION AMONG TEENAGERS FROM HUMANIST TREND MULTIPLE-AGED GROUPS by Larisa A. Krapivina

    Published 2015-06-01
    “…The paper studies the problems of social development of adolescents in multiple-aged groups (MAG).Methods. The methods involve socio-personal approach, consideration of the subject in a certain ideological humanistic orientation, comparative analysis, and comparison of historical facts, the study of social phenomena of different ages, long-term scientific observations, reflections, a retrospective analysis of personal experience.Results. …”
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  13. 5193

    Optimization of the defense forces personnel under mobilization conditions: The role of occupational selection as a personnel allocator by V. V. Kalnysh, A. V. Shvets

    Published 2024-12-01
    “… The purpose was to improve the conceptual model for optimization of occupational selection system in the defense forces during martial law. Materials and methods. Using the methods of systematic, bibliosemantic and retrospective analysis, scientific publications on the occupational psychophysiological selection of military personnel in special conditions have been studied. …”
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  14. 5194

    Innovations in modern low-LET radiotherapy regimens for locally advanced non-small cell lung cancer: a meta-analysis and systematic review of high-dose-rate brachytherapy, stereota... by Mingyu Tan, Lu Li, Bangxian Tan, Jinxin Yang

    Published 2025-05-01
    “…Abstract Background This study assesses recent treatments for locally advanced non-small cell lung cancer (LA-NSCLC) ineligible for surgery, comparing high-dose-rate (HDR) brachytherapy with conventional low linear energy transfer (LET) hypofractionated radiotherapy methods. Methods From 9435 papers, 8 meeting criteria were selected, covering 484 LA-NSCLC patients (2005–2019). …”
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  15. 5195

    Single-Cell Transcriptional Analysis Reveals the Mechanism of AZD6738 in HCC Immunotherapy via EZH2 Targeting by Li RP, Wu GZ, Fang XD, Yang WW, Zhang HY, Yue HX, Zheng Y, Wang YP, Zhou YN

    Published 2025-04-01
    “…Ren-peng Li,1– 3,* Guo-zhi Wu,1– 3,* Xi-dong Fang,1– 3,* Wen-wen Yang,1– 3 Hui-yun Zhang,1– 3 Han-xun Yue,1– 3 Ya Zheng,2,3 Yu-ping Wang,2,3 Yong-ning Zhou2,3 1The First Clinical Medical College, Lanzhou University, Lanzhou, People’s Republic of China; 2Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, People’s Republic of China; 3Gansu Province Clinical Research Center for Digestive Diseases, The First Hospital of Lanzhou University, Lanzhou, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yong-ning Zhou, Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, 730000, People’s Republic of China, Email zhouyn@lzu.edu.cn Yu-ping Wang, Department of Gastroenterology, The First Hospital of Lanzhou University, Lanzhou, Gansu, 730000, People’s Republic of China, Email wangyuping@lzu.edu.cnObjective: This study aims to identify specific molecular targets sensitive to AZD6738 through the integration of network pharmacology and transcriptomic methods, and to assess their potential role in the treatment of hepatocellular carcinoma (HCC). …”
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  16. 5196

    Barriers to and enablers of the early diagnosis of breast cancer among women from ethnic minority backgrounds in the UK: protocol for a qualitative evidence synthesis by Nia Roberts, Toral Gathani, Shoba Dawson, S Shepperd, Priya Sajjad, Bep Dhaliwal

    Published 2024-11-01
    “…Studies that use quantitative methodologies or collect data using qualitative methods but analysed quantitatively (eg, open-ended survey questions where free-text responses are analysed using descriptive statistics) will be excluded. …”
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  17. 5197

    Knowledge, Attitude and Practice towards Medical Research among Interns and Postgraduate Students of a Government Medical College: A Cross-sectional Study by Sukanya Badami, Vasundara S Gayakwad, Mahesh Baragundi, Srinivasa Arer

    Published 2025-04-01
    “…The latest information on skills of scientific principles and methods is essential for the conduct of research. …”
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  18. 5198

    The Safety and Effectiveness of Multi-Segment Cortical Bone Trajectory Screws in Adult Degenerative Scoliosis with Stenosis Among the Elderly: Minimum 5-year Follow-up Study by Wang J, Ding Z, Liu Y, Hai Y

    Published 2025-07-01
    “…Jie Wang,1,* Zihao Ding,1,* Yuzeng Liu,1 Yong Hai1– 4 1Department of Orthopedic Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, 100020, People’s Republic of China; 2Joint Laboratory for Research & Treatment of Spinal Cord Injury in Spinal Deformity, Capital Medical University, Beijing, 100069, People’s Republic of China; 3Laboratory for Clinical Medicine, Capital Medical University, Beijing, 100069, People’s Republic of China; 4Clinical Center for Spinal Deformity, Capital Medical University, Beijing, 100069, People’s Republic of China*These authors contributed equally to this workCorrespondence: Yuzeng Liu, Email beijingspine2010@163.com Yong Hai, Email yong.hai@ccmu.edu.cnPurpose: To evaluate the long-term efficacy and safety of multi-segment cortical bone trajectory screws for treating mild adult degenerative scoliosis with stenosis among the elderly.Patients and Methods: From January 2018 to December 2019, a total of 41 patients of mild adult degenerative scoliosis with stenosis underwent posterior lumbar decompression, bone graft fusion, and internal fixation, which were retrospectively divided into pedicle screw (PS) group and cortical bone trajectory (CBT) screw group according to different internal fixation methods. …”
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  19. 5199

    Recurrent Rhegmatogenous Retinal Detachment: Characteristics, Risk Factors, and Outcomes by Aleshawi A, Al-Dwairi R, Saleh OA, Adi S, Al Beiruti S, Alasheh A, Alsaadi MA, Ouda ZH, Allouh MZ

    Published 2025-04-01
    “…Using proper statistical methods, the results were generated.Results: The study comprised 348 patients with primary RRD, of whom 44.5% had a previous ocular surgical history. …”
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  20. 5200

    Implementation and Strategy in Developmental Care Practice in Infants with Congenital Heart Disease in Intensive Care Unit: Scoping Review by Rhamelani P, Rakhmawati W

    Published 2025-05-01
    “…The strategies in implementing the intervention include aspects of health workers (experience, training, and licensing); aspects of intervention protocols; and aspects of intervention methods and models (socialization, strict supervision, and the Plan-Do-Study-Act (PDSA) model). …”
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